JP2010265302A5 - - Google Patents
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- JP2010265302A5 JP2010265302A5 JP2010158334A JP2010158334A JP2010265302A5 JP 2010265302 A5 JP2010265302 A5 JP 2010265302A5 JP 2010158334 A JP2010158334 A JP 2010158334A JP 2010158334 A JP2010158334 A JP 2010158334A JP 2010265302 A5 JP2010265302 A5 JP 2010265302A5
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- JP
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- Prior art keywords
- optionally substituted
- alkyl
- composition
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 38
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 26
- 201000010099 disease Diseases 0.000 claims 16
- 208000035475 disorder Diseases 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- -1 carboalkoxy Chemical group 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000003107 substituted aryl group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 7
- 108091000080 Phosphotransferase Proteins 0.000 claims 6
- 102000020233 phosphotransferase Human genes 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000004953 trihalomethyl group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 102000001253 Protein Kinase Human genes 0.000 claims 2
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 2
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 2
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 claims 2
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 claims 2
- 125000004442 acylamino group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 108060006633 protein kinase Proteins 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003456 sulfonamides Chemical class 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 2
- YHIIJNLSGULWAA-UHFFFAOYSA-N 1,4-thiazinane 1-oxide Chemical compound O=S1CCNCC1 YHIIJNLSGULWAA-UHFFFAOYSA-N 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- ZQHJAAMMKABEBS-UHFFFAOYSA-N morpholin-2-one Chemical compound O=C1CNCCO1 ZQHJAAMMKABEBS-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- USDPNUDGXLLJKG-UHFFFAOYSA-N COc(c(OC)cc1ncc2)cc1c2Oc(ncc(NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O)c1)c1Cl Chemical compound COc(c(OC)cc1ncc2)cc1c2Oc(ncc(NC(C1(CC1)C(Nc(cc1)ccc1F)=O)=O)c1)c1Cl USDPNUDGXLLJKG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50618103P | 2003-09-26 | 2003-09-26 | |
| US60/506,181 | 2003-09-26 | ||
| US53537704P | 2004-01-09 | 2004-01-09 | |
| US60/535,377 | 2004-01-09 | ||
| US57738404P | 2004-06-04 | 2004-06-04 | |
| US60/577,384 | 2004-06-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528265A Division JP4638436B2 (ja) | 2003-09-26 | 2004-09-24 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010265302A JP2010265302A (ja) | 2010-11-25 |
| JP2010265302A5 true JP2010265302A5 (https=) | 2011-08-18 |
| JP5325172B2 JP5325172B2 (ja) | 2013-10-23 |
Family
ID=34397024
Family Applications (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528265A Expired - Fee Related JP4638436B2 (ja) | 2003-09-26 | 2004-09-24 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158334A Expired - Lifetime JP5325172B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158337A Expired - Fee Related JP5325173B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158335A Expired - Lifetime JP5185331B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158336A Expired - Fee Related JP5185332B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010256317A Withdrawn JP2011042686A (ja) | 2003-09-26 | 2010-11-16 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268454A Expired - Lifetime JP5694501B2 (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268453A Ceased JP2014074059A (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268455A Pending JP2014055191A (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2015087327A Withdrawn JP2015131859A (ja) | 2003-09-26 | 2015-04-22 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2017123131A Withdrawn JP2017160270A (ja) | 2003-09-26 | 2017-06-23 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2019002497A Withdrawn JP2019070015A (ja) | 2003-09-26 | 2019-01-10 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2020209919A Withdrawn JP2021050233A (ja) | 2003-09-26 | 2020-12-18 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2023201921A Pending JP2024023447A (ja) | 2003-09-26 | 2023-11-29 | ｃ－Ｍｅｔモジュレーターおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528265A Expired - Fee Related JP4638436B2 (ja) | 2003-09-26 | 2004-09-24 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
Family Applications After (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010158337A Expired - Fee Related JP5325173B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158335A Expired - Lifetime JP5185331B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010158336A Expired - Fee Related JP5185332B2 (ja) | 2003-09-26 | 2010-07-12 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2010256317A Withdrawn JP2011042686A (ja) | 2003-09-26 | 2010-11-16 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268454A Expired - Lifetime JP5694501B2 (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268453A Ceased JP2014074059A (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2013268455A Pending JP2014055191A (ja) | 2003-09-26 | 2013-12-26 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2015087327A Withdrawn JP2015131859A (ja) | 2003-09-26 | 2015-04-22 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2017123131A Withdrawn JP2017160270A (ja) | 2003-09-26 | 2017-06-23 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2019002497A Withdrawn JP2019070015A (ja) | 2003-09-26 | 2019-01-10 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2020209919A Withdrawn JP2021050233A (ja) | 2003-09-26 | 2020-12-18 | ｃ−Ｍｅｔモジュレーターおよびその使用 |
| JP2023201921A Pending JP2024023447A (ja) | 2003-09-26 | 2023-11-29 | ｃ－Ｍｅｔモジュレーターおよびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (14) | US9174947B2 (https=) |
| EP (9) | EP2392564B1 (https=) |
| JP (14) | JP4638436B2 (https=) |
| AT (3) | ATE517091T1 (https=) |
| AU (3) | AU2004275842B2 (https=) |
| BE (1) | BE2014C055I2 (https=) |
| CA (2) | CA2537812C (https=) |
| CY (3) | CY1111956T1 (https=) |
| DK (4) | DK2210607T3 (https=) |
| ES (6) | ES2369652T3 (https=) |
| FR (1) | FR14C0067I2 (https=) |
| HR (4) | HRP20110707T1 (https=) |
| HU (1) | HUS1400052I1 (https=) |
| LU (1) | LU92508I2 (https=) |
| NL (1) | NL300678I2 (https=) |
| PL (3) | PL2213661T3 (https=) |
| PT (2) | PT2213661E (https=) |
| SI (4) | SI2213661T1 (https=) |
| WO (1) | WO2005030140A2 (https=) |
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| JP3366959B2 (ja) | 1998-06-19 | 2003-01-14 | 三洋昭和パネルシステム株式会社 | 高さ調整自在な幅木 |
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| ATE508747T1 (de) | 2003-03-10 | 2011-05-15 | Eisai R&D Man Co Ltd | C-kit kinase-hemmer |
| WO2005028469A1 (en) | 2003-09-19 | 2005-03-31 | Astrazeneca Ab | Quinazoline derivatives |
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| US7683172B2 (en) | 2003-11-11 | 2010-03-23 | Eisai R&D Management Co., Ltd. | Urea derivative and process for preparing the same |
| US20050192314A1 (en) | 2003-11-13 | 2005-09-01 | Ambit Biosciences Corporation | Urea derivatives as C-kit modulators |
| WO2005073224A2 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| EP1719762B1 (en) * | 2004-02-27 | 2012-06-27 | Eisai R&D Management Co., Ltd. | Novel pyridine derivative and pyrimidine derivative (1) |
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| US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
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| US20110059081A1 (en) | 2009-09-09 | 2011-03-10 | Quintiles Transnational Corp. | Methods and compositions for the treatment of receptor tyrosine kinase mediated diseases or disorders |
| JP5461213B2 (ja) | 2010-01-29 | 2014-04-02 | 三洋電機株式会社 | 空気調和装置の室外ユニット |
| US20120070368A1 (en) * | 2010-04-16 | 2012-03-22 | Exelixis, Inc. | Methods of Using C-Met Modulators |
| US20120252840A1 (en) * | 2011-04-04 | 2012-10-04 | Exelixis, Inc. | Method of Treating Cancer |
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