EA201070012A1 - МЕТАБОЛИТЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА, ИНГИБИТОРА JANUS КИНАЗ - Google Patents
МЕТАБОЛИТЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА, ИНГИБИТОРА JANUS КИНАЗInfo
- Publication number
- EA201070012A1 EA201070012A1 EA201070012A EA201070012A EA201070012A1 EA 201070012 A1 EA201070012 A1 EA 201070012A1 EA 201070012 A EA201070012 A EA 201070012A EA 201070012 A EA201070012 A EA 201070012A EA 201070012 A1 EA201070012 A1 EA 201070012A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrrolo
- pyrazol
- pyrimidin
- janus
- metabolites
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Genetics & Genomics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
Abstract
Данное изобретение предлагает активные метаболиты 3-(4-(7Н-пирроло[2,3-d]пиримидин-4-ил)-1Н-пиразол-1-ил)-3-циклопентилпропаннитрила, которые модулируют активность Janus киназ и которые используют для лечения заболеваний, связанных с активностью Janus киназ, включая, например, связанные с иммунной системой болезни, кожные заболевания, миелоидные пролиферативные нарушения, рак и другие болезни.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94369507P | 2007-06-13 | 2007-06-13 | |
PCT/US2008/066658 WO2008157207A2 (en) | 2007-06-13 | 2008-06-12 | Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3- cyclopentylpropanenitrile |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201070012A1 true EA201070012A1 (ru) | 2010-06-30 |
EA017790B1 EA017790B1 (ru) | 2013-03-29 |
Family
ID=40029276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070012A EA017790B1 (ru) | 2007-06-13 | 2008-06-12 | МЕТАБОЛИТЫ (R)-3-(4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ)-3-ЦИКЛОПЕНТИЛПРОПАННИТРИЛА, ИНГИБИТОРА JANUS КИНАЗ |
Country Status (26)
Country | Link |
---|---|
US (5) | US7834022B2 (ru) |
EP (1) | EP2173751B1 (ru) |
JP (1) | JP5479331B2 (ru) |
KR (1) | KR20100049008A (ru) |
CN (1) | CN101815717B (ru) |
AR (1) | AR067024A1 (ru) |
AU (1) | AU2008266182B8 (ru) |
BR (1) | BRPI0812563A2 (ru) |
CA (1) | CA2689158C (ru) |
CL (1) | CL2008001709A1 (ru) |
CO (1) | CO6251255A2 (ru) |
CR (1) | CR11149A (ru) |
EA (1) | EA017790B1 (ru) |
EC (1) | ECSP099821A (ru) |
ES (1) | ES2448868T3 (ru) |
GE (1) | GEP20125534B (ru) |
HK (1) | HK1141020A1 (ru) |
IL (1) | IL202429A0 (ru) |
MX (2) | MX339139B (ru) |
NZ (1) | NZ581801A (ru) |
PL (1) | PL2173751T3 (ru) |
PT (1) | PT2173751E (ru) |
TW (1) | TWI426911B (ru) |
UA (1) | UA99465C2 (ru) |
WO (1) | WO2008157207A2 (ru) |
ZA (1) | ZA200908820B (ru) |
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