DE69105222T2 - Auf quervernetzte Polymere aufgebrachte und mit Polymerfilmen beschichtete therapeutische Zusammensetzungen mit kontrollierter Freisetzung von Medikamenten und deren Herstellungsverfahren. - Google Patents
Auf quervernetzte Polymere aufgebrachte und mit Polymerfilmen beschichtete therapeutische Zusammensetzungen mit kontrollierter Freisetzung von Medikamenten und deren Herstellungsverfahren.Info
- Publication number
- DE69105222T2 DE69105222T2 DE69105222T DE69105222T DE69105222T2 DE 69105222 T2 DE69105222 T2 DE 69105222T2 DE 69105222 T DE69105222 T DE 69105222T DE 69105222 T DE69105222 T DE 69105222T DE 69105222 T2 DE69105222 T2 DE 69105222T2
- Authority
- DE
- Germany
- Prior art keywords
- medicament
- coated
- cross
- manufacturing processes
- polymer films
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19571A IT1241417B (it) | 1990-03-06 | 1990-03-06 | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69105222D1 DE69105222D1 (de) | 1995-01-05 |
DE69105222T2 true DE69105222T2 (de) | 1995-04-06 |
Family
ID=11159155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69105222T Expired - Lifetime DE69105222T2 (de) | 1990-03-06 | 1991-03-04 | Auf quervernetzte Polymere aufgebrachte und mit Polymerfilmen beschichtete therapeutische Zusammensetzungen mit kontrollierter Freisetzung von Medikamenten und deren Herstellungsverfahren. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5275824A (de) |
EP (1) | EP0446753B1 (de) |
JP (1) | JP3240387B2 (de) |
KR (1) | KR0175935B1 (de) |
AT (1) | ATE114242T1 (de) |
CA (1) | CA2037410C (de) |
DE (1) | DE69105222T2 (de) |
ES (1) | ES2067068T3 (de) |
HU (1) | HUT59588A (de) |
IT (1) | IT1241417B (de) |
PL (1) | PL289322A1 (de) |
RU (1) | RU2067859C1 (de) |
YU (1) | YU34491A (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2572673B2 (ja) * | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
US6764697B1 (en) * | 1991-06-27 | 2004-07-20 | Alza Corporation | System for delaying drug delivery up to seven hours |
GB2258613B (en) * | 1991-08-12 | 1996-01-10 | Euro Celtique Sa | Pharmaceutical diltiazem formulation |
KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
IT1252867B (it) * | 1991-12-31 | 1995-06-28 | Gentili Ist Spa | Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita' |
US5262173A (en) * | 1992-03-02 | 1993-11-16 | American Cyanamid Company | Pulsatile once-a-day delivery systems for minocycline |
DE4236090C1 (de) * | 1992-10-26 | 1994-01-05 | Asta Medica Arzneimittel | Pharmazeutische Zubereitung für die Fluoridionen-Versorgung |
JPH09502698A (ja) * | 1993-03-05 | 1997-03-18 | ヘクサル・アクチエンゲゼルシャフト | 塩酸ラニチジンの結晶シクロデキストリン複合体、その製造方法およびその複合体を含有する薬剤組成物 |
GB9318880D0 (en) * | 1993-09-11 | 1993-10-27 | Smithkline Beecham Plc | Pharmaceutical composition |
US5484607A (en) * | 1993-10-13 | 1996-01-16 | Horacek; H. Joseph | Extended release clonidine formulation |
FR2711804B1 (fr) * | 1993-10-22 | 1996-01-19 | Pf Medicament | Procédé de contrôle de la dissolution de formes galéniques à libération modifiée à l'aide d'un réactif solide et sachet dose contenant un tel réactif. |
AT403988B (de) * | 1994-05-18 | 1998-07-27 | Lannacher Heilmittel | Festes orales retardpräparat |
WO1995034582A1 (en) * | 1994-06-16 | 1995-12-21 | Pharmacia S.P.A. | Bioadhesive starches and process for their preparation |
US5576311A (en) * | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
AU4844796A (en) * | 1995-03-02 | 1996-09-18 | Takeda Chemical Industries Ltd. | A prolonged release composition, use and production thereof |
JP3471977B2 (ja) * | 1995-06-02 | 2003-12-02 | 信越化学工業株式会社 | 液体状可塑剤を用いる無溶媒腸溶性コーティング剤で被覆した腸溶性製剤 |
EP0761209A3 (de) * | 1995-09-01 | 1998-02-04 | J.B. Chemicals & Pharmaceuticals Ltd. | Ranitidinformulierungen mit gesteuerter Freisetzung |
US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
HUP9600758A2 (en) * | 1996-03-27 | 1998-03-02 | Cyclolab Ciklodextrin Kutato F | Diclofenac composition of diminished gastrointestinal irritation and enhanced biological resorption |
IT1282381B1 (it) * | 1996-04-29 | 1998-03-20 | Trans Bussan S A | Nuove formulazioni di diacereina, ottenute per inclusione del principio attivo in idrogel polisaccaridi |
FR2757397B1 (fr) * | 1996-12-23 | 1999-03-05 | Mazal Pharma | Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree |
US5788987A (en) * | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
US6890524B1 (en) | 1997-04-04 | 2005-05-10 | Monsanto Company | Hydrolyzable delivery system using cross-linked polymeric resins as vehicles |
AU6783498A (en) | 1997-04-04 | 1998-10-30 | Monsanto Company | Ph-selective delivery system using cross-linked polymeric resins as vehicles |
US6096834A (en) * | 1997-04-04 | 2000-08-01 | Monsanto Company | Hydrolyzable delivery system using crosslinked polymeric resins as vehicles |
FR2766709B1 (fr) * | 1997-07-31 | 2000-04-07 | Dominique Cingotti | Procede pour la preparation d'un extrait de principes actifs sous forme de microgranules a base de fibres alimentaires entierement solubles destines a differentes formes galeniques |
IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
US6048736A (en) * | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
US7091192B1 (en) | 1998-07-01 | 2006-08-15 | California Institute Of Technology | Linear cyclodextrin copolymers |
US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
FR2785539B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Particules enrobees d'ibuprofene cristallin granule |
FR2792528A1 (fr) * | 1999-04-22 | 2000-10-27 | Ethypharm Lab Prod Ethiques | Microgranules de ketoprofene, procede de preparation et compositions pharmaceutiques |
AU5152900A (en) * | 1999-05-24 | 2000-12-12 | Purepac Pharmaceutical Co. | A pharmaceutical composition containing an active agent that is maintained in solid amorphous form and method of making the same |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
IL150053A0 (en) * | 1999-12-06 | 2002-12-01 | Mendell Co Inc Edward | Pharmaceutical superdisintegrant |
US7108866B1 (en) | 1999-12-10 | 2006-09-19 | Biovall Laboratories International Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
US20060153914A1 (en) * | 1999-12-10 | 2006-07-13 | Biovail Laboratories International S.R.L. | Chronotherapeutic diltiazem formulations and the administration thereof |
US20030190360A1 (en) * | 2001-03-13 | 2003-10-09 | Baichwal Anand R. | Chronotherapeutic dosage forms containing glucocorticosteroid and methods of treatment |
KR20010069756A (ko) * | 2001-05-08 | 2001-07-25 | 유형선 | 소염진통제인 아세메타신을 함유하며 장관내 특히대장에서의 약물 방출 속도가 조절되는 약물 전달 체계에대한 약제학적 경구용 조성물 및 그에 대한 제조방법 |
EP1269994A3 (de) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten |
US20040166155A1 (en) * | 2001-06-29 | 2004-08-26 | Luca Dobetti | Drug activation process and vibrational mill therefor |
ES2295379T3 (es) * | 2001-06-29 | 2008-04-16 | Eurand Pharmaceuticals Ltd. | Procedimiento de activacion termodinamica de medicamentos insolubles en agua cargados en polimeros reticulados. |
US7060498B1 (en) | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
JP3966459B2 (ja) | 2002-05-23 | 2007-08-29 | 株式会社日立製作所 | ストレージ機器管理方法、システム、およびプログラム |
KR20120104412A (ko) | 2002-09-06 | 2012-09-20 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
DE10247037A1 (de) | 2002-10-09 | 2004-04-22 | Abbott Gmbh & Co. Kg | Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
US20060063832A1 (en) * | 2003-03-31 | 2006-03-23 | Pliva-Lachema A.S. A Czech Republic Corporation | Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof |
NZ545921A (en) * | 2003-09-19 | 2009-09-25 | Penwest Pharmaceuticals Co | Delayed released dosage forms |
US20050118267A1 (en) * | 2003-09-19 | 2005-06-02 | Penwest Pharmaceuticals Co. | Chronotherapeutic dosage forms |
US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
JP2008507508A (ja) * | 2004-07-22 | 2008-03-13 | 株式會社アモーレパシフィック | トピラメート徐放性製剤及びその製造方法 |
US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
WO2007096902A2 (en) * | 2006-02-23 | 2007-08-30 | Lupin Limited | Solid oral dosage forms of griseofulvin |
CA2647348A1 (en) | 2006-03-28 | 2007-10-04 | Javelin Pharmaceuticals, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
US20080102128A1 (en) * | 2006-07-28 | 2008-05-01 | Flamel Technologies, Inc. | Modified-release microparticles based on amphiphilic copolymer and on active principles(s) and pharmaceutical formulations comprising them |
US7964182B2 (en) * | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
CA2661987C (en) * | 2006-09-01 | 2012-11-06 | Usv Limited | Process for the preparation of sevelamer hydrochloride and formulation thereof |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
MX2009013384A (es) * | 2007-06-08 | 2010-01-25 | Addrenex Pharmaceuticals Inc | Formulacion de liberacion extendida, y metodo para tratar disregulacion adrenergica. |
US20100172991A1 (en) * | 2007-06-08 | 2010-07-08 | Henry Joseph Horacek | Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
BRPI0812966A2 (pt) * | 2007-06-25 | 2017-05-16 | Encysive Pharmaceuticals Inc | formulações de n-(2-acetil-4,6-dimetilfenil)-3-{[(3,4 dimetil-5-isoxazolil)amino]sulfonil}-2-tiofenocarboxamida |
US20090024570A1 (en) * | 2007-07-20 | 2009-01-22 | Oracle Internatonal Corporation | User defined query rewrite mechanism |
EP2471516A3 (de) | 2007-09-14 | 2012-12-26 | Wockhardt Limited | Rhein- oder Diacereinzusammensetzungen |
NZ599268A (en) | 2007-09-27 | 2012-11-30 | Wockhardt Research Center | Pharmaceutical compositions of rhein or diacerein made by wet granulation process |
AU2013200968B2 (en) * | 2007-09-27 | 2013-11-21 | Wockhardt Limited | Pharmaceutical compositions of rhein or diacerein |
US20100285114A1 (en) * | 2007-09-27 | 2010-11-11 | Rahul Dabre | Pharmaceutical compositions of rhein or diacerein |
US8946277B2 (en) * | 2008-04-18 | 2015-02-03 | Warsaw Orthopedic, Inc. | Clonidine formulations in a biodegradable polymer carrier |
TWI473610B (zh) * | 2008-10-28 | 2015-02-21 | Twi Biotechnology Inc | 包含雙醋瑞因(diacerein)之醫藥組合物 |
WO2010086881A2 (en) * | 2009-01-22 | 2010-08-05 | Usv Limited | Pharmaceutical compositions comprising phosphate-binding polymer |
CN102781237A (zh) * | 2009-11-23 | 2012-11-14 | 天蓝制药公司 | 用于传递治疗剂的基于环糊精的聚合物 |
IE20100799A1 (en) * | 2010-12-22 | 2012-08-01 | Eurand Pharmaceuticals Ltd | Pharmaceutical composites of poorly water soluble drugs and polymers |
RU2648353C2 (ru) * | 2011-06-01 | 2018-03-23 | Нитто Денко Корпорейшн | Композиция в виде частиц и способ ее получения |
US9452107B2 (en) | 2012-04-16 | 2016-09-27 | New Jersey Institute Of Technology | Systems and methods for superdisintegrant-based composite particles for dispersion and dissolution of agents |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
US8999393B1 (en) | 2013-01-09 | 2015-04-07 | Edgemont Pharmaceuticals Llc | Sustained release formulations of lorazepam |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CA3012698A1 (en) * | 2016-02-05 | 2017-08-10 | Entrega Inc. | Oral dosage form with drying agent for delivery of active agent |
ES2938609T3 (es) | 2017-09-20 | 2023-04-13 | Tillotts Pharma Ag | Preparación de formas farmacéuticas sólidas que comprenden anticuerpos mediante estratificación de solución/suspensión |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1218102A (en) | 1968-03-15 | 1971-01-06 | Philips Nv | Improvements in medicaments comprising drug/ion-exchange resin compounds |
DE2643004A1 (de) | 1975-09-25 | 1977-06-16 | Mitchell Beazley Encyclopedias | Audiovisuelles informationssystem - system zum anordnen und wiederauffinden von informationen |
US4221778A (en) | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
HU189534B (en) | 1981-09-09 | 1986-07-28 | Chinoin Rt.,Hu | Process for producing new tablets containing cyclodextrin polymer as desintegrator |
EP0078430B2 (de) | 1981-10-29 | 1993-02-10 | Bayer Ag | Verfahren zur Herstellung von festen, schnellfreisetzenden Arzneizubereitungen mit Dihydropyridinen |
EP0147780A3 (de) | 1984-01-03 | 1987-03-11 | Merck & Co. Inc. | Vorrichtung zur Freisetzung von Arzneistoffen |
GB8403359D0 (en) | 1984-02-08 | 1984-03-14 | Erba Farmitalia | Pharmaceutical compositions |
CA1236023A (en) | 1984-07-18 | 1988-05-03 | Yegnaswami Raghunathan | Controlled release pharmaceutical preparations |
IE63321B1 (en) | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
DE3769707D1 (de) * | 1986-06-17 | 1991-06-06 | Recordati Chem Pharm | Therapeutisches system mit geregelter wirkstoffabgabe. |
JPH0819004B2 (ja) | 1986-12-26 | 1996-02-28 | 日清製粉株式会社 | 徐放性医薬製剤 |
GB8705083D0 (en) * | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
US4894239A (en) | 1987-06-02 | 1990-01-16 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and production thereof |
US4795644A (en) | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
IE63242B1 (en) * | 1988-06-24 | 1995-04-05 | Abbott Lab | Pharmaceutical granules and tablets made therefrom |
-
1990
- 1990-03-06 IT IT19571A patent/IT1241417B/it active IP Right Grant
- 1990-12-03 US US07/620,651 patent/US5275824A/en not_active Expired - Lifetime
-
1991
- 1991-02-27 YU YU34491A patent/YU34491A/sh unknown
- 1991-03-01 CA CA002037410A patent/CA2037410C/en not_active Expired - Lifetime
- 1991-03-04 AT AT91103224T patent/ATE114242T1/de not_active IP Right Cessation
- 1991-03-04 ES ES91103224T patent/ES2067068T3/es not_active Expired - Lifetime
- 1991-03-04 DE DE69105222T patent/DE69105222T2/de not_active Expired - Lifetime
- 1991-03-04 KR KR1019910003465A patent/KR0175935B1/ko not_active IP Right Cessation
- 1991-03-04 EP EP91103224A patent/EP0446753B1/de not_active Expired - Lifetime
- 1991-03-05 HU HU91707A patent/HUT59588A/hu unknown
- 1991-03-06 PL PL28932291A patent/PL289322A1/xx unknown
- 1991-03-06 RU SU4894969/14A patent/RU2067859C1/ru not_active IP Right Cessation
- 1991-03-06 JP JP06373291A patent/JP3240387B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IT1241417B (it) | 1994-01-14 |
HUT59588A (en) | 1992-06-29 |
YU34491A (sh) | 1994-06-10 |
JP3240387B2 (ja) | 2001-12-17 |
RU2067859C1 (ru) | 1996-10-20 |
CA2037410A1 (en) | 1991-09-07 |
US5275824A (en) | 1994-01-04 |
JPH0769927A (ja) | 1995-03-14 |
CA2037410C (en) | 2001-09-04 |
ATE114242T1 (de) | 1994-12-15 |
EP0446753A1 (de) | 1991-09-18 |
KR0175935B1 (ko) | 1999-03-20 |
PL289322A1 (en) | 1992-05-04 |
DE69105222D1 (de) | 1995-01-05 |
HU910707D0 (en) | 1991-09-30 |
EP0446753B1 (de) | 1994-11-23 |
IT9019571A0 (it) | 1990-03-06 |
ES2067068T3 (es) | 1995-03-16 |
IT9019571A1 (it) | 1991-09-06 |
KR910016320A (ko) | 1991-11-05 |
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