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WO2008013987A3 - N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones - Google Patents

N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones

Info

Publication number
WO2008013987A3
WO2008013987A3 PCT/US2007/016996 US2007016996W WO2008013987A3 WO 2008013987 A3 WO2008013987 A3 WO 2008013987A3 US 2007016996 W US2007016996 W US 2007016996W WO 2008013987 A3 WO2008013987 A3 WO 2008013987A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
compounds
cancer
addition
piperazinylmethylquinazolinones
compositions
Prior art date
Application number
PCT/US2007/016996
Other languages
French (fr)
Other versions
WO2008013987A2 (en )
Inventor
Michael Pierce
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Raj Gopal Venkat
Original Assignee
Michael Pierce
Prolexys Pharmaceuticals Inc
Longwu Qi
Paul B Robbins
Sudhir R Sahasrabudhe
Robert Selliah
Raj Gopal Venkat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Compounds represented by Structural Formula (I) : are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
PCT/US2007/016996 2006-07-27 2007-07-27 N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones WO2008013987A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US83402706 true 2006-07-27 2006-07-27
US60/834,027 2006-07-27

Publications (2)

Publication Number Publication Date
WO2008013987A2 true WO2008013987A2 (en) 2008-01-31
WO2008013987A3 true true WO2008013987A3 (en) 2008-10-30

Family

ID=38951450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016996 WO2008013987A3 (en) 2006-07-27 2007-07-27 N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones

Country Status (1)

Country Link
WO (1) WO2008013987A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255108B2 (en) 2012-04-10 2016-02-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9359365B2 (en) 2013-10-04 2016-06-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009002553A1 (en) * 2007-06-25 2008-12-31 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
CN102391287B (en) * 2011-09-28 2013-11-06 河南省健康伟业生物医药研究股份有限公司 Levo-fluoroquinolone C3 bisazole methyl sulfide, preparation method and application thereof
CN102443011B (en) * 2011-09-28 2013-09-25 河南大学 Levorotatory fluoroquinolone C3 diazole methyl sulfide quaternary ammonium salt, preparation method and application thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018058A2 (en) * 2002-08-21 2004-03-04 Cytokinetics, Inc. Compounds, compositions, and methods
US20040248221A1 (en) * 2003-01-29 2004-12-09 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
WO2006081331A2 (en) * 2005-01-25 2006-08-03 Prolexys Pharmaceuticals, Inc. Quinoxaline derivatives as antitumor agents
WO2006081337A2 (en) * 2005-01-25 2006-08-03 Whitehead Institute For Biomedical Research Erastin analogues and their uses for killing cancer cells
WO2007076087A2 (en) * 2005-12-22 2007-07-05 Prolexys Pharmaceuticals, Inc. 3-aryl-substituted quinazolones, and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018058A2 (en) * 2002-08-21 2004-03-04 Cytokinetics, Inc. Compounds, compositions, and methods
US20040248221A1 (en) * 2003-01-29 2004-12-09 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
WO2006081331A2 (en) * 2005-01-25 2006-08-03 Prolexys Pharmaceuticals, Inc. Quinoxaline derivatives as antitumor agents
WO2006081337A2 (en) * 2005-01-25 2006-08-03 Whitehead Institute For Biomedical Research Erastin analogues and their uses for killing cancer cells
WO2007076087A2 (en) * 2005-12-22 2007-07-05 Prolexys Pharmaceuticals, Inc. 3-aryl-substituted quinazolones, and uses thereof

Non-Patent Citations (13)

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Title
ABDEL-ALIM A-A M ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 6-BROMO-2,3-DISUBSTITUTED-4-(3 H)-QUINAZOLINONES", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC, INCL.MEDICINAL, PUBLICATIONS & INFORMATIONS DIRECTORATE, NEW DELHI, vol. 33B, 1 March 1994 (1994-03-01), pages 260 - 265, XP008066973, ISSN: 0019-5103 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466896 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466897 *
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DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466899 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466900 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466902 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY LTD.: "CHEMICAL LIBRARY", XP002466903 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 29 May 2006 (2006-05-29), MICROCHEMISTRY: "CHEMICAL LIBRARY", XP002466901 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 8 August 2004 (2004-08-08), AMBINTER: "CHEMICAL LIBRARY", XP002466904 *
DATABASE REGISTRY CHEMICAL ABSTRACTS, COLUMBUS, OHIO; 8 August 2004 (2004-08-08), AMBINTER: "CHEMICAL LIBRARY", XP002466905 *
DOLMA S ET AL: "Identification of genotype-selective antitumor agnets using synthetic lethal chemical screening in engineered human tumor cells", CANCER CELL, XX, US, vol. 3, 2003, pages 285 - 296, XP002392895, ISSN: 1535-6108 *
TANI J ET AL: "STUDIES ON BIOLOGICALLY ACTIVE HALOGENATED COMPOUNDS. ÖII. CHEMICAL MODIFICATIONS OF 6-AMINO-2-FLUOROMETHYL-3-(O-TOLY)-4(3H)-QUINAZOLINONE AND THE CNS DEPRESSANT ACTIVITIES OF RELATED COMPOUNDS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, vol. 27, no. 11, 1 November 1979 (1979-11-01), pages 2675 - 2687, XP000608776, ISSN: 0009-2363 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255108B2 (en) 2012-04-10 2016-02-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9359365B2 (en) 2013-10-04 2016-06-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

Also Published As

Publication number Publication date Type
WO2008013987A2 (en) 2008-01-31 application

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