CR10125A - Compuestos de azaindol inhibidores de aurora quinasas - Google Patents

Compuestos de azaindol inhibidores de aurora quinasas

Info

Publication number
CR10125A
CR10125A CR10125A CR10125A CR10125A CR 10125 A CR10125 A CR 10125A CR 10125 A CR10125 A CR 10125A CR 10125 A CR10125 A CR 10125A CR 10125 A CR10125 A CR 10125A
Authority
CR
Costa Rica
Prior art keywords
quinasas
azurindol
aurora
compounds
compounds inhibitors
Prior art date
Application number
CR10125A
Other languages
English (en)
Inventor
Jerry Leroy Adams
Nicholas D Adams
Jeffrey Michael Axten
Amita M Chaudhari
Dashyant Dhanak
Toshihiro Hamajima
Kenneth Allen Newlander
Cynthia A Parrish
Martha A Sarpong
Domingos J Silva
Jun Tang
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CR10125A publication Critical patent/CR10125A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto representado por la fórmula (I): y sales farmacéuticamente aceptables. Los compuestos de la presente invención inhiben la Aurora quinasa, lo cual hace que sean especialmente adecuados para el tratamiento de varias enfermedades, incluyendo cánceres de tumores sólidos y cánceres hematológicos.
CR10125A 2005-12-23 2008-06-27 Compuestos de azaindol inhibidores de aurora quinasas CR10125A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75338305P 2005-12-23 2005-12-23

Publications (1)

Publication Number Publication Date
CR10125A true CR10125A (es) 2008-09-23

Family

ID=38218797

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10125A CR10125A (es) 2005-12-23 2008-06-27 Compuestos de azaindol inhibidores de aurora quinasas

Country Status (22)

Country Link
US (4) US7282588B2 (es)
EP (1) EP1962830B1 (es)
JP (1) JP5140600B2 (es)
KR (1) KR20080083680A (es)
CN (1) CN101389324A (es)
AR (1) AR058614A1 (es)
AU (1) AU2006330587B2 (es)
BR (1) BRPI0620341A2 (es)
CA (1) CA2634787C (es)
CR (1) CR10125A (es)
DK (1) DK1962830T3 (es)
EA (1) EA200870117A1 (es)
ES (1) ES2408318T3 (es)
IL (1) IL192351A0 (es)
MA (1) MA30069B1 (es)
MX (1) MX2008008320A (es)
NO (1) NO20083267L (es)
PL (1) PL1962830T3 (es)
PT (1) PT1962830E (es)
SI (1) SI1962830T1 (es)
TW (1) TW200800990A (es)
WO (1) WO2007076348A2 (es)

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JP2009521504A (ja) 2005-12-22 2009-06-04 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性阻害剤
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US20080004308A1 (en) 2008-01-03
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WO2007076348A3 (en) 2007-11-01
CN101389324A (zh) 2009-03-18
AR058614A1 (es) 2008-02-13
IL192351A0 (en) 2008-12-29
DK1962830T3 (da) 2013-06-24
US7495102B2 (en) 2009-02-24
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CA2634787C (en) 2014-10-21
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US20080081808A1 (en) 2008-04-03
US7605266B2 (en) 2009-10-20
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EP1962830A2 (en) 2008-09-03
AU2006330587A1 (en) 2007-07-05

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