DK1051158T3 - Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering - Google Patents

Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering

Info

Publication number
DK1051158T3
DK1051158T3 DK99910199T DK99910199T DK1051158T3 DK 1051158 T3 DK1051158 T3 DK 1051158T3 DK 99910199 T DK99910199 T DK 99910199T DK 99910199 T DK99910199 T DK 99910199T DK 1051158 T3 DK1051158 T3 DK 1051158T3
Authority
DK
Denmark
Prior art keywords
extrusion
spheronization
pharmaceutical preparations
polymeric microparticles
microparticles prepared
Prior art date
Application number
DK99910199T
Other languages
English (en)
Inventor
Fabio Carli
Tiziana Canal
Paolo Gambini
Massimo Bresciani
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Int filed Critical Eurand Int
Application granted granted Critical
Publication of DK1051158T3 publication Critical patent/DK1051158T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK99910199T 1998-02-06 1999-02-05 Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering DK1051158T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
PCT/EP1999/000781 WO1999039692A2 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization

Publications (1)

Publication Number Publication Date
DK1051158T3 true DK1051158T3 (da) 2002-04-02

Family

ID=11378855

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99910199T DK1051158T3 (da) 1998-02-06 1999-02-05 Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering

Country Status (15)

Country Link
US (1) US6355273B1 (da)
EP (1) EP1051158B1 (da)
JP (1) JP2002502809A (da)
KR (1) KR20010040727A (da)
AT (1) ATE209905T1 (da)
AU (1) AU738029B2 (da)
BR (1) BR9907682A (da)
CA (1) CA2319463A1 (da)
DE (1) DE69900544T2 (da)
DK (1) DK1051158T3 (da)
ES (1) ES2168855T3 (da)
IT (1) IT1298574B1 (da)
NZ (1) NZ506639A (da)
PT (1) PT1051158E (da)
WO (1) WO1999039692A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024380A1 (en) * 1998-10-27 2000-05-04 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
ES2295379T3 (es) * 2001-06-29 2008-04-16 Eurand Pharmaceuticals Ltd. Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados.
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
US6572889B1 (en) * 2002-03-07 2003-06-03 Noveon Ip Holdings Corp. Controlled release solid dosage carbamazepine formulations
WO2003077886A1 (fr) * 2002-03-20 2003-09-25 Hosokawa Micron Corporation Procede de fabrication de particules composites contenant un produit chimique
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
DK1539101T3 (da) * 2002-07-31 2009-04-27 Alza Corp Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf
JP2007515464A (ja) * 2003-12-23 2007-06-14 テムレル・リミテッド 医薬組成物用ペレットの製造方法
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
RU2549450C2 (ru) * 2008-12-05 2015-04-27 Байер Интеллектуэль Проперти Гмбх Экструдаты с игловидными действующими веществами
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
ES2882639T3 (es) * 2017-12-28 2021-12-02 Imerys Usa Inc Copolímeros anfifílicos como modificadores de superficie para la producción de polvos de carbonato de calcio mejorados
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
DE69530973T2 (de) * 1994-02-16 2004-05-19 Abbott Laboratories, Abbott Park Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen
DE19504831A1 (de) * 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose

Also Published As

Publication number Publication date
DE69900544D1 (de) 2002-01-17
KR20010040727A (ko) 2001-05-15
EP1051158B1 (en) 2001-12-05
CA2319463A1 (en) 1999-08-12
ITMI980233A1 (it) 1999-08-06
WO1999039692A2 (en) 1999-08-12
ATE209905T1 (de) 2001-12-15
NZ506639A (en) 2003-05-30
US6355273B1 (en) 2002-03-12
AU2925199A (en) 1999-08-23
AU738029B2 (en) 2001-09-06
JP2002502809A (ja) 2002-01-29
EP1051158A2 (en) 2000-11-15
DE69900544T2 (de) 2002-08-22
BR9907682A (pt) 2000-11-14
IT1298574B1 (it) 2000-01-12
PT1051158E (pt) 2002-05-31
WO1999039692A3 (en) 1999-09-23
ES2168855T3 (es) 2002-06-16

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