SI1843749T1 - Sestavki z nadzorovanim sproščanjem za interferon na osnovi PEGT/PBT blok kopolimerov - Google Patents

Sestavki z nadzorovanim sproščanjem za interferon na osnovi PEGT/PBT blok kopolimerov

Info

Publication number
SI1843749T1
SI1843749T1 SI200630366T SI200630366T SI1843749T1 SI 1843749 T1 SI1843749 T1 SI 1843749T1 SI 200630366 T SI200630366 T SI 200630366T SI 200630366 T SI200630366 T SI 200630366T SI 1843749 T1 SI1843749 T1 SI 1843749T1
Authority
SI
Slovenia
Prior art keywords
composition
pegt
controlled release
block copolymers
release compositions
Prior art date
Application number
SI200630366T
Other languages
English (en)
Inventor
Anne Chantal Bechet
Dijkhuizen-Radersma Riemke Van
Martin Stigter
Jeroen Mattijs Bezemer
Original Assignee
Biolex Therapeutics Inc
Octoplus Polyactive Sciences B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics Inc, Octoplus Polyactive Sciences B V filed Critical Biolex Therapeutics Inc
Publication of SI1843749T1 publication Critical patent/SI1843749T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200630366T 2005-01-07 2006-01-06 Sestavki z nadzorovanim sproščanjem za interferon na osnovi PEGT/PBT blok kopolimerov SI1843749T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05075043A EP1679065A1 (en) 2005-01-07 2005-01-07 Controlled release compositions for interferon based on PEGT/PBT block copolymers
EP06700417A EP1843749B1 (en) 2005-01-07 2006-01-06 Controlled release compositions for interferon based on pegt/pbt block copolymers

Publications (1)

Publication Number Publication Date
SI1843749T1 true SI1843749T1 (sl) 2009-10-31

Family

ID=34937981

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200630366T SI1843749T1 (sl) 2005-01-07 2006-01-06 Sestavki z nadzorovanim sproščanjem za interferon na osnovi PEGT/PBT blok kopolimerov

Country Status (24)

Country Link
US (3) US7736674B2 (sl)
EP (4) EP1679065A1 (sl)
JP (2) JP2008526837A (sl)
KR (2) KR101354521B1 (sl)
CN (2) CN101137349B (sl)
AT (1) ATE431134T1 (sl)
AU (2) AU2006213168B2 (sl)
BR (1) BRPI0606514A2 (sl)
CA (1) CA2594434A1 (sl)
CY (1) CY1109297T1 (sl)
DE (1) DE602006006797D1 (sl)
DK (1) DK1843749T3 (sl)
ES (1) ES2327267T3 (sl)
HK (1) HK1152644A1 (sl)
HR (1) HRP20090434T1 (sl)
IL (2) IL184431A (sl)
MX (1) MX2007008293A (sl)
PL (1) PL1843749T3 (sl)
PT (1) PT1843749E (sl)
RS (1) RS51129B (sl)
RU (2) RU2409348C2 (sl)
SG (1) SG158856A1 (sl)
SI (1) SI1843749T1 (sl)
WO (1) WO2006085747A1 (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
WO2009015336A2 (en) * 2007-07-25 2009-01-29 Biolex Therapeutics, Inc. Controlled release interferon drug products and treatment of hcv infection using same
JP5733981B2 (ja) 2007-10-23 2015-06-10 コーニンクレッカ フィリップス エヌ ヴェ ポリマー微粒子を調製する方法及びデバイス
EP2055299A1 (en) * 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
WO2010001325A2 (en) * 2008-06-30 2010-01-07 Silenseed Ltd Methods, compositions and systems for local delivery of drugs
AU2010220324A1 (en) 2009-03-05 2011-09-01 Ascendis Pharma As Interferon alpha carrier prodrugs
EA201391392A1 (ru) * 2011-03-25 2014-04-30 Селекта Байосайенсиз, Инк. Синтетические наноносители с осмотически опосредованным высвобождением
AU2013201532B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
CH707029B1 (de) 2011-10-21 2015-03-13 Abbvie Inc Verfahren zur Behandlung von HCV, umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin, aber nicht Interferon.
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
WO2016046817A1 (en) 2014-09-24 2016-03-31 Vital Beverages Global Inc. Compositions and methods for selective gi tract delivery
US11192914B2 (en) 2016-04-28 2021-12-07 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
JP2022539602A (ja) 2019-07-12 2022-09-12 ビーエーエスエフ ソシエタス・ヨーロピア 揮発性有機活性剤が充填された微粒子を製造する方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL280825A (sl) * 1962-07-11
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
EP0637229B1 (en) 1992-04-24 2002-11-20 Osteotech, Inc., Devices for preventing tissue adhesion
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
DE69316101T2 (de) * 1992-08-07 1998-10-22 Takeda Chemical Industries Ltd Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten
US5643605A (en) 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5612052A (en) 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
WO1997020047A1 (en) 1995-11-30 1997-06-05 Board Of Regents, The University Of Texas System Methods and compositions for the diagnosis and treatment of cancer
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
DK0990440T3 (da) 1997-02-27 2009-02-23 Novartis Ag Farmaceutisk sammensætning indeholdende 2-amino-2[2-(4-octylphenyl)-ethyl]-propan-1,3-diol, en lecithin og et saccharid
EP0975334B1 (en) * 1997-04-17 2003-10-22 Amgen Inc., Biodegradable microparticles for the sustained delivery of therapeutic drugs
TW577759B (en) 1997-04-18 2004-03-01 Ipsen Pharma Biotech Sustained release compositions in the form of microcapsules or implants and the process for their preparation
US6531154B1 (en) 1997-06-10 2003-03-11 Brown University Research Foundation Modulated release from biocompatible polymers
HUP0004169A3 (en) * 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
CA2360232A1 (en) * 1999-01-12 2000-07-20 Tamio Mizukami Telomerase inhibitors
US6204308B1 (en) 1999-03-01 2001-03-20 Novartis Ag Organic compounds
US20030206928A1 (en) * 1999-04-07 2003-11-06 Pertti Tormala Bioactive, bioabsorbable surgical polyethylene glycol and polybutylene terephtalate copolymer composites and devices
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
AU5853000A (en) 1999-07-15 2001-02-05 Takeda Chemical Industries Ltd. Sustained release compositions, process for producing the same and use thereof
EP1090928B1 (en) 1999-09-30 2004-05-26 Chienna B.V. Polymers loaded with bioactive agents
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6479065B2 (en) 2000-08-10 2002-11-12 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
US6471995B1 (en) 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
JP4557409B2 (ja) * 2000-11-13 2010-10-06 日東電工株式会社 多孔質ポリイミドの製造方法及び多孔質ポリイミド
EP1341522B1 (de) 2000-12-13 2005-11-16 Merckle Gmbh Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung
US8637077B2 (en) 2000-12-28 2014-01-28 Takeda Pharmaceutical Company Limited Sustained-release preparation
RU2191012C1 (ru) 2001-06-20 2002-10-20 Научно-исследовательский испытательный центр (медико-биологической защиты) Государственного научно-исследовательского испытательного института военной медицины МО РФ Глазные капли для лечения эндотелиально-эпителиальной дистрофии роговицы
WO2003035030A1 (en) 2001-10-24 2003-05-01 Pari Gmbh Kit for the preparation of a pharmaceutical composition
WO2003041689A1 (en) * 2001-11-12 2003-05-22 Alkermes Controlled Therapeutics, Inc. Biocompatible polymer blends and uses thereof
TWI252111B (en) 2001-12-14 2006-04-01 Solvay Pharm Gmbh Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
KR100994658B1 (ko) 2001-12-26 2010-11-16 다케다 야쿠힌 고교 가부시키가이샤 신규 마이크로스피어 및 이들의 제조 방법
ES2605402T3 (es) 2002-06-25 2017-03-14 Takeda Pharmaceutical Company Limited Procedimiento para producir una composición de liberación sostenida
US8871269B2 (en) 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
EP2409707B8 (en) 2004-04-15 2015-05-06 Alkermes Pharma Ireland Limited Polymer-based sustained release device
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers

Also Published As

Publication number Publication date
CN101137349A (zh) 2008-03-05
AU2010224413A1 (en) 2010-10-14
AU2006213168B2 (en) 2011-09-15
US20080008733A1 (en) 2008-01-10
EP1886668A1 (en) 2008-02-13
CA2594434A1 (en) 2006-08-17
PT1843749E (pt) 2009-08-17
RS51129B (sr) 2010-10-31
EP2266535A3 (en) 2011-06-15
KR20100109983A (ko) 2010-10-11
RU2007130090A (ru) 2009-02-20
RU2409348C2 (ru) 2011-01-20
CN101137349B (zh) 2013-01-02
IL208175A0 (en) 2010-12-30
HK1152644A1 (en) 2012-03-09
JP2008526837A (ja) 2008-07-24
EP1843749A1 (en) 2007-10-17
RU2010138739A (ru) 2012-03-27
CY1109297T1 (el) 2014-07-02
SG158856A1 (en) 2010-02-26
EP2266535B1 (en) 2013-03-06
BRPI0606514A2 (pt) 2010-01-19
US7867518B2 (en) 2011-01-11
ATE431134T1 (de) 2009-05-15
IL184431A (en) 2012-03-29
US20100074868A1 (en) 2010-03-25
US8163307B2 (en) 2012-04-24
WO2006085747A1 (en) 2006-08-17
EP1886668B1 (en) 2012-11-14
AU2006213168A1 (en) 2006-08-17
PL1843749T3 (pl) 2009-10-30
KR101354521B1 (ko) 2014-01-22
EP1843749B1 (en) 2009-05-13
KR20070118225A (ko) 2007-12-14
CN101791396A (zh) 2010-08-04
EP1679065A1 (en) 2006-07-12
JP4887542B2 (ja) 2012-02-29
EP2266535A2 (en) 2010-12-29
MX2007008293A (es) 2007-12-07
DK1843749T3 (da) 2009-09-07
IL184431A0 (en) 2007-10-31
US20090226532A1 (en) 2009-09-10
AU2010224413B2 (en) 2012-03-22
ES2327267T3 (es) 2009-10-27
US7736674B2 (en) 2010-06-15
JP2011016836A (ja) 2011-01-27
HRP20090434T1 (hr) 2009-09-30
DE602006006797D1 (de) 2009-06-25

Similar Documents

Publication Publication Date Title
SI1843749T1 (sl) Sestavki z nadzorovanim sproščanjem za interferon na osnovi PEGT/PBT blok kopolimerov
GEP20074016B (en) Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2007127440A3 (en) Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
PT1759001E (pt) Conjugados de libertação óssea e método de utilização dos mesmos para direccionar proteínas ao osso
WO2006105172A3 (en) Peg-polyacetal and peg-polyacetal-poe graft copolymers and pharmaceutical compositions
WO2007043048A3 (en) Self-assembled fmoc-ff hydrogels
EP1721625A3 (en) Biodegradable medical devices with enhanced mechanical strength and pharmacological functions
WO2007050387A3 (en) Keratin bioceramic compositions
NZ600958A (en) Methods and compositions for live attentuated viruses
IL188774A0 (en) Compositions for delivery of drug combinations
EP2266590A3 (en) Active agent delivery sytems and methods for protecting and administering active agents
TNSN06071A1 (en) Use of modified cyclosporins for the treatment of hcv disorders
EP1943669A4 (en) LINEAR AND NETWORKED HIGHLY MOLECULAR POLYSILANES, POLYGERMANES AND COPOLYMERS THEREOF, COMPOSITIONS CONTAINING THEM AND METHOD FOR THE PREPARATION AND USE OF SUCH COMPOUNDS AND COMPOSITIONS
LU91989I9 (sl)
MXPA03010103A (es) Peptidos y composiciones anti-microbianos.
EA200700435A1 (ru) Рентгеноконтрастные полимерные стенты
WO2004087229A3 (en) Bone cement compositions
HK1071079A1 (en) Use of soluble fgl2 as an immunosuppressant
AU2003251728A8 (en) Placental growth factor as a target for the treatment of osteoporosis
EP1620061A4 (en) ANTIVIRAL AGENTS FOR THE TREATMENT, CONTROL AND PREVENTION OF INFECTIONS BY CORONAVIRES
TW200716178A (en) Macromolecular conjugates of bone morphogenetic protein-7
WO2006079121A3 (en) Methods of treating disease with glycosylated interferon
PL1633440T3 (pl) Kompozycja farmaceutyczna zawierająca białka i/lub polipeptydy oraz cząstki koloidalne
RU2006144370A (ru) Способ профилактики послеоперационного остеомиелита
MXPA02001852A (es) Composiciones de polimeros altos no gelificantes y mezclas termoplsticas derivadas.