SMP201000002B - Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile - Google Patents

Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile

Info

Publication number
SMP201000002B
SMP201000002B SM201000002T SM201000002T SMP201000002B SM P201000002 B SMP201000002 B SM P201000002B SM 201000002 T SM201000002 T SM 201000002T SM 201000002 T SM201000002 T SM 201000002T SM P201000002 B SMP201000002 B SM P201000002B
Authority
SM
San Marino
Prior art keywords
cyclopentylpropanonitrile
kanase
janus
pyrrolo
pyrimidin
Prior art date
Application number
SM201000002T
Other languages
English (en)
Other versions
SMAP201000002A (it
Inventor
James D Rodgers
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMP201000002(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of SMAP201000002A publication Critical patent/SMAP201000002A/it
Publication of SMP201000002B publication Critical patent/SMP201000002B/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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SM201000002T 2007-06-13 2010-01-08 Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile SMP201000002B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
PCT/US2008/066662 WO2008157208A2 (en) 2007-06-13 2008-06-12 Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Publications (2)

Publication Number Publication Date
SMAP201000002A SMAP201000002A (it) 2010-05-07
SMP201000002B true SMP201000002B (it) 2010-07-13

Family

ID=40029273

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201000002T SMP201000002B (it) 2007-06-13 2010-01-08 Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile

Country Status (41)

Country Link
US (10) US20080312259A1 (it)
EP (6) EP4011883B1 (it)
JP (1) JP5475653B2 (it)
KR (2) KR101549876B1 (it)
CN (2) CN103524509B (it)
AU (1) AU2008266183B2 (it)
BR (1) BRPI0814254B8 (it)
CA (1) CA2689663C (it)
CO (1) CO6251256A2 (it)
CR (1) CR11151A (it)
CU (2) CU24179B1 (it)
CY (3) CY1115145T1 (it)
DK (3) DK2740731T3 (it)
DO (1) DOP2009000280A (it)
EA (1) EA019784B1 (it)
EC (1) ECSP099802A (it)
ES (4) ES2903444T3 (it)
GE (1) GEP20125533B (it)
GT (1) GT200900314A (it)
HR (3) HRP20140541T4 (it)
HU (2) HUE029236T2 (it)
IL (5) IL202524A (it)
LT (1) LT3070090T (it)
MA (1) MA31517B1 (it)
ME (1) ME00960B (it)
MX (2) MX2009013402A (it)
MY (1) MY154969A (it)
NI (1) NI200900216A (it)
NO (1) NO2019025I1 (it)
NZ (1) NZ581803A (it)
PL (3) PL2740731T3 (it)
PT (2) PT2173752E (it)
RS (3) RS54878B1 (it)
SG (3) SG10201509887UA (it)
SI (3) SI2740731T1 (it)
SM (1) SMP201000002B (it)
TN (1) TN2009000514A1 (it)
TR (1) TR201903488T4 (it)
UA (1) UA99467C2 (it)
WO (1) WO2008157208A2 (it)
ZA (1) ZA200908826B (it)

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JP5480813B2 (ja) * 2007-11-16 2014-04-23 インサイト・コーポレイション Ｊａｎｕｓキナーゼ阻害剤としての置換複素環
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JP5948337B2 (ja) * 2010-11-02 2016-07-06 ザ トラスティース オブ コロンビア ユニバーシティ インザ シティ オブ ニューヨーク 脱毛症の治療方法
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