DE69528016D1 - Konjugate von Methyltrithio-Antitumormitteln und Zwischenprodukte für deren Herstellung - Google Patents

Konjugate von Methyltrithio-Antitumormitteln und Zwischenprodukte für deren Herstellung

Info

Publication number
DE69528016D1
DE69528016D1 DE69528016T DE69528016T DE69528016D1 DE 69528016 D1 DE69528016 D1 DE 69528016D1 DE 69528016 T DE69528016 T DE 69528016T DE 69528016 T DE69528016 T DE 69528016T DE 69528016 D1 DE69528016 D1 DE 69528016D1
Authority
DE
Germany
Prior art keywords
conjugates
carrier
intermediates
manufacture
antitumor agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528016T
Other languages
English (en)
Other versions
DE69528016T2 (de
Inventor
Philip Ross Hamann
Lois Hinman
Irwin Hollander
Ryan Holcomb
Hwei-Ru Tsou
William Hallett
Martin J Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22962074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69528016(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE69528016D1 publication Critical patent/DE69528016D1/de
Publication of DE69528016T2 publication Critical patent/DE69528016T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69528016T 1994-06-03 1995-06-01 Konjugate von Methyltrithio-Antitumormitteln und Zwischenprodukte für deren Herstellung Expired - Lifetime DE69528016T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/253,877 US5773001A (en) 1994-06-03 1994-06-03 Conjugates of methyltrithio antitumor agents and intermediates for their synthesis

Publications (2)

Publication Number Publication Date
DE69528016D1 true DE69528016D1 (de) 2002-10-10
DE69528016T2 DE69528016T2 (de) 2003-01-02

Family

ID=22962074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528016T Expired - Lifetime DE69528016T2 (de) 1994-06-03 1995-06-01 Konjugate von Methyltrithio-Antitumormitteln und Zwischenprodukte für deren Herstellung

Country Status (20)

Country Link
US (4) US5773001A (de)
EP (1) EP0689845B1 (de)
JP (2) JP3650165B2 (de)
KR (1) KR100408376B1 (de)
AT (1) ATE223234T1 (de)
AU (1) AU697280B2 (de)
BR (2) BR1100990A (de)
CA (1) CA2150785C (de)
CY (1) CY2334B1 (de)
DE (1) DE69528016T2 (de)
DK (1) DK0689845T3 (de)
ES (1) ES2181752T3 (de)
FI (1) FI117690B (de)
IL (1) IL113984A (de)
NO (1) NO313617B1 (de)
NZ (3) NZ272274A (de)
PT (1) PT689845E (de)
SI (1) SI0689845T1 (de)
TW (1) TW394778B (de)
ZA (1) ZA954570B (de)

Families Citing this family (702)

* Cited by examiner, † Cited by third party
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US5767285A (en) 1998-06-16
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