EA200800258A1 - Эмульсионные композиции пропофола для внутривенного введения, имеющие консервирующую эффективность - Google Patents

Эмульсионные композиции пропофола для внутривенного введения, имеющие консервирующую эффективность

Info

Publication number
EA200800258A1
EA200800258A1 EA200800258A EA200800258A EA200800258A1 EA 200800258 A1 EA200800258 A1 EA 200800258A1 EA 200800258 A EA200800258 A EA 200800258A EA 200800258 A EA200800258 A EA 200800258A EA 200800258 A1 EA200800258 A1 EA 200800258A1
Authority
EA
Eurasian Patent Office
Prior art keywords
prophofol
intravenous administration
emulsion compositions
monoglyceryl ester
monocaprin
Prior art date
Application number
EA200800258A
Other languages
English (en)
Inventor
Гаутам Винод Дафтари
Срикант Аннаппа Пай
Гирши Нарасимха Шанбхаг
Сангеета Ханурмеш Риванкар
Original Assignee
Бхарат Сирумс Энд Вэксинс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Сирумс Энд Вэксинс Лтд. filed Critical Бхарат Сирумс Энд Вэксинс Лтд.
Publication of EA200800258A1 publication Critical patent/EA200800258A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение относится к стабильным композициям пропофола типа эмульсия «масло в воде» для внутривенного введения, имеющим консервирующую активность. В соответствии с данным изобретением имеется стабильная композиция для внутривенного введения эмульсии «масло в воде» пропофола, содержащая масла триглицерида; эмульгаторы, выбираемые из очищенных или/и модифицированных природных фосфатидов; воду; агенты, модифицирующие тонус; и систему консервантов, содержащую сложный эфир моноглицерил лауриновой кислоты (монолаурин) и элемент, выбираемый из каприновой кислоты, или/и ее растворимых щелочных солей, или ее моноглицерил сложного эфира (монокаприн); эдетата и каприновой кислоты, или/и ее растворимых щелочных солей, или ее моноглицерил сложного эфира (монокаприн) и эдетата. В композиции эмульсии «масло в воде» пропофола система консервантов присутствует в достаточной концентрации, чтобы предотвратить не более чем десятикратное увеличение роста каждого из Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538) и Candida albicans (ATCC 10231) в течение, по меньшей мере, суток после добавочного внешнего загрязнения.
EA200800258A 2005-08-05 2006-08-04 Эмульсионные композиции пропофола для внутривенного введения, имеющие консервирующую эффективность EA200800258A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN906MU2005 2005-08-05
PCT/IN2006/000281 WO2007052288A2 (en) 2005-08-05 2006-08-04 Intravenous propofol emulsion compositions having preservative efficacy

Publications (1)

Publication Number Publication Date
EA200800258A1 true EA200800258A1 (ru) 2008-06-30

Family

ID=38006301

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800258A EA200800258A1 (ru) 2005-08-05 2006-08-04 Эмульсионные композиции пропофола для внутривенного введения, имеющие консервирующую эффективность

Country Status (16)

Country Link
US (1) US8759404B2 (ru)
EP (1) EP1922060B1 (ru)
JP (1) JP2009503059A (ru)
KR (1) KR20080043793A (ru)
CN (1) CN101304728A (ru)
AT (1) ATE420625T1 (ru)
AU (1) AU2006310113A1 (ru)
BR (1) BRPI0614084A2 (ru)
CA (1) CA2618026A1 (ru)
DE (1) DE602006004887D1 (ru)
EA (1) EA200800258A1 (ru)
ES (1) ES2318802T3 (ru)
IL (1) IL189310A0 (ru)
MX (1) MX2008001746A (ru)
WO (1) WO2007052288A2 (ru)
ZA (1) ZA200801227B (ru)

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WO2008023384A1 (en) * 2006-08-24 2008-02-28 Bharat Serums & Vaccines Ltd. Propofol emulsion compositions for intravenous administration
BRPI0604377A (pt) * 2006-10-27 2008-06-24 Cristalia Prod Quimicos Farm microemulsão óleo/água de propofol estável e pronta-para-uso
JP2010163397A (ja) * 2009-01-16 2010-07-29 Japan Ecologia Co Ltd 抗菌性組成物
KR101656121B1 (ko) 2010-03-17 2016-09-08 노바리크 게엠베하 안압 증가를 치료하기 위한 약학 조성물
KR101805087B1 (ko) * 2010-09-16 2017-12-05 주식회사 엘지화학 높은 방부력을 제공하는 오일 주사 제형
EP2444063A1 (en) 2010-10-20 2012-04-25 Novaliq GmbH Liquid pharmaceutical compositions for the delivery of active ingredients
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
DK2661280T3 (en) 2011-01-04 2019-03-04 Novaliq Gmbh O / V EMULSIONS INCLUDING SEMIFLUORINATED ALKANES
CN103596554A (zh) 2011-05-25 2014-02-19 诺瓦利克有限责任公司 基于半氟化烷烃类的外用药物组合物
KR101773648B1 (ko) 2011-05-25 2017-08-31 노바리크 게엠베하 조갑에 투여를 위한 제약학적 조성물
PL2806886T3 (pl) 2012-01-23 2017-08-31 Novaliq Gmbh Stabilizowane kompozycje białkowe oparte na semifluorowanych alkanach
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EP3488847B1 (en) 2012-09-12 2023-11-08 Novaliq GmbH Semifluorinated alkane compositions
CN106511322B (zh) 2012-09-12 2021-09-17 诺瓦利克有限责任公司 包含半氟化烷烃的混合物的组合物
MX370207B (es) 2013-07-23 2019-12-05 Novaliq Gmbh Composiciones estabilizadas de anticuerpos.
CA2991084A1 (en) * 2015-07-01 2017-01-05 Fresenius Kabi Deutschland Gmbh Propofol emulsion for parenteral administration
JP6642935B2 (ja) 2015-09-30 2020-02-12 ノバリック ゲーエムベーハー 眼投与用の半フッ素化化合物
PL3355990T3 (pl) 2015-09-30 2019-11-29 Novaliq Gmbh Semifluorowane związki oraz ich kompozycje
JP2019520357A (ja) 2016-06-23 2019-07-18 ノバリック ゲーエムベーハー 局所投与方法
AU2017329772B2 (en) 2016-09-22 2023-02-02 Novaliq Gmbh Pharmaceutical compositions for use in the therapy of blepharitis
ES2965677T3 (es) 2016-09-23 2024-04-16 Novaliq Gmbh Composiciones oftálmicas que comprenden ciclosporina
WO2018193093A1 (en) 2017-04-21 2018-10-25 Novaliq Gmbh Iodine compositions
WO2018206656A1 (en) 2017-05-12 2018-11-15 Novaliq Gmbh Pharmaceutical compositions comprosing semifluorinated alkanes for the treatment of contact lense-related conditions
KR20200059272A (ko) 2017-09-27 2020-05-28 노바리크 게엠베하 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물
WO2019068763A1 (en) 2017-10-04 2019-04-11 Novaliq Gmbh OPHTHALMIC COMPOSITIONS COMPRISING F6H8
WO2019123221A1 (en) * 2017-12-20 2019-06-27 Aurobindo Pharma Limited Pharmaceutical composition comprising clevidipine and process for preparation thereof
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Also Published As

Publication number Publication date
MX2008001746A (es) 2008-04-07
KR20080043793A (ko) 2008-05-19
CA2618026A1 (en) 2007-05-10
AU2006310113A1 (en) 2007-05-10
US20070249730A1 (en) 2007-10-25
EP1922060A2 (en) 2008-05-21
JP2009503059A (ja) 2009-01-29
US8759404B2 (en) 2014-06-24
WO2007052288A2 (en) 2007-05-10
ES2318802T3 (es) 2009-05-01
ATE420625T1 (de) 2009-01-15
ZA200801227B (en) 2008-12-31
EP1922060B1 (en) 2009-01-14
BRPI0614084A2 (pt) 2011-03-09
WO2007052288A3 (en) 2007-08-30
IL189310A0 (en) 2008-06-05
DE602006004887D1 (de) 2009-03-05
CN101304728A (zh) 2008-11-12

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