MX2009013403A - Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. - Google Patents

Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.

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Publication number
MX2009013403A
MX2009013403A MX2009013403A MX2009013403A MX2009013403A MX 2009013403 A MX2009013403 A MX 2009013403A MX 2009013403 A MX2009013403 A MX 2009013403A MX 2009013403 A MX2009013403 A MX 2009013403A MX 2009013403 A MX2009013403 A MX 2009013403A
Authority
MX
Mexico
Prior art keywords
pyrrolo
pyrazol
pyrimidin
cyclopentylpropanenitrile
metabolites
Prior art date
Application number
MX2009013403A
Other languages
English (en)
Inventor
James D Rodgers
Argyrios G Arvanitis
Jack Guoen Shi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2009013403A publication Critical patent/MX2009013403A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención provee metabolitos activos de 3-(4-(7H-pirrolo[2, 3-djpirimidin-4-il)-1H-pirazol-1-il)-3-ciclope ntilpropanonitrilo que modulan la actividad de Janus cinasas y son útiles para el tratamiento de enfermedades relacionadas con la actividad de Janus cinasas que incluyen, por ejemplo, enfermedades relacionadas con el sistema inmine, trastornos cutáneos, trastornos proliferativos mieloides, cáncer y otras enfermedades.
MX2009013403A 2007-06-13 2008-06-12 Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo. MX2009013403A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94369507P 2007-06-13 2007-06-13
PCT/US2008/066658 WO2008157207A2 (en) 2007-06-13 2008-06-12 Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile

Publications (1)

Publication Number Publication Date
MX2009013403A true MX2009013403A (es) 2010-02-24

Family

ID=40029276

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012004948A MX339139B (es) 2007-06-13 2008-06-12 Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo.
MX2009013403A MX2009013403A (es) 2007-06-13 2008-06-12 Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012004948A MX339139B (es) 2007-06-13 2008-06-12 Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo.

Country Status (26)

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US (5) US7834022B2 (es)
EP (1) EP2173751B1 (es)
JP (1) JP5479331B2 (es)
KR (1) KR20100049008A (es)
CN (1) CN101815717B (es)
AR (1) AR067024A1 (es)
AU (1) AU2008266182B8 (es)
BR (1) BRPI0812563A2 (es)
CA (1) CA2689158C (es)
CL (1) CL2008001709A1 (es)
CO (1) CO6251255A2 (es)
CR (1) CR11149A (es)
EA (1) EA017790B1 (es)
EC (1) ECSP099821A (es)
ES (1) ES2448868T3 (es)
GE (1) GEP20125534B (es)
HK (1) HK1141020A1 (es)
IL (1) IL202429A0 (es)
MX (2) MX339139B (es)
NZ (1) NZ581801A (es)
PL (1) PL2173751T3 (es)
PT (1) PT2173751E (es)
TW (1) TWI426911B (es)
UA (1) UA99465C2 (es)
WO (1) WO2008157207A2 (es)
ZA (1) ZA200908820B (es)

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