BRPI0607372A2 - medicamento destinado à administração oral, compreendendo um inibidor da ciclooxigenase-2, e método de preparação do mesmo - Google Patents
medicamento destinado à administração oral, compreendendo um inibidor da ciclooxigenase-2, e método de preparação do mesmoInfo
- Publication number
- BRPI0607372A2 BRPI0607372A2 BRPI0607372-7A BRPI0607372A BRPI0607372A2 BR PI0607372 A2 BRPI0607372 A2 BR PI0607372A2 BR PI0607372 A BRPI0607372 A BR PI0607372A BR PI0607372 A2 BRPI0607372 A2 BR PI0607372A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitor
- agglomerate
- cyclooxygenase
- medicament
- oral administration
- Prior art date
Links
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 4
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000002245 particle Substances 0.000 abstract 4
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 238000005507 spraying Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
MEDICAMENTO DESTINADO à ADMINISTRAçãO ORAL, COMPREENDENDO UM INIBIDOR DA CICLOOXIGENASE-2, E MéTODO DE PREPARAçãO DO MESMO. A presente invenção refere-se a um medicamento destinado a administração oral, que compreende um inibidor da ciclooxigenase-2 e que tem melhor biodisponibilidade, e a um método de preparação do dito medicamento. O medicamento da invenção compreende um aglomerado à base de partículas sólidas inertes à base de pelo menos um excipiente, o dito aglomerado compreendendo um inibidor da ciclooxigenase-2 e pelo menos um polímero hidrofílico. De acordo com a invenção, o aglomerado compreende uma pulverização que é aplicada às partículas acima mencionadas, consistindo em uma solução ou suspensão de grãos micronizados do inibidor no(s) dito(s) polímero(s), para aglomerar as ditas partículas. O método da invenção compreende essencialmente as seguintes etapas, a saber, (i) a preparação de um líquido pulverizável à base dos grãos micronizados do dito inibidor em solução ou em suspensão em pelo menos um polímero hidrofilico, e (ii) a pulverização do liquido sobre as partículas sólidas, para obter o aglomerado por meio de granulação a úmido, o dito aglomerado compreendendo a pulverização de solução ou suspensão de grãos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0500708A FR2881049B1 (fr) | 2005-01-24 | 2005-01-24 | Medicament destine a etre administre par voie orale comprenant un inhibiteur de la cyclo-oxygenase-2, et son procede de preparation |
| FR0500708 | 2005-01-24 | ||
| PCT/FR2006/000144 WO2006077334A2 (fr) | 2005-01-24 | 2006-01-23 | Medicament destine a etre administre par voie orale comprenant un inhibiteur de la cyclo-oxygenase-2, et son procede de preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0607372A2 true BRPI0607372A2 (pt) | 2009-09-01 |
| BRPI0607372B1 BRPI0607372B1 (pt) | 2019-04-30 |
| BRPI0607372B8 BRPI0607372B8 (pt) | 2021-05-25 |
Family
ID=34954944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607372A BRPI0607372B8 (pt) | 2005-01-24 | 2006-01-23 | medicamento destinado à administração oral, compreendendo um inibidor da ciclooxigenase-2, e método de preparação do mesmo |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080213376A1 (pt) |
| EP (1) | EP1845959B1 (pt) |
| JP (1) | JP5106119B2 (pt) |
| KR (2) | KR20080007543A (pt) |
| CN (1) | CN101119712B (pt) |
| AU (1) | AU2006207396B2 (pt) |
| BR (1) | BRPI0607372B8 (pt) |
| CA (1) | CA2595496C (pt) |
| FR (1) | FR2881049B1 (pt) |
| IL (1) | IL184759A (pt) |
| MX (1) | MX2007008878A (pt) |
| NZ (1) | NZ556707A (pt) |
| PL (1) | PL1845959T3 (pt) |
| RU (1) | RU2391099C2 (pt) |
| UA (1) | UA93868C2 (pt) |
| WO (1) | WO2006077334A2 (pt) |
| ZA (1) | ZA200705996B (pt) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU670567B2 (en) * | 1992-03-05 | 1996-07-25 | American Home Products Corporation | Pharmaceutical coated cores |
| AR024222A1 (es) * | 1998-10-16 | 2002-09-25 | Palau Pharma Sa | Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen |
| AU784572B2 (en) * | 1999-12-08 | 2006-05-04 | Pharmacia Corporation | Solid-state form of celecoxib having enhanced bioavailability |
| KR100717549B1 (ko) * | 1999-12-22 | 2007-05-11 | 파마시아 코포레이션 | 시클로옥시게나제-2 억제제의 이중-방출 조성물 |
| IL150352A0 (en) * | 1999-12-22 | 2002-12-01 | Pharmacia Corp | Sustained-release formulation of a cyclooxygenase-2 inhibitor |
| AU2002221273A1 (en) * | 2000-10-26 | 2002-05-06 | Atul M. Mehta | Delayed and sustained release formulations and method of use thereof |
-
2005
- 2005-01-24 FR FR0500708A patent/FR2881049B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-23 EP EP06709146.2A patent/EP1845959B1/fr not_active Not-in-force
- 2006-01-23 BR BRPI0607372A patent/BRPI0607372B8/pt not_active IP Right Cessation
- 2006-01-23 AU AU2006207396A patent/AU2006207396B2/en not_active Ceased
- 2006-01-23 KR KR1020077019460A patent/KR20080007543A/ko not_active Application Discontinuation
- 2006-01-23 JP JP2007551709A patent/JP5106119B2/ja not_active Expired - Fee Related
- 2006-01-23 UA UAA200709319A patent/UA93868C2/ru unknown
- 2006-01-23 MX MX2007008878A patent/MX2007008878A/es active IP Right Grant
- 2006-01-23 NZ NZ556707A patent/NZ556707A/en not_active IP Right Cessation
- 2006-01-23 WO PCT/FR2006/000144 patent/WO2006077334A2/fr active Application Filing
- 2006-01-23 US US11/814,626 patent/US20080213376A1/en not_active Abandoned
- 2006-01-23 PL PL06709146T patent/PL1845959T3/pl unknown
- 2006-01-23 CA CA2595496A patent/CA2595496C/fr not_active Expired - Fee Related
- 2006-01-23 CN CN2006800050019A patent/CN101119712B/zh not_active Expired - Fee Related
- 2006-01-23 RU RU2007132017/15A patent/RU2391099C2/ru active
- 2006-01-23 KR KR1020137028765A patent/KR20130128019A/ko not_active Application Discontinuation
-
2007
- 2007-07-17 ZA ZA200705996A patent/ZA200705996B/xx unknown
- 2007-07-22 IL IL184759A patent/IL184759A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2881049B1 (fr) | 2008-12-26 |
| JP5106119B2 (ja) | 2012-12-26 |
| US20080213376A1 (en) | 2008-09-04 |
| KR20080007543A (ko) | 2008-01-22 |
| RU2007132017A (ru) | 2009-02-27 |
| CA2595496C (fr) | 2014-06-03 |
| CN101119712A (zh) | 2008-02-06 |
| BRPI0607372B1 (pt) | 2019-04-30 |
| RU2391099C2 (ru) | 2010-06-10 |
| PL1845959T3 (pl) | 2015-10-30 |
| IL184759A (en) | 2012-10-31 |
| ZA200705996B (en) | 2009-03-25 |
| WO2006077334A3 (fr) | 2007-04-12 |
| EP1845959B1 (fr) | 2015-04-15 |
| KR20130128019A (ko) | 2013-11-25 |
| FR2881049A1 (fr) | 2006-07-28 |
| CN101119712B (zh) | 2013-05-01 |
| AU2006207396B2 (en) | 2011-05-19 |
| JP2008528462A (ja) | 2008-07-31 |
| EP1845959A2 (fr) | 2007-10-24 |
| CA2595496A1 (fr) | 2006-07-27 |
| UA93868C2 (ru) | 2011-03-25 |
| MX2007008878A (es) | 2007-10-11 |
| BRPI0607372B8 (pt) | 2021-05-25 |
| WO2006077334A2 (fr) | 2006-07-27 |
| AU2006207396A1 (en) | 2006-07-27 |
| NZ556707A (en) | 2010-05-28 |
| IL184759A0 (en) | 2007-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/01/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2758 DE 14-11-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |