FI952720A - Kasvainten vastaisten metyylitrioyhdisteiden konjugaatteja ja välituotteita niiden synteesiä varten - Google Patents

Kasvainten vastaisten metyylitrioyhdisteiden konjugaatteja ja välituotteita niiden synteesiä varten Download PDF

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Publication number
FI952720A
FI952720A FI952720A FI952720A FI952720A FI 952720 A FI952720 A FI 952720A FI 952720 A FI952720 A FI 952720A FI 952720 A FI952720 A FI 952720A FI 952720 A FI952720 A FI 952720A
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FI
Finland
Prior art keywords
conjugates
synthesis
carrier
triothio
intermediates
Prior art date
Application number
FI952720A
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English (en)
Swedish (sv)
Other versions
FI117690B (fi
FI952720A0 (fi
Inventor
Philip Ross Hamann
Lois Hinman
Irwin Hollander
Ryan Holcomb
William Hallett
Hwei-Ru Tsou
Martin J Weiss
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22962074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI952720(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI952720A0 publication Critical patent/FI952720A0/fi
Publication of FI952720A publication Critical patent/FI952720A/fi
Application granted granted Critical
Publication of FI117690B publication Critical patent/FI117690B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI952720A 1994-06-03 1995-06-02 Kasvainten vastaisten metyylitritioyhdisteiden konjugaatteja ja välituotteita niiden synteesiä varten FI117690B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/253,877 US5773001A (en) 1994-06-03 1994-06-03 Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US25387794 1994-06-03

Publications (3)

Publication Number Publication Date
FI952720A0 FI952720A0 (fi) 1995-06-02
FI952720A true FI952720A (fi) 1995-12-04
FI117690B FI117690B (fi) 2007-01-31

Family

ID=22962074

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952720A FI117690B (fi) 1994-06-03 1995-06-02 Kasvainten vastaisten metyylitritioyhdisteiden konjugaatteja ja välituotteita niiden synteesiä varten

Country Status (20)

Country Link
US (4) US5773001A (fi)
EP (1) EP0689845B1 (fi)
JP (2) JP3650165B2 (fi)
KR (1) KR100408376B1 (fi)
AT (1) ATE223234T1 (fi)
AU (1) AU697280B2 (fi)
BR (2) BR1100990A (fi)
CA (1) CA2150785C (fi)
CY (1) CY2334B1 (fi)
DE (1) DE69528016T2 (fi)
DK (1) DK0689845T3 (fi)
ES (1) ES2181752T3 (fi)
FI (1) FI117690B (fi)
IL (1) IL113984A (fi)
NO (1) NO313617B1 (fi)
NZ (3) NZ272274A (fi)
PT (1) PT689845E (fi)
SI (1) SI0689845T1 (fi)
TW (1) TW394778B (fi)
ZA (1) ZA954570B (fi)

Families Citing this family (717)

* Cited by examiner, † Cited by third party
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KR100408376B1 (ko) 2004-03-09
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US5767285A (en) 1998-06-16
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