ATE520403T1 - N-ä3-fluoro-4-(ä6-(methyloxy)-7-ä(3-morpholin-4 ylpropyl)oxyüquinolin-4-ylüoxy)phenylü-n'-(4- fluorophenyl)cyclopropane-1,1-dicarboxamid zur behandlung von krebs - Google Patents
N-ä3-fluoro-4-(ä6-(methyloxy)-7-ä(3-morpholin-4 ylpropyl)oxyüquinolin-4-ylüoxy)phenylü-n'-(4- fluorophenyl)cyclopropane-1,1-dicarboxamid zur behandlung von krebsInfo
- Publication number
- ATE520403T1 ATE520403T1 AT10160517T AT10160517T ATE520403T1 AT E520403 T1 ATE520403 T1 AT E520403T1 AT 10160517 T AT10160517 T AT 10160517T AT 10160517 T AT10160517 T AT 10160517T AT E520403 T1 ATE520403 T1 AT E520403T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- ylüoxy
- phenylü
- oxyüquinolin
- ylpropyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 abstract 1
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 abstract 1
- 229940111121 antirheumatic drug quinolines Drugs 0.000 abstract 1
- 238000003782 apoptosis assay Methods 0.000 abstract 1
- 230000012292 cell migration Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000005522 programmed cell death Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003246 quinazolines Chemical class 0.000 abstract 1
- 150000003248 quinolines Chemical class 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- G—PHYSICS
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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| US50618103P | 2003-09-26 | 2003-09-26 | |
| US53537704P | 2004-01-09 | 2004-01-09 | |
| US57738404P | 2004-06-04 | 2004-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| AT04789057T ATE532782T1 (de) | 2003-09-26 | 2004-09-24 | C-met-modulatoren und anwendungsverfahren |
| AT10160518T ATE517091T1 (de) | 2003-09-26 | 2004-09-24 | C-met-modulatoren und verwendungsverfahren |
| AT10160517T ATE520403T1 (de) | 2003-09-26 | 2004-09-24 | N-ä3-fluoro-4-(ä6-(methyloxy)-7-ä(3-morpholin-4 ylpropyl)oxyüquinolin-4-ylüoxy)phenylü-n'-(4- fluorophenyl)cyclopropane-1,1-dicarboxamid zur behandlung von krebs |
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| AT04789057T ATE532782T1 (de) | 2003-09-26 | 2004-09-24 | C-met-modulatoren und anwendungsverfahren |
| AT10160518T ATE517091T1 (de) | 2003-09-26 | 2004-09-24 | C-met-modulatoren und verwendungsverfahren |
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| EP (9) | EP2392564B1 (de) |
| JP (14) | JP4638436B2 (de) |
| AT (3) | ATE532782T1 (de) |
| AU (3) | AU2004275842B2 (de) |
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| CA (2) | CA2744997A1 (de) |
| CY (3) | CY1111956T1 (de) |
| DK (4) | DK2213661T3 (de) |
| ES (6) | ES2651730T3 (de) |
| FR (1) | FR14C0067I2 (de) |
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