ES2531646T3 - Composiciones de emulsión farmacéuticas con bajo contenido de aceite que comprenden progestágeno - Google Patents
Composiciones de emulsión farmacéuticas con bajo contenido de aceite que comprenden progestágeno Download PDFInfo
- Publication number
- ES2531646T3 ES2531646T3 ES11717561.2T ES11717561T ES2531646T3 ES 2531646 T3 ES2531646 T3 ES 2531646T3 ES 11717561 T ES11717561 T ES 11717561T ES 2531646 T3 ES2531646 T3 ES 2531646T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- vol
- progestogen
- low oil
- emulsion compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
Una composición de emulsión aceite en agua farmacéutica, estéril, lista para su uso, para administración por vía parenteral que comprende: * 0.015 a 0.5% en peso/vol., preferiblemente de 0.05 a 0.4% en peso/vol. de progesterona; * 0.5 a 10% en peso/vo l. de aceite, en donde el aceite comprende al menos 85% en peso/peso de triglicéridos; * 0.0425 a 4.1% en peso/vol., preferiblemente de 0.064 a 3.4% en peso/vol. de fosfolípido; * 80 a 99.4% en peso/vol. de medio acuoso; en donde la composición tiene una osmolalidad en el intervalo de 200-1000 mOsm/kg, y en donde la emulsión contiene no más de 1.2% en peso/peso de polietilenglicol 15-hidroxiestearato.
Description
-
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- EJEMPLO 4B
- NO ESTÉRIL ESTERILIZADO 1x ESTERILIZADO 2x ESTERILIZADO 3x 3 SEMANAS, 60°C 4 SEMANAS, 60°C
- MASTERSIZER UNIFORMIDAD
- 0.587 0.587 0.590 0.589 0.590 0.583
- MASTERSIZER d(0,5) [M]
- 0.176 0.176 0.174 0.175 0.174 0.179
- ACCUSIZER [%]
- 0.02 0.02 0.03 0.02 0.02 0.02
- VALOR DE PH
- 8.3 7.9 7.6 7.4 6.4 6.5
- EJEMPLO 4C
- NO ESTÉRIL ESTERILIZADO 1x ESTERILIZADO 2x ESTERILIZADO 3x 3 SEMANAS, 60°C 4 SEMANAS, 60°C
- Apariencia
- BLANCO,HOMOGÉNEO BLANCO,HOMOGÉNEO BLANCO,HOMOGÉNEO BLANCO,HOMOGÉNEO BLANCO,HOMOGÉNEO BLANCO,HOMOGÉNEO
- CONTROL VISUAL
- SIN PARTÍCULAS SIN PARTÍCULAS SIN PARTÍCULAS SIN PARTÍCULAS SIN PARTÍCULAS SIN PARTÍCULAS
- MASTERSIZER D[4,3] [M]
- 0.228 0.229 0.228 0.229 0.232 0.227
- MASTERSIZER SPAN
- 2.065 2.059 2.069 2.066 2.041 2.069
- MASTERSIZER UNIFORMIDAD
- 0.633 0.632 0.635 0.635 0.628 0.637
- MASTERSIZER d(0.5) [M]
- 0.181 0.182 0.180 0.182 0.185 0.80
- ACCUSIZER [%] (USP 729)
- 0.01 0.01 0.03 0.01 0.02 0.02
- VALOR DE PH
- 8.2 8.0 7.8 7.6 7.2 6.8
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32795910P | 2010-04-26 | 2010-04-26 | |
US32796310P | 2010-04-26 | 2010-04-26 | |
US32796810P | 2010-04-26 | 2010-04-26 | |
EP10161032 | 2010-04-26 | ||
US327968P | 2010-04-26 | ||
EP10161029 | 2010-04-26 | ||
EP10161029 | 2010-04-26 | ||
EP10161034 | 2010-04-26 | ||
EP10161032 | 2010-04-26 | ||
US327959P | 2010-04-26 | ||
EP10161034 | 2010-04-26 | ||
US327963P | 2010-04-26 | ||
US201061424402P | 2010-12-17 | 2010-12-17 | |
US201061424407P | 2010-12-17 | 2010-12-17 | |
US201061424411P | 2010-12-17 | 2010-12-17 | |
EP10195766 | 2010-12-17 | ||
EP10195760 | 2010-12-17 | ||
US424407P | 2010-12-17 | ||
EP10195764 | 2010-12-17 | ||
EP10195766 | 2010-12-17 | ||
EP10195760 | 2010-12-17 | ||
US424411P | 2010-12-17 | ||
EP10195764 | 2010-12-17 | ||
US424402P | 2010-12-17 | ||
PCT/EP2011/056548 WO2011134944A2 (en) | 2010-04-26 | 2011-04-26 | Low-oil pharmaceutical emulsion compositions comprising progestogen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2531646T3 true ES2531646T3 (es) | 2015-03-18 |
Family
ID=44001967
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11716893.0T Active ES2514690T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones farmacéuticas de emulsión que comprenden progestógeno |
ES14176970.3T Active ES2576190T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones farmacéuticas de emulsión que comprenden progestógeno |
ES11717561.2T Active ES2531646T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones de emulsión farmacéuticas con bajo contenido de aceite que comprenden progestágeno |
ES14196653.1T Active ES2606585T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones de emulsión farmacéuticas con bajo contenido de aceite que comprenden progestágeno |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11716893.0T Active ES2514690T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones farmacéuticas de emulsión que comprenden progestógeno |
ES14176970.3T Active ES2576190T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones farmacéuticas de emulsión que comprenden progestógeno |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14196653.1T Active ES2606585T3 (es) | 2010-04-26 | 2011-04-26 | Composiciones de emulsión farmacéuticas con bajo contenido de aceite que comprenden progestágeno |
Country Status (22)
Country | Link |
---|---|
US (4) | US8476252B2 (es) |
EP (4) | EP2563335B1 (es) |
JP (1) | JP5886273B2 (es) |
KR (1) | KR101822680B1 (es) |
CN (2) | CN102946864A (es) |
AR (1) | AR081542A1 (es) |
AU (1) | AU2011246527B2 (es) |
BR (1) | BR112012027279B1 (es) |
CA (2) | CA2797253C (es) |
EA (1) | EA022460B1 (es) |
ES (4) | ES2514690T3 (es) |
GE (1) | GEP20166457B (es) |
HK (1) | HK1181998A1 (es) |
IL (2) | IL222710A (es) |
MX (1) | MX2012012491A (es) |
MY (1) | MY156858A (es) |
NZ (1) | NZ603176A (es) |
PL (1) | PL2563335T3 (es) |
PT (1) | PT2563335E (es) |
SG (1) | SG185025A1 (es) |
TW (1) | TW201138782A (es) |
WO (2) | WO2011134944A2 (es) |
Families Citing this family (36)
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---|---|---|---|---|
TW201138782A (en) | 2010-04-26 | 2011-11-16 | Besins Healthcare Lu Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
HUE055562T2 (hu) | 2011-11-23 | 2021-11-29 | Therapeuticsmd Inc | Természetes kombinációjú hormon helyettesítõ kiszerelések, és terápiák ezekkel |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
MX2014010445A (es) | 2012-02-29 | 2014-10-13 | Braun Melsungen Ag | Emulsion que contiene hormona que comprende fosfolipidos de kril. |
TW201334808A (zh) * | 2012-02-29 | 2013-09-01 | Braun Melsungen Ag | 含有荷爾蒙之包含磷蝦磷脂質的乳劑 |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
JP2016515530A (ja) * | 2013-03-15 | 2016-05-30 | ファーマジェネシス, インコーポレイテッド | 免疫調節薬および抗がん剤としてのトリプトリドの静脈内乳剤 |
US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
ES2921531T3 (es) * | 2013-12-06 | 2022-08-29 | Broad Inst Inc | Formulaciones para vacunas contra la neoplasia |
WO2015095811A2 (en) | 2013-12-20 | 2015-06-25 | The Board Institute Inc. | Combination therapy with neoantigen vaccine |
EP3145489A1 (en) | 2014-05-22 | 2017-03-29 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
AU2015296609A1 (en) | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
WO2016100977A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Methods for profiling the t-cel- receptor repertoire |
WO2016156528A1 (en) * | 2015-03-31 | 2016-10-06 | Fresenius Kabi Deutschland Gmbh | Emulsions for parenteral administration |
MX2017014700A (es) | 2015-05-20 | 2018-08-15 | Broad Inst Inc | Neoantigenos compartidos. |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
BR112018070199A2 (pt) | 2016-04-01 | 2019-01-29 | Therapeuticsmd Inc | composição farmacêutica de hormônio esteroide |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
CN106074383B (zh) * | 2016-07-27 | 2019-03-08 | 武汉科福新药有限责任公司 | 孕激素药物脂微球注射液及其制备方法 |
US10729650B2 (en) * | 2017-01-23 | 2020-08-04 | United States Of America As Represented By The Secretary Of The Air Force | Skin punch biopsy and wound-debridgement training model |
US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
WO2020123551A1 (en) * | 2018-12-10 | 2020-06-18 | Halo Science LLC | Stable formulations of anesthetics and associated dosage forms |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
EP3878434A1 (en) * | 2020-03-12 | 2021-09-15 | Lipoid GmbH | Sunflower phospholipid composition containing phosphatidylcholine |
WO2023034317A1 (en) * | 2021-08-30 | 2023-03-09 | Premier Nutrition Company, Llc | Sleep-inducing beverage composition, its method of production and the method of use |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS60258110A (ja) | 1984-06-05 | 1985-12-20 | Daigo Eiyou Kagaku Kk | 静脈注射可能なプロゲステロン乳化注射液 |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
IL89856A (en) | 1989-04-05 | 1993-05-13 | Yissum Res Dev Co | Medical emulsions for liphophilic drugs containing a medium-chain triglyceride oil as a carrier |
SE9301171D0 (sv) * | 1993-04-07 | 1993-04-07 | Ab Astra | Pharmaceutical composition containing lipophilic drugs |
SE9403389D0 (sv) | 1994-10-06 | 1994-10-06 | Astra Ab | Pharmaceutical composition containing derivattves of sex hormones |
JP2003520777A (ja) | 1999-07-22 | 2003-07-08 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 防腐医薬製剤 |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
US6327968B1 (en) | 2000-03-17 | 2001-12-11 | Pizza Hut, Inc. | System and method for producing par-baked pizza crusts |
EP1488785A1 (de) | 2003-06-18 | 2004-12-22 | B. Braun Melsungen Ag | Ölemulsion zur postnatalen Hormonsubstitution |
US20050238675A1 (en) | 2004-04-26 | 2005-10-27 | Wenjie Li | Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications |
ATE439123T1 (de) | 2004-07-02 | 2009-08-15 | Novagali Pharma Sa | Verwendung von emulsionen zur intra- und periocularen injection |
PL1868614T3 (pl) | 2005-03-24 | 2013-01-31 | Univ Emory | Schemat dawkowania do leczenia urazowego uszkodzenia mózgu progesteronem |
US7473687B2 (en) | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
EP2001438A2 (en) * | 2006-02-09 | 2008-12-17 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
CN101152186B (zh) * | 2007-09-05 | 2011-07-06 | 杭州平和安康医药科技有限公司 | 黄体酮注射液及其制备方法 |
TW201138782A (en) | 2010-04-26 | 2011-11-16 | Besins Healthcare Lu Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
-
2011
- 2011-04-22 TW TW100114105A patent/TW201138782A/zh unknown
- 2011-04-25 AR ARP110101417A patent/AR081542A1/es not_active Application Discontinuation
- 2011-04-25 US US13/093,612 patent/US8476252B2/en active Active
- 2011-04-25 US US13/093,608 patent/US8765149B2/en active Active
- 2011-04-26 WO PCT/EP2011/056548 patent/WO2011134944A2/en active Application Filing
- 2011-04-26 EP EP11717561.2A patent/EP2563335B1/en active Active
- 2011-04-26 EP EP14176970.3A patent/EP2801353B1/en active Active
- 2011-04-26 MY MYPI2012004715A patent/MY156858A/en unknown
- 2011-04-26 JP JP2013506625A patent/JP5886273B2/ja active Active
- 2011-04-26 KR KR1020127030500A patent/KR101822680B1/ko active IP Right Grant
- 2011-04-26 EA EA201291108A patent/EA022460B1/ru unknown
- 2011-04-26 GE GEAP201112903A patent/GEP20166457B/en unknown
- 2011-04-26 ES ES11716893.0T patent/ES2514690T3/es active Active
- 2011-04-26 PL PL11717561T patent/PL2563335T3/pl unknown
- 2011-04-26 EP EP11716893.0A patent/EP2563334B1/en active Active
- 2011-04-26 NZ NZ603176A patent/NZ603176A/en unknown
- 2011-04-26 ES ES14176970.3T patent/ES2576190T3/es active Active
- 2011-04-26 CN CN2011800315010A patent/CN102946864A/zh active Pending
- 2011-04-26 ES ES11717561.2T patent/ES2531646T3/es active Active
- 2011-04-26 BR BR112012027279-9A patent/BR112012027279B1/pt active IP Right Grant
- 2011-04-26 WO PCT/EP2011/056539 patent/WO2011134937A2/en active Application Filing
- 2011-04-26 MX MX2012012491A patent/MX2012012491A/es active IP Right Grant
- 2011-04-26 CA CA2797253A patent/CA2797253C/en active Active
- 2011-04-26 ES ES14196653.1T patent/ES2606585T3/es active Active
- 2011-04-26 PT PT11717561T patent/PT2563335E/pt unknown
- 2011-04-26 SG SG2012078994A patent/SG185025A1/en unknown
- 2011-04-26 AU AU2011246527A patent/AU2011246527B2/en active Active
- 2011-04-26 CN CN201180031551.9A patent/CN102946865B/zh active Active
- 2011-04-26 CA CA2797141A patent/CA2797141C/en active Active
- 2011-04-26 EP EP14196653.1A patent/EP2857042B1/en active Active
-
2012
- 2012-10-25 IL IL222710A patent/IL222710A/en active IP Right Grant
- 2012-10-28 IL IL222738A patent/IL222738A/en active IP Right Grant
-
2013
- 2013-06-12 US US13/916,288 patent/US9572818B2/en active Active
- 2013-08-08 HK HK13109274.3A patent/HK1181998A1/xx unknown
-
2014
- 2014-05-16 US US14/279,834 patent/US20140335133A1/en not_active Abandoned
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