SA520412192B1 - مشتقات 5-(2-(2، 5-داي فلورو فنيل)بيروليدين-1-يل) -3-(1h-بيرازول-1-يل) بيرازولو[1، 5-a] بيريميدين والمركبات ذات الصلة كمثبطات كيناز trk لعلاج السرطان - Google Patents
مشتقات 5-(2-(2، 5-داي فلورو فنيل)بيروليدين-1-يل) -3-(1h-بيرازول-1-يل) بيرازولو[1، 5-a] بيريميدين والمركبات ذات الصلة كمثبطات كيناز trk لعلاج السرطانInfo
- Publication number
- SA520412192B1 SA520412192B1 SA520412192A SA520412192A SA520412192B1 SA 520412192 B1 SA520412192 B1 SA 520412192B1 SA 520412192 A SA520412192 A SA 520412192A SA 520412192 A SA520412192 A SA 520412192A SA 520412192 B1 SA520412192 B1 SA 520412192B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- pyrazolo
- difluorophenyl
- pyrazol
- pyrrolidin
- treating cancer
- Prior art date
Links
- FWDOVLGKHCXRFF-UHFFFAOYSA-N FC1=C(C=C(C=C1)F)C1N(CCC1)C1=NC=2N(C=C1)N=CC=2N1N=CC=C1 Chemical class FC1=C(C=C(C=C1)F)C1N(CCC1)C1=NC=2N(C=C1)N=CC=2N1N=CC=C1 FWDOVLGKHCXRFF-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
يتعلق الاختراع الحالي بمثبطات كيناز Trk inhibitors of Trk kinases مفيدة لعلاج الأمراض diseases والإضطرابات disorders المرتبطة بكيناز kinase Trk، لها الصيغة التالية: (IV) حيث يتم وصف A، L ، X ، X1، و Y هنا .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762599490P | 2017-12-15 | 2017-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520412192B1 true SA520412192B1 (ar) | 2022-08-11 |
Family
ID=65139120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520412192A SA520412192B1 (ar) | 2017-12-15 | 2020-06-13 | مشتقات 5-(2-(2، 5-داي فلورو فنيل)بيروليدين-1-يل) -3-(1h-بيرازول-1-يل) بيرازولو[1، 5-a] بيريميدين والمركبات ذات الصلة كمثبطات كيناز trk لعلاج السرطان |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11230546B2 (ar) |
| EP (2) | EP4053128A1 (ar) |
| JP (1) | JP7321183B2 (ar) |
| KR (1) | KR20200099557A (ar) |
| CN (1) | CN111819179B (ar) |
| AU (1) | AU2018383571B2 (ar) |
| BR (1) | BR112020011775A2 (ar) |
| CA (1) | CA3084814A1 (ar) |
| DK (1) | DK3724191T3 (ar) |
| EA (1) | EA202091475A1 (ar) |
| ES (1) | ES2908773T3 (ar) |
| HR (1) | HRP20220464T1 (ar) |
| HU (1) | HUE059313T2 (ar) |
| IL (1) | IL275059B2 (ar) |
| LT (1) | LT3724191T (ar) |
| MX (1) | MX2020006293A (ar) |
| PL (1) | PL3724191T3 (ar) |
| PT (1) | PT3724191T (ar) |
| SA (1) | SA520412192B1 (ar) |
| SG (1) | SG11202005237SA (ar) |
| SI (1) | SI3724191T1 (ar) |
| TW (1) | TW201936194A (ar) |
| WO (1) | WO2019118584A1 (ar) |
| ZA (2) | ZA202003483B (ar) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11739096B2 (en) | 2017-12-15 | 2023-08-29 | Pyramid Biosciences, Inc. | 5-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo [1,5-A]pyrimidine derivatives and related compounds as Trk kinase inhibitors for treating cancer |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201813791D0 (en) * | 2018-08-23 | 2018-10-10 | Benevolental Bio Ltd | Organic compounds |
| CN111718350B (zh) * | 2019-03-19 | 2021-04-13 | 华中师范大学 | 吡唑取代的吡唑并嘧啶化合物和药物组合物及其应用 |
| WO2020187291A1 (zh) * | 2019-03-19 | 2020-09-24 | 华中师范大学 | 吡唑并嘧啶化合物和药物组合物及其应用 |
| CN111848626B (zh) * | 2019-04-30 | 2021-11-30 | 江苏柯菲平医药股份有限公司 | Trk激酶抑制剂及其用途 |
| CN112979654B (zh) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | 杂芳基稠环化合物、其制备方法及应用 |
| MX2022012437A (es) * | 2020-04-15 | 2022-10-27 | Pyramid Biosciences Inc | Metodos para preparar inhibidores del receptor de la tirosina quinasa. |
| CN114437077B (zh) * | 2020-11-04 | 2024-01-30 | 浙江同源康医药股份有限公司 | 用作激酶抑制剂的化合物及其应用 |
| CN114437075A (zh) * | 2020-11-03 | 2022-05-06 | 上海瑶琪生物科技有限公司 | 用作ntrk激酶抑制剂的化合物及其应用 |
| KR102541026B1 (ko) * | 2020-11-11 | 2023-06-12 | 주식회사 한독 | Trk 억제제 화합물의 제조 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140128A2 (en) | 2008-05-13 | 2009-11-19 | Irm Llc | Compounds and compositions as kinase inhibitors |
| SG10201914059WA (en) * | 2008-10-22 | 2020-03-30 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| AU2009308675A1 (en) | 2008-10-31 | 2010-05-06 | Genentech, Inc. | Pyrazolopyrimidine JAK inhibitor compounds and methods |
| US8591943B2 (en) | 2009-04-09 | 2013-11-26 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors |
| WO2012034095A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2012125668A1 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| US20140288043A1 (en) | 2013-03-19 | 2014-09-25 | Genentech, Inc. | Pyrazolopyridine compounds |
| WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| FR3029769A1 (fr) * | 2014-12-10 | 2016-06-17 | Tornier Sa | Kit pour une prothese d'epaule |
| CA2971024C (en) | 2014-12-15 | 2023-09-26 | Handok Inc. | Fused ring heteroaryl compounds and their use as trk inhibitors |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| JP6475084B2 (ja) | 2015-05-21 | 2019-02-27 | 臼井国際産業株式会社 | トルクセンサ用シャフトの製造設備およびその製造方法 |
| AU2018383571B2 (en) | 2017-12-15 | 2023-09-21 | Pyramid Biosciences, Inc. | 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1H-pyrazol-1-yl)pyrazolo(1,5-a)pyrimidine derivatives and related compounds as Trk kinase inhibitors for treating cancer |
| MX2022012437A (es) | 2020-04-15 | 2022-10-27 | Pyramid Biosciences Inc | Metodos para preparar inhibidores del receptor de la tirosina quinasa. |
-
2018
- 2018-12-12 AU AU2018383571A patent/AU2018383571B2/en active Active
- 2018-12-12 IL IL275059A patent/IL275059B2/en unknown
- 2018-12-12 SG SG11202005237SA patent/SG11202005237SA/en unknown
- 2018-12-12 PT PT188369771T patent/PT3724191T/pt unknown
- 2018-12-12 DK DK18836977.1T patent/DK3724191T3/da active
- 2018-12-12 TW TW107144769A patent/TW201936194A/zh unknown
- 2018-12-12 WO PCT/US2018/065187 patent/WO2019118584A1/en active Application Filing
- 2018-12-12 KR KR1020207020360A patent/KR20200099557A/ko not_active Application Discontinuation
- 2018-12-12 EP EP22152688.2A patent/EP4053128A1/en active Pending
- 2018-12-12 ES ES18836977T patent/ES2908773T3/es active Active
- 2018-12-12 SI SI201830632T patent/SI3724191T1/sl unknown
- 2018-12-12 EP EP18836977.1A patent/EP3724191B9/en active Active
- 2018-12-12 EA EA202091475A patent/EA202091475A1/ru unknown
- 2018-12-12 CA CA3084814A patent/CA3084814A1/en active Pending
- 2018-12-12 CN CN201880080978.XA patent/CN111819179B/zh active Active
- 2018-12-12 MX MX2020006293A patent/MX2020006293A/es unknown
- 2018-12-12 JP JP2020551775A patent/JP7321183B2/ja active Active
- 2018-12-12 LT LTEPPCT/US2018/065187T patent/LT3724191T/lt unknown
- 2018-12-12 US US16/772,253 patent/US11230546B2/en active Active
- 2018-12-12 BR BR112020011775-7A patent/BR112020011775A2/pt unknown
- 2018-12-12 PL PL18836977T patent/PL3724191T3/pl unknown
- 2018-12-12 HU HUE18836977A patent/HUE059313T2/hu unknown
- 2018-12-12 HR HRP20220464TT patent/HRP20220464T1/hr unknown
-
2020
- 2020-06-10 ZA ZA2020/03483A patent/ZA202003483B/en unknown
- 2020-06-13 SA SA520412192A patent/SA520412192B1/ar unknown
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2021
- 2021-11-23 US US17/533,954 patent/US20220235055A1/en not_active Abandoned
-
2022
- 2022-05-27 ZA ZA2022/05900A patent/ZA202205900B/en unknown
- 2022-12-08 US US18/078,087 patent/US11739096B2/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11739096B2 (en) | 2017-12-15 | 2023-08-29 | Pyramid Biosciences, Inc. | 5-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo [1,5-A]pyrimidine derivatives and related compounds as Trk kinase inhibitors for treating cancer |
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