ATE193533T1 - Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents

Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Info

Publication number
ATE193533T1
ATE193533T1 AT96913578T AT96913578T ATE193533T1 AT E193533 T1 ATE193533 T1 AT E193533T1 AT 96913578 T AT96913578 T AT 96913578T AT 96913578 T AT96913578 T AT 96913578T AT E193533 T1 ATE193533 T1 AT E193533T1
Authority
AT
Austria
Prior art keywords
taxal
derivatives
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT96913578T
Other languages
English (en)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE193533T1 publication Critical patent/ATE193533T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96913578T 1995-04-14 1996-04-12 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen ATE193533T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9504559A FR2732968B1 (fr) 1995-04-14 1995-04-14 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/000559 WO1996032387A1 (fr) 1995-04-14 1996-04-12 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE193533T1 true ATE193533T1 (de) 2000-06-15

Family

ID=9478163

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96913578T ATE193533T1 (de) 1995-04-14 1996-04-12 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Country Status (16)

Country Link
US (1) US5906990A (de)
EP (1) EP0820448B1 (de)
JP (1) JP4308905B2 (de)
AR (1) AR002041A1 (de)
AT (1) ATE193533T1 (de)
AU (1) AU5652296A (de)
DE (1) DE69608680T2 (de)
DK (1) DK0820448T3 (de)
ES (1) ES2148758T3 (de)
FR (1) FR2732968B1 (de)
GR (1) GR3033591T3 (de)
IL (1) IL117878A (de)
PT (1) PT820448E (de)
TW (1) TW349095B (de)
WO (1) WO1996032387A1 (de)
ZA (1) ZA962900B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010233A1 (en) 1995-09-11 1997-03-20 Enzymed, Inc. Biocatalytic methods for synthesizing and identifying biologically active compounds
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
EP0982028A1 (de) * 1998-08-20 2000-03-01 Aventis Pharma S.A. Neue Verwendung von Taxoidverbindungen
JP2002523364A (ja) * 1998-08-20 2002-07-30 アベンテイス・フアルマ・ソシエテ・アノニム タキソイド誘導体の新規な使用
CA2365776A1 (en) * 1999-05-03 2000-11-09 Alain Renard Method for treating abnormal cell proliferation in the brain
RO121269B1 (ro) 2000-02-02 2007-02-28 Florida State University Research Foundation, Inc. Taxani substituiţi cu carbonat la c10, folosiţica agenţi antitumorali
HUP0200721A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found C10 carbamoyloxy substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
WO2002066448A1 (en) * 2001-02-20 2002-08-29 Dabur India Limited Method of preparation of paclitaxel (taxol) using 3-(alk-2-ynyloxy) carbonyl-5-oxazolidine carboxylic acid
US6956124B2 (en) 2003-04-14 2005-10-18 Aventis Pharma S.A. Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
FR2853651B1 (fr) * 2003-04-14 2005-05-20 Aventis Pharma Sa Procede de preparation du 4,10 beta-diacetoxy-2 alpha- benzoyloxy-5 beta, 20-epoxy-1, 13 alpha-dihydroxy-9-oxo-19- norcyclopropa[g]tax-11-ene
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
CA2597682A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
US20090076127A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched larotaxel
WO2009145981A1 (en) * 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
EP2177630A1 (de) * 2008-10-02 2010-04-21 Institut Gustave Roussy Verfahren für die Prognose oder Überwachung, ob ein Patient mit Krebsleiden auf eine Behandlung mit einem Molekül aus der Taxoid-Familie anspricht

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710642B1 (fr) * 1993-09-29 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5395850A (en) * 1994-03-10 1995-03-07 Bristol-Myers Squibb Company 6,7-epoxy paclitaxels
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.

Also Published As

Publication number Publication date
DE69608680D1 (de) 2000-07-06
FR2732968B1 (fr) 1997-05-16
EP0820448B1 (de) 2000-05-31
ES2148758T3 (es) 2000-10-16
WO1996032387A1 (fr) 1996-10-17
TW349095B (en) 1999-01-01
IL117878A0 (en) 1996-08-04
AR002041A1 (es) 1998-01-07
GR3033591T3 (en) 2000-09-29
AU5652296A (en) 1996-10-30
JPH11503443A (ja) 1999-03-26
PT820448E (pt) 2000-09-29
DE69608680T2 (de) 2000-10-19
US5906990A (en) 1999-05-25
ZA962900B (en) 1996-07-30
IL117878A (en) 2001-03-19
DK0820448T3 (da) 2000-08-21
JP4308905B2 (ja) 2009-08-05
FR2732968A1 (fr) 1996-10-18
EP0820448A1 (de) 1998-01-28

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