CN103509024B - 嘧啶并苯并氮杂卓类化合物及其作为抗肿瘤药物的应用 - Google Patents
嘧啶并苯并氮杂卓类化合物及其作为抗肿瘤药物的应用 Download PDFInfo
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- CN103509024B CN103509024B CN201210218159.1A CN201210218159A CN103509024B CN 103509024 B CN103509024 B CN 103509024B CN 201210218159 A CN201210218159 A CN 201210218159A CN 103509024 B CN103509024 B CN 103509024B
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- fluorophenyl
- cyclopropane
- diamide
- nitrae
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
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CN201210218159.1A CN103509024B (zh) | 2012-06-28 | 2012-06-28 | 嘧啶并苯并氮杂卓类化合物及其作为抗肿瘤药物的应用 |
PCT/CN2013/078318 WO2014000686A1 (zh) | 2012-06-28 | 2013-06-28 | 嘧啶并苯并氮杂卓类化合物及其作为抗肿瘤药物的应用 |
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CN112159411A (zh) * | 2020-10-15 | 2021-01-01 | 南京工业大学 | 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法 |
CN114835716B (zh) * | 2022-05-06 | 2023-05-12 | 徐州医科大学 | 一种苯并二氮卓并吡咯类化合物及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009384A2 (en) * | 2003-07-21 | 2005-02-03 | Imclone Systems Incorporated | Egfr tyrosine kinase inhibitors |
WO2005030140A2 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
CN101198590A (zh) * | 2005-08-24 | 2008-06-11 | 卫材R&D管理有限公司 | 新型吡啶衍生物及嘧啶衍生物(3) |
CN101257948A (zh) * | 2005-02-18 | 2008-09-03 | 阿特努奥恩公司 | 嘧啶并二氮䓬衍生物及吲哚并蝶啶化合物 |
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NZ547517A (en) * | 2004-02-27 | 2009-04-30 | Eisai R&D Man Co Ltd | Novel pyridine and pyrimidine derivatives for hepatocyte growth and tumour inihibition |
KR20090090365A (ko) * | 2007-02-23 | 2009-08-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Hgfr 유전자 증폭 세포주에 대하여 우수한 세포 증식 억제 효과 및 항종양 효과를 나타내는 피리딘 유도체 또는 피리미딘 유도체 |
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2012
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009384A2 (en) * | 2003-07-21 | 2005-02-03 | Imclone Systems Incorporated | Egfr tyrosine kinase inhibitors |
WO2005030140A2 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
CN101257948A (zh) * | 2005-02-18 | 2008-09-03 | 阿特努奥恩公司 | 嘧啶并二氮䓬衍生物及吲哚并蝶啶化合物 |
CN101198590A (zh) * | 2005-08-24 | 2008-06-11 | 卫材R&D管理有限公司 | 新型吡啶衍生物及嘧啶衍生物(3) |
Non-Patent Citations (1)
Title |
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Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors;Leon Smith, II等;《Bioorganic & Medicinal Chemistry Letters》;20060118;第1643–1646页,尤其是Table 1 * |
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