IT1241417B - Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione - Google Patents

Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione

Info

Publication number
IT1241417B
IT1241417B IT19571A IT1957190A IT1241417B IT 1241417 B IT1241417 B IT 1241417B IT 19571 A IT19571 A IT 19571A IT 1957190 A IT1957190 A IT 1957190A IT 1241417 B IT1241417 B IT 1241417B
Authority
IT
Italy
Prior art keywords
medicament
coated
therapeutic compositions
controlled release
cross
Prior art date
Application number
IT19571A
Other languages
English (en)
Other versions
IT9019571A1 (it
IT9019571A0 (it
Inventor
Fabio Carli
Italo Colombo
Leonardo Rabaglia
Original Assignee
Vectorpharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vectorpharma Int filed Critical Vectorpharma Int
Publication of IT9019571A0 publication Critical patent/IT9019571A0/it
Priority to IT19571A priority Critical patent/IT1241417B/it
Priority to US07/620,651 priority patent/US5275824A/en
Priority to YU34491A priority patent/YU34491A/sh
Priority to CA002037410A priority patent/CA2037410C/en
Priority to AT91103224T priority patent/ATE114242T1/de
Priority to KR1019910003465A priority patent/KR0175935B1/ko
Priority to DE69105222T priority patent/DE69105222T2/de
Priority to ES91103224T priority patent/ES2067068T3/es
Priority to EP91103224A priority patent/EP0446753B1/en
Priority to HU91707A priority patent/HUT59588A/hu
Priority to JP06373291A priority patent/JP3240387B2/ja
Priority to SU4894969/14A priority patent/RU2067859C1/ru
Priority to PL28932291A priority patent/PL289322A1/xx
Publication of IT9019571A1 publication Critical patent/IT9019571A1/it
Application granted granted Critical
Publication of IT1241417B publication Critical patent/IT1241417B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
IT19571A 1990-03-06 1990-03-06 Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione IT1241417B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT19571A IT1241417B (it) 1990-03-06 1990-03-06 Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
US07/620,651 US5275824A (en) 1990-03-06 1990-12-03 Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process
YU34491A YU34491A (sh) 1990-03-06 1991-02-27 Postupak za pravljenje terapeutskih preparata sa kontrolisanim oslobadjanjem lekova
CA002037410A CA2037410C (en) 1990-03-06 1991-03-01 Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process
DE69105222T DE69105222T2 (de) 1990-03-06 1991-03-04 Auf quervernetzte Polymere aufgebrachte und mit Polymerfilmen beschichtete therapeutische Zusammensetzungen mit kontrollierter Freisetzung von Medikamenten und deren Herstellungsverfahren.
KR1019910003465A KR0175935B1 (ko) 1990-03-06 1991-03-04 가교결합된 중합체 상에 지지되고 중합체 박막으로 피복된 약제의 방출이 조절되는 치료학적 조성물 및 이의 제조방법
AT91103224T ATE114242T1 (de) 1990-03-06 1991-03-04 Auf quervernetzte polymere aufgebrachte und mit polymerfilmen beschichtete therapeutische zusammensetzungen mit kontrollierter freisetzung von medikamenten und deren herstellungsverfahren.
ES91103224T ES2067068T3 (es) 1990-03-06 1991-03-04 Composiciones terapeuticas con liberacion controlada de medicamentos soportados en polimeros reticulados y recubiertos con peliculas polimericas y sus procesos de preparacion.
EP91103224A EP0446753B1 (en) 1990-03-06 1991-03-04 Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films and their preparation process
HU91707A HUT59588A (en) 1990-03-06 1991-03-05 Retarde composition and process for producing it
JP06373291A JP3240387B2 (ja) 1990-03-06 1991-03-06 架橋ポリマーで支持されポリマーフィルムで被覆された薬剤の制御された放出を伴なう治療組成物、及びそれらの調整方法
SU4894969/14A RU2067859C1 (ru) 1990-03-06 1991-03-06 Композиция с регулируемым выделением лекарственного средства
PL28932291A PL289322A1 (en) 1990-03-06 1991-03-06 Method of obtaining a composition of controllable release of medicine contained therein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19571A IT1241417B (it) 1990-03-06 1990-03-06 Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione

Publications (3)

Publication Number Publication Date
IT9019571A0 IT9019571A0 (it) 1990-03-06
IT9019571A1 IT9019571A1 (it) 1991-09-06
IT1241417B true IT1241417B (it) 1994-01-14

Family

ID=11159155

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19571A IT1241417B (it) 1990-03-06 1990-03-06 Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione

Country Status (13)

Country Link
US (1) US5275824A (it)
EP (1) EP0446753B1 (it)
JP (1) JP3240387B2 (it)
KR (1) KR0175935B1 (it)
AT (1) ATE114242T1 (it)
CA (1) CA2037410C (it)
DE (1) DE69105222T2 (it)
ES (1) ES2067068T3 (it)
HU (1) HUT59588A (it)
IT (1) IT1241417B (it)
PL (1) PL289322A1 (it)
RU (1) RU2067859C1 (it)
YU (1) YU34491A (it)

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IT9019571A1 (it) 1991-09-06
DE69105222T2 (de) 1995-04-06
HU910707D0 (en) 1991-09-30
HUT59588A (en) 1992-06-29
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US5275824A (en) 1994-01-04
ES2067068T3 (es) 1995-03-16
ATE114242T1 (de) 1994-12-15
EP0446753B1 (en) 1994-11-23
KR910016320A (ko) 1991-11-05
JPH0769927A (ja) 1995-03-14
DE69105222D1 (de) 1995-01-05
JP3240387B2 (ja) 2001-12-17
KR0175935B1 (ko) 1999-03-20
CA2037410A1 (en) 1991-09-07
IT9019571A0 (it) 1990-03-06
YU34491A (sh) 1994-06-10
PL289322A1 (en) 1992-05-04
RU2067859C1 (ru) 1996-10-20
CA2037410C (en) 2001-09-04

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