MXPA03007766A - Emulsiones inyectables de agua en aceite. - Google Patents

Emulsiones inyectables de agua en aceite.

Info

Publication number
MXPA03007766A
MXPA03007766A MXPA03007766A MXPA03007766A MXPA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A MX PA03007766 A MXPA03007766 A MX PA03007766A
Authority
MX
Mexico
Prior art keywords
adjuvants
acid
atloxreg
arlacel
ooc
Prior art date
Application number
MXPA03007766A
Other languages
English (en)
Inventor
Theodorus Jansen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MXPA03007766A publication Critical patent/MXPA03007766A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Abstract

La presente invencion proporciona adyuvantes, para su uso en la formulacion de vacunas, que comprende una emulsion de agua en aceite, caracterizada porque dicha emulsion comprende un emulsor polimerico que es un copolimero de bloque que tiene una formula general A-COO-B-OOC-A, en la cual B es el residuo bivalente de un glicol de polialquileno soluble en agua y A es el residuo de un acido monocarboxilico complejo soluble en aceite. Tal emulsor polimerico, asi como tambien la preparacion del mismo, se han descrito en GB 2002400 y WO9607689. Preferentemente en los copolimeros de bloque de la formula A-COO-B-OOC-A, el componente B se deriva de glicol de polietileno y los componentes A se derivan de acido polihidroxiestearico, preferentemente a partir de poli(acido 12-hidroxi-estearico). Los emulsores mas preferidos utilizados en los adyuvantes de acuerdo con la invencion son Arlacel P135, un Dipolihidroxiestearato de PEG 30. Otro emulsor similar, preferido para su uso con la invencion es ATLOX(r) 4912. Tanto Arlacel P135 como ATLOX(r)4912 son copolimeros de bloque (A-B-A) de glicol de polietileno y acido hidroxiestearico con un peso molecular de aproximadamente 5000 comercialmente disponibles por ICI. Se ha descubierto que con el uso de estos emulsores pueden obtenerse emulsores basados en emulsiones de ag./ac. que son estables y que tienen una viscosidad baja que pueden basarse en aceites metabolizables. Dichos adyuvantes tienen una excelente actividad adyuvante, y son bien toleradas.
MXPA03007766A 2001-02-28 2002-02-26 Emulsiones inyectables de agua en aceite. MXPA03007766A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200745 2001-02-28
PCT/EP2002/002145 WO2002067899A1 (en) 2001-02-28 2002-02-26 Injectable water-in-oil emulsions

Publications (1)

Publication Number Publication Date
MXPA03007766A true MXPA03007766A (es) 2004-03-16

Family

ID=8179948

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007766A MXPA03007766A (es) 2001-02-28 2002-02-26 Emulsiones inyectables de agua en aceite.

Country Status (13)

Country Link
US (1) US8496939B2 (es)
EP (1) EP1367997B1 (es)
JP (1) JP4057423B2 (es)
AT (1) ATE438382T1 (es)
AU (1) AU2002253085B2 (es)
BR (1) BR0207698A (es)
CA (1) CA2438692C (es)
DE (1) DE60233206D1 (es)
DK (1) DK1367997T3 (es)
ES (1) ES2331058T3 (es)
MX (1) MXPA03007766A (es)
WO (1) WO2002067899A1 (es)
ZA (1) ZA200306204B (es)

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FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2860717B1 (fr) * 2003-10-13 2006-02-03 Ethypharm Sa Compositions de particules lipidiques solides monodisperses
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7485451B2 (en) * 2004-11-18 2009-02-03 Regents Of The University Of California Storage stable compositions of biological materials
FR2878746B1 (fr) * 2004-12-02 2007-02-23 Vetoquinol Sa Sa Nouvelle composition pharmaceutique utilisable dans le domaine des vaccins
FR2903602B1 (fr) * 2006-07-12 2012-10-26 Seppic Sa Formulation injectable a liberation prolongee de principes actifs, procede pour sa preparation
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
NZ603854A (en) 2008-08-29 2015-03-27 Boehringer Ingelheim Vetmed West nile virus vaccine
WO2010075129A2 (en) 2008-12-22 2010-07-01 Henkel Ag & Co. Kgaa Water-based cleaner for cleaning solvent-based paints
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WO2013174622A1 (en) 2012-05-21 2013-11-28 Basf Se Inverse dispersion comprising a cationic polymer and a stabilizing agent
EP2666789A1 (en) 2012-05-21 2013-11-27 Basf Se Inverse dispersion comprising an anionic or a nonionic polymer and a stabilizing agent
US9102900B2 (en) 2012-05-21 2015-08-11 Basf Se Inverse dispersion comprising a cationic polymer and a stabilizing agent
MX2017000979A (es) 2014-07-23 2017-04-27 Procter & Gamble Composiciones de tratamiento para el cuidado de las telas y el hogar.
WO2016014802A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
WO2016014733A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
MX2017000978A (es) 2014-07-23 2017-04-27 Procter & Gamble Composiciones de tratamiento para el cuidado de las telas y el hogar.
US10538719B2 (en) 2014-07-23 2020-01-21 The Procter & Gamble Company Treatment compositions
US10519402B2 (en) 2014-07-23 2019-12-31 The Procter & Gamble Company Treatment compositions
CA2952990C (en) 2014-07-23 2020-04-28 The Procter & Gamble Company Treatment compositions
WO2016073719A1 (en) 2014-11-06 2016-05-12 The Procter & Gamble Company Apertured webs and methods for making the same
GB201506948D0 (en) 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
WO2017132099A1 (en) 2016-01-25 2017-08-03 The Procter & Gamble Company Treatment compositions
WO2017132100A1 (en) 2016-01-25 2017-08-03 The Procter & Gamble Company Treatment compositions
EP3582733B1 (en) 2017-02-16 2022-08-17 The Procter & Gamble Company Absorbent articles with substrates having repeating patterns of apertures comprising a plurality of repeat units
WO2020078958A1 (en) 2018-10-16 2020-04-23 Intervet International B.V. Stable emulsions of bacterial antigens
WO2020078941A1 (en) 2018-10-16 2020-04-23 Intervet International B.V. Emulsion vaccine for fish

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Also Published As

Publication number Publication date
US8496939B2 (en) 2013-07-30
ZA200306204B (en) 2004-09-09
US20040071716A1 (en) 2004-04-15
EP1367997A1 (en) 2003-12-10
CA2438692A1 (en) 2002-09-06
CA2438692C (en) 2010-04-27
WO2002067899A1 (en) 2002-09-06
DK1367997T3 (da) 2009-11-30
ATE438382T1 (de) 2009-08-15
ES2331058T3 (es) 2009-12-21
EP1367997B1 (en) 2009-08-05
AU2002253085B2 (en) 2006-03-09
JP4057423B2 (ja) 2008-03-05
DE60233206D1 (de) 2009-09-17
JP2004523551A (ja) 2004-08-05
BR0207698A (pt) 2004-04-20

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