AR067024A1 - Metabolitos del inhibidor de janus quinasa (r)-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo - Google Patents

Metabolitos del inhibidor de janus quinasa (r)-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo

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Publication number
AR067024A1
AR067024A1 ARP080102565A ARP080102565A AR067024A1 AR 067024 A1 AR067024 A1 AR 067024A1 AR P080102565 A ARP080102565 A AR P080102565A AR P080102565 A ARP080102565 A AR P080102565A AR 067024 A1 AR067024 A1 AR 067024A1
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AR
Argentina
Prior art keywords
pyrrolo
pyrazol
pyrimidin
janus
metabolites
Prior art date
Application number
ARP080102565A
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English (en)
Inventor
James D Rodgers
Argyrios G Arvanitis
Sung-Hyuk Shin
Original Assignee
Incyte Corp
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Publication date
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Publication of AR067024A1 publication Critical patent/AR067024A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

La presente provee metabolitos activos de 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo que modulan la actividad de Janus quinasas y son utiles para el tratamiento de enfermedades relacionadas con la actividad de Janus quinasas que incluyen, por ejemplo, enfermedades relacionadas con el sistema inmune, trastornos cutáneos, trastornos proliferativos mieloides, cáncer y otras enfermedades. Reivindicacion 1: Un compuesto seleccionado, caracterizado porque: 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-(3-hidroxiciclopentil)propanonitrilo; 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-iI)-3-(2-hidroxiciclopentil)propanonitrilo; y 3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-iI)-3-(3-oxociclopentil)propanonitrilo, o una de sus sales farmacéuticamente aceptables.
ARP080102565A 2007-06-13 2008-06-17 Metabolitos del inhibidor de janus quinasa (r)-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo AR067024A1 (es)

Applications Claiming Priority (1)

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US94369507P 2007-06-13 2007-06-13

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AR067024A1 true AR067024A1 (es) 2009-09-30

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ARP080102565A AR067024A1 (es) 2007-06-13 2008-06-17 Metabolitos del inhibidor de janus quinasa (r)-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo

Country Status (26)

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US (5) US7834022B2 (es)
EP (1) EP2173751B1 (es)
JP (1) JP5479331B2 (es)
KR (1) KR20100049008A (es)
CN (1) CN101815717B (es)
AR (1) AR067024A1 (es)
AU (1) AU2008266182B8 (es)
BR (1) BRPI0812563A2 (es)
CA (1) CA2689158C (es)
CL (1) CL2008001709A1 (es)
CO (1) CO6251255A2 (es)
CR (1) CR11149A (es)
EA (1) EA017790B1 (es)
EC (1) ECSP099821A (es)
ES (1) ES2448868T3 (es)
GE (1) GEP20125534B (es)
HK (1) HK1141020A1 (es)
IL (1) IL202429A0 (es)
MX (2) MX339139B (es)
NZ (1) NZ581801A (es)
PL (1) PL2173751T3 (es)
PT (1) PT2173751E (es)
TW (1) TWI426911B (es)
UA (1) UA99465C2 (es)
WO (1) WO2008157207A2 (es)
ZA (1) ZA200908820B (es)

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