WO2007100758A3 - Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same - Google Patents

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same Download PDF

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Publication number
WO2007100758A3
WO2007100758A3 PCT/US2007/004912 US2007004912W WO2007100758A3 WO 2007100758 A3 WO2007100758 A3 WO 2007100758A3 US 2007004912 W US2007004912 W US 2007004912W WO 2007100758 A3 WO2007100758 A3 WO 2007100758A3
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WIPO (PCT)
Prior art keywords
pharmaceutical compositions
ion
methods
same
amide derivatives
Prior art date
Application number
PCT/US2007/004912
Other languages
French (fr)
Other versions
WO2007100758A2 (en
Inventor
Michael G Kelly
Carl J Kaub
John Kincaid
Satyanarayana Janagani
Guoxian Wu
Zhi-Liang Wei
Kiran Sahasrabudhe
Matthew Duncton
Ravindra B Upasani
Yunfeng Fang
Matthew Cox
Original Assignee
Renovis Inc
Michael G Kelly
Carl J Kaub
John Kincaid
Satyanarayana Janagani
Guoxian Wu
Zhi-Liang Wei
Kiran Sahasrabudhe
Matthew Duncton
Ravindra B Upasani
Yunfeng Fang
Matthew Cox
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008556465A priority Critical patent/JP2009527575A/en
Priority to AP2008004620A priority patent/AP2008004620A0/en
Priority to AU2007221118A priority patent/AU2007221118A1/en
Priority to EP07751654A priority patent/EP1954132A4/en
Priority to EA200870287A priority patent/EA200870287A1/en
Priority to US12/224,357 priority patent/US20100004222A1/en
Priority to CA002641781A priority patent/CA2641781A1/en
Priority to GB0814753A priority patent/GB2452142A/en
Application filed by Renovis Inc, Michael G Kelly, Carl J Kaub, John Kincaid, Satyanarayana Janagani, Guoxian Wu, Zhi-Liang Wei, Kiran Sahasrabudhe, Matthew Duncton, Ravindra B Upasani, Yunfeng Fang, Matthew Cox filed Critical Renovis Inc
Priority to BRPI0710080-9A priority patent/BRPI0710080A2/en
Publication of WO2007100758A2 publication Critical patent/WO2007100758A2/en
Publication of WO2007100758A3 publication Critical patent/WO2007100758A3/en
Priority to IL193346A priority patent/IL193346A0/en
Priority to TNP2008000328A priority patent/TNSN08328A1/en
Priority to NO20083898A priority patent/NO20083898L/en

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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
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    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D498/04—Ortho-condensed systems

Abstract

Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
PCT/US2007/004912 2005-02-28 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same WO2007100758A2 (en)

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CA002641781A CA2641781A1 (en) 2006-02-23 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
AU2007221118A AU2007221118A1 (en) 2005-02-28 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP07751654A EP1954132A4 (en) 2005-02-28 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EA200870287A EA200870287A1 (en) 2006-02-23 2007-02-22 AMIDIC DERIVATIVES AS THE LIGANDS OF IONAL CHANNELS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF THEIR APPLICATION
US12/224,357 US20100004222A1 (en) 2006-02-23 2007-02-22 Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
JP2008556465A JP2009527575A (en) 2006-02-23 2007-02-22 Amide derivatives and pharmaceutical compositions as ion channel ligands and methods of using them
GB0814753A GB2452142A (en) 2006-02-23 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
AP2008004620A AP2008004620A0 (en) 2006-02-23 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
BRPI0710080-9A BRPI0710080A2 (en) 2006-02-23 2007-02-22 compound, pharmaceutical composition, methods for preventing, treating, ameliorating or controlling a disease or condition, for preparing a compound and for treating a mammal, use of a compound or a pharmaceutically acceptable salt, solvate or composition thereof, and, combination
IL193346A IL193346A0 (en) 2006-02-23 2008-08-10 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
TNP2008000328A TNSN08328A1 (en) 2006-02-23 2008-08-11 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
NO20083898A NO20083898L (en) 2006-02-23 2008-09-11 Amide derivatives such as ion channel ligands and pharmaceutical compositions and methods for their use

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US65698405P 2005-02-28 2005-02-28
US71044505P 2005-08-23 2005-08-23
US77603306P 2006-02-23 2006-02-23
US77610606P 2006-02-23 2006-02-23
US77594906P 2006-02-23 2006-02-23
US77605706P 2006-02-23 2006-02-23
US77610506P 2006-02-23 2006-02-23
US77605606P 2006-02-23 2006-02-23
US77593006P 2006-02-23 2006-02-23
US77606406P 2006-02-23 2006-02-23
US77594506P 2006-02-23 2006-02-23
US77605806P 2006-02-23 2006-02-23
US60/776,058 2006-02-23
US60/776,057 2006-02-23
US60/776,056 2006-02-23
US60/775,949 2006-02-23
US60/776,105 2006-02-23
US60/776,106 2006-02-23
US60/776,033 2006-02-23
US60/776,064 2006-02-23
US60/775,945 2006-02-23
US60/775,930 2006-02-23
US83999406P 2006-08-24 2006-08-24
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KR20070119655A (en) * 2005-02-28 2007-12-20 레노비스, 인크. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
CA2680177A1 (en) 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
CN101795689B (en) * 2007-06-03 2014-11-19 范德比尔特大学 Benzamide mGluR5 positive allosteric modulators and methods of making and using same
WO2009064449A1 (en) * 2007-11-13 2009-05-22 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
NZ586082A (en) * 2007-11-16 2013-03-28 Neuraxon Inc Indole compounds and methods for treating visceral pain
FR2933977B1 (en) * 2008-07-18 2013-04-26 Centre Nat Rech Scient HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
US8809380B2 (en) 2009-08-04 2014-08-19 Raqualia Pharma Inc. Picolinamide derivatives as TTX-S blockers
US20140113824A1 (en) 2011-05-10 2014-04-24 Bayer Intellectual Property Gmbh Bicyclic (thio)carbonylamidines
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AP2007004119A0 (en) 2007-08-31
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