ATE406356T1 - Thiadiazole als cxc- und cc- chemokinrezeptorliganden - Google Patents
Thiadiazole als cxc- und cc- chemokinrezeptorligandenInfo
- Publication number
- ATE406356T1 ATE406356T1 AT04814266T AT04814266T ATE406356T1 AT E406356 T1 ATE406356 T1 AT E406356T1 AT 04814266 T AT04814266 T AT 04814266T AT 04814266 T AT04814266 T AT 04814266T AT E406356 T1 ATE406356 T1 AT E406356T1
- Authority
- AT
- Austria
- Prior art keywords
- cxc
- thiadiazoles
- chemokine receptor
- receptor ligands
- ligands
- Prior art date
Links
- 108091008927 CC chemokine receptors Proteins 0.000 title 1
- 102000005674 CCR Receptors Human genes 0.000 title 1
- 108091008928 CXC chemokine receptors Proteins 0.000 title 1
- 102000054900 CXCR Receptors Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000004867 thiadiazoles Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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| US53131103P | 2003-12-19 | 2003-12-19 | |
| US53171303P | 2003-12-22 | 2003-12-22 |
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| ATE406356T1 true ATE406356T1 (de) | 2008-09-15 |
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| AT04814266T ATE406356T1 (de) | 2003-12-19 | 2004-12-16 | Thiadiazole als cxc- und cc- chemokinrezeptorliganden |
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| EP (1) | EP1694659B8 (de) |
| JP (2) | JP4939229B2 (de) |
| CN (1) | CN1918138B (de) |
| AR (1) | AR046791A1 (de) |
| AT (1) | ATE406356T1 (de) |
| CA (1) | CA2550189A1 (de) |
| DE (1) | DE602004016211D1 (de) |
| ES (1) | ES2308299T3 (de) |
| MX (1) | MXPA06007076A (de) |
| MY (1) | MY139808A (de) |
| TW (1) | TW200528450A (de) |
| WO (1) | WO2005066147A1 (de) |
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| WO2005113534A2 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| DE602006017849D1 (de) * | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
| US7718678B2 (en) * | 2005-06-29 | 2010-05-18 | Schering Corporation | Di-substituted oxadiazoles as CXC-chemokine receptor ligands |
| DK3184526T3 (en) * | 2005-12-13 | 2019-01-14 | Incyte Holdings Corp | PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR |
| DK2740731T3 (en) | 2007-06-13 | 2016-04-11 | Incyte Holdings Corp | CRYSTALLINE SALTS OF JANUSKINASEINHIBITOREN (R) -3- (4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-CYCLOPENTYLPROPANNITRIL |
| WO2009019167A1 (en) | 2007-08-08 | 2009-02-12 | Merck Serono S.A. | 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis |
| SG176464A1 (en) * | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| WO2010050445A1 (ja) | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| AU2010249443B2 (en) | 2009-05-22 | 2015-08-13 | Incyte Holdings Corporation | 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane- or heptane-nitrile as JAK inhibitors |
| MY156727A (en) | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| US20130085133A1 (en) * | 2010-02-08 | 2013-04-04 | Sourthern Research Institute Office of Commercialization and Intellectual Prop. | Anti-viral treatment and assay to screenfor anti-viral agent |
| AU2011224484A1 (en) | 2010-03-10 | 2012-09-27 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors |
| MY161078A (en) | 2010-05-21 | 2017-04-14 | Incyte Holdings Corp | Topical formulation for a jak inhibitor |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EP2640723A1 (de) | 2010-11-19 | 2013-09-25 | Incyte Corporation | Cyclobutyl-substituierte pyrrolopyridin- und pyrrolopyrimidinderivate als jak-inhibitoren |
| KR20140040819A (ko) | 2011-06-20 | 2014-04-03 | 인사이트 코포레이션 | Jak 저해제로서의 아제티디닐 페닐, 피리딜 또는 피라지닐 카르복스아미드 유도체 |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| PH12020551186B1 (en) | 2012-11-15 | 2024-03-20 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| JP6397831B2 (ja) | 2013-03-06 | 2018-09-26 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤の製造方法及びその中間体 |
| KR20160045081A (ko) | 2013-08-07 | 2016-04-26 | 인사이트 코포레이션 | Jak1 억제제용 지속 방출 복용 형태 |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| CN112105608B (zh) | 2018-01-30 | 2023-07-14 | 因赛特公司 | 制备(1-(3-氟-2-(三氟甲基)异烟碱基)哌啶-4-酮)的方法 |
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-
2004
- 2004-12-16 DE DE602004016211T patent/DE602004016211D1/de not_active Expired - Lifetime
- 2004-12-16 MX MXPA06007076A patent/MXPA06007076A/es active IP Right Grant
- 2004-12-16 JP JP2006545364A patent/JP4939229B2/ja not_active Expired - Fee Related
- 2004-12-16 WO PCT/US2004/042060 patent/WO2005066147A1/en not_active Ceased
- 2004-12-16 ES ES04814266T patent/ES2308299T3/es not_active Expired - Lifetime
- 2004-12-16 CA CA002550189A patent/CA2550189A1/en not_active Abandoned
- 2004-12-16 MY MYPI20045183A patent/MY139808A/en unknown
- 2004-12-16 US US11/013,753 patent/US7338968B2/en not_active Expired - Fee Related
- 2004-12-16 EP EP04814266A patent/EP1694659B8/de not_active Expired - Lifetime
- 2004-12-16 TW TW093139212A patent/TW200528450A/zh unknown
- 2004-12-16 CN CN2004800416952A patent/CN1918138B/zh not_active Expired - Fee Related
- 2004-12-16 AT AT04814266T patent/ATE406356T1/de not_active IP Right Cessation
- 2004-12-17 AR ARP040104753A patent/AR046791A1/es not_active Application Discontinuation
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2007
- 2007-09-26 US US11/861,870 patent/US7786149B2/en not_active Expired - Fee Related
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2011
- 2011-02-15 JP JP2011030301A patent/JP2011093943A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1918138B (zh) | 2011-05-04 |
| CA2550189A1 (en) | 2005-07-21 |
| US20060223864A1 (en) | 2006-10-05 |
| MXPA06007076A (es) | 2006-08-31 |
| AR046791A1 (es) | 2005-12-21 |
| JP2011093943A (ja) | 2011-05-12 |
| MY139808A (en) | 2009-10-30 |
| TW200528450A (en) | 2005-09-01 |
| WO2005066147A1 (en) | 2005-07-21 |
| JP2007514746A (ja) | 2007-06-07 |
| EP1694659A1 (de) | 2006-08-30 |
| HK1087711A1 (en) | 2006-10-20 |
| US7786149B2 (en) | 2010-08-31 |
| JP4939229B2 (ja) | 2012-05-23 |
| EP1694659B1 (de) | 2008-08-27 |
| EP1694659B8 (de) | 2008-10-08 |
| ES2308299T3 (es) | 2008-12-01 |
| US7338968B2 (en) | 2008-03-04 |
| US20080090823A1 (en) | 2008-04-17 |
| CN1918138A (zh) | 2007-02-21 |
| DE602004016211D1 (en) | 2008-10-09 |
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