ES2168855T3 - Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion. - Google Patents

Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion.

Info

Publication number
ES2168855T3
ES2168855T3 ES99910199T ES99910199T ES2168855T3 ES 2168855 T3 ES2168855 T3 ES 2168855T3 ES 99910199 T ES99910199 T ES 99910199T ES 99910199 T ES99910199 T ES 99910199T ES 2168855 T3 ES2168855 T3 ES 2168855T3
Authority
ES
Spain
Prior art keywords
extrusion
pharmaceutical compositions
spheroidization
polymer microparticles
microparticles obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99910199T
Other languages
English (en)
Inventor
Fabio Carli
Massimo Bresciani
Tiziana Canal
Paolo Gambini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Eurand International SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA filed Critical Eurand International SpA
Application granted granted Critical
Publication of ES2168855T3 publication Critical patent/ES2168855T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Procedimiento para la preparación de composiciones farmacéuticas en forma de micropartículas poliméricas, que comprende: a) la preparación de una mezcla homogénea de sustancias en forma de polvo a la que se añade un líquido hasta obtener una consistencia pastosa; b) la extrusión de la mezcla de la etapa a) mediante una malla perforada para obtener filamentos cilíndricos; c) la esferoidización de los filamentos cilíndricos de la etapa b) para obtener micropartículas en forma esférica, d) el secado de las micropartículas de la etapa c), e) opcionalmente el fármaco se deposita sobre la superficie de la micropartículas, caracterizado porque dicha mezcla de sustancias en forma de polvo consiste en uno o más polímeros anfífilos reticulados y opcionalmente en uno o más fármacos, excipientes, una sustancia bioadhesiva y/o una sustancia que tenga una densidad elevada.
ES99910199T 1998-02-06 1999-02-05 Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion. Expired - Lifetime ES2168855T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione

Publications (1)

Publication Number Publication Date
ES2168855T3 true ES2168855T3 (es) 2002-06-16

Family

ID=11378855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99910199T Expired - Lifetime ES2168855T3 (es) 1998-02-06 1999-02-05 Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion.

Country Status (15)

Country Link
US (1) US6355273B1 (es)
EP (1) EP1051158B1 (es)
JP (1) JP2002502809A (es)
KR (1) KR20010040727A (es)
AT (1) ATE209905T1 (es)
AU (1) AU738029B2 (es)
BR (1) BR9907682A (es)
CA (1) CA2319463A1 (es)
DE (1) DE69900544T2 (es)
DK (1) DK1051158T3 (es)
ES (1) ES2168855T3 (es)
IT (1) IT1298574B1 (es)
NZ (1) NZ506639A (es)
PT (1) PT1051158E (es)
WO (1) WO1999039692A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024380A1 (en) * 1998-10-27 2000-05-04 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
ES2295379T3 (es) * 2001-06-29 2008-04-16 Eurand Pharmaceuticals Ltd. Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
US6572889B1 (en) * 2002-03-07 2003-06-03 Noveon Ip Holdings Corp. Controlled release solid dosage carbamazepine formulations
WO2003077886A1 (fr) * 2002-03-20 2003-09-25 Hosokawa Micron Corporation Procede de fabrication de particules composites contenant un produit chimique
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
DK1539101T3 (da) * 2002-07-31 2009-04-27 Alza Corp Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf
JP2007515464A (ja) * 2003-12-23 2007-06-14 テムレル・リミテッド 医薬組成物用ペレットの製造方法
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
RU2549450C2 (ru) * 2008-12-05 2015-04-27 Байер Интеллектуэль Проперти Гмбх Экструдаты с игловидными действующими веществами
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
ES2882639T3 (es) * 2017-12-28 2021-12-02 Imerys Usa Inc Copolímeros anfifílicos como modificadores de superficie para la producción de polvos de carbonato de calcio mejorados
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
DE69530973T2 (de) * 1994-02-16 2004-05-19 Abbott Laboratories, Abbott Park Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen
DE19504831A1 (de) * 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose

Also Published As

Publication number Publication date
DE69900544D1 (de) 2002-01-17
KR20010040727A (ko) 2001-05-15
EP1051158B1 (en) 2001-12-05
CA2319463A1 (en) 1999-08-12
ITMI980233A1 (it) 1999-08-06
WO1999039692A2 (en) 1999-08-12
ATE209905T1 (de) 2001-12-15
NZ506639A (en) 2003-05-30
US6355273B1 (en) 2002-03-12
AU2925199A (en) 1999-08-23
AU738029B2 (en) 2001-09-06
JP2002502809A (ja) 2002-01-29
EP1051158A2 (en) 2000-11-15
DE69900544T2 (de) 2002-08-22
BR9907682A (pt) 2000-11-14
IT1298574B1 (it) 2000-01-12
DK1051158T3 (da) 2002-04-02
PT1051158E (pt) 2002-05-31
WO1999039692A3 (en) 1999-09-23

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