UA117572C2 - Трициклічні конденсовані похідні тіофену як інгібітори jak - Google Patents

Трициклічні конденсовані похідні тіофену як інгібітори jak

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Publication number
UA117572C2
UA117572C2 UAA201505321A UAA201505321A UA117572C2 UA 117572 C2 UA117572 C2 UA 117572C2 UA A201505321 A UAA201505321 A UA A201505321A UA A201505321 A UAA201505321 A UA A201505321A UA 117572 C2 UA117572 C2 UA 117572C2
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Ukraine
Prior art keywords
thiophene derivatives
tricyclic fused
fused thiophene
jak inhibitors
jak
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UAA201505321A
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English (en)
Inventor
Юнь-Лун Лі
Веньюй Чжу
Сун Мей
Джозеф Глєнн
Original Assignee
Інсайт Холдинґс Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49578588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA117572(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Інсайт Холдинґс Корпорейшн filed Critical Інсайт Холдинґс Корпорейшн
Publication of UA117572C2 publication Critical patent/UA117572C2/uk

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

У цьому винаході пропонуються трициклічні конденсовані похідні тіофену, а також їхні композиції і способи застосування, які модулюють активність янус-кінази (JAK) і придатні для лікування захворювань, пов'язаних з активністю JAK, зокрема, наприклад, запальних розладів, аутоімунних розладів, раку та інших захворювань.
UAA201505321A 2012-11-01 2013-10-31 Трициклічні конденсовані похідні тіофену як інгібітори jak UA117572C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261721308P 2012-11-01 2012-11-01
US201361783850P 2013-03-14 2013-03-14
PCT/US2013/067794 WO2014071031A1 (en) 2012-11-01 2013-10-31 Tricyclic fused thiophene derivatives as jak inhibitors

Publications (1)

Publication Number Publication Date
UA117572C2 true UA117572C2 (uk) 2018-08-27

Family

ID=49578588

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201505321A UA117572C2 (uk) 2012-11-01 2013-10-31 Трициклічні конденсовані похідні тіофену як інгібітори jak

Country Status (22)

Country Link
US (6) US9181271B2 (uk)
EP (1) EP2917221A1 (uk)
JP (2) JP6359546B2 (uk)
KR (1) KR20150074193A (uk)
CN (2) CN104918945B (uk)
AR (1) AR093308A1 (uk)
AU (2) AU2013337824B2 (uk)
BR (1) BR112015009942A2 (uk)
CA (1) CA2888816A1 (uk)
CL (1) CL2015001160A1 (uk)
CR (1) CR20150255A (uk)
EA (1) EA031882B1 (uk)
HK (1) HK1214823A1 (uk)
IL (2) IL238410B (uk)
MX (1) MX2015005428A (uk)
NZ (1) NZ707495A (uk)
PE (1) PE20151141A1 (uk)
PH (1) PH12015500963B1 (uk)
SG (2) SG11201503141TA (uk)
TW (1) TWI646099B (uk)
UA (1) UA117572C2 (uk)
WO (1) WO2014071031A1 (uk)

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