DK2699264T3 - Antistoffer og andre molekyler, der binder b7-h1 og pd-1 - Google Patents
Antistoffer og andre molekyler, der binder b7-h1 og pd-1 Download PDFInfo
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- DK2699264T3 DK2699264T3 DK12774724.4T DK12774724T DK2699264T3 DK 2699264 T3 DK2699264 T3 DK 2699264T3 DK 12774724 T DK12774724 T DK 12774724T DK 2699264 T3 DK2699264 T3 DK 2699264T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Claims (11)
1. Antistof eller et antigenbindende fragment deraf, der binder til human PD-1, der omfatter en variabel region af let kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 98, og en variabel region af tung kæde, der omfatter aminosyresekvensen ifølge SEQ ID NO: 106.
2. Antistof eller antigenbindende fragment deraf ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf (A) svækker evnen hos en ligand til PD-1 til at binde til PD-1; (B) svækker eller fuldstændigt neutraliserer evnen hos PD-1 til at mediere signaltransduktion; (C) medierer T-celleproliferation; eller (D) øger produktionen af IFN-γ.
3. Antistof eller antigenbindende fragment deraf ifølge krav 1 eller krav 2, der omfatter mindst en del af en konstant region af immunoglobulin (Fc) .
4. Antistof eller antigenbindende fragment deraf ifølge krav 3, hvor den konstante region af immunoglobulin (Fc) er en konstant region af human immunoglobulin (Fc).
5. Antistof eller antigenbindende fragment deraf ifølge krav 4, hvor de humane konstante domæner er IgA-, IgD-, IgE-, IgG-eller IgM-domæner.
6. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 3 til 5, hvor humane IgG-konstante domæner er IgGl-, IgG2-, IgG3- eller IgG4-domæner.
7. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 6, hvor antistoffet eller det antigenbindende fragment deraf er påviseligt mærket eller omfatter et konjugeret toksin, lægemiddel eller enzym eller en konjugeret receptor eller receptorligand.
8. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 7, hvor antistoffet er et monoklonalt antistof, et humant antistof, et kimært antistof, et humaniseret antistof eller et enkeltkædet antistof.
9. Antistof eller antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 8, hvor antistoffet er et bispecifikt, trispecifikt eller multispecifikt antistof.
10. Farmaceutisk sammensætning, der omfatter antistoffet eller det antigenbindende fragment deraf ifølge et hvilket som helst af kravene 1 til 9 og et fysiologisk acceptabelt bæremiddel eller excipiens.
11. Farmaceutisk sammensætning ifølge krav 10 til anvendelse til behandling af cancer eller en infektionssygdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477414P | 2011-04-20 | 2011-04-20 | |
| PCT/US2012/034223 WO2012145493A1 (en) | 2011-04-20 | 2012-04-19 | Antibodies and other molecules that bind b7-h1 and pd-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2699264T3 true DK2699264T3 (da) | 2018-06-25 |
Family
ID=47041916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12774724.4T DK2699264T3 (da) | 2011-04-20 | 2012-04-19 | Antistoffer og andre molekyler, der binder b7-h1 og pd-1 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9205148B2 (da) |
| EP (2) | EP2699264B1 (da) |
| JP (2) | JP6072771B2 (da) |
| KR (1) | KR101970025B1 (da) |
| CN (1) | CN103608040B (da) |
| AU (1) | AU2012245477C1 (da) |
| CA (1) | CA2833636A1 (da) |
| CY (1) | CY1120626T1 (da) |
| DK (1) | DK2699264T3 (da) |
| ES (1) | ES2669310T3 (da) |
| HR (1) | HRP20180893T1 (da) |
| HU (1) | HUE037651T2 (da) |
| LT (1) | LT2699264T (da) |
| MX (1) | MX338353B (da) |
| PL (1) | PL2699264T3 (da) |
| PT (1) | PT2699264T (da) |
| RS (1) | RS57324B1 (da) |
| RU (1) | RU2625034C2 (da) |
| SI (1) | SI2699264T1 (da) |
| WO (1) | WO2012145493A1 (da) |
Families Citing this family (681)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0917592B1 (pt) | 2008-12-09 | 2021-08-17 | Genentech, Inc | Anticorpo anti-pd-l1, composição, artigos manufaturados e usos de uma composição |
| JP2013532153A (ja) * | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| HUE052198T2 (hu) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology Inc | Heterociklusos protein kináz inhibitorok |
| WO2013173223A1 (en) | 2012-05-15 | 2013-11-21 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
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-
2012
- 2012-04-19 KR KR1020137030691A patent/KR101970025B1/ko active IP Right Grant
- 2012-04-19 US US14/111,402 patent/US9205148B2/en not_active Expired - Fee Related
- 2012-04-19 MX MX2013012088A patent/MX338353B/es active IP Right Grant
- 2012-04-19 PL PL12774724T patent/PL2699264T3/pl unknown
- 2012-04-19 EP EP12774724.4A patent/EP2699264B1/en active Active
- 2012-04-19 EP EP18161596.4A patent/EP3403672A1/en not_active Withdrawn
- 2012-04-19 JP JP2014506544A patent/JP6072771B2/ja not_active Expired - Fee Related
- 2012-04-19 PT PT127747244T patent/PT2699264T/pt unknown
- 2012-04-19 WO PCT/US2012/034223 patent/WO2012145493A1/en active Application Filing
- 2012-04-19 DK DK12774724.4T patent/DK2699264T3/da active
- 2012-04-19 LT LTEP12774724.4T patent/LT2699264T/lt unknown
- 2012-04-19 AU AU2012245477A patent/AU2012245477C1/en not_active Ceased
- 2012-04-19 RU RU2013151455A patent/RU2625034C2/ru not_active IP Right Cessation
- 2012-04-19 CA CA2833636A patent/CA2833636A1/en not_active Abandoned
- 2012-04-19 RS RS20180683A patent/RS57324B1/sr unknown
- 2012-04-19 SI SI201231320T patent/SI2699264T1/en unknown
- 2012-04-19 ES ES12774724.4T patent/ES2669310T3/es active Active
- 2012-04-19 CN CN201280030691.9A patent/CN103608040B/zh not_active Expired - Fee Related
- 2012-04-19 HU HUE12774724A patent/HUE037651T2/hu unknown
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2015
- 2015-10-29 US US14/926,732 patent/US20160130348A1/en not_active Abandoned
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2016
- 2016-12-28 JP JP2016254558A patent/JP2017101042A/ja active Pending
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2018
- 2018-06-07 HR HRP20180893TT patent/HRP20180893T1/hr unknown
- 2018-06-13 CY CY181100615T patent/CY1120626T1/el unknown
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| Publication number | Publication date |
|---|---|
| AU2012245477A1 (en) | 2013-10-31 |
| KR101970025B1 (ko) | 2019-04-17 |
| EP2699264B1 (en) | 2018-03-14 |
| RU2625034C2 (ru) | 2017-07-11 |
| SI2699264T1 (en) | 2018-08-31 |
| EP3403672A1 (en) | 2018-11-21 |
| LT2699264T (lt) | 2018-07-10 |
| EP2699264A4 (en) | 2014-10-08 |
| KR20140048121A (ko) | 2014-04-23 |
| MX338353B (es) | 2016-04-13 |
| HRP20180893T1 (hr) | 2018-07-27 |
| RU2013151455A (ru) | 2015-05-27 |
| JP6072771B2 (ja) | 2017-02-01 |
| US20160130348A1 (en) | 2016-05-12 |
| WO2012145493A1 (en) | 2012-10-26 |
| CN103608040B (zh) | 2017-03-01 |
| PT2699264T (pt) | 2018-05-23 |
| PL2699264T3 (pl) | 2018-08-31 |
| MX2013012088A (es) | 2014-04-30 |
| JP2017101042A (ja) | 2017-06-08 |
| EP2699264A1 (en) | 2014-02-26 |
| AU2012245477B2 (en) | 2017-03-23 |
| JP2014523401A (ja) | 2014-09-11 |
| CY1120626T1 (el) | 2019-12-11 |
| ES2669310T3 (es) | 2018-05-24 |
| US20140044738A1 (en) | 2014-02-13 |
| HUE037651T2 (hu) | 2018-09-28 |
| AU2012245477C1 (en) | 2017-06-15 |
| CN103608040A (zh) | 2014-02-26 |
| CA2833636A1 (en) | 2012-10-26 |
| RS57324B1 (sr) | 2018-08-31 |
| US9205148B2 (en) | 2015-12-08 |
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