DE69900544D1 - Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen - Google Patents

Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen

Info

Publication number
DE69900544D1
DE69900544D1 DE69900544T DE69900544T DE69900544D1 DE 69900544 D1 DE69900544 D1 DE 69900544D1 DE 69900544 T DE69900544 T DE 69900544T DE 69900544 T DE69900544 T DE 69900544T DE 69900544 D1 DE69900544 D1 DE 69900544D1
Authority
DE
Germany
Prior art keywords
extrusion
pharmaceutical compositions
balls
formation
polymeric microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69900544T
Other languages
English (en)
Other versions
DE69900544T2 (de
Inventor
Fabio Carli
Massimo Bresciani
Tiziana Canal
Paolo Gambini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptalis Pharma SRL
Original Assignee
Eurand International SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA filed Critical Eurand International SpA
Publication of DE69900544D1 publication Critical patent/DE69900544D1/de
Application granted granted Critical
Publication of DE69900544T2 publication Critical patent/DE69900544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69900544T 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen Expired - Lifetime DE69900544T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
PCT/EP1999/000781 WO1999039692A2 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization

Publications (2)

Publication Number Publication Date
DE69900544D1 true DE69900544D1 (de) 2002-01-17
DE69900544T2 DE69900544T2 (de) 2002-08-22

Family

ID=11378855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69900544T Expired - Lifetime DE69900544T2 (de) 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen

Country Status (15)

Country Link
US (1) US6355273B1 (de)
EP (1) EP1051158B1 (de)
JP (1) JP2002502809A (de)
KR (1) KR20010040727A (de)
AT (1) ATE209905T1 (de)
AU (1) AU738029B2 (de)
BR (1) BR9907682A (de)
CA (1) CA2319463A1 (de)
DE (1) DE69900544T2 (de)
DK (1) DK1051158T3 (de)
ES (1) ES2168855T3 (de)
IT (1) IT1298574B1 (de)
NZ (1) NZ506639A (de)
PT (1) PT1051158E (de)
WO (1) WO1999039692A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1323400A (en) * 1998-10-27 2000-05-15 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
ES2295379T3 (es) * 2001-06-29 2008-04-16 Eurand Pharmaceuticals Ltd. Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
US6572889B1 (en) * 2002-03-07 2003-06-03 Noveon Ip Holdings Corp. Controlled release solid dosage carbamazepine formulations
US20050191357A1 (en) * 2002-03-20 2005-09-01 Yoshiaki Kawashima Method of manufacturing chemical-containing composite particles
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CN1684663A (zh) * 2002-07-31 2005-10-19 阿尔萨公司 可注射的多模式聚合物储库组合物以及其用途
AU2002359397B2 (en) * 2002-07-31 2009-01-29 Durect Corporation Injectable depot compositions and uses thereof
JP2007515464A (ja) * 2003-12-23 2007-06-14 テムレル・リミテッド 医薬組成物用ペレットの製造方法
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
WO2010063387A1 (de) * 2008-12-05 2010-06-10 Bayer Animal Health Gmbh Extrudate mit nadelförmigen wirkstoffen
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
PL3505574T3 (pl) * 2017-12-28 2022-01-03 Imerys Usa, Inc. Amfifilowe kopolimery jako modyfikatory powierzchni do wytwarzania ulepszonych proszków węglanu wapnia
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
WO1995022319A1 (en) * 1994-02-16 1995-08-24 Abbott Laboratories Process for preparing fine particle pharmaceutical formulations
DE19504831A1 (de) * 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose

Also Published As

Publication number Publication date
ATE209905T1 (de) 2001-12-15
DK1051158T3 (da) 2002-04-02
CA2319463A1 (en) 1999-08-12
ES2168855T3 (es) 2002-06-16
EP1051158B1 (de) 2001-12-05
KR20010040727A (ko) 2001-05-15
PT1051158E (pt) 2002-05-31
AU2925199A (en) 1999-08-23
JP2002502809A (ja) 2002-01-29
IT1298574B1 (it) 2000-01-12
AU738029B2 (en) 2001-09-06
WO1999039692A2 (en) 1999-08-12
NZ506639A (en) 2003-05-30
ITMI980233A1 (it) 1999-08-06
DE69900544T2 (de) 2002-08-22
EP1051158A2 (de) 2000-11-15
US6355273B1 (en) 2002-03-12
WO1999039692A3 (en) 1999-09-23
BR9907682A (pt) 2000-11-14

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