MX342814B - Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. - Google Patents

Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.

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Publication number
MX342814B
MX342814B MX2013005828A MX2013005828A MX342814B MX 342814 B MX342814 B MX 342814B MX 2013005828 A MX2013005828 A MX 2013005828A MX 2013005828 A MX2013005828 A MX 2013005828A MX 342814 B MX342814 B MX 342814B
Authority
MX
Mexico
Prior art keywords
pyrrolo
pyrazol
cyclopentylpropanenitrile
rimidin
salts
Prior art date
Application number
MX2013005828A
Other languages
English (en)
Inventor
Li Hui-Yin
D Rodgers James
Original Assignee
Incyte Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX342814(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX342814B publication Critical patent/MX342814B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

La presente invención proporciona formas de sal de (R)-3-(4-(7H-pirrolo{2, 3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-cic lopentilpropanitrilo que son útiles en la modulación de la actividad de la cinasa Janus que incluye, por ejemplo, enfermedades relacionadas con el sistema inmunitario, trastornos de la piel, trastornos proliferativos mieloides, cáncer, y otras enfermedades.
MX2013005828A 2007-06-13 2008-06-12 Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. MX342814B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
PCT/US2008/066662 WO2008157208A2 (en) 2007-06-13 2008-06-12 Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
MX342814B true MX342814B (es) 2016-10-13

Family

ID=40029273

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009013402A MX2009013402A (es) 2007-06-13 2008-06-12 Sales de inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3-d]piri midin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.
MX2013005828A MX342814B (es) 2007-06-13 2008-06-12 Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009013402A MX2009013402A (es) 2007-06-13 2008-06-12 Sales de inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3-d]piri midin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.

Country Status (42)

Country Link
US (10) US20080312259A1 (es)
EP (5) EP2173752B2 (es)
JP (1) JP5475653B2 (es)
KR (2) KR20150036210A (es)
CN (2) CN101932582B (es)
AU (1) AU2008266183B2 (es)
BR (1) BRPI0814254B8 (es)
CA (1) CA2689663C (es)
CO (1) CO6251256A2 (es)
CR (1) CR11151A (es)
CU (2) CU24179B1 (es)
CY (3) CY1115145T1 (es)
DK (3) DK2173752T4 (es)
DO (1) DOP2009000280A (es)
EA (1) EA019784B1 (es)
EC (1) ECSP099802A (es)
ES (4) ES2903444T3 (es)
GE (1) GEP20125533B (es)
GT (1) GT200900314A (es)
HK (2) HK1143161A1 (es)
HR (3) HRP20140541T4 (es)
HU (2) HUE029236T2 (es)
IL (5) IL202524A (es)
LT (1) LT3070090T (es)
MA (1) MA31517B1 (es)
ME (1) ME00960B (es)
MX (2) MX2009013402A (es)
MY (1) MY154969A (es)
NI (1) NI200900216A (es)
NO (1) NO2019025I1 (es)
NZ (1) NZ581803A (es)
PL (3) PL2173752T5 (es)
PT (2) PT2173752E (es)
RS (3) RS53245B2 (es)
SG (3) SG10201912675VA (es)
SI (3) SI2173752T2 (es)
SM (1) SMP201000002B (es)
TN (1) TN2009000514A1 (es)
TR (1) TR201903488T4 (es)
UA (1) UA99467C2 (es)
WO (1) WO2008157208A2 (es)
ZA (1) ZA200908826B (es)

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US7528143B2 (en) 2005-11-01 2009-05-05 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
UA98449C2 (en) 2005-12-13 2012-05-25 Инсайт Корпорейшин Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
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RS53245B2 (sr) 2007-06-13 2022-10-31 Incyte Holdings Corp Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila
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AR075633A1 (es) 2009-02-27 2011-04-20 Ambit Biosciences Corp Compuestos moduladores de jak quinasa y sus metodos de uso
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SA111320200B1 (ar) 2010-02-17 2014-02-16 ديبيوفارم اس ايه مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
CA2790070C (en) * 2010-02-18 2018-03-06 Incyte Corporation Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
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