EA199700110A1 - Композиция с высоким содержанием ацетаминофена для прямого прессования - Google Patents

Композиция с высоким содержанием ацетаминофена для прямого прессования

Info

Publication number
EA199700110A1
EA199700110A1 EA199700110A EA199700110A EA199700110A1 EA 199700110 A1 EA199700110 A1 EA 199700110A1 EA 199700110 A EA199700110 A EA 199700110A EA 199700110 A EA199700110 A EA 199700110A EA 199700110 A1 EA199700110 A1 EA 199700110A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acetaminophen
direct compression
carrier
dosage forms
methods
Prior art date
Application number
EA199700110A
Other languages
English (en)
Other versions
EA000223B1 (ru
Inventor
Эдвард А. Хантер
Боб Е. Шервуд
Юзеф А. Зелезник
Original Assignee
Эдвард Менделл Ко.. Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эдвард Менделл Ко.. Инк. filed Critical Эдвард Менделл Ко.. Инк.
Publication of EA199700110A1 publication Critical patent/EA199700110A1/ru
Publication of EA000223B1 publication Critical patent/EA000223B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предложены твердые фармацевтические лекарственные формы, получаемые прямым прессованием, которые содержат: a) от около 40 до около 95 мас.% ацетаминофена; b) от около 1 до около 60 мас.% носителя для прямого прессования, содержащего микрокристаллическую целлюлозу; c) от около 0,01 до около 4,0 мас.% фармацевтически приемлемого смазывающего вещества. Ацетаминофен и носитель для прямого прессования смешиваются в условиях высоких усилий сдвига, которые достаточны для превращения ацетаминофена и носителя для прямого прессования в гомогенную гранулированную смесь без разложения. В предпочтительных аспектах изобретения смазывающее вещество также смешивают с ацетаминофеном и носителем для прямого прессования при высоких усилиях сдвига. Также предложены способы получения твердых фармацевтических лекарственных форм путем прямого прессования и способы лечения при помощи этих лекарственных форм. Предложенные способы особенно хорошо подходят для получения прямым прессованием лекарственных форм, содержащих высокие (вплоть до 80% или выше) концентрации ацетаминофена по отношению к общей массе таблетки.
EA199700110A 1995-11-15 1996-11-12 Твердая, полученная прямым прессованием, лекарственная форма и способ её получения EA000223B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/558,335 US5733578A (en) 1995-11-15 1995-11-15 Directly compressible high load acetaminophen formulations
PCT/US1996/018903 WO1997017947A1 (en) 1995-11-15 1996-11-12 Directly compressible high load acetaminophen formulations

Publications (2)

Publication Number Publication Date
EA199700110A1 true EA199700110A1 (ru) 1997-12-30
EA000223B1 EA000223B1 (ru) 1998-12-24

Family

ID=24229152

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700110A EA000223B1 (ru) 1995-11-15 1996-11-12 Твердая, полученная прямым прессованием, лекарственная форма и способ её получения

Country Status (12)

Country Link
US (3) US5733578A (ru)
EP (1) EP0805675A4 (ru)
JP (2) JP3334885B2 (ru)
KR (1) KR100236326B1 (ru)
CN (1) CN1168094A (ru)
AU (1) AU709212B2 (ru)
BR (1) BR9607710A (ru)
CA (1) CA2208322C (ru)
EA (1) EA000223B1 (ru)
NO (1) NO973123L (ru)
TW (1) TW518237B (ru)
WO (1) WO1997017947A1 (ru)

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CA2208322C (en) 2004-01-20
JP2002060338A (ja) 2002-02-26
AU1123997A (en) 1997-06-05
MX9705281A (es) 1998-06-30
CN1168094A (zh) 1997-12-17
NO973123D0 (no) 1997-07-04
JPH10506412A (ja) 1998-06-23
EP0805675A1 (en) 1997-11-12
JP3334885B2 (ja) 2002-10-15
BR9607710A (pt) 1999-01-05
TW518237B (en) 2003-01-21
US5733578A (en) 1998-03-31
KR100236326B1 (ko) 1999-12-15
CA2208322A1 (en) 1997-05-22
US5965166A (en) 1999-10-12
EP0805675A4 (en) 2000-10-04
AU709212B2 (en) 1999-08-26
WO1997017947A1 (en) 1997-05-22
EA000223B1 (ru) 1998-12-24
NO973123L (no) 1997-08-14
US6217907B1 (en) 2001-04-17

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