CN110117254B - 卡博替尼的制备方法 - Google Patents
卡博替尼的制备方法 Download PDFInfo
- Publication number
- CN110117254B CN110117254B CN201910538757.9A CN201910538757A CN110117254B CN 110117254 B CN110117254 B CN 110117254B CN 201910538757 A CN201910538757 A CN 201910538757A CN 110117254 B CN110117254 B CN 110117254B
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- formula
- cabozantinib
- reaction
- quinoline
- dimethoxy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201910538757.9A CN110117254B (zh) | 2019-06-20 | 2019-06-20 | 卡博替尼的制备方法 |
Applications Claiming Priority (1)
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CN201910538757.9A CN110117254B (zh) | 2019-06-20 | 2019-06-20 | 卡博替尼的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN110117254A CN110117254A (zh) | 2019-08-13 |
CN110117254B true CN110117254B (zh) | 2022-05-13 |
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CN201910538757.9A Active CN110117254B (zh) | 2019-06-20 | 2019-06-20 | 卡博替尼的制备方法 |
Country Status (1)
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CN (1) | CN110117254B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030140A2 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
CN102227164A (zh) * | 2008-09-26 | 2011-10-26 | 葛兰素史密斯克莱有限责任公司 | 喹啉基氧基二苯基环丙烷二甲酰胺的制备 |
CN103664776A (zh) * | 2012-09-26 | 2014-03-26 | 正大天晴药业集团股份有限公司 | 一种酪氨酸激酶抑制剂及其中间体的制备方法 |
WO2015051149A1 (en) * | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
CN105218445A (zh) * | 2015-08-25 | 2016-01-06 | 江苏中邦制药有限公司 | 一种络氨酸酶抑制剂Foretinib的制备方法 |
CN109232396A (zh) * | 2018-11-27 | 2019-01-18 | 聊城大学 | 酰胺吡啶类衍生物及其用途 |
-
2019
- 2019-06-20 CN CN201910538757.9A patent/CN110117254B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030140A2 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and methods of use |
CN102227164A (zh) * | 2008-09-26 | 2011-10-26 | 葛兰素史密斯克莱有限责任公司 | 喹啉基氧基二苯基环丙烷二甲酰胺的制备 |
CN103664776A (zh) * | 2012-09-26 | 2014-03-26 | 正大天晴药业集团股份有限公司 | 一种酪氨酸激酶抑制剂及其中间体的制备方法 |
WO2015051149A1 (en) * | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
CN105218445A (zh) * | 2015-08-25 | 2016-01-06 | 江苏中邦制药有限公司 | 一种络氨酸酶抑制剂Foretinib的制备方法 |
CN109232396A (zh) * | 2018-11-27 | 2019-01-18 | 聊城大学 | 酰胺吡啶类衍生物及其用途 |
Non-Patent Citations (4)
Title |
---|
(S)-苹果酸卡博替尼的合成工艺改进;张立娟;《中国医药工业杂志》;20190401;第50卷(第03期);284-286 * |
Syntheses and antiproliferative activities of novel diarylthiosemicarbazide derivatives;Xin Zhai等;《Chemical Research in Chinese Universities》;20130116;第29卷(第1期);62-66 * |
喹啉-2-甲酸的合成;李小清等;《浙江化工》;20110930;第42卷(第9期);17-18 * |
李小清等.喹啉-2-甲酸的合成.《浙江化工》.2011,第42卷(第9期),17-18. * |
Also Published As
Publication number | Publication date |
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CN110117254A (zh) | 2019-08-13 |
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Address after: 223800 No. 38 Yangzi Road, Eco-chemical Science and Technology Industrial Park, Suyu District, Suqian City, Jiangsu Province Applicant after: Jiangsu junruo Pharmaceutical Co., Ltd Applicant after: HAIMEN BAIKANG PHARMACEUTICAL Co.,Ltd. Applicant after: Nanjing Junruo Biomedical Research Institute Co.,Ltd. Address before: 223800 No. 38 Yangzi Road, Eco-chemical Science and Technology Industrial Park, Suyu District, Suqian City, Jiangsu Province Applicant before: JIANGSU JUNRUO PHARMACEUTICAL Co.,Ltd. Applicant before: HAIMEN BAIKANG PHARMACEUTICAL Co.,Ltd. Applicant before: Nanjing Junruo Biomedical Research Institute Co.,Ltd. |
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Address after: 223800 No. 38, Yangzi Road, ecological Chemical Technology Industrial Park, Suyu District, Suqian City, Jiangsu Province Applicant after: Jiangsu junruo Pharmaceutical Co.,Ltd. Applicant after: Nantong Baikang biomedical Co.,Ltd. Applicant after: Nanjing Junruo Biomedical Research Institute Co.,Ltd. Address before: 223800 No. 38, Yangzi Road, ecological Chemical Technology Industrial Park, Suyu District, Suqian City, Jiangsu Province Applicant before: Jiangsu junruo Pharmaceutical Co.,Ltd. Applicant before: HAIMEN BAIKANG PHARMACEUTICAL Co.,Ltd. Applicant before: Nanjing Junruo Biomedical Research Institute Co.,Ltd. |
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