BRPI0814254A8 - Sais do inibidor de janus quinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrila, seu método de preparação e composição que os compreende - Google Patents

Sais do inibidor de janus quinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrila, seu método de preparação e composição que os compreende

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Publication number
BRPI0814254A8
BRPI0814254A8 BRPI0814254A BRPI0814254A BRPI0814254A8 BR PI0814254 A8 BRPI0814254 A8 BR PI0814254A8 BR PI0814254 A BRPI0814254 A BR PI0814254A BR PI0814254 A BRPI0814254 A BR PI0814254A BR PI0814254 A8 BRPI0814254 A8 BR PI0814254A8
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BR
Brazil
Prior art keywords
janus kinase
pyrimidin
salts
cyclopentylpropanonitrile
pyrolo
Prior art date
Application number
BRPI0814254A
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English (en)
Inventor
D Rodgers James
Li Hui-Yin
Original Assignee
Incyte Corp
Incyte Holdings Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0814254(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp, Incyte Holdings Corp filed Critical Incyte Corp
Publication of BRPI0814254A2 publication Critical patent/BRPI0814254A2/pt
Publication of BRPI0814254A8 publication Critical patent/BRPI0814254A8/pt
Publication of BRPI0814254B1 publication Critical patent/BRPI0814254B1/pt
Publication of BRPI0814254B8 publication Critical patent/BRPI0814254B8/pt

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

SAIS DO INIBIDOR DE JANUS QUINASE (R)-3-(4- (7H PlRROLO[2,3-d]PlRlMIDIN4-IL)-1H-PIR&OL-1-IL)-3-ClCLOPENTIL- PROPANONITRILA A presente invenção fornece formas de sal de (R)-3-(4-(7H- pirrolo[2,3-d]pirimidin-4-i|)-|H-pirazo|-l-il)-3-ciclopentilpropanonitri|a que são úteis na modulação de atividade de Janus quinase e são úteis no tratamento de doenças relacionadas com a atividade de Janus quinases incluindo, por exemplo, doenças imunorrelacionadas, distúrbios da pele, distúrbios proliferativos mieloides, câncer, e outras doenças.
BRPI0814254A 2007-06-13 2008-06-12 sais do inibidor de janus quinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrila, seu método de preparação e composição que os compreende BRPI0814254B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
US60/943,705 2007-06-13
PCT/US2008/066662 WO2008157208A2 (en) 2007-06-13 2008-06-12 Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Publications (4)

Publication Number Publication Date
BRPI0814254A2 BRPI0814254A2 (pt) 2015-01-06
BRPI0814254A8 true BRPI0814254A8 (pt) 2017-07-11
BRPI0814254B1 BRPI0814254B1 (pt) 2021-03-16
BRPI0814254B8 BRPI0814254B8 (pt) 2021-05-25

Family

ID=40029273

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814254A BRPI0814254B8 (pt) 2007-06-13 2008-06-12 sais do inibidor de janus quinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrila, seu método de preparação e composição que os compreende

Country Status (42)

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US (10) US20080312259A1 (pt)
EP (5) EP3495369B1 (pt)
JP (1) JP5475653B2 (pt)
KR (2) KR101549876B1 (pt)
CN (2) CN103524509B (pt)
AU (1) AU2008266183B2 (pt)
BR (1) BRPI0814254B8 (pt)
CA (1) CA2689663C (pt)
CO (1) CO6251256A2 (pt)
CR (1) CR11151A (pt)
CU (2) CU24179B1 (pt)
CY (3) CY1115145T1 (pt)
DK (3) DK2740731T3 (pt)
DO (1) DOP2009000280A (pt)
EA (1) EA019784B1 (pt)
EC (1) ECSP099802A (pt)
ES (4) ES2575797T3 (pt)
GE (1) GEP20125533B (pt)
GT (1) GT200900314A (pt)
HK (2) HK1143161A1 (pt)
HR (3) HRP20140541T4 (pt)
HU (2) HUE043732T2 (pt)
IL (5) IL202524A (pt)
LT (1) LT3070090T (pt)
MA (1) MA31517B1 (pt)
ME (1) ME00960B (pt)
MX (2) MX2009013402A (pt)
MY (1) MY154969A (pt)
NI (1) NI200900216A (pt)
NO (1) NO2019025I1 (pt)
NZ (1) NZ581803A (pt)
PL (3) PL3070090T3 (pt)
PT (2) PT2173752E (pt)
RS (3) RS58449B1 (pt)
SG (3) SG10201509887UA (pt)
SI (3) SI2173752T2 (pt)
SM (1) SMP201000002B (pt)
TN (1) TN2009000514A1 (pt)
TR (1) TR201903488T4 (pt)
UA (1) UA99467C2 (pt)
WO (1) WO2008157208A2 (pt)
ZA (1) ZA200908826B (pt)

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