EP1165084A4 - Inhibiteurs de prenyl-proteine transferases - Google Patents
Inhibiteurs de prenyl-proteine transferasesInfo
- Publication number
- EP1165084A4 EP1165084A4 EP00910386A EP00910386A EP1165084A4 EP 1165084 A4 EP1165084 A4 EP 1165084A4 EP 00910386 A EP00910386 A EP 00910386A EP 00910386 A EP00910386 A EP 00910386A EP 1165084 A4 EP1165084 A4 EP 1165084A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- prenyl
- inhibitors
- protein transferases
- transferases
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12297199P | 1999-03-03 | 1999-03-03 | |
US122971P | 1999-03-03 | ||
US12725299P | 1999-03-31 | 1999-03-31 | |
US127252P | 1999-03-31 | ||
PCT/US2000/005354 WO2000051614A1 (fr) | 1999-03-03 | 2000-03-01 | Inhibiteurs de prenyl-proteine transferases |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1165084A1 EP1165084A1 (fr) | 2002-01-02 |
EP1165084A4 true EP1165084A4 (fr) | 2002-05-15 |
Family
ID=26821069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00910386A Withdrawn EP1165084A4 (fr) | 1999-03-03 | 2000-03-01 | Inhibiteurs de prenyl-proteine transferases |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1165084A4 (fr) |
JP (1) | JP2002538121A (fr) |
AU (1) | AU3248600A (fr) |
CA (1) | CA2362495A1 (fr) |
WO (1) | WO2000051614A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10035928A1 (de) | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
DE10035927A1 (de) | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
AU2003246571B2 (en) * | 2002-06-29 | 2008-06-26 | Zentaris Gmbh | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases |
SI2348023T1 (sl) | 2005-12-13 | 2015-10-30 | Incyte Corporation | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
KR20090061041A (ko) | 2006-09-11 | 2009-06-15 | 노파르티스 아게 | 대사성 글루타메이트 수용체의 조절제로서의 니코틴산 유도체 |
CU24179B1 (es) | 2007-06-13 | 2016-04-25 | Incyte Corp | SALES DE ÁCIDO MALEICO Y DE ÁCIDO SULFÚRICO DE (R)-3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLOPENTILPROPANITRILO |
US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
HUE046493T2 (hu) | 2009-05-22 | 2020-03-30 | Incyte Holdings Corp | 3-[4-(7H-Pirrolo[2,3-d]pirimidin-4-il)-lH-pirazol-l-il]oktán- vagy heptán-nitril JAK inhibitorokként |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
JP5894540B2 (ja) | 2010-02-18 | 2016-03-30 | ブイティーブイ・セラピューティクス・エルエルシー | フェニル−ヘテロアリール誘導体とその使用の方法 |
DK3050882T3 (en) | 2010-03-10 | 2018-03-19 | Incyte Holdings Corp | PIPERIDIN-4-YL-AZETIDINE DERIVATIVES AS JAK1 INHIBITORS |
ME02445B (fr) | 2010-05-21 | 2016-09-20 | Incyte Holdings Corp | Formulation topique pour inhibiteur de jak |
NZ604035A (en) | 2010-06-04 | 2015-02-27 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
UA113156C2 (xx) | 2010-11-19 | 2016-12-26 | Циклобутилзаміщені похідні піролопіридину й піролопіримідину як інгібітори jak | |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲jak抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
PE20151157A1 (es) | 2012-11-15 | 2015-08-19 | Incyte Corp | Formas de dosificacion de ruxolitinib de liberacion sostenida |
PE20151902A1 (es) | 2013-03-06 | 2015-12-26 | Incyte Corp | Proceso e intermedios para hacer un inhibidor de jak |
RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
WO2015070367A1 (fr) * | 2013-11-12 | 2015-05-21 | Merck Sharp & Dohme Corp. | Dérivés d'imidazole et de triazole liés à la pipéridine ou la pipérazine et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
AU2016295693B2 (en) | 2015-07-17 | 2020-05-21 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
CN111225672B (zh) | 2017-10-16 | 2023-09-29 | 清华大学 | 甲羟戊酸通路抑制剂及其药物组合物 |
WO2019113487A1 (fr) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs |
MA51771B1 (fr) | 2018-01-30 | 2022-03-31 | Incyte Corp | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) |
CN112423759A (zh) | 2018-03-30 | 2021-02-26 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093726A (en) * | 1976-12-02 | 1978-06-06 | Abbott Laboratories | N-(2-benzimidazolyl)-piperazines |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
JPS63183565A (ja) * | 1986-09-24 | 1988-07-28 | Ss Pharmaceut Co Ltd | イミダゾ−ル誘導体 |
JPH01132579A (ja) * | 1987-11-19 | 1989-05-25 | Ss Pharmaceut Co Ltd | インドール誘導体 |
US4940793A (en) * | 1984-08-14 | 1990-07-10 | Ravizza S.P.A. | Pharmacologically active piperazino derivatives |
EP0463756A1 (fr) * | 1990-06-20 | 1992-01-02 | Pfizer Limited | Pyrazolopyrimidones comme agents antiangineux |
US5306719A (en) * | 1986-07-31 | 1994-04-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106663A (en) * | 1980-12-23 | 1982-07-02 | Kyorin Pharmaceut Co Ltd | 1,4-disubstituted piperazine derivative and its preparation |
US5856326A (en) * | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
-
2000
- 2000-03-01 EP EP00910386A patent/EP1165084A4/fr not_active Withdrawn
- 2000-03-01 WO PCT/US2000/005354 patent/WO2000051614A1/fr not_active Application Discontinuation
- 2000-03-01 AU AU32486/00A patent/AU3248600A/en not_active Abandoned
- 2000-03-01 JP JP2000602082A patent/JP2002538121A/ja not_active Withdrawn
- 2000-03-01 CA CA002362495A patent/CA2362495A1/fr not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093726A (en) * | 1976-12-02 | 1978-06-06 | Abbott Laboratories | N-(2-benzimidazolyl)-piperazines |
US4159331A (en) * | 1978-05-05 | 1979-06-26 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
US4940793A (en) * | 1984-08-14 | 1990-07-10 | Ravizza S.P.A. | Pharmacologically active piperazino derivatives |
US5306719A (en) * | 1986-07-31 | 1994-04-26 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
JPS63183565A (ja) * | 1986-09-24 | 1988-07-28 | Ss Pharmaceut Co Ltd | イミダゾ−ル誘導体 |
JPH01132579A (ja) * | 1987-11-19 | 1989-05-25 | Ss Pharmaceut Co Ltd | インドール誘導体 |
EP0463756A1 (fr) * | 1990-06-20 | 1992-01-02 | Pfizer Limited | Pyrazolopyrimidones comme agents antiangineux |
Non-Patent Citations (14)
Title |
---|
BOOTH ET AL., J. AM. CHEM. SOC., vol. 119, no. 21, 1997, pages 4882 - 4886 * |
CURTIN M L ET AL: "Discovery an Evaluation of a Series of 3-Acylindole Imidazopyridine Platelet-Activating Factor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 1, 1998, pages 74 - 95, XP002109994, ISSN: 0022-2623 * |
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002193469, Database accession no. 6443926,6446913,6447198,6447609,6448837,6453688 * |
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002193470, Database accession no. 5967252,5979619 * |
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002193471, Database accession no. 5470544,5471348,5486918,5487504 * |
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002193472, Database accession no. 562408,575956 * |
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002193473, Database accession no. 7775462 * |
DUBEY ET AL., J. MED. CHEM., vol. 28, no. 11, 1985, pages 1748 - 1750 * |
ELLINGBOE ET AL., J. MED. CHEM., vol. 35, no. 4, 1992, pages 705 - 716 * |
GHOSH ET AL., INDIAN J. CHEM., vol. 1, 1963, pages 528- - 529 * |
KLIOZE ET AL., J. MED. CHEM., vol. 23, no. 6, 1980, pages 677 - 679 * |
PATENT ABSTRACTS OF JAPAN vol. 012, no. 462 (C - 549) 5 December 1988 (1988-12-05) * |
PATENT ABSTRACTS OF JAPAN vol. 013, no. 384 (C - 629) 24 August 1989 (1989-08-24) * |
See also references of WO0051614A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000051614A1 (fr) | 2000-09-08 |
AU3248600A (en) | 2000-09-21 |
EP1165084A1 (fr) | 2002-01-02 |
JP2002538121A (ja) | 2002-11-12 |
CA2362495A1 (fr) | 2000-09-08 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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17P | Request for examination filed |
Effective date: 20011004 |
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Free format text: 7C 07D 401/12 A, 7C 07D 233/54 B, 7C 07D 403/12 B, 7C 07D 405/12 B, 7A 61K 31/4164 B, 7A 61P 35/00 B |
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A4 | Supplementary search report drawn up and despatched |
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