MX2012001298A - Acido r-7-(3-aminometil-4-metoxiimino-3-metil-pirrolidin-1-il)-1-c iclopropil-6-fluoro-4-oxo-1,4-dihidro-[1,8]naftiridin-3-carboxili co y sal de acido l-aspartico, proceso para la preparacion de los mismos y composicion farmaceutica que comprende los mismos para antimicrobiano. - Google Patents

Acido r-7-(3-aminometil-4-metoxiimino-3-metil-pirrolidin-1-il)-1-c iclopropil-6-fluoro-4-oxo-1,4-dihidro-[1,8]naftiridin-3-carboxili co y sal de acido l-aspartico, proceso para la preparacion de los mismos y composicion farmaceutica que comprende los mismos para antimicrobiano.

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Publication number
MX2012001298A
MX2012001298A MX2012001298A MX2012001298A MX2012001298A MX 2012001298 A MX2012001298 A MX 2012001298A MX 2012001298 A MX2012001298 A MX 2012001298A MX 2012001298 A MX2012001298 A MX 2012001298A MX 2012001298 A MX2012001298 A MX 2012001298A
Authority
MX
Mexico
Prior art keywords
yclopropyl
methoxyimino
naphthyridine
pyrrolidin
aminomethyl
Prior art date
Application number
MX2012001298A
Other languages
English (en)
Inventor
Jei Man Ryu
Dong Rack Choi
Jin Yang
Sue Hye Yoon
Seung Hwan Kim
Sung Jae Pyun
Seung-Kyoo Seong
Original Assignee
Arimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arimed Inc filed Critical Arimed Inc
Publication of MX2012001298A publication Critical patent/MX2012001298A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a ácido R-7-(3-aminometil-4-metox iimino-3-metil-pirrolidin-1-il)-1-ciclopropil-6-fluoro-4-oxo-1,4- dihidro-[1,8] naftiridin-3-carboxílico y sal de ácido L-aspártico, procesos para la preparación de los mismos y composiciones farmacéuticas que comprenden los mismos para antimicrobianos. Debido a que el ácido R-7-(3-aminometil-4-metoxii mino-3-metil-pirrolidin1-il)-1-ciclopropil-6-fluoro-4-oxo-1,4-dih idro-[l,8]naftiridin-3-carboxílico y sal de ácido L-aspártico es más soluble y menos tóxico y tiene menos efectos secundarios como un agente antimicrobiano que el clorhidrato y las otras sales (D-aspartato y fosfato) convencionalmente usadas, la sal puede ser útil para administración oral e inyectable.
MX2012001298A 2009-07-27 2010-07-27 Acido r-7-(3-aminometil-4-metoxiimino-3-metil-pirrolidin-1-il)-1-c iclopropil-6-fluoro-4-oxo-1,4-dihidro-[1,8]naftiridin-3-carboxili co y sal de acido l-aspartico, proceso para la preparacion de los mismos y composicion farmaceutica que comprende los mismos para antimicrobiano. MX2012001298A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090068396A KR101468659B1 (ko) 2009-07-27 2009-07-27 Ｒ-7-(3-아미노메틸-4-메톡시이미노-3-메틸-피롤리딘-1-일)-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1,8]나프티리딘-3-카르복실산 ｌ-아스파르트산염, 이의 제조방법 및 이를 포함하는 항균용 약학적 조성물
PCT/KR2010/004938 WO2011013992A2 (en) 2009-07-27 2010-07-27 R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and l-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial

Publications (1)

Publication Number Publication Date
MX2012001298A true MX2012001298A (es) 2012-02-28

Family

ID=43529859

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001298A MX2012001298A (es) 2009-07-27 2010-07-27 Acido r-7-(3-aminometil-4-metoxiimino-3-metil-pirrolidin-1-il)-1-c iclopropil-6-fluoro-4-oxo-1,4-dihidro-[1,8]naftiridin-3-carboxili co y sal de acido l-aspartico, proceso para la preparacion de los mismos y composicion farmaceutica que comprende los mismos para antimicrobiano.

Country Status (10)

Country Link
US (5) US8664240B2 (es)
EP (1) EP2459550B1 (es)
JP (1) JP5357335B2 (es)
KR (1) KR101468659B1 (es)
CN (1) CN102574840B (es)
AU (1) AU2010277947B2 (es)
BR (1) BR112012001897A2 (es)
CA (1) CA2768290C (es)
MX (1) MX2012001298A (es)
WO (1) WO2011013992A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101468659B1 (ko) 2009-07-27 2014-12-05 주식회사 아리바이오 Ｒ-7-(3-아미노메틸-4-메톡시이미노-3-메틸-피롤리딘-1-일)-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1,8]나프티리딘-3-카르복실산 ｌ-아스파르트산염, 이의 제조방법 및 이를 포함하는 항균용 약학적 조성물
US10573202B2 (en) * 2016-09-09 2020-02-25 R.R. Donnelley & Sons Company Self-erectable display with free floating stop and method for forming the same

Family Cites Families (7)

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ZA824096B (en) * 1981-06-11 1983-04-27 Warner Lambert Co Salts of antimicrobial naphthyridine and quinoline compounds
KR0174373B1 (ko) 1995-08-03 1999-02-18 성재갑 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
ES2296618T3 (es) * 1999-05-20 2008-05-01 Dong Wha Pharmaceutical Industrial Co. Ltd. Derivados opticamente activos de acidos quinolin-carboxilicos que tienen sustituyentes de 7-pirrolidina que provocan actividad optica y un procedimiento para la preparacion de estos.
KR20010029698A (ko) * 1999-05-20 2001-04-06 황규언 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
CN101679416B (zh) * 2007-04-13 2012-06-27 同和药品株式会社 1-环丙基-6-氟代-7-(8-甲氧基亚氨基-2,6-二氮杂-螺环[3,4]辛-6-基)-4-氧代-1,4-二氢-[1,8]萘啶-3-羧酸的天冬氨酸盐、其制备方法、以及包含其的抗微生物药物组合物
US7767860B2 (en) * 2007-09-06 2010-08-03 Auspex Pharmaceuticals, Inc Substituted amino alcohols
KR101468659B1 (ko) 2009-07-27 2014-12-05 주식회사 아리바이오 Ｒ-7-(3-아미노메틸-4-메톡시이미노-3-메틸-피롤리딘-1-일)-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1,8]나프티리딘-3-카르복실산 ｌ-아스파르트산염, 이의 제조방법 및 이를 포함하는 항균용 약학적 조성물

Also Published As

Publication number Publication date
AU2010277947A1 (en) 2012-02-02
US20140128610A1 (en) 2014-05-08
KR101468659B1 (ko) 2014-12-05
EP2459550A2 (en) 2012-06-06
US20120130075A1 (en) 2012-05-24
JP2013500251A (ja) 2013-01-07
US20150105558A1 (en) 2015-04-16
JP5357335B2 (ja) 2013-12-04
CA2768290A1 (en) 2011-02-03
US9452158B2 (en) 2016-09-27
KR20110010988A (ko) 2011-02-08
CN102574840A (zh) 2012-07-11
US20150374674A1 (en) 2015-12-31
EP2459550B1 (en) 2013-10-09
CN102574840B (zh) 2014-05-28
BR112012001897A2 (pt) 2016-03-15
US8664240B2 (en) 2014-03-04
US9751840B2 (en) 2017-09-05
EP2459550A4 (en) 2013-01-02
WO2011013992A3 (en) 2011-06-30
US9150576B2 (en) 2015-10-06
AU2010277947B2 (en) 2013-05-16
WO2011013992A2 (en) 2011-02-03
CA2768290C (en) 2014-05-06
US8952164B2 (en) 2015-02-10
US20160362377A1 (en) 2016-12-15

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