MX2020006293A - Derivados de 5-(2-2,5-difluorofenil)pirrolidin-1-il)-3-(1h-pirazol -1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de trk cinasa para el tratamiento de cancer. - Google Patents

Derivados de 5-(2-2,5-difluorofenil)pirrolidin-1-il)-3-(1h-pirazol -1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de trk cinasa para el tratamiento de cancer.

Info

Publication number
MX2020006293A
MX2020006293A MX2020006293A MX2020006293A MX2020006293A MX 2020006293 A MX2020006293 A MX 2020006293A MX 2020006293 A MX2020006293 A MX 2020006293A MX 2020006293 A MX2020006293 A MX 2020006293A MX 2020006293 A MX2020006293 A MX 2020006293A
Authority
MX
Mexico
Prior art keywords
treating cancer
kinase inhibitors
difluorophenyl
pyrazol
pyrrolidin
Prior art date
Application number
MX2020006293A
Other languages
English (en)
Inventor
Stephane Ciblat
Nicolas Bruneau-Latour
Kollol Pal
Vincent Albert
Jonathan Boudreault
Original Assignee
Pyramid Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pyramid Biosciences Inc filed Critical Pyramid Biosciences Inc
Publication of MX2020006293A publication Critical patent/MX2020006293A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La solicitud hace referencia a derivados de pirazolo[1,5-a]pirimid ina de la fórmula (IV) como inhibidores de Trk cinasa para el tratamiento de cáncer y enfermedades inflamatorias.
MX2020006293A 2017-12-15 2018-12-12 Derivados de 5-(2-2,5-difluorofenil)pirrolidin-1-il)-3-(1h-pirazol -1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de trk cinasa para el tratamiento de cancer. MX2020006293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762599490P 2017-12-15 2017-12-15
PCT/US2018/065187 WO2019118584A1 (en) 2017-12-15 2018-12-12 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer

Publications (1)

Publication Number Publication Date
MX2020006293A true MX2020006293A (es) 2020-12-03

Family

ID=65139120

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006293A MX2020006293A (es) 2017-12-15 2018-12-12 Derivados de 5-(2-2,5-difluorofenil)pirrolidin-1-il)-3-(1h-pirazol -1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de trk cinasa para el tratamiento de cancer.

Country Status (24)

Country Link
US (3) US11230546B2 (es)
EP (2) EP3724191B9 (es)
JP (1) JP7321183B2 (es)
KR (1) KR20200099557A (es)
CN (1) CN111819179B (es)
AU (1) AU2018383571B2 (es)
BR (1) BR112020011775A2 (es)
CA (1) CA3084814A1 (es)
DK (1) DK3724191T3 (es)
EA (1) EA202091475A1 (es)
ES (1) ES2908773T3 (es)
HR (1) HRP20220464T1 (es)
HU (1) HUE059313T2 (es)
IL (1) IL275059B2 (es)
LT (1) LT3724191T (es)
MX (1) MX2020006293A (es)
PL (1) PL3724191T3 (es)
PT (1) PT3724191T (es)
SA (1) SA520412192B1 (es)
SG (1) SG11202005237SA (es)
SI (1) SI3724191T1 (es)
TW (1) TW201936194A (es)
WO (1) WO2019118584A1 (es)
ZA (2) ZA202003483B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201936194A (zh) 2017-12-15 2019-09-16 美商金字塔生技公司 肌旋蛋白激酶抑制劑
GB201813791D0 (en) * 2018-08-23 2018-10-10 Benevolental Bio Ltd Organic compounds
EP3932923B1 (en) * 2019-03-19 2023-05-03 Central China Normal University Pyrazolopyrimidine compound, pharmaceutical composition, and application therefor
CN111718350B (zh) * 2019-03-19 2021-04-13 华中师范大学 吡唑取代的吡唑并嘧啶化合物和药物组合物及其应用
CN111848626B (zh) * 2019-04-30 2021-11-30 江苏柯菲平医药股份有限公司 Trk激酶抑制剂及其用途
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
CA3172681A1 (en) * 2020-04-15 2021-10-21 Kollol Pal Methods for preparing tyrosine receptor kinase inhibitors
CN114437077B (zh) * 2020-11-04 2024-01-30 浙江同源康医药股份有限公司 用作激酶抑制剂的化合物及其应用
CN114437075A (zh) * 2020-11-03 2022-05-06 上海瑶琪生物科技有限公司 用作ntrk激酶抑制剂的化合物及其应用
KR102541026B1 (ko) * 2020-11-11 2023-06-12 주식회사 한독 Trk 억제제 화합물의 제조 방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8507488B2 (en) 2008-05-13 2013-08-13 Irm Llc Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
DK3106463T6 (da) 2008-10-22 2020-02-24 Array Biopharma Inc Pyrazolo[1,5-]pyrimidinforbindelse som trk-kinasehæmmer
PE20131197A1 (es) 2008-10-31 2013-11-06 Genentech Inc Compuestos de pirazolopirimidina como inhibidores de jak y composiciones farmaceuticas que los contienen
EP2417138B1 (en) 2009-04-09 2019-11-27 Merck Sharp & Dohme Corp. Pyrazolo[1, 5-a]pyrimidine derivatives as mtor inhibitors
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012125668A1 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
US20140288043A1 (en) 2013-03-19 2014-09-25 Genentech, Inc. Pyrazolopyridine compounds
WO2015143652A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
FR3029769A1 (fr) * 2014-12-10 2016-06-17 Tornier Sa Kit pour une prothese d'epaule
RU2708674C2 (ru) 2014-12-15 2019-12-11 СиЭмДжи ФАРМАСЬЮТИКАЛ КО., ЛТД. Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk
TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
JP6475084B2 (ja) 2015-05-21 2019-02-27 臼井国際産業株式会社 トルクセンサ用シャフトの製造設備およびその製造方法
TW201936194A (zh) 2017-12-15 2019-09-16 美商金字塔生技公司 肌旋蛋白激酶抑制劑
CA3172681A1 (en) 2020-04-15 2021-10-21 Kollol Pal Methods for preparing tyrosine receptor kinase inhibitors

Also Published As

Publication number Publication date
JP2021506954A (ja) 2021-02-22
IL275059A (en) 2020-07-30
AU2018383571B2 (en) 2023-09-21
EP3724191B1 (en) 2022-01-26
ZA202205900B (en) 2023-11-29
ES2908773T3 (es) 2022-05-03
US20210094956A1 (en) 2021-04-01
EP3724191A1 (en) 2020-10-21
JP7321183B2 (ja) 2023-08-04
US11230546B2 (en) 2022-01-25
HRP20220464T1 (hr) 2022-05-27
SA520412192B1 (ar) 2022-08-11
LT3724191T (lt) 2022-04-25
HUE059313T2 (hu) 2022-11-28
PT3724191T (pt) 2022-03-07
BR112020011775A2 (pt) 2020-11-17
EP4053128A1 (en) 2022-09-07
PL3724191T3 (pl) 2022-04-25
TW201936194A (zh) 2019-09-16
EP3724191B9 (en) 2022-05-18
EA202091475A1 (ru) 2020-09-09
US11739096B2 (en) 2023-08-29
AU2018383571A1 (en) 2020-06-18
US20230124248A1 (en) 2023-04-20
DK3724191T3 (da) 2022-03-14
WO2019118584A1 (en) 2019-06-20
IL275059B2 (en) 2023-11-01
SG11202005237SA (en) 2020-07-29
CN111819179A (zh) 2020-10-23
CA3084814A1 (en) 2019-06-20
ZA202003483B (en) 2023-01-25
IL275059B1 (en) 2023-07-01
US20220235055A1 (en) 2022-07-28
CN111819179B (zh) 2023-09-01
KR20200099557A (ko) 2020-08-24
SI3724191T1 (sl) 2022-06-30

Similar Documents

Publication Publication Date Title
MX2020006293A (es) Derivados de 5-(2-2,5-difluorofenil)pirrolidin-1-il)-3-(1h-pirazol -1-il)pirazolo[1,5-a]pirimidina y compuestos relacionados como inhibidores de trk cinasa para el tratamiento de cancer.
ZA201808534B (en) Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide
MD3755703T2 (ro) Derivați N-(fenil)-2-(fenil)pirimidin-4-carboxamidă și compuși înrudiți ca inhibitori HPK1 pentru tratarea cancerului
MX2021013110A (es) Compuestos heterociclicos como inhibidores de la cinasa ret.
NZ598086A (en) Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
EP4104837A3 (en) Heterocyclic compounds as ret kinase inhibitors
TN2019000107A1 (en) Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
PH12018500532A1 (en) 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2- one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer
PE20090506A1 (es) DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZIN COMO INHIBIDORES DE ALK5 Y/O ALK4
PH12014501355A1 (en) Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors
UA106054C2 (uk) ЗАМІЩЕНІ ПІРАЗОЛО[1,5-a]ПІРИМІДИНОВІ СПОЛУКИ ЯК ІНГІБІТОРИ TРK-КІНАЗИ
NZ630719A (en) Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
MY196260A (en) Small Molecule Inhibitors of the Jak Family Of Kinases
NZ711540A (en) Fused heterocyclic compounds as protein kinase inhibitors
EA201000615A1 (ru) Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы)
MX2021003517A (es) Composiciones de inhibidor de tirosina quinasa, metodos de fabricacion y metodos de uso.
MX2014011326A (es) Derivados de 6-(4-(1-amino-3-hidroxiciclobutil) fenil)-5-fenil (furo, tieno o pirrolo) [2, 3-d] pirimidin 4-ona para el tratamiento de cancer.
EP3952865A4 (en) HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS FOR THERAPEUTIC USES
MX2021009426A (es) Derivados de indazolil-isoxazol para el tratamiento de enfermedades tales como cancer.
PH12020550485A1 (en) Crystalline salts of a b-raf kinase inhibitor
PH12019500478A1 (en) 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridinyl compounds, compositions and methods of use thereof
WO2009047216A3 (en) Use of indolocarbazole imides as protein kinase inhibitors for the treatment of hematologic and solid tumors
MX2022000794A (es) Derivados de 4-(imidazo[1,2-a]piridin-3-il)pirimidina.
EA202091983A1 (ru) Производные n-(фенил)-2-(фенил)пиримидин-4-карбоксамида и родственные соединения в качестве ингибиторов hpk1 для лечения рака
EA202091616A2 (ru) ГЕТЕРОАРИЛЗАМЕЩЕННЫЕ ПИРРОЛО[2,3-b]ПИРИДИНЫ И ПИРРОЛО[2,3-b]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ