BR9910281A - Molécola de ligação que é um polipeptìdeo recombinante, ácido nucleico isolado, célula hospedeira, processo para produzir uma molécula de ligação, uso de uma molécula de ligação ou ácido nucleico, preparação farmacêutica, e, oligonucleotìdeo - Google Patents

Molécola de ligação que é um polipeptìdeo recombinante, ácido nucleico isolado, célula hospedeira, processo para produzir uma molécula de ligação, uso de uma molécula de ligação ou ácido nucleico, preparação farmacêutica, e, oligonucleotìdeo

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Publication number
BR9910281A
BR9910281A BR9910281-1A BR9910281A BR9910281A BR 9910281 A BR9910281 A BR 9910281A BR 9910281 A BR9910281 A BR 9910281A BR 9910281 A BR9910281 A BR 9910281A
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Brazil
Prior art keywords
molecule
binding
binding molecule
nucleic acid
domain
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BR9910281-1A
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English (en)
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Kathryn Lesley Armour
Michael Ronald Clark
Lorna Mcleod Williamson
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Univ Cambridge Tech
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Publication of BR9910281A publication Critical patent/BR9910281A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

''MOLéCULA DE LIGAçãO QUE é UM POLIPEPTìDEO RECOMBINANTE, áCIDO NUCLEICO ISOLADO, CéLULA HOSPEDEIRA, PROCESSO PARA PRODUZIR UMA MOLéCULA DE LIGAçãO, USO DE UMA MOLéCULA DE LIGAçãO OU áCIDO NUCLEICO, PREPARAçãO FARMACêUTICA, E, OLIGONUCLEOTìDEO'' São descritas moléculas de ligação que são polipeptídeos recombinantes compreendendo: (i) um domínio de ligação capaz de ligar uma molécula alvo e (ii) um domínio executor tendo uma seq³ência aminoácida substancialmente homóloga a todo ou parte de um domínio constante de uma cadeia pesada de imunoglobulina humana; caracterizado pelo fato de que a molécula de ligação é capaz de ligar-se à molécula alvo sem deflagrar significativa lise dependente de complemento, ou destruição do alvo mediada por célula, e, mais preferivelmente, em que o domínio executor é capaz de especificamente ligar-se a FcRn e/ou FcyRIIb. Isto é geralmente baseado nos domínios quiméricos que são derivados de duas ou mais domínios de cadeia pesada de imunoglobulina humana C~ H~2. Nas versões preferidas as regiões 233-236 e 327-331 são modificadas, cimo há mais resíduos para tornar a molécula nula alotípica. O domínio de ligação pode derivar-se de qualquer fonte apropriada à aplicação (usualmente clínica) para a molécula e pode ser de, p. ex., um anticorpo; uma enzima; um hormónio; um receptor; uma citoquina ou um antígeno; um ligando e uma molécula de adesão. Também são descritos ácidos nucleicos, células hospedeiras, processos e materiais de produção e usos, p.ex., para inibir a ativação da célula B; degranulação de mastócito; fagocitose, ou para inibir a ligação de uma segunda molécula de ligação à molécula alvo. Também são descritas preparações farmacêuticas.
BR9910281-1A 1998-05-08 1999-05-07 Molécola de ligação que é um polipeptìdeo recombinante, ácido nucleico isolado, célula hospedeira, processo para produzir uma molécula de ligação, uso de uma molécula de ligação ou ácido nucleico, preparação farmacêutica, e, oligonucleotìdeo BR9910281A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9809951.8A GB9809951D0 (en) 1998-05-08 1998-05-08 Binding molecules
PCT/GB1999/001441 WO1999058572A1 (en) 1998-05-08 1999-05-07 Binding molecules derived from immunoglobulins which do not trigger complement mediated lysis

Publications (1)

Publication Number Publication Date
BR9910281A true BR9910281A (pt) 2001-01-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910281-1A BR9910281A (pt) 1998-05-08 1999-05-07 Molécola de ligação que é um polipeptìdeo recombinante, ácido nucleico isolado, célula hospedeira, processo para produzir uma molécula de ligação, uso de uma molécula de ligação ou ácido nucleico, preparação farmacêutica, e, oligonucleotìdeo

Country Status (22)

Country Link
US (1) US7597889B1 (pt)
EP (1) EP1075496B1 (pt)
JP (1) JP4511035B2 (pt)
KR (1) KR100634853B1 (pt)
CN (1) CN1250570C (pt)
AT (1) ATE461940T1 (pt)
AU (1) AU752185C (pt)
BR (1) BR9910281A (pt)
CA (1) CA2326501C (pt)
DE (1) DE69942178D1 (pt)
EE (1) EE200000643A (pt)
ES (1) ES2342238T3 (pt)
GB (1) GB9809951D0 (pt)
HK (1) HK1039624A1 (pt)
HU (1) HUP0101915A3 (pt)
NO (1) NO328687B1 (pt)
NZ (1) NZ507694A (pt)
PL (1) PL343931A1 (pt)
RU (1) RU2226196C2 (pt)
TR (1) TR200003292T2 (pt)
WO (1) WO1999058572A1 (pt)
ZA (1) ZA200005870B (pt)

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