BR112015012497A2 - combinações farmacêuticas - Google Patents
combinações farmacêuticasInfo
- Publication number
- BR112015012497A2 BR112015012497A2 BR112015012497A BR112015012497A BR112015012497A2 BR 112015012497 A2 BR112015012497 A2 BR 112015012497A2 BR 112015012497 A BR112015012497 A BR 112015012497A BR 112015012497 A BR112015012497 A BR 112015012497A BR 112015012497 A2 BR112015012497 A2 BR 112015012497A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- combination
- protein kinase
- pharmaceutical combinations
- acceptable salt
- Prior art date
Links
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo "combinações farmacêuticas". uma combinação farmacêutica compreendendo: (a) um composto inibidor de proteína quinase c (pkc), ou um sal farmaceuticamente aceitável do mesmo, e (b) pelo menos um inibidor de proteína quinase ativado por mitógeno (mek) ou um sal farmaceuticamente aceitável do mesmo, e, opcionalmente, um carreador farmaceuticamente aceitável, para administração simultânea, separada ou sequencial; as utilizações de tal combinação no tratamento de doenças proliferativas; e métodos de tratamento de um sujeito que sofre de uma doença proliferativa que compreende a administração de uma quantidade terapeuticamente eficaz de tal combinação.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261731174P | 2012-11-29 | 2012-11-29 | |
US61/731,174 | 2012-11-29 | ||
US201261731555P | 2012-11-30 | 2012-11-30 | |
US61/731,555 | 2012-11-30 | ||
US201361755520P | 2013-01-23 | 2013-01-23 | |
US61/755,520 | 2013-01-23 | ||
PCT/US2013/071852 WO2014085381A1 (en) | 2012-11-29 | 2013-11-26 | Pharmaceutical combinations |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015012497A2 true BR112015012497A2 (pt) | 2017-07-11 |
BR112015012497A8 BR112015012497A8 (pt) | 2019-10-01 |
BR112015012497B1 BR112015012497B1 (pt) | 2022-05-17 |
Family
ID=49753513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015012497-6A BR112015012497B1 (pt) | 2012-11-29 | 2013-11-26 | Combinações e composições farmacêuticas, seus usos, preparação combinada, e embalagem comercial |
Country Status (17)
Country | Link |
---|---|
US (1) | US9446043B2 (pt) |
EP (1) | EP2925366B1 (pt) |
JP (1) | JP6437444B2 (pt) |
CN (1) | CN104812415A (pt) |
AU (1) | AU2013352379B2 (pt) |
BR (1) | BR112015012497B1 (pt) |
CA (1) | CA2892578C (pt) |
DK (1) | DK2925366T3 (pt) |
ES (1) | ES2669248T3 (pt) |
HK (1) | HK1215789A1 (pt) |
HU (1) | HUE037618T2 (pt) |
NZ (1) | NZ708802A (pt) |
PL (1) | PL2925366T3 (pt) |
RU (1) | RU2674995C2 (pt) |
TR (1) | TR201806682T4 (pt) |
UA (1) | UA115250C2 (pt) |
WO (1) | WO2014085381A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201904851D0 (en) | 2019-04-05 | 2019-05-22 | Katholieke Univ Leven | Melanoma treatment |
US11086278B2 (en) | 2019-08-29 | 2021-08-10 | Inventus Holdings, Llc | Adaptive system monitoring using incremental regression model development |
EP4322953A1 (en) * | 2021-04-15 | 2024-02-21 | Ideaya Biosciences, Inc. | Combination therapy comprising a pkc inhibitor and a mek inhibitor |
WO2024044774A2 (en) * | 2022-08-26 | 2024-02-29 | Ideaya Biosciences, Inc. | Methods of treating uveal melanoma with a pkc inhibitor |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5489608A (en) | 1989-12-21 | 1996-02-06 | Goedecke Aktiengesellschaft | Indolocarbazole derivatives and the use thereof |
US5475085A (en) | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
HU219709B (hu) | 1993-12-07 | 2001-06-28 | Eli Lilly And Co. | Proteinkináz C gátló hatású kondenzált indolszármazékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények |
DK0817627T3 (da) | 1993-12-23 | 2005-06-06 | Lilly Co Eli | Inhibitorer af proteinkinase C |
US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
HU226821B1 (en) | 1995-11-20 | 2009-11-30 | Lilly Co Eli | The mesylate salt of a macrocyclic bis-indolyl-maleimide derivative, process for its preparation, use thereof and pharmaceutical compositions containing the same |
US6960614B2 (en) | 2000-07-19 | 2005-11-01 | Warner-Lambert Company | Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids |
US6645970B2 (en) | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
EP1337527B1 (en) | 2000-11-07 | 2009-10-14 | Novartis AG | Indolylmaleimide derivatives as protein kinase c inhibitors |
ES2407849T3 (es) * | 2002-03-13 | 2013-06-14 | Array Biopharma, Inc. | Derivados de bencimidazol alquilados N3 como inhibidores de MEK |
TWI324064B (en) | 2002-04-03 | 2010-05-01 | Novartis Ag | Indolylmaleimide derivatives |
US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
RU2364596C2 (ru) | 2004-06-11 | 2009-08-20 | Джапан Тобакко Инк. | ПРОИЗВОДНЫЕ 5-АМИНО-2,4,7-ТРИОКСО-3,4,7,8-ТЕТРАГИДРО-2Н-ПИРИДО[2,3-d] ПИРИМИДИНА, ОБЛАДАЮЩИЕ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ |
MY149960A (en) | 2005-05-18 | 2013-11-15 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
KR20080023732A (ko) | 2005-07-11 | 2008-03-14 | 노파르티스 아게 | 인돌릴말레이미드 유도체 |
-
2013
- 2013-11-26 HU HUE13802815A patent/HUE037618T2/hu unknown
- 2013-11-26 EP EP13802815.4A patent/EP2925366B1/en active Active
- 2013-11-26 CN CN201380061889.8A patent/CN104812415A/zh active Pending
- 2013-11-26 JP JP2015545170A patent/JP6437444B2/ja active Active
- 2013-11-26 UA UAA201505167A patent/UA115250C2/uk unknown
- 2013-11-26 RU RU2015124954A patent/RU2674995C2/ru active
- 2013-11-26 WO PCT/US2013/071852 patent/WO2014085381A1/en active Application Filing
- 2013-11-26 PL PL13802815T patent/PL2925366T3/pl unknown
- 2013-11-26 TR TR2018/06682T patent/TR201806682T4/tr unknown
- 2013-11-26 NZ NZ70880213A patent/NZ708802A/en unknown
- 2013-11-26 US US14/647,939 patent/US9446043B2/en active Active
- 2013-11-26 DK DK13802815.4T patent/DK2925366T3/en active
- 2013-11-26 BR BR112015012497-6A patent/BR112015012497B1/pt active IP Right Grant
- 2013-11-26 ES ES13802815.4T patent/ES2669248T3/es active Active
- 2013-11-26 AU AU2013352379A patent/AU2013352379B2/en active Active
- 2013-11-26 CA CA2892578A patent/CA2892578C/en active Active
-
2016
- 2016-03-31 HK HK16103725.8A patent/HK1215789A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2013352379B2 (en) | 2018-09-06 |
DK2925366T3 (en) | 2018-06-06 |
RU2674995C2 (ru) | 2018-12-14 |
CA2892578C (en) | 2021-01-12 |
AU2013352379A1 (en) | 2015-06-11 |
RU2015124954A (ru) | 2017-01-11 |
JP6437444B2 (ja) | 2018-12-12 |
ES2669248T3 (es) | 2018-05-24 |
US9446043B2 (en) | 2016-09-20 |
CA2892578A1 (en) | 2014-06-05 |
JP2016501222A (ja) | 2016-01-18 |
BR112015012497A8 (pt) | 2019-10-01 |
TR201806682T4 (tr) | 2018-06-21 |
WO2014085381A1 (en) | 2014-06-05 |
NZ708802A (en) | 2019-09-27 |
CN104812415A (zh) | 2015-07-29 |
UA115250C2 (uk) | 2017-10-10 |
EP2925366B1 (en) | 2018-02-21 |
PL2925366T3 (pl) | 2018-08-31 |
US20150306101A1 (en) | 2015-10-29 |
HUE037618T2 (hu) | 2018-09-28 |
EP2925366A1 (en) | 2015-10-07 |
BR112015012497B1 (pt) | 2022-05-17 |
HK1215789A1 (zh) | 2016-09-15 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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