EA201291108A1 - Фармацевтические композиции в виде эмульсии с низким содержанием масла, содержащие прогестоген - Google Patents

Фармацевтические композиции в виде эмульсии с низким содержанием масла, содержащие прогестоген

Info

Publication number
EA201291108A1
EA201291108A1 EA201291108A EA201291108A EA201291108A1 EA 201291108 A1 EA201291108 A1 EA 201291108A1 EA 201291108 A EA201291108 A EA 201291108A EA 201291108 A EA201291108 A EA 201291108A EA 201291108 A1 EA201291108 A1 EA 201291108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oil
emulsion
pharmaceutical compositions
low content
containing progestogen
Prior art date
Application number
EA201291108A
Other languages
English (en)
Other versions
EA022460B1 (ru
Inventor
Лаура Пикерсджилл
Ева-Мария Ди Хойзер
Георг Ахляйтнер
Original Assignee
Безен Хелткэа Люксембург Сарл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Безен Хелткэа Люксембург Сарл filed Critical Безен Хелткэа Люксембург Сарл
Publication of EA201291108A1 publication Critical patent/EA201291108A1/ru
Publication of EA022460B1 publication Critical patent/EA022460B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Изобретение относится к стерильной, готовой к применению фармацевтической композиции в виде эмульсии типа масло-в-воде для парентерального введения, содержащей от 0,015 до 0,5% мас./об. прогестерона; от 0,5 до 10% мас./об. масла, где масло содержит по меньшей мере 85% мас./мас. триглицерида; от 0,0425 до 4,1% мас./об. фосфолипидов; от 80 до 99,4% мас./об. водной среды; где композиция имеет осмоляльность в пределах 200-1000 мосмоль/кг. Изобретение также относится к применению вышеуказанной композиции в терапевтическом или профилактическом лечении, включающем внутривенное ведение фармацевтической эмульсии.
EA201291108A 2010-04-26 2011-04-26 Фармацевтические композиции в виде эмульсии с низким содержанием масла, содержащие прогестоген EA022460B1 (ru)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US32795910P 2010-04-26 2010-04-26
US32796310P 2010-04-26 2010-04-26
US32796810P 2010-04-26 2010-04-26
EP10161029 2010-04-26
EP10161034 2010-04-26
EP10161032 2010-04-26
US201061424411P 2010-12-17 2010-12-17
US201061424407P 2010-12-17 2010-12-17
US201061424402P 2010-12-17 2010-12-17
EP10195764 2010-12-17
EP10195760 2010-12-17
EP10195766 2010-12-17
PCT/EP2011/056548 WO2011134944A2 (en) 2010-04-26 2011-04-26 Low-oil pharmaceutical emulsion compositions comprising progestogen

Publications (2)

Publication Number Publication Date
EA201291108A1 true EA201291108A1 (ru) 2013-04-30
EA022460B1 EA022460B1 (ru) 2016-01-29

Family

ID=44001967

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291108A EA022460B1 (ru) 2010-04-26 2011-04-26 Фармацевтические композиции в виде эмульсии с низким содержанием масла, содержащие прогестоген

Country Status (22)

Country Link
US (4) US8476252B2 (ru)
EP (4) EP2563334B1 (ru)
JP (1) JP5886273B2 (ru)
KR (1) KR101822680B1 (ru)
CN (2) CN102946864A (ru)
AR (1) AR081542A1 (ru)
AU (1) AU2011246527B2 (ru)
BR (1) BR112012027279B1 (ru)
CA (2) CA2797141C (ru)
EA (1) EA022460B1 (ru)
ES (4) ES2606585T3 (ru)
GE (1) GEP20166457B (ru)
HK (1) HK1181998A1 (ru)
IL (2) IL222710A (ru)
MX (1) MX2012012491A (ru)
MY (1) MY156858A (ru)
NZ (1) NZ603176A (ru)
PL (1) PL2563335T3 (ru)
PT (1) PT2563335E (ru)
SG (1) SG185025A1 (ru)
TW (1) TW201138782A (ru)
WO (2) WO2011134944A2 (ru)

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Also Published As

Publication number Publication date
BR112012027279B1 (pt) 2020-12-29
EP2857042A1 (en) 2015-04-08
ES2531646T3 (es) 2015-03-18
AU2011246527B2 (en) 2016-09-15
CN102946865A (zh) 2013-02-27
US8476252B2 (en) 2013-07-02
PT2563335E (pt) 2015-03-31
CN102946865B (zh) 2016-06-22
US20140147474A1 (en) 2014-05-29
WO2011134944A2 (en) 2011-11-03
MX2012012491A (es) 2013-02-15
US9572818B2 (en) 2017-02-21
EP2563335B1 (en) 2014-12-17
US20140335133A1 (en) 2014-11-13
JP5886273B2 (ja) 2016-03-16
KR101822680B1 (ko) 2018-01-26
NZ603176A (en) 2014-05-30
HK1181998A1 (en) 2013-11-22
AU2011246527A1 (en) 2012-11-15
IL222710A0 (en) 2012-12-31
WO2011134937A3 (en) 2012-02-02
JP2013525402A (ja) 2013-06-20
EP2857042B1 (en) 2016-08-31
EP2563334B1 (en) 2014-07-16
GEP20166457B (en) 2016-04-11
KR20130069638A (ko) 2013-06-26
EP2563335A2 (en) 2013-03-06
US20110262494A1 (en) 2011-10-27
BR112012027279A2 (pt) 2018-05-15
IL222738A0 (en) 2012-12-31
EP2801353A1 (en) 2014-11-12
TW201138782A (en) 2011-11-16
CA2797253C (en) 2019-02-05
SG185025A1 (en) 2012-11-29
CN102946864A (zh) 2013-02-27
WO2011134937A2 (en) 2011-11-03
IL222738A (en) 2015-11-30
AR081542A1 (es) 2012-10-03
MY156858A (en) 2016-04-15
EA022460B1 (ru) 2016-01-29
ES2576190T3 (es) 2016-07-06
ES2606585T3 (es) 2017-03-24
EP2801353B1 (en) 2016-03-30
WO2011134944A3 (en) 2012-02-09
ES2514690T3 (es) 2014-10-28
IL222710A (en) 2015-11-30
CA2797141C (en) 2018-05-15
US8765149B2 (en) 2014-07-01
CA2797141A1 (en) 2011-11-03
EP2563334A2 (en) 2013-03-06
US20110262495A1 (en) 2011-10-27
PL2563335T3 (pl) 2015-05-29
CA2797253A1 (en) 2011-11-03

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