DK1414414T3 - Fremgangsmåde til termodynamisk aktivering af vand-uoplöselige lægemidler hvormed tværbundne polymerer er ladet - Google Patents
Fremgangsmåde til termodynamisk aktivering af vand-uoplöselige lægemidler hvormed tværbundne polymerer er ladetInfo
- Publication number
- DK1414414T3 DK1414414T3 DK02754615T DK02754615T DK1414414T3 DK 1414414 T3 DK1414414 T3 DK 1414414T3 DK 02754615 T DK02754615 T DK 02754615T DK 02754615 T DK02754615 T DK 02754615T DK 1414414 T3 DK1414414 T3 DK 1414414T3
- Authority
- DK
- Denmark
- Prior art keywords
- water
- cross
- drug
- charged
- insoluble drugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20010628 | 2001-06-29 | ||
| PCT/EP2002/006052 WO2003002097A1 (en) | 2001-06-29 | 2002-06-03 | Process of thermodynamical activation of water-insoluble drugs loaded into cross-linked polymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1414414T3 true DK1414414T3 (da) | 2008-03-03 |
Family
ID=11042810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02754615T DK1414414T3 (da) | 2001-06-29 | 2002-06-03 | Fremgangsmåde til termodynamisk aktivering af vand-uoplöselige lægemidler hvormed tværbundne polymerer er ladet |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8889182B2 (da) |
| EP (1) | EP1414414B1 (da) |
| JP (1) | JP2005503360A (da) |
| AT (1) | ATE377413T1 (da) |
| AU (1) | AU2002321061B2 (da) |
| CA (1) | CA2452575C (da) |
| DE (1) | DE60223382T2 (da) |
| DK (1) | DK1414414T3 (da) |
| ES (1) | ES2295379T3 (da) |
| NZ (1) | NZ530826A (da) |
| WO (1) | WO2003002097A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| ES2380318T3 (es) * | 2002-04-12 | 2012-05-10 | Alkermes Pharma Ireland Limited | Formulaciones nanoparticulares de megestrol |
| BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
| JP2007535774A (ja) * | 2004-04-30 | 2007-12-06 | ヒルクレスト・ラボラトリーズ・インコーポレイテッド | 自由空間ポインティングデバイスにおける意図的でない動きを除去するための方法およびデバイス |
| GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| CN102083418A (zh) * | 2008-04-24 | 2011-06-01 | 伊万斯彻有限公司 | 口服避孕药剂及其制备方法 |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CN102264354B (zh) | 2008-10-28 | 2015-03-25 | 艾尼纳制药公司 | 用于治疗5-ht2a5-羟色胺受体相关障碍的5-ht2a5-羟色胺受体调节剂组合物 |
| ITMI20120092A1 (it) * | 2012-01-26 | 2013-07-27 | Micro Macinazione S A | Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia |
| RU2017145976A (ru) | 2015-06-12 | 2019-07-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна |
| US10034859B2 (en) | 2015-07-15 | 2018-07-31 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2634004B2 (de) | 1976-07-29 | 1978-08-10 | Bernhard Dr. 8000 Muenchen Lippold | Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen |
| DE3320583A1 (de) | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung |
| GB8403359D0 (en) * | 1984-02-08 | 1984-03-14 | Erba Farmitalia | Pharmaceutical compositions |
| US5225192A (en) * | 1988-10-17 | 1993-07-06 | Vectorpharma International S.P.A. | Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate |
| IT1227626B (it) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| IT1246188B (it) * | 1990-07-27 | 1994-11-16 | Resa Farma | Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute. |
| IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
-
2002
- 2002-06-03 DK DK02754615T patent/DK1414414T3/da active
- 2002-06-03 ES ES02754615T patent/ES2295379T3/es not_active Expired - Lifetime
- 2002-06-03 JP JP2003508336A patent/JP2005503360A/ja active Pending
- 2002-06-03 DE DE60223382T patent/DE60223382T2/de not_active Expired - Lifetime
- 2002-06-03 WO PCT/EP2002/006052 patent/WO2003002097A1/en active IP Right Grant
- 2002-06-03 AU AU2002321061A patent/AU2002321061B2/en not_active Ceased
- 2002-06-03 AT AT02754615T patent/ATE377413T1/de not_active IP Right Cessation
- 2002-06-03 US US10/481,938 patent/US8889182B2/en active Active
- 2002-06-03 NZ NZ530826A patent/NZ530826A/en not_active IP Right Cessation
- 2002-06-03 EP EP02754615A patent/EP1414414B1/en not_active Expired - Lifetime
- 2002-06-03 CA CA2452575A patent/CA2452575C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002321061B2 (en) | 2006-08-24 |
| EP1414414A1 (en) | 2004-05-06 |
| US20040213840A1 (en) | 2004-10-28 |
| JP2005503360A (ja) | 2005-02-03 |
| WO2003002097A1 (en) | 2003-01-09 |
| ATE377413T1 (de) | 2007-11-15 |
| ES2295379T3 (es) | 2008-04-16 |
| NZ530826A (en) | 2004-09-24 |
| CA2452575C (en) | 2010-11-02 |
| CA2452575A1 (en) | 2003-01-09 |
| DE60223382D1 (de) | 2007-12-20 |
| EP1414414B1 (en) | 2007-11-07 |
| DE60223382T2 (de) | 2008-09-11 |
| US8889182B2 (en) | 2014-11-18 |
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