ES8604020A1 - Un procedimiento para la obtencion de polimeros porosos reticulados para liberacion controlada de farmacos - Google Patents

Un procedimiento para la obtencion de polimeros porosos reticulados para liberacion controlada de farmacos

Info

Publication number
ES8604020A1
ES8604020A1 ES535129A ES535129A ES8604020A1 ES 8604020 A1 ES8604020 A1 ES 8604020A1 ES 535129 A ES535129 A ES 535129A ES 535129 A ES535129 A ES 535129A ES 8604020 A1 ES8604020 A1 ES 8604020A1
Authority
ES
Spain
Prior art keywords
water
cross
etoh
drug release
controlled drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535129A
Other languages
English (en)
Other versions
ES535129A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8604020A1 publication Critical patent/ES8604020A1/es
Publication of ES535129A0 publication Critical patent/ES535129A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Materials For Medical Uses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Organic Insulating Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA COMPOSICION DE POLIMEROS POROSOS RETICULADOS PARA LA LIBERACION CONTROLADA DE FARMACOS. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UNA COMPOSICION FORMADA POR UN 50 A UN 99% EN PESO DE UN COPOLIMERO DE UN MONOMERO MONOOLEFINICO ACUOINSOLUBLE, CON UN 0 A UN 45% EN PESO DE MONOMEROS DE UN MONOMERO MONOOLEFINICO ACUOSOLUBLE, Y CON UN 50 A UN 1% EN PESO DE UN COPOLIMERO DE UN AGENTE RETICULANTE DE DIVINILO O POLIVINILO, PARA FORMAR UN COPOLIMERO RETICULADO CAPAZ DE HINCHARSE EN AGUA Y EN ETANOL; SEGUNDA, SE SOMETE A LA COMPOSICION FORMADA A UN PROCESO DE COPOLIMERIZACION PARA OBTENER EL COPOLIMERO MENCIONADO; Y POR ULTIMO, SE EQUILIBRA EL COPOLIMERO EN UNA SOLUCION DE UN MEDICAMENTO FARMACEUTICO, CUYO DISOLVENTE HINCHA EL COPOLIMERO.
ES535129A 1983-08-15 1984-08-14 Un procedimiento para la obtencion de polimeros porosos reticulados para liberacion controlada de farmacos Expired ES8604020A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/523,236 US4548990A (en) 1983-08-15 1983-08-15 Crosslinked, porous polymers for controlled drug delivery

Publications (2)

Publication Number Publication Date
ES8604020A1 true ES8604020A1 (es) 1986-01-16
ES535129A0 ES535129A0 (es) 1986-01-16

Family

ID=24084203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535129A Expired ES8604020A1 (es) 1983-08-15 1984-08-14 Un procedimiento para la obtencion de polimeros porosos reticulados para liberacion controlada de farmacos

Country Status (16)

Country Link
US (1) US4548990A (es)
EP (1) EP0140828B1 (es)
JP (1) JPS6067435A (es)
AT (1) ATE60997T1 (es)
AU (1) AU570712B2 (es)
CA (1) CA1225030A (es)
DE (1) DE3484165D1 (es)
DK (1) DK390584A (es)
ES (1) ES8604020A1 (es)
FI (1) FI80283C (es)
GR (1) GR80109B (es)
IL (1) IL72664A (es)
NO (1) NO167360C (es)
NZ (1) NZ209213A (es)
PT (1) PT79054B (es)
ZA (1) ZA846301B (es)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795436A (en) * 1983-11-14 1989-01-03 Bio-Mimetics, Inc. Bioadhesive composition and method of treatment therewith
US4983392A (en) * 1983-11-14 1991-01-08 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
US4675414A (en) * 1985-03-08 1987-06-23 The United States Of America As Represented By The Secretary Of The Navy Maleimidomethyl-carbonate polyethers
EP0200213B1 (en) * 1985-05-02 1992-07-22 Ciba-Geigy Ag Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof
WO1986007541A1 (en) * 1985-06-19 1986-12-31 Yasushi Zyo Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood
CA1295941C (en) * 1985-08-16 1992-02-18 Rajan Bawa Sustained-release formulation comprising a hydrophobic polymer system
US4713244A (en) * 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
US4668506A (en) * 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
US4783335A (en) * 1985-11-18 1988-11-08 The Kendall Company Controlled topical application of bioactive reagent
US5145675A (en) * 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
US5955109A (en) * 1985-12-18 1999-09-21 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of retinoic acid
US5879716A (en) * 1985-12-18 1999-03-09 Advanced Polymer Systems, Inc. Methods and compositions for topical delivery of benzoyl peroxide
US4873086A (en) * 1986-03-03 1989-10-10 Ciba-Geigy Corporation Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US4983400A (en) * 1986-06-16 1991-01-08 Merck & Co., Inc. Controlled release combination of carbidopa/levodopa
IL86211A (en) * 1987-05-04 1992-03-29 Ciba Geigy Ag Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation
US4894239A (en) * 1987-06-02 1990-01-16 Takeda Chemical Industries, Ltd. Sustained-release preparation and production thereof
US5057560A (en) * 1987-10-05 1991-10-15 Ciba-Geigy Corporation Thermotropic copolymer hydrogels from N,N-dimethylacrylamide and methoxy-ethyl (meth) acrylate
US5147923A (en) * 1987-10-05 1992-09-15 Ciba-Geigy Corporation Thermotropic biphilic hydrogels and hydroplastics
US5104954A (en) * 1987-10-05 1992-04-14 Ciba-Geigy Corporation Thermostropic biphilic hydrogels and hydroplastics
US4910015A (en) * 1987-10-19 1990-03-20 Massachusetts Institute Of Technology Surface-active polysiloxanes and drug releasing materials thereof
JPH01113322A (ja) * 1987-10-23 1989-05-02 Tomoaki Fukuda アクリル系エマルジョンおよびこれを用いたｐＨ非依存性遅延放出型製剤
US4983668A (en) * 1987-11-25 1991-01-08 Aristech Chemical Corporation Polymer partculates for molding and the like
US5019377A (en) * 1987-12-11 1991-05-28 The Procter & Gamble Company Low glass transistion temperature adhesive copolymers for use in hair styling products
EP0347145A3 (en) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US5073381A (en) * 1988-08-15 1991-12-17 University Of Akron Amphiphilic networks
EP0406432B1 (en) * 1988-10-27 1994-04-06 MITSUI TOATSU CHEMICALS, Inc. Process for producing particulate polymer
DK0500807T3 (da) * 1989-10-31 2000-02-07 Columbia Lab Inc Præparat og fremgangsmåde til befugtning af væv
US6017521A (en) * 1989-10-31 2000-01-25 Columbia Laboratories, Inc. Use of polycarboxylic acid polymers to treat vaginal infections
DK0431719T3 (da) 1989-10-31 1995-02-27 Columbia Lab Inc Vaginalt vævsbefugtende præparat
US5120532A (en) * 1990-04-06 1992-06-09 The Procter & Gamble Company Hair styling shampoos
US5104642A (en) * 1990-04-06 1992-04-14 The Procter & Gamble Company Hair styling compositions containing particular hair styling polymers and non-aqueous solvents
US5120531A (en) * 1990-04-06 1992-06-09 The Procter & Gamble Company Hair styling conditioners
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5262450A (en) * 1990-12-28 1993-11-16 Isp Investments Inc. Abrasion and water-resistant radiation curable coatings
DE4138513A1 (de) * 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5681585A (en) * 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US7070806B2 (en) * 1992-01-27 2006-07-04 Purdue Pharma Lp Controlled release formulations coated with aqueous dispersions of acrylic polymers
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
JPH0819391B2 (ja) * 1992-11-30 1996-02-28 日東電工株式会社 感圧接着剤とその接着シ―ト類
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5474985A (en) * 1993-12-22 1995-12-12 The Regents Of The University Of California Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US5674888A (en) * 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US5969068A (en) 1995-06-19 1999-10-19 The Lubrizol Corporation Dispersant-viscosity improvers for lubricating oil compositions
US5821313A (en) 1995-06-19 1998-10-13 The Lubrizol Corporation Dispersant-viscosity improvers for lubricating oil compositions
KR100405285B1 (ko) * 1996-08-20 2003-11-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 합성 티로이드 호르몬을 포함하는 약제 조성물
DE69834195T2 (de) 1997-07-02 2007-03-29 Euro-Celtique S.A. Stabilisierte tramadol formulierungen mit verzögerter freisetzung
US6124249A (en) 1998-12-22 2000-09-26 The Lubrizol Corporation Viscosity improvers for lubricating oil compositions
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
DE19843903A1 (de) * 1998-09-24 2000-03-30 Basf Ag Feste Dosierungsform mit copolymerem Bindemittel
ATE254908T1 (de) 1998-09-30 2003-12-15 Basf Ag Verwendung von wasserlöslichen oder wasserdispergierbaren polyether-haltigen pfropfpolymerisaten als überzugsmittel, bindemittel und/oder filmbildender hilfsstoff in pharmazeutischen darreichungsformen
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
US6521431B1 (en) 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
US6558607B1 (en) 1999-09-30 2003-05-06 University Of Massachusetts Crystallization of constrained polymers
MXPA02004293A (es) 1999-10-29 2002-10-31 Euro Celtique Sa Formulaciones de hidrocodona de liberacion controlada..
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
WO2002020663A2 (en) 2000-09-06 2002-03-14 Ap Pharma, Inc. Degradable polyacetal polymers
EP1337244A4 (en) 2000-10-30 2006-01-11 Euro Celtique Sa HYDROCODON FORMULATIONS WITH CONTROLLED RELEASE
UA81224C2 (uk) * 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
DE10128531A1 (de) * 2001-06-13 2002-12-19 Basf Ag Verwendung von wasserlöslichen oder wasserdispergierbaren Polyetherblöcke enthaltenden Pfropfpolymerisaten als Beschichtungsmittel, Matrixbildner und/oder Verpackungsmaterial für Agrochemikalien
US6921390B2 (en) 2001-07-23 2005-07-26 Boston Scientific Scimed, Inc. Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
US6524606B1 (en) 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
FR2833961B1 (fr) * 2001-12-20 2004-04-02 Virsol Procede de preparation de films a base de poly(oxyde d'ethylene) reticule
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
WO2005027714A2 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20070208058A1 (en) * 2004-10-25 2007-09-06 Bryant Roy W Stable Pharmaceutical Compositions and Methods of Making and Using Same
HUE030235T2 (en) 2005-12-13 2017-04-28 Incyte Holdings Corp Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors
AU2007275034A1 (en) * 2006-07-21 2008-01-24 Lab International Srl Hydrophilic abuse deterrent delivery system
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
US20090005362A1 (en) * 2007-06-26 2009-01-01 Vo Toan P Compositions Comprising Antihistamines or Mast Cell Stabilizers, and Methods of Making and Using Same
US7795231B2 (en) 2007-10-04 2010-09-14 Insite Vision Incorporated Concentrated aqueous azalide formulations
ES2602577T3 (es) 2008-03-11 2017-02-21 Incyte Holdings Corporation Derivados de azetidina y ciclobutano como inhibidores de JAK
GB0812742D0 (en) * 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
CL2009001884A1 (es) 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
US8501800B2 (en) 2009-03-05 2013-08-06 Insite Vision Incorporated Controlled-release ophthalmic vehicles
US8778999B2 (en) 2009-03-05 2014-07-15 Insite Vision Incorporated Non-steroidal anti-inflammatory ophthalmic compositions
US20170128481A9 (en) 2009-03-06 2017-05-11 Insite Vision Corporation Ocular treatment with reduced intraocular pressure
US10201548B2 (en) 2009-03-06 2019-02-12 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US10980818B2 (en) 2009-03-06 2021-04-20 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
SG174464A1 (en) 2009-03-19 2011-10-28 Agency Science Tech & Res Forming copolymer from bicontinuous microemulsion comprising monomers of different hydrophilicity
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
EA020494B1 (ru) 2009-05-22 2014-11-28 Инсайт Корпорейшн 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ
US8563760B2 (en) * 2009-08-31 2013-10-22 Mayo Foundation For Medical Education And Research Process for the synthesis of long-chain fatty acids
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
MX347851B (es) 2010-03-10 2017-05-16 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
EP3087972A1 (en) 2010-05-21 2016-11-02 Incyte Holdings Corporation Topical formulation for a jak inhibitor
EP2640725B1 (en) 2010-11-19 2015-01-07 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
SG190839A1 (en) 2010-11-19 2013-07-31 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
AR086983A1 (es) 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
FR2987561B1 (fr) * 2012-03-02 2014-04-11 Pf Medicament Dispositif transdermique comprenant des micro-particules poreuses
AR091079A1 (es) 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
EP2917238A1 (en) 2012-11-08 2015-09-16 Eleven Biotherapeutics, Inc. Il-6 antagonists and uses thereof
KR20220162825A (ko) 2012-11-15 2022-12-08 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
WO2014107737A2 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Local delivery of il-17 inhibitors for treating ocular disease
AU2014225938B2 (en) 2013-03-06 2018-07-19 Incyte Holdings Corporation Processes and intermediates for making a JAK inhibitor
US9044508B2 (en) 2013-03-15 2015-06-02 Insite Vision Corporation Concentrated aqueous azalide formulations
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
KR20160045081A (ko) 2013-08-07 2016-04-26 인사이트 코포레이션 Jak1 억제제용 지속 방출 복용 형태
WO2015142853A1 (en) 2014-03-17 2015-09-24 Encompass Development, Inc. Ocular formulations
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CA2936748C (en) 2014-10-31 2017-08-08 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
WO2016073894A1 (en) 2014-11-07 2016-05-12 Eleven Biotherapeutics, Inc. Therapeutic agents with increased ocular retention
PT3215530T (pt) 2014-11-07 2019-11-21 Sesen Bio Inc Anticorpos de il-6 melhorados
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3278115A2 (en) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
JP2018522070A (ja) 2015-07-27 2018-08-09 キャタコア・インコーポレイテッドＣａｔａｃｏｒｅ， Ｉｎｃ． 白内障の処置用組成物
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
TWI797242B (zh) 2018-01-30 2023-04-01 美商英塞特公司 製備ｊａｋ抑制劑之方法及中間物
MX2022012285A (es) 2018-03-30 2023-08-15 Incyte Corp Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
KR102151051B1 (ko) 2019-01-10 2020-09-02 고려대학교 산학협력단 당뇨병성 백내장 치료 또는 예방용 조성물
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297357A (es) * 1962-08-31
CH468192A (de) * 1964-06-19 1969-02-15 Ciba Geigy Verfahren zur Herstellung von Arzneimitteln in Perlenform
US3538214A (en) * 1969-04-22 1970-11-03 Merck & Co Inc Controlled release medicinal tablets
US4184020A (en) * 1970-11-24 1980-01-15 Ceskoslovenska Akademie Ved Preparation of hydrophilic material for gel chromatography
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
GB1456365A (en) * 1972-10-06 1976-11-24 Gist Brocades Nv Controlled release composition
US4192827A (en) * 1974-06-27 1980-03-11 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers
US4177056A (en) * 1974-06-27 1979-12-04 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides
HU174057B (hu) * 1976-09-17 1979-10-28 Richter Gedeon Vegyeszet Sostav dlja pokrytij obespechivajuhhij uregulirovannuju otdachy aktivnogo vehhestva biologicheski aktivnykh preparatov i sposob poluchenija takikh preparatov s uregulirovannoj otdachej aktivnogo vehhestva
US4136250A (en) * 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4224427A (en) * 1978-06-01 1980-09-23 Ciba-Geigy Corporation Process for preparing hydrogels as spherical beads of large size
US4379864A (en) * 1979-02-09 1983-04-12 Syntex (U.S.A.) Inc. Polymeric compositions and hydrogels formed therefrom
JPS55149212A (en) * 1979-05-11 1980-11-20 Toray Ind Inc Gradually releasing preparation of methotrexate

Also Published As

Publication number Publication date
AU3189684A (en) 1985-02-21
DK390584A (da) 1985-02-16
PT79054A (en) 1984-09-01
FI80283B (fi) 1990-01-31
NO843237L (no) 1985-02-18
CA1225030A (en) 1987-08-04
FI843190A0 (fi) 1984-08-13
ES535129A0 (es) 1986-01-16
FI843190A (fi) 1985-02-16
AU570712B2 (en) 1988-03-24
EP0140828A2 (de) 1985-05-08
FI80283C (fi) 1990-05-10
DE3484165D1 (de) 1991-04-04
NZ209213A (en) 1986-12-05
GR80109B (en) 1984-12-14
EP0140828B1 (de) 1991-02-27
EP0140828A3 (en) 1987-02-04
IL72664A0 (en) 1984-11-30
ZA846301B (en) 1985-05-29
NO167360B (no) 1991-07-22
PT79054B (en) 1987-06-03
NO167360C (no) 1991-10-30
DK390584D0 (da) 1984-08-14
JPS6067435A (ja) 1985-04-17
US4548990A (en) 1985-10-22
IL72664A (en) 1988-03-31
ATE60997T1 (de) 1991-03-15

Similar Documents

Publication Publication Date Title
ES8604020A1 (es) Un procedimiento para la obtencion de polimeros porosos reticulados para liberacion controlada de farmacos
DE3587269D1 (de) Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung.
US3721657A (en) Hydrophilic gel polymers of vinylpyrrolidine and hydroxyalkyl methacrylate
EP0669129A3 (de) Expandierbare Arzneiformen mit kontrollierter Wirkstoffabgabe.
CA2085641A1 (en) Hair treatment composition
EP0213083A3 (en) Controlled release tablet
CA2085640A1 (en) Hair treatment composition
IT1241417B (it) Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
CA2019410A1 (en) Liquid polymer composition, and method of use
WO1995020610A3 (en) Two-phase acidic aqueous compositions for diffusion transfer products
WO1998022097A3 (en) Controlled release matrix composition using polar polymer or monomer and poly(acrylic acid) blend
CA2000744A1 (en) Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
EP0609793A3 (de) Bei Raumtemperatur vernetzbares wässriges Bindemittel.
ATE29386T1 (de) Verwendung eines sulfonierten homo- oder copolymeren des styrols zur herstellung eines antikonzeptionsmittels.
EP0340019A3 (en) Resin composition
JPS55129442A (en) Water-containing gel material
IL101207A0 (en) Surface-porous crosslinked copolymer beads and their preparation
EP0190996A3 (en) Crosslinked, porous polymers for controlled delivery of agricultural ingredients
TW337591B (en) Anti-reflection coating material
JPS52105992A (en) Preparation of hydrophilic high polymers
Seymour The Synthesis of Block and Graft Copolymers From Macroradicals
RU95119046A (ru) Микрогранулированный кормовой препарат
JPS56166941A (en) Water absorbing agent
ES467201A1 (es) Procedimiento de preparar granulos copolimericos

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603