HK1011560A1 - Method of diagnosing and treating epithelioma - Google Patents

Method of diagnosing and treating epithelioma

Info

Publication number
HK1011560A1
HK1011560A1 HK98112910A HK98112910A HK1011560A1 HK 1011560 A1 HK1011560 A1 HK 1011560A1 HK 98112910 A HK98112910 A HK 98112910A HK 98112910 A HK98112910 A HK 98112910A HK 1011560 A1 HK1011560 A1 HK 1011560A1
Authority
HK
Hong Kong
Prior art keywords
epithelioma
diagnosing
treating
vff
gene
Prior art date
Application number
HK98112910A
Inventor
Gunther R Adolf
Erik Patzelt
Karl-Heinz Heider
Elinborg Ostermann
Marlies Sproll
Original Assignee
Boehringer Ingelheim Int
Karlsruhe Forschzent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19545472A external-priority patent/DE19545472A1/en
Application filed by Boehringer Ingelheim Int, Karlsruhe Forschzent filed Critical Boehringer Ingelheim Int
Publication of HK1011560A1 publication Critical patent/HK1011560A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention concerns a method of diagnosing and treating epithelioma, the method being based on the expression of the variant exon v6 of the CD44 gene as the molecular target. In a preferred embodiment, v6-specific antibody molecules, in particular the monoclonal antibody BIWA-1 (VFF-18), are used for this purpose.
HK98112910A 1995-12-06 1998-12-07 Method of diagnosing and treating epithelioma HK1011560A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19545472A DE19545472A1 (en) 1995-12-06 1995-12-06 Diagnosis of squamous epithelial cell carcinoma
DE19615074 1996-04-17
PCT/EP1996/005448 WO1997021104A1 (en) 1995-12-06 1996-12-05 Method of diagnosing and treating epithelioma

Publications (1)

Publication Number Publication Date
HK1011560A1 true HK1011560A1 (en) 1999-07-16

Family

ID=26020988

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98112910A HK1011560A1 (en) 1995-12-06 1998-12-07 Method of diagnosing and treating epithelioma

Country Status (26)

Country Link
EP (1) EP0865609B1 (en)
JP (1) JP2000502067A (en)
KR (1) KR100473824B1 (en)
CN (1) CN1151377C (en)
AR (1) AR004360A1 (en)
AT (1) ATE235056T1 (en)
AU (1) AU726704B2 (en)
BG (1) BG62985B1 (en)
BR (1) BR9611901A (en)
CA (1) CA2239709A1 (en)
CO (1) CO4520233A1 (en)
CZ (1) CZ174198A3 (en)
DE (1) DE59610248D1 (en)
DK (1) DK0865609T3 (en)
EE (1) EE03783B1 (en)
ES (1) ES2190484T3 (en)
HK (1) HK1011560A1 (en)
MX (1) MX9804459A (en)
NO (1) NO319903B1 (en)
NZ (1) NZ324314A (en)
PL (1) PL184521B1 (en)
PT (1) PT865609E (en)
SK (1) SK284378B6 (en)
TR (1) TR199801027T2 (en)
UY (1) UY24389A1 (en)
WO (1) WO1997021104A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
EP1258255A1 (en) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
WO2002094879A1 (en) * 2001-05-18 2002-11-28 Boehringer Ingelheim International Gmbh Antibodies specific for cd44v6
EP1391213A1 (en) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
PL2531527T3 (en) * 2010-02-04 2014-08-29 Univ Miami A monoclonal antibody to cd44 for use in the treatment of head and neck squamous cell carcinoma
US9218450B2 (en) * 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
WO2019161528A1 (en) * 2018-02-22 2019-08-29 Abmart Shanghai Co., Ltd. Therapeutic antibody and uses thereof
WO2023227644A2 (en) 2022-05-25 2023-11-30 Akiram Therapeutics Ab Binding protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69406664T2 (en) * 1993-06-18 1998-06-04 Biotie Therapies Oy COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODY AGAINST CD44V6
EP0767378A1 (en) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Method for the diagnosis and analysis of stomach carcinoma
DE4326573A1 (en) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Polypeptides encoded by exon v5 of the CD44 gene as targets for immunotherapy and immunoscintigraphy of tumors
UA58482C2 (en) * 1994-06-08 2003-08-15 Бьорінгер Інгельхайм Інтернаціональ Гмбх MONOCLONAL ANTIBODY VFF-18 AGAINST CD44v6 AND ITS FRAGMENTS

Also Published As

Publication number Publication date
EP0865609B1 (en) 2003-03-19
NO319903B1 (en) 2005-09-26
AU726704B2 (en) 2000-11-16
PT865609E (en) 2003-08-29
BR9611901A (en) 1999-03-02
AU1177397A (en) 1997-06-27
TR199801027T2 (en) 1998-10-21
UY24389A1 (en) 2001-10-25
EE03783B1 (en) 2002-06-17
CN1151377C (en) 2004-05-26
EP0865609A1 (en) 1998-09-23
CZ174198A3 (en) 1999-02-17
CO4520233A1 (en) 1997-10-15
MX9804459A (en) 1998-09-30
BG102513A (en) 1999-02-26
KR19990071952A (en) 1999-09-27
SK73698A3 (en) 1999-01-11
WO1997021104A1 (en) 1997-06-12
EE9800164A (en) 1998-12-15
BG62985B1 (en) 2000-12-29
NZ324314A (en) 2000-02-28
NO982588D0 (en) 1998-06-05
PL327066A1 (en) 1998-11-23
CN1207811A (en) 1999-02-10
SK284378B6 (en) 2005-02-04
KR100473824B1 (en) 2005-09-30
DK0865609T3 (en) 2003-06-23
JP2000502067A (en) 2000-02-22
AR004360A1 (en) 1998-11-04
ES2190484T3 (en) 2003-08-01
DE59610248D1 (en) 2003-04-24
CA2239709A1 (en) 1997-06-12
PL184521B1 (en) 2002-11-29
ATE235056T1 (en) 2003-04-15
NO982588L (en) 1998-08-05

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20061205