WO2008013987A3 - N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones - Google Patents

N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones Download PDF

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Publication number
WO2008013987A3
WO2008013987A3 PCT/US2007/016996 US2007016996W WO2008013987A3 WO 2008013987 A3 WO2008013987 A3 WO 2008013987A3 US 2007016996 W US2007016996 W US 2007016996W WO 2008013987 A3 WO2008013987 A3 WO 2008013987A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperazinylmethylquinazolinones
azepanylmethylquinazolinones
compounds
alkyl substituted
cancer
Prior art date
Application number
PCT/US2007/016996
Other languages
French (fr)
Other versions
WO2008013987A2 (en
Inventor
Michael Pierce
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Raj Gopal Venkat
Original Assignee
Prolexys Pharmaceuticals Inc
Michael Pierce
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Raj Gopal Venkat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolexys Pharmaceuticals Inc, Michael Pierce, Longwu Qi, Paul B Robbins, Sudhir R Sahasrabudhe, Robert Selliah, Raj Gopal Venkat filed Critical Prolexys Pharmaceuticals Inc
Publication of WO2008013987A2 publication Critical patent/WO2008013987A2/en
Publication of WO2008013987A3 publication Critical patent/WO2008013987A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Compounds represented by Structural Formula (I) : are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
PCT/US2007/016996 2006-07-27 2007-07-27 N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones WO2008013987A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83402706P 2006-07-27 2006-07-27
US60/834,027 2006-07-27

Publications (2)

Publication Number Publication Date
WO2008013987A2 WO2008013987A2 (en) 2008-01-31
WO2008013987A3 true WO2008013987A3 (en) 2008-10-30

Family

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Application Number Title Priority Date Filing Date
PCT/US2007/016996 WO2008013987A2 (en) 2006-07-27 2007-07-27 N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones

Country Status (1)

Country Link
WO (1) WO2008013987A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255108B2 (en) 2012-04-10 2016-02-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9359365B2 (en) 2013-10-04 2016-06-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

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US20110123486A1 (en) * 2007-06-25 2011-05-26 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
CN102391287B (en) * 2011-09-28 2013-11-06 河南省健康伟业生物医药研究股份有限公司 Levo-fluoroquinolone C3 bisazole methyl sulfide, preparation method and application thereof
CN102443011B (en) * 2011-09-28 2013-09-25 河南大学 Levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt, preparation method and application thereof
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6701088B2 (en) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
CN106459011B (en) 2014-04-01 2019-11-15 华盛顿大学 σ -2 receptors ligand drug conjugate, its preparation method and use as antitumoral compounds
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
KR20180058741A (en) 2015-09-14 2018-06-01 인피니티 파마슈티칼스, 인코포레이티드 Solid form of isoquinolines, a process for their preparation, compositions comprising them and methods for using them
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TW201815787A (en) 2016-09-23 2018-05-01 美商基利科學股份有限公司 Phosphatidylinositol 3-kinase inhibitors
TW201813963A (en) 2016-09-23 2018-04-16 美商基利科學股份有限公司 Phosphatidylinositol 3-kinase inhibitors
TW201825465A (en) 2016-09-23 2018-07-16 美商基利科學股份有限公司 Phosphatidylinositol 3-kinase inhibitors
DE102017117369A1 (en) 2017-08-01 2019-02-07 Gustav Klauke Gmbh Building with a metallic, electrically conductive pipe and laid in such a pipe electrical line and metallic, electrically conductive pipe for this purpose
EP3806848A2 (en) 2018-06-15 2021-04-21 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly

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Patent Citations (5)

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WO2004018058A2 (en) * 2002-08-21 2004-03-04 Cytokinetics, Inc. Compounds, compositions, and methods
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255108B2 (en) 2012-04-10 2016-02-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9359365B2 (en) 2013-10-04 2016-06-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

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