MA31517B1 - Sels de l'inhibiteur (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile de la janus kinase - Google Patents

Sels de l'inhibiteur (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile de la janus kinase

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Publication number
MA31517B1
MA31517B1 MA32505A MA32505A MA31517B1 MA 31517 B1 MA31517 B1 MA 31517B1 MA 32505 A MA32505 A MA 32505A MA 32505 A MA32505 A MA 32505A MA 31517 B1 MA31517 B1 MA 31517B1
Authority
MA
Morocco
Prior art keywords
janus kinase
cyclopentylpropanenitrile
pyrrolo
pyrazol
pyrimidin
Prior art date
Application number
MA32505A
Other languages
Arabic (ar)
English (en)
Inventor
James D Rodgers
Hui-Yin Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40029273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31517(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MA31517B1 publication Critical patent/MA31517B1/fr

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

La présente invention concerne des formes de sel de (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile qui se révèlent utiles pour la modulation de l'activité janus kinase et se révèlent utiles pour le traitement de maladies liées à l'activité des janus kinases, notamment des maladies liées à l'immunité, des troubles cutanés, des troubles myéloïdes proliférants, le cancer et d'autres maladies.
MA32505A 2007-06-13 2010-01-12 Sels de l'inhibiteur (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile de la janus kinase MA31517B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94370507P 2007-06-13 2007-06-13
PCT/US2008/066662 WO2008157208A2 (fr) 2007-06-13 2008-06-12 Sels de l'inhibiteur (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile de la janus kinase

Publications (1)

Publication Number Publication Date
MA31517B1 true MA31517B1 (fr) 2010-07-01

Family

ID=40029273

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32505A MA31517B1 (fr) 2007-06-13 2010-01-12 Sels de l'inhibiteur (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile de la janus kinase

Country Status (42)

Country Link
US (10) US20080312259A1 (fr)
EP (5) EP3495369B1 (fr)
JP (1) JP5475653B2 (fr)
KR (2) KR20150036210A (fr)
CN (2) CN103524509B (fr)
AU (1) AU2008266183B2 (fr)
BR (1) BRPI0814254B8 (fr)
CA (1) CA2689663C (fr)
CO (1) CO6251256A2 (fr)
CR (1) CR11151A (fr)
CU (2) CU24179B1 (fr)
CY (3) CY1115145T1 (fr)
DK (3) DK2173752T4 (fr)
DO (1) DOP2009000280A (fr)
EA (1) EA019784B1 (fr)
EC (1) ECSP099802A (fr)
ES (4) ES2467665T5 (fr)
GE (1) GEP20125533B (fr)
GT (1) GT200900314A (fr)
HK (2) HK1143161A1 (fr)
HR (3) HRP20140541T4 (fr)
HU (2) HUE043732T2 (fr)
IL (5) IL202524A (fr)
LT (1) LT3070090T (fr)
MA (1) MA31517B1 (fr)
ME (1) ME00960B (fr)
MX (2) MX2009013402A (fr)
MY (1) MY154969A (fr)
NI (1) NI200900216A (fr)
NO (1) NO2019025I1 (fr)
NZ (1) NZ581803A (fr)
PL (3) PL3070090T3 (fr)
PT (2) PT2173752E (fr)
RS (3) RS54878B1 (fr)
SG (3) SG10201912675VA (fr)
SI (3) SI2173752T2 (fr)
SM (1) SMP201000002B (fr)
TN (1) TN2009000514A1 (fr)
TR (1) TR201903488T4 (fr)
UA (1) UA99467C2 (fr)
WO (1) WO2008157208A2 (fr)
ZA (1) ZA200908826B (fr)

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EP2432472B1 (fr) 2009-05-22 2019-10-02 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- ou heptane-nitrile en tant qu'inhibiteurs de jak
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JP5858434B2 (ja) * 2010-02-18 2016-02-10 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｎｕｓキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体
EP4036088B1 (fr) 2010-03-10 2024-04-03 Incyte Holdings Corporation Dérivés de pipéridine-4-yl azétidine utilisés en tant qu'inhibiteurs de jak1
EP3087972A1 (fr) * 2010-05-21 2016-11-02 Incyte Holdings Corporation Formulation topique pour un inhibiteur jak
KR20130102060A (ko) 2010-09-01 2013-09-16 암비트 바이오사이언시즈 코포레이션 퀴나졸린 화합물 및 이의 사용 방법
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