BR0316487A - Método todo de tratamento da rejeição de transplantes - Google Patents
Método todo de tratamento da rejeição de transplantesInfo
- Publication number
- BR0316487A BR0316487A BR0316487-0A BR0316487A BR0316487A BR 0316487 A BR0316487 A BR 0316487A BR 0316487 A BR0316487 A BR 0316487A BR 0316487 A BR0316487 A BR 0316487A
- Authority
- BR
- Brazil
- Prior art keywords
- transplant rejection
- whole method
- treating transplant
- treating
- whole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"MéTODO TODO DE TRATAMENTO DA REJEIçãO DE TRANSPLANTES". Método de tratamento ou prevenção da rejeição crónica de órgãos transplantados compreendendo a administração de um composto de fórmula em que R¬ 1¬, R¬ 2¬ e R¬ 3¬ são como definido acima.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42978402P | 2002-11-26 | 2002-11-26 | |
PCT/IB2003/005229 WO2004047843A1 (en) | 2002-11-26 | 2003-11-17 | Method of treatment of transplant rejection |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0316487A true BR0316487A (pt) | 2005-10-11 |
Family
ID=32393587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0316487-0A BR0316487A (pt) | 2002-11-26 | 2003-11-17 | Método todo de tratamento da rejeição de transplantes |
Country Status (15)
Country | Link |
---|---|
US (1) | US7250420B2 (pt) |
EP (1) | EP1572213A1 (pt) |
JP (1) | JP2006509000A (pt) |
KR (1) | KR20050086784A (pt) |
CN (1) | CN1717236A (pt) |
AU (1) | AU2003276591A1 (pt) |
BR (1) | BR0316487A (pt) |
CA (1) | CA2507392A1 (pt) |
MX (1) | MXPA05005576A (pt) |
MY (1) | MY137250A (pt) |
NZ (1) | NZ539901A (pt) |
PL (1) | PL378246A1 (pt) |
TW (1) | TW200418482A (pt) |
WO (1) | WO2004047843A1 (pt) |
ZA (1) | ZA200503811B (pt) |
Families Citing this family (64)
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---|---|---|---|---|
PT1235830E (pt) | 1999-12-10 | 2004-04-30 | Pfizer Prod Inc | Compostos de pirrolo¬2,3-d|pirimidina como inibidores das proteina cinases |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
DK1534286T3 (da) | 2002-07-29 | 2010-04-26 | Rigel Pharmaceuticals Inc | Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser |
WO2004047843A1 (en) | 2002-11-26 | 2004-06-10 | Pfizer Products Inc. | Method of treatment of transplant rejection |
CN1849318B (zh) | 2003-07-30 | 2011-10-12 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物预防和治疗自体免疫疾病的方法 |
US20050137684A1 (en) * | 2003-12-17 | 2005-06-23 | Pfizer Inc | Stent with therapeutically active drug coated thereon |
AU2004305317A1 (en) * | 2003-12-17 | 2005-07-07 | Pfizer Products Inc. | Pyrrolo [2,3-D] pyrimidine compounds for treating transplant rejection |
AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
US7884109B2 (en) * | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
CA2604161A1 (en) * | 2005-04-05 | 2006-10-12 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US7491732B2 (en) | 2005-06-08 | 2009-02-17 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
KR20080026654A (ko) | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
EP2270014A1 (en) | 2005-09-22 | 2011-01-05 | Incyte Corporation | Azepine inhibitors of janus kinases |
KR101391900B1 (ko) | 2005-12-13 | 2014-05-02 | 인사이트 코포레이션 | 야누스 키나아제 억제제로서의 헤테로아릴 치환된 피롤로[2,3-b]피리딘 및 피롤로[2,3-b]피리미딘 |
US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
WO2007098507A2 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US7919490B2 (en) * | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
US7915268B2 (en) * | 2006-10-04 | 2011-03-29 | Wyeth Llc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
ATE497496T1 (de) | 2006-10-19 | 2011-02-15 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen |
US20080119496A1 (en) * | 2006-11-16 | 2008-05-22 | Pharmacopeia Drug Discovery, Inc. | 7-Substituted Purine Derivatives for Immunosuppression |
JP5492565B2 (ja) | 2006-12-22 | 2014-05-14 | インサイト・コーポレイション | Janusキナーゼ阻害剤としての置換複素環 |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
KR101549876B1 (ko) | 2007-06-13 | 2015-09-03 | 인사이트 코포레이션 | 야누스 키나제 억제제(R)―3―(4―(7H―피롤로[2,3-d]피리미딘―4―일)―1H―피라졸―1―일)―3―사이클로펜틸프로판니트릴의 염 |
PL2265607T3 (pl) | 2008-02-15 | 2017-07-31 | Rigel Pharmaceuticals, Inc. | Związki pirymidyno-2-aminowe i ich zastosowanie jako inhibitory kinaz JAK |
EP2288610B8 (en) | 2008-03-11 | 2016-10-12 | Incyte Holdings Corporation | Azetidine and cyclobutane derivatives as jak inhibitors |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
BRPI0910921B1 (pt) | 2008-04-16 | 2022-06-21 | Portola Pharmaceuticals, Inc | Inibidores de proteína syk quinase, composição farmacêutica, kit e usos dos referidos inibidores |
CA2723185A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
MX2011001259A (es) * | 2008-08-01 | 2011-03-15 | Biocryst Pharm Inc | Derivados de piperidina como inhibidores jak3. |
SI2384326T1 (sl) | 2008-08-20 | 2014-06-30 | Zoetis Llc | Pirolo(2,3-d)pirimidinske spojine |
EP2421867B1 (en) | 2009-04-20 | 2015-09-02 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
ES2487542T3 (es) | 2009-05-22 | 2014-08-21 | Incyte Corporation | Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus |
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CN102596960B (zh) | 2009-10-09 | 2016-01-20 | 因西特控股公司 | 3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的羟基衍生物、酮基衍生物和葡糖苷酸衍生物 |
SI3050882T1 (en) | 2010-03-10 | 2018-06-29 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives, as inhibitors of JAK1 |
TWI499421B (zh) | 2010-05-21 | 2015-09-11 | Incyte Corp | Jak抑制劑的局部製劑 |
US9102625B2 (en) | 2010-11-01 | 2015-08-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as JAK kinase modulators |
PE20140146A1 (es) | 2010-11-19 | 2014-02-06 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
CN103732226B (zh) | 2011-02-18 | 2016-01-06 | 诺瓦提斯药物公司 | mTOR/JAK抑制剂组合疗法 |
WO2012127506A1 (en) | 2011-03-22 | 2012-09-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
ES2560611T3 (es) | 2011-06-20 | 2016-02-22 | Incyte Holdings Corporation | Derivados de fenil de azetidinilo, carboxamida de piridilo o pirazinilo como inhibidores de JAK |
EP2741747A1 (en) | 2011-08-10 | 2014-06-18 | Novartis Pharma AG | JAK P13K/mTOR COMBINATION THERAPY |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
US8877760B2 (en) | 2011-11-23 | 2014-11-04 | Portola Pharmaceuticals, Inc. | Substituted pyrazine-2-carboxamide kinase inhibitors |
TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
EP2897962A1 (en) | 2012-09-21 | 2015-07-29 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
EP2903970A4 (en) | 2012-10-08 | 2016-11-30 | Portola Pharm Inc | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS |
UA120834C2 (uk) | 2012-11-15 | 2020-02-25 | Інсайт Холдінгс Корпорейшн | Лікарські форми руксолітинібу зі сповільненим вивільненням |
CN103896826B (zh) * | 2012-12-26 | 2016-08-03 | 上海朴颐化学科技有限公司 | 氮保护的(3r,4r)-3-甲氨基-4-甲基哌啶的不对称合成方法、相关中间体及原料制备方法 |
CA3091179C (en) | 2013-03-06 | 2023-01-17 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
CN105579032A (zh) | 2013-08-07 | 2016-05-11 | 因赛特公司 | Jak1抑制剂的持续释放剂型 |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
CN107602569A (zh) * | 2017-10-23 | 2018-01-19 | 上海博悦生物科技有限公司 | 一种新型吡咯并[2,3‑d]嘧啶化合物及其合成方法和用途 |
WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
MA51771B1 (fr) | 2018-01-30 | 2022-03-31 | Incyte Corp | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) |
SG11202009441PA (en) | 2018-03-30 | 2020-10-29 | Incyte Corp | Treatment of hidradenitis suppurativa using jak inhibitors |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
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-
2003
- 2003-11-17 WO PCT/IB2003/005229 patent/WO2004047843A1/en not_active Application Discontinuation
- 2003-11-17 JP JP2004554807A patent/JP2006509000A/ja not_active Withdrawn
- 2003-11-17 CN CNA2003801042374A patent/CN1717236A/zh active Pending
- 2003-11-17 EP EP03811831A patent/EP1572213A1/en not_active Withdrawn
- 2003-11-17 BR BR0316487-0A patent/BR0316487A/pt not_active IP Right Cessation
- 2003-11-17 KR KR1020057009377A patent/KR20050086784A/ko not_active Application Discontinuation
- 2003-11-17 PL PL378246A patent/PL378246A1/pl not_active Application Discontinuation
- 2003-11-17 MX MXPA05005576A patent/MXPA05005576A/es unknown
- 2003-11-17 NZ NZ539901A patent/NZ539901A/en unknown
- 2003-11-17 AU AU2003276591A patent/AU2003276591A1/en not_active Abandoned
- 2003-11-17 CA CA002507392A patent/CA2507392A1/en not_active Abandoned
- 2003-11-20 TW TW092132613A patent/TW200418482A/zh unknown
- 2003-11-21 MY MYPI20034496A patent/MY137250A/en unknown
- 2003-11-24 US US10/720,600 patent/US7250420B2/en not_active Expired - Fee Related
-
2005
- 2005-05-11 ZA ZA200503811A patent/ZA200503811B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2004047843A1 (en) | 2004-06-10 |
MY137250A (en) | 2009-01-30 |
AU2003276591A1 (en) | 2004-06-18 |
US7250420B2 (en) | 2007-07-31 |
EP1572213A1 (en) | 2005-09-14 |
ZA200503811B (en) | 2006-07-26 |
NZ539901A (en) | 2007-09-28 |
US20040116449A1 (en) | 2004-06-17 |
TW200418482A (en) | 2004-10-01 |
JP2006509000A (ja) | 2006-03-16 |
CA2507392A1 (en) | 2004-06-10 |
KR20050086784A (ko) | 2005-08-30 |
MXPA05005576A (es) | 2005-07-27 |
CN1717236A (zh) | 2006-01-04 |
PL378246A1 (pl) | 2006-03-20 |
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