KR910007516A - 서방성 활성 화합물을 함유한 압착물 - Google Patents

서방성 활성 화합물을 함유한 압착물 Download PDF

Info

Publication number
KR910007516A
KR910007516A KR1019900016325A KR900016325A KR910007516A KR 910007516 A KR910007516 A KR 910007516A KR 1019900016325 A KR1019900016325 A KR 1019900016325A KR 900016325 A KR900016325 A KR 900016325A KR 910007516 A KR910007516 A KR 910007516A
Authority
KR
South Korea
Prior art keywords
homo
copolymer
solid
dissolved
polylactic acid
Prior art date
Application number
KR1019900016325A
Other languages
English (en)
Inventor
코르사트코-밥네크 브리지타
코르사트코 베르너
Original Assignee
우르스 요트. 헹기
베테에프 바이오테크놀로기셔 포슝스게젤샤프트 엠.베. 하.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우르스 요트. 헹기, 베테에프 바이오테크놀로기셔 포슝스게젤샤프트 엠.베. 하. filed Critical 우르스 요트. 헹기
Publication of KR910007516A publication Critical patent/KR910007516A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

내용 없음

Description

서방성 활성 화합물을 함유한 압착물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 내지 제3도는 정제시 초기 활성화합물의 총량에 대한 각시간 후의 해리된 활성 화합물의 중량%를 나타낸 그래프이다.

Claims (10)

1이상의 고체 약제학적 활성 화합물, 포리락트산 및 D(-)3-하이드록시티르산의 단독-또는 공중합체를 함유함을 특징으로 하는, 약제의 경구 또는 비경구 투여용 서방성 활성 화합물을 지닌 압착물.
제1항에 있어서, 분자량이 3,000내지 150,000인 폴리락트산을 함유하는 압착물.
제1항에 있어서, 분자량이 50,000내지 800,000인 D(-)3-하이드록시부티르산의 단독-또는 공중합체를 함유하는 압착물.
제1항 내지 3항 중 어느 한 항에 있어서, 10:90내지 90:10의 중량비로 존재하는 폴리락트산 및 D(-)-3-하이드록시부티르산의 단독-또는 공중합체를 함유하는 압착물.
제1내지 4항중 어느 한 항에 있어서, 압착물이 고체 약제학적 화합물 5내지 80중량%를 함유함을 특징으로 하는 압착물.
고체, 용해 또는 현탁된 형태의 1개 이상의 고체 약제학적 활성 화합물을 고체 또는 용해된 폴리락트산 및 고체 또는 용해된 D(-)-3-하이드록시부티르산의 단독-또는 공중합체와 배합 및 혼합하고, 존재하는 용매 또는 희석제를 증발시킨 후, 잔사를 건조 및 분쇄시키거나 이를 행하지 않고 압축시킴을 특징으로 하는, 약제의 경구 또는 비경구 투여용 서방성 활성 화합물을 함유한 압착물의 제조방법.
제6항중에 있어서, 1개 이상의 고체 약제학적 활성 화합물과 고체 폴리락트산 및 D(-)-3-하이드록시부티르산의 단독-또는 공중합체를 혼합하고 압축시키는 방법.
제6항중에 있어서, 유동층 제립기내의 1개 이상의 고체 약제학적 활성 화합물 또는 그의 과립에 폴리락트산 및 D(-)-3-하이드록시부티르산의 단독-또는 공중합체를 분무한 후, 건조시키고 압축시키는 방법.
제6항에 있어서, 폴리락트산 및 D(-)-3-하이드록시부티르산의 단독-또는 공중합체에 대한 용매 중에 1개 이상의 고체 약제학적 활성 화합물을 현탁시키고, 용해된 폴리락트산 및 용해된 D(-)-3-하이드록시부티르산의 단독-또는 공중합체를 혼합시킨 후, 용매를 증발시키고, 잔사를 건조 및 분쇄한 후 압축시키는 방법.
제6항에 있어서, 폴리락트산 및 D(-)-3-하이드록시부티르산의 단독-또는 공중합체에 대한 용매 중에 1개 이상의 고체 약제학적 활성 화합물을 용해시키고, 용해된 폴리락트산 및 용해된 D(-)-3-하이드록시부티르산의 단독-또는 공중합체를 가하여 혼합시키며, 용매를 증발시키고, 잔사를 건조 및 분쇄한 후 압축시키는 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900016325A 1989-10-16 1990-10-15 서방성 활성 화합물을 함유한 압착물 KR910007516A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT2367/89 1989-10-16
AT236789 1989-10-16

Publications (1)

Publication Number Publication Date
KR910007516A true KR910007516A (ko) 1991-05-30

Family

ID=3533052

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900016325A KR910007516A (ko) 1989-10-16 1990-10-15 서방성 활성 화합물을 함유한 압착물

Country Status (8)

Country Link
US (1) US5128144A (ko)
EP (1) EP0423484B1 (ko)
JP (1) JPH03133922A (ko)
KR (1) KR910007516A (ko)
AU (1) AU632370B2 (ko)
CA (1) CA2025453A1 (ko)
DE (1) DE59003337D1 (ko)
ZA (1) ZA907930B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0568651B1 (en) * 1991-02-01 2002-04-17 Massachusetts Institute Of Technology Biodegradable polymer blends for drug delivery
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5773019A (en) * 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
EP2258742A1 (en) * 1997-12-22 2010-12-08 Metabolix, Inc. Polyhydroxyalkanoate compositons having controlled degradation rates
US6514515B1 (en) 1999-03-04 2003-02-04 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
DK1163019T3 (da) * 1999-03-25 2008-03-03 Metabolix Inc Medicinske indretninger og anvendelser af polyhydroxyalkanoatpolymere
US6608170B1 (en) * 1999-03-31 2003-08-19 Cornell Research Foundation, Inc. Syndiotactic poly(lactic acid)
EP1282406A1 (en) * 2000-03-31 2003-02-12 Nycomed Austria GmbH Pharmaceutical kit comprising midodrine as an active drug substance
US6761904B2 (en) * 2000-03-31 2004-07-13 Nycomed Austria Gmbh Pharmaceutical kit comprising midodrine as active drug substance
DE60107399D1 (de) * 2000-03-31 2004-12-30 Nycomed Austria Gmbh Linz Pharmazeutische zusammensetzung mit gesteuerter freigabe enthaltend midodrin und/oder desglymidodrin
US7070803B2 (en) 2000-03-31 2006-07-04 Nycomed Austria Gmbh Controlled release pharmaceutical composition for oral use containing midodrine and/or active metabolite, desglymidodrine
JP2007525601A (ja) 2003-05-08 2007-09-06 テファ， インコーポレイテッド ポリヒドロキシアルカノエート医療用織物および医療用繊維
CA2531833C (en) * 2003-07-08 2009-10-20 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20060287659A1 (en) * 2003-08-22 2006-12-21 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
DK1778305T3 (da) 2004-08-03 2010-10-18 Tepha Inc Ikke-krøllende polyhydroxyalkanoatsuturer
WO2006081517A2 (en) * 2005-01-28 2006-08-03 Tepha, Inc. Embolization using poly-4-hydroxybutyrate particles
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
JP2009245846A (ja) * 2008-03-31 2009-10-22 Suzhou Marsleds Optoelectronics Co Ltd Ｌｅｄ街路灯
US20120065221A1 (en) 2009-02-26 2012-03-15 Theraquest Biosciences, Inc. Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016094669A1 (en) 2014-12-11 2016-06-16 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
EP3518910A4 (en) 2016-09-30 2020-11-04 Xenamed Corporation MIDODRIN COMPOSITIONS AND METHOD OF USE THEREOF

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2856901D2 (de) * 1977-06-07 1980-11-13 Garching Instrumente Form of implant medicament and preparation process
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
AT382076B (de) * 1982-10-15 1987-01-12 Chemie Linz Ag Verfahren zur herstellung von presslingen mit retardierter wirkstofffreisetzung
HUT35524A (en) * 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3343551A1 (de) * 1983-12-01 1985-06-13 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur biotechnologischen herstellung von poly-d(-)-3-hydroxybuttersaeure
DE3410380A1 (de) * 1984-03-21 1985-10-10 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München S(-)-celiprolol, dessen pharmazeutisch vertraegliche salze, verfahren zu dessen herstellung, verwendung in der therapie und pharmazeutische zubereitungen
DE3417576A1 (de) * 1984-05-11 1985-11-14 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Retardformen des alpha-(2,5-dimethoxy-phenyl)-ss-glycinamidoaethanols und verfahren zu ihrer herstellung
AT383270B (de) * 1984-05-15 1987-06-10 Chemie Linz Ag Verfahren zur herstellung von oralen retardformen des alpha-(2,5-dimethoxy-phenyl)-betaglycinamido|thanols
NL8401912A (nl) * 1984-06-15 1986-01-02 Tno Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan.
DE3430131A1 (de) * 1984-08-16 1986-02-27 Heidelberger Druckmaschinen Ag, 6900 Heidelberg Bogenuebertragungszylinder in bogenrotationsdruckmaschinen
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
DE3636209A1 (de) * 1986-10-24 1988-04-28 Lentia Gmbh Verfahren zur herstellung eines bindemittelfreien tablettierfaehigen celiprololhydrochlorid-granulates
DE3701625A1 (de) * 1987-01-21 1988-08-04 Boehringer Ingelheim Kg Perorale arzneimittelzubereitung mit verzoegerter wirkstofffreigabe
DE3712095A1 (de) * 1987-04-10 1988-10-20 Lentia Gmbh Bindemittelfreies granulat mit verzoegerter wirkstoffabgabe
JPH0613602B2 (ja) * 1987-07-14 1994-02-23 三井東圧化学株式会社 ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
AU2377288A (en) * 1987-11-27 1989-07-13 Ici Australia Operations Proprietary Limited Livestock treatment

Also Published As

Publication number Publication date
CA2025453A1 (en) 1991-04-17
EP0423484B1 (de) 1993-11-03
ZA907930B (en) 1991-08-28
US5128144A (en) 1992-07-07
JPH03133922A (ja) 1991-06-07
EP0423484A1 (de) 1991-04-24
DE59003337D1 (de) 1993-12-09
AU632370B2 (en) 1992-12-24
AU6379690A (en) 1991-04-18

Similar Documents

Publication Publication Date Title
KR910007516A (ko) 서방성 활성 화합물을 함유한 압착물
KR890004688B1 (ko) 서방형 약제의 담체 조성물
IL111647A0 (en) Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles, their preparation and pharmaceutical compositions containing them
BE1003093A3 (fr) Procede de preparation d'une composition pharmaceutique sous forme de microparticules.
KR870006896A (ko) 서방성 약제학적 제제의 제조방법
KR890001526A (ko) 경구용 서방성 아세트 아미노펜 제형 및 이의 제조방법
KR850000975A (ko) 발프로익산과 그 염의 혼합물을 토대로 한 조성물
EA199700110A1 (ru) Композиция с высоким содержанием ацетаминофена для прямого прессования
CA2101742A1 (en) Biodegradable polymer blends for drug delivery
RU2000109583A (ru) Твердая дозированная лекарственная форма для орального применения, содержащая комбинацию метформина и глибенкламида
ATE45283T1 (de) Zusammensetzungen fuer die herstellung von mikropartikeln durch extrusion fuer verzoegerte abgabe von biologisch aktiven substanzen und so erhaltene mikropartikel.
KR840005661A (ko) 지속성 매트릭스 정제 조성물의 제조방법
CA2367020A1 (en) Method for producing solid dosage forms containing cyclodextrin
KR850700212A (ko) 서방성 약제학적 캼셀제
KR880000095A (ko) 케토티펜 함유 약학적 조성물
IE873006L (en) Salt of diclofenac with a cyclic organic base and¹pharmaceutical compositions which contain it
TR199900548A2 (xx) D���k kesme kuvvetli taneleme kullan�larak dozaj birimlerinin yap�m�.
KR850004393A (ko) 경구 투여용 지효성(遲效性) 아세틸살리실산 제제
KR910011241A (ko) 정제로 직접 압착 가능한 약제학적 분말 조성물을 제조하기 위한 분무 건조법
KR840004347A (ko) 불안정한 약물 또는 음식물 첨가물의 안정화
CA2185242C (en) Sustained release tablet containing diclofenac-na
JPH029007B2 (ko)
ATE54049T1 (de) Retardformen des alpha-(2,5-dimethoxy-phenyl)beta-lycinamido-aethanols und verfahren zu ihrer herstellung.
EP0159777A1 (en) Stabilized 4-carbamoyl-imidazolium-5-olate
EP0352800A3 (en) Aqueous polymeric dispersion of cellulosic and acrylic based polymers for preparing pharmaceutical dosage forms and dosage forms thereof

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid