CR20230170A - ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) - Google Patents

ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485)

Info

Publication number
CR20230170A
CR20230170A CR20230170A CR20230170A CR20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A CR 20230170 A CR20230170 A CR 20230170A
Authority
CR
Costa Rica
Prior art keywords
trem2
methods
trem2 antibodies
antibodies
compositions
Prior art date
Application number
CR20230170A
Other languages
English (en)
Inventor
Philip Kong
Eric Brown
Arnon Rosenthal
Robert Pejchal
Ilaria Tassi
Nels P Nielson
Tina Schwabe
Seung-Joo Lee
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of CR20230170A publication Critical patent/CR20230170A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripción hace referencia, en líneas generales, a composiciones que incluyen anticuerpos, por ejemplo, anticuerpos monoclonales, quiméricos, humanizados, fragmentos de anticuerpos, etc., que se unen específicamente a uno o más epítopos de una proteína CD33, por ejemplo, CD33 humana o CD33 de mamífero y tienen características funcionales mejoradas y/o potenciadas, y al uso de dichas composiciones para prevenir, reducir el riesgo y tratar a un individuo que lo necesite.
CR20230170A 2017-08-03 2018-08-02 ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485) CR20230170A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541019P 2017-08-03 2017-08-03
US201862636095P 2018-02-27 2018-02-27
PCT/US2018/045068 WO2019028292A1 (en) 2017-08-03 2018-08-02 ANTI-TREM2 ANTIBODIES AND METHODS OF USE

Publications (1)

Publication Number Publication Date
CR20230170A true CR20230170A (es) 2023-05-31

Family

ID=63364160

Family Applications (3)

Application Number Title Priority Date Filing Date
CR20190485A CR20190485A (es) 2017-08-03 2018-08-02 Anticuerpos anti-trem2 y métodos para utilizarlos
CR20230170A CR20230170A (es) 2017-08-03 2018-08-02 ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485)
CR20230169A CR20230169A (es) 2017-08-03 2018-08-02 ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR20190485A CR20190485A (es) 2017-08-03 2018-08-02 Anticuerpos anti-trem2 y métodos para utilizarlos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20230169A CR20230169A (es) 2017-08-03 2018-08-02 ANTICUERPOS ANTI-TREM2 Y MÉTODOS PARA UTILIZARLOS (divisional 2019-0485)

Country Status (31)

Country Link
US (3) US10676525B2 (es)
EP (2) EP3601358B1 (es)
JP (2) JP2020533948A (es)
KR (1) KR20200033794A (es)
CN (1) CN110621696A (es)
AU (1) AU2018311055A1 (es)
BR (1) BR112019022752A2 (es)
CA (1) CA3061755A1 (es)
CL (2) CL2019003093A1 (es)
CO (1) CO2019012210A2 (es)
CR (3) CR20190485A (es)
DK (1) DK3601358T3 (es)
EC (1) ECSP19078429A (es)
ES (1) ES2952982T3 (es)
FI (1) FI3601358T3 (es)
HR (1) HRP20230675T1 (es)
HU (1) HUE062436T2 (es)
LT (1) LT3601358T (es)
MD (1) MD3601358T2 (es)
MX (1) MX2019012868A (es)
MY (1) MY201526A (es)
NZ (1) NZ758301A (es)
PE (1) PE20200148A1 (es)
PH (1) PH12019502459A1 (es)
PL (1) PL3601358T3 (es)
PT (1) PT3601358T (es)
RS (1) RS64419B1 (es)
SI (1) SI3601358T1 (es)
TW (2) TWI811229B (es)
WO (1) WO2019028292A1 (es)
ZA (2) ZA201906730B (es)

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