MX2008008320A - Inhibidores de azaindol de aurora cinasas. - Google Patents

Inhibidores de azaindol de aurora cinasas.

Info

Publication number
MX2008008320A
MX2008008320A MX2008008320A MX2008008320A MX2008008320A MX 2008008320 A MX2008008320 A MX 2008008320A MX 2008008320 A MX2008008320 A MX 2008008320A MX 2008008320 A MX2008008320 A MX 2008008320A MX 2008008320 A MX2008008320 A MX 2008008320A
Authority
MX
Mexico
Prior art keywords
aurora kinases
present
azaindole
inhibitors
azaindole inhibitors
Prior art date
Application number
MX2008008320A
Other languages
English (en)
Inventor
Jun Tang
Domingos J Silva
Jerry Leroy Adams
Nicholas D Adams
Jeffrey Michael Axten
Amita M Chaudhari
Dashyant Dhanak
Kenneth Allen Newlander
Cynthia A Parrish
Martha A Sarpong
Toshihiro Hamajima
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MX2008008320A publication Critical patent/MX2008008320A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto representado por la fórmula (I): (ver fórmula (I)) y sales farmacéuticamente aceptables; los compuestos de la presente invención inhiben la aurora cinasa, haciéndola especialmente adecuada para el tratamiento de un número de enfermedades, incluyendo cánceres de tumores sólidos y cánceres hematológicos.
MX2008008320A 2005-12-23 2006-12-19 Inhibidores de azaindol de aurora cinasas. MX2008008320A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75338305P 2005-12-23 2005-12-23
PCT/US2006/062289 WO2007076348A2 (en) 2005-12-23 2006-12-19 Azaindole inhibitors of aurora kinases

Publications (1)

Publication Number Publication Date
MX2008008320A true MX2008008320A (es) 2008-09-03

Family

ID=38218797

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008008320A MX2008008320A (es) 2005-12-23 2006-12-19 Inhibidores de azaindol de aurora cinasas.

Country Status (22)

Country Link
US (4) US7282588B2 (es)
EP (1) EP1962830B1 (es)
JP (1) JP5140600B2 (es)
KR (1) KR20080083680A (es)
CN (1) CN101389324A (es)
AR (1) AR058614A1 (es)
AU (1) AU2006330587B2 (es)
BR (1) BRPI0620341A2 (es)
CA (1) CA2634787C (es)
CR (1) CR10125A (es)
DK (1) DK1962830T3 (es)
EA (1) EA200870117A1 (es)
ES (1) ES2408318T3 (es)
IL (1) IL192351A0 (es)
MA (1) MA30069B1 (es)
MX (1) MX2008008320A (es)
NO (1) NO20083267L (es)
PL (1) PL1962830T3 (es)
PT (1) PT1962830E (es)
SI (1) SI1962830T1 (es)
TW (1) TW200800990A (es)
WO (1) WO2007076348A2 (es)

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US7419988B2 (en) 2008-09-02
US7495102B2 (en) 2009-02-24
US20080004308A1 (en) 2008-01-03
CR10125A (es) 2008-09-23
US20080081808A1 (en) 2008-04-03
US20070149561A1 (en) 2007-06-28
EP1962830B1 (en) 2013-03-27
TW200800990A (en) 2008-01-01
EP1962830A2 (en) 2008-09-03
PL1962830T3 (pl) 2013-08-30
JP5140600B2 (ja) 2013-02-06
WO2007076348A3 (en) 2007-11-01
CN101389324A (zh) 2009-03-18
CA2634787A1 (en) 2007-07-05
KR20080083680A (ko) 2008-09-18
BRPI0620341A2 (pt) 2011-11-08
AU2006330587B2 (en) 2012-12-13
EP1962830A4 (en) 2010-01-06
AU2006330587A1 (en) 2007-07-05
JP2009521492A (ja) 2009-06-04
PT1962830E (pt) 2013-05-29
US20080306120A1 (en) 2008-12-11
NO20083267L (no) 2008-09-04
AR058614A1 (es) 2008-02-13
EA200870117A1 (ru) 2008-12-30
MA30069B1 (fr) 2008-12-01
WO2007076348A2 (en) 2007-07-05
ES2408318T3 (es) 2013-06-20
DK1962830T3 (da) 2013-06-24
US7605266B2 (en) 2009-10-20
CA2634787C (en) 2014-10-21
IL192351A0 (en) 2008-12-29
US7282588B2 (en) 2007-10-16
SI1962830T1 (sl) 2013-07-31

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