US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
JP2002543044A
(ja)
|
1999-03-01 |
2002-12-17 |
ジェネンテック・インコーポレーテッド |
癌の治療及び診断のための抗体
|
DK1157041T3
(da)
*
|
1999-03-01 |
2005-10-03 |
Genentech Inc |
Antistoffer til diagnose og behandling af cancer
|
EP1074563A1
(de)
|
1999-08-02 |
2001-02-07 |
F. Hoffmann-La Roche Ag |
Erhöhte Bildung von Chimären Polypeptiden durch Ausbildung von Dimeren mittels elektrostatischen wechselwirkungen und Disulfidbindungen sowie Verfahren zur Herstellung und Anwendungen
|
SE0000597D0
(sv)
*
|
2000-02-24 |
2000-02-24 |
Active Biotech Ab |
Novel antibody
|
JP2004506408A
(ja)
*
|
2000-04-26 |
2004-03-04 |
イルーシス セラポーティクス,インコーポレーテッド |
二重特異性分子及びその用途
|
EP2354149B1
(de)
|
2000-12-12 |
2017-08-30 |
MedImmune, LLC |
Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung
|
RU2316337C2
(ru)
|
2001-04-24 |
2008-02-10 |
Мерк Патент Гмбх |
КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α
|
WO2003087163A1
(fr)
|
2002-04-15 |
2003-10-23 |
Chugai Seiyaku Kabushiki Kaisha |
Procede d'elaboration d'une banque scdb
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
DK1523496T3
(da)
*
|
2002-07-18 |
2011-10-17 |
Merus B V |
Rekombinant fremstilling af blanding af antistoffer
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
AU2013200009B2
(en)
*
|
2002-07-18 |
2015-05-07 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
WO2004065611A1
(ja)
*
|
2003-01-21 |
2004-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の軽鎖スクリーニング方法
|
ES2408582T3
(es)
|
2003-05-30 |
2013-06-21 |
Merus B.V. |
Biblioteca de Fab para la preparación de una mezcla de anticuerpos
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
WO2004111233A1
(ja)
|
2003-06-11 |
2004-12-23 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の製造方法
|
WO2005035753A1
(ja)
|
2003-10-10 |
2005-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
機能蛋白質を代替する二重特異性抗体
|
EP1693386A4
(de)
*
|
2003-11-04 |
2008-12-31 |
Chugai Pharmaceutical Co Ltd |
Verfahren zur herstellung von antikörpern
|
TW200530269A
(en)
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Anti-Mpl antibodies
|
WO2005068622A2
(en)
|
2004-01-20 |
2005-07-28 |
Merus B.V. |
Mixtures of binding proteins
|
ATE516048T1
(de)
*
|
2004-06-01 |
2011-07-15 |
Merck Sharp & Dohme |
Mit hiv gp41 in wechselwirkung stehende menschliche antikörper
|
JP5057967B2
(ja)
|
2005-03-31 |
2012-10-24 |
中外製薬株式会社 |
sc(Fv)2構造異性体
|
JP5620626B2
(ja)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
SI1876236T1
(sl)
*
|
2005-04-08 |
2014-11-28 |
Chugai Seiyaku Kabushiki Kaisha |
Protitelo, ki funkcionalno nadomesti faktor viii za koagulacijo krvi
|
KR101367544B1
(ko)
|
2005-06-10 |
2014-02-26 |
추가이 세이야쿠 가부시키가이샤 |
메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용
|
KR101360671B1
(ko)
|
2005-06-10 |
2014-02-07 |
추가이 세이야쿠 가부시키가이샤 |
sc(Fv)2를 함유하는 의약조성물
|
AR056142A1
(es)
|
2005-10-21 |
2007-09-19 |
Amgen Inc |
Metodos para generar el anticuerpo igg monovalente
|
EP2338518A1
(de)
|
2006-01-18 |
2011-06-29 |
Merck Patent GmbH |
Spezifische Krebsbehandlung mit Integrin-Liganden
|
DK3056568T3
(da)
|
2006-03-31 |
2021-11-01 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
|
EP3345616A1
(de)
|
2006-03-31 |
2018-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antikörpermodifizierungsverfahren zur reinigung von bispezifischem antikörper
|
ES2353084T3
(es)
*
|
2006-04-07 |
2011-02-25 |
Novo Nordisk Health Care Ag |
Complejo covalente de factor vii y factor tisular.
|
WO2007145840A2
(en)
|
2006-06-13 |
2007-12-21 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
WO2007147901A1
(en)
*
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
ATE555383T1
(de)
|
2006-06-22 |
2012-05-15 |
Novo Nordisk As |
Lösliche heterodimere rezeptoren und ihre verwendung
|
PL2064325T3
(pl)
|
2006-09-01 |
2012-05-31 |
Therapeutic Human Polyclonals Inc |
Zwiększona ekspresja ludzkiej lub humanizowanej immunoglobuliny u zwierząt transgenicznych innych niż człowiek
|
PL2066694T3
(pl)
|
2006-09-29 |
2016-04-29 |
Oncomed Pharm Inc |
Kompozycje i sposoby diagnozowania i leczenia nowotworu
|
BRPI0806596A2
(pt)
|
2007-01-18 |
2013-07-23 |
Merck Patent Ges Mit Berchraenkter Haftung |
medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer
|
WO2008091641A2
(en)
|
2007-01-24 |
2008-07-31 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
WO2008119353A1
(en)
|
2007-03-29 |
2008-10-09 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
SG193868A1
(en)
|
2007-09-26 |
2013-10-30 |
Chugai Pharmaceutical Co Ltd |
Modified antibody constant region
|
JP5334319B2
(ja)
|
2007-09-26 |
2013-11-06 |
中外製薬株式会社 |
Cdrのアミノ酸置換により抗体の等電点を改変する方法
|
DK2202307T4
(da)
|
2007-10-15 |
2021-10-04 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåde til fremstiling af et antistof
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
AU2008346734A1
(en)
|
2008-01-03 |
2009-07-16 |
The Scripps Research Institute |
Antibody targeting through a modular recognition domain
|
EP3521311A1
(de)
|
2008-04-11 |
2019-08-07 |
Chugai Seiyaku Kabushiki Kaisha |
Zur wiederholten bindung an zwei oder mehr antigenmoleküle fähiges, antigenbindendes molekül
|
EP3456190B1
(de)
*
|
2008-06-27 |
2021-11-24 |
Merus N.V. |
Antikörperproduzierende transgene murine tiere
|
DK2307051T3
(en)
|
2008-07-08 |
2015-04-20 |
Oncomed Pharm Inc |
Notch-binding substances, and antagonists and methods of use thereof
|
US9132189B2
(en)
|
2008-07-08 |
2015-09-15 |
Oncomed Pharmaceuticals, Inc. |
Notch1 binding agents and methods of use thereof
|
WO2010019702A2
(en)
|
2008-08-12 |
2010-02-18 |
Oncomed Pharmaceuticals, Inc. |
Ddr1-binding agents and methods of use thereof
|
US8298533B2
(en)
|
2008-11-07 |
2012-10-30 |
Medimmune Limited |
Antibodies to IL-1R1
|
WO2010068722A1
(en)
|
2008-12-12 |
2010-06-17 |
Medimmune, Llc |
Crystals and structure of a human igg fc variant with enhanced fcrn binding
|
EP2409991B1
(de)
|
2009-03-19 |
2017-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
Variante einer konstanten antikörperregion
|
TWI544077B
(zh)
|
2009-03-19 |
2016-08-01 |
Chugai Pharmaceutical Co Ltd |
Antibody constant region change body
|
PE20120591A1
(es)
|
2009-04-02 |
2012-05-23 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
|
ES2708124T3
(es)
|
2009-04-27 |
2019-04-08 |
Oncomed Pharm Inc |
Procedimiento para preparar moléculas heteromultiméricas
|
MX2011012491A
(es)
|
2009-05-25 |
2011-12-14 |
Merck Patent Gmbh |
Administracion continua de cilengitida en tratamientos contra el cancer.
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
EP2421357B1
(de)
|
2009-07-08 |
2013-01-23 |
Kymab Limited |
Tiermodelle und therapeutische moleküle
|
US20120302737A1
(en)
|
2009-09-16 |
2012-11-29 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
JP5837821B2
(ja)
|
2009-09-24 |
2015-12-24 |
中外製薬株式会社 |
抗体定常領域改変体
|
HUE029661T2
(en)
|
2009-10-16 |
2017-03-28 |
Oncomed Pharm Inc |
A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
|
ES2565208T3
(es)
|
2009-12-11 |
2016-04-01 |
F. Hoffmann-La Roche Ag |
Anticuerpos anti-VEGF-C y métodos de uso de los mismos
|
DK2516465T3
(en)
|
2009-12-23 |
2016-06-06 |
Hoffmann La Roche |
ANTI-BV8 ANTIBODIES AND APPLICATIONS THEREOF
|
EP2522724B1
(de)
|
2009-12-25 |
2020-02-05 |
Chugai Seiyaku Kabushiki Kaisha |
Polypeptidmodifikationsverfahren zur aufreinigung von polypeptidmultimeren
|
EP2530109A4
(de)
|
2010-01-29 |
2013-08-28 |
Toray Industries |
Harzfolie auf polymilchsäurebasis
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
RU2724663C2
(ru)
|
2010-02-08 |
2020-06-25 |
Ридженерон Фармасьютикалз, Инк. |
Мышь с общей легкой цепью
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
EP2543730B1
(de)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Variante einer konstanten antikörperregion
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
KR101930964B1
(ko)
|
2010-04-20 |
2018-12-19 |
젠맵 에이/에스 |
이종이량체 항체 fc-함유 단백질 및 그의 생산 방법
|
US9637557B2
(en)
|
2010-04-23 |
2017-05-02 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
US20120100166A1
(en)
|
2010-07-15 |
2012-04-26 |
Zyngenia, Inc. |
Ang-2 Binding Complexes and Uses Thereof
|
JP2013532628A
(ja)
|
2010-07-16 |
2013-08-19 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
乳癌および/または骨転移の処置に用いるためのペプチド
|
AU2011283694B2
(en)
|
2010-07-29 |
2017-04-13 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
EP2603525A1
(de)
|
2010-08-13 |
2013-06-19 |
F.Hoffmann-La Roche Ag |
Antikörper gegen il-1beta und il-18 zur behandlung von krankheiten
|
CA2808482C
(en)
*
|
2010-08-16 |
2021-10-26 |
Novimmune S.A. |
Methods for the generation of multispecific and multivalent antibodies
|
KR101586128B1
(ko)
|
2010-08-24 |
2016-01-15 |
에프. 호프만-라 로슈 아게 |
디술피드 안정화 ― Fv 단편을 포함하는 이중특이적 항체
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
SI2644698T1
(en)
*
|
2010-11-17 |
2018-05-31 |
Chugai Seiyaku Kabushiki Kaisha |
MULTISPECIFIC ANTIGEN-TUBULAR MOLECULAR, WITH AN ALTERNATIVE FUNCTION TO THE FACTOR OF BLOOD VIOLATION VIII
|
RU2642318C2
(ru)
|
2010-11-30 |
2018-01-24 |
Чугаи Сейяку Кабусики Кайся |
Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
|
BR112013013311A2
(pt)
|
2010-11-30 |
2017-09-19 |
Chugai Pharmaceutical Co Ltd |
agente terapêutico de indução de citotoxicidade
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
RU2013140685A
(ru)
*
|
2011-02-04 |
2015-03-10 |
Дженентек, Инк. |
ВАРИАНТЫ Fc, СПОСОБЫ ИХ ПОЛУЧЕНИЯ
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
RU2607038C2
(ru)
|
2011-02-28 |
2017-01-10 |
Ф. Хоффманн-Ля Рош Аг |
Антигенсвязывающие белки
|
EP2681240B1
(de)
|
2011-02-28 |
2017-08-16 |
F. Hoffmann-La Roche AG |
Monovalente antigenbindende proteine
|
AU2012222833B2
(en)
|
2011-03-03 |
2017-03-16 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
WO2012122512A1
(en)
|
2011-03-10 |
2012-09-13 |
Hco Antibody, Inc. |
Recombinant production of mixtures of single chain antibodies
|
CN103619876A
(zh)
|
2011-03-10 |
2014-03-05 |
Hco抗体股份有限公司 |
双特异性三链抗体样分子
|
IN2013MN01438A
(de)
|
2011-03-17 |
2015-06-12 |
Univ Ramot |
|
EA028804B1
(ru)
|
2011-03-25 |
2018-01-31 |
Гленмарк Фармасьютикалс С.А. |
Гетеродимерные иммуноглобулины
|
WO2012162561A2
(en)
|
2011-05-24 |
2012-11-29 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
GB201109965D0
(en)
|
2011-06-10 |
2011-07-27 |
Cancer Res Inst Royal |
Materials and methods for treating estrogen receptor alpher(ER) positive cancer
|
GB201109966D0
(en)
|
2011-06-10 |
2011-07-27 |
Cancer Res Inst Royal |
Materials and methods for treating pten mutated or deficient cancer
|
KR20140033152A
(ko)
|
2011-06-20 |
2014-03-17 |
교와 핫꼬 기린 가부시키가이샤 |
항erbB3 항체
|
CA2839539C
(en)
|
2011-06-30 |
2021-06-08 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
RU2014103185A
(ru)
|
2011-07-18 |
2015-08-27 |
Артс Байолоджикс А/С |
Биологически активное соединение на основе лютеинизирующего гормона (lh) с пролонгированным действием
|
SI2739740T1
(sl)
|
2011-08-05 |
2019-12-31 |
Regeneron Pharmaceuticals, Inc. |
Humanizirane univerzalne lahkoverižne miši
|
CA2844540C
(en)
|
2011-08-23 |
2018-10-16 |
Roche Glycart Ag |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
AU2012311286B2
(en)
|
2011-09-19 |
2018-07-26 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
HUE042192T2
(hu)
|
2011-09-23 |
2019-06-28 |
Oncomed Pharm Inc |
VEGF/DLL4-kötõ ágensek és alkalmazásaik
|
CA2791109C
(en)
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
MX359384B
(es)
|
2011-10-11 |
2018-09-25 |
Genentech Inc |
Conjunto mejorado de anticuerpos bisespecificos.
|
WO2013063155A2
(en)
|
2011-10-24 |
2013-05-02 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
SI2771364T1
(sl)
*
|
2011-10-27 |
2019-10-30 |
Genmab As |
Produkcija heterodimernih proteinov
|
US11851476B2
(en)
|
2011-10-31 |
2023-12-26 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain
|
ES2816078T3
(es)
|
2011-12-20 |
2021-03-31 |
Medimmune Llc |
Polipéptidos modificados para armazones de anticuerpo biespecífico
|
SG11201403445YA
(en)
*
|
2011-12-22 |
2014-07-30 |
Hoffmann La Roche |
Full length antibody display system for eukaryotic cells and its use
|
CN104105711B
(zh)
*
|
2012-02-10 |
2018-11-30 |
弗·哈夫曼-拉罗切有限公司 |
单链抗体及其他异多聚体
|
CA2865645A1
(en)
|
2012-03-16 |
2013-09-19 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals expressing immunoglobulin sequences ph-sensitive for antigen building
|
EP2825035A1
(de)
|
2012-03-16 |
2015-01-21 |
Regeneron Pharmaceuticals, Inc. |
Mäuse zur produktion antigenbindender proteine mit ph-abhängigen bindungseigenschaften
|
SI2883449T1
(en)
|
2012-03-16 |
2018-05-31 |
Regeneron Pharmaceuticals, Inc. |
Light-chain modified antibodies with histidine and genetically modified rodents for their production
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
WO2013150043A1
(en)
|
2012-04-05 |
2013-10-10 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies against human tweak and human il17 and uses thereof
|
EP3594232A1
(de)
|
2012-04-20 |
2020-01-15 |
Merus N.V. |
Verfahren und mittel zur herstellung von ig-like-molekülen
|
KR102023401B1
(ko)
|
2012-05-10 |
2019-11-04 |
바이오아트라, 엘엘씨 |
다중-특이적 모노클로날 항체
|
WO2013187495A1
(ja)
|
2012-06-14 |
2013-12-19 |
中外製薬株式会社 |
改変されたFc領域を含む抗原結合分子
|
CN104395339A
(zh)
|
2012-06-27 |
2015-03-04 |
弗·哈夫曼-拉罗切有限公司 |
用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
|
CN104411718B
(zh)
|
2012-06-27 |
2018-04-24 |
弗·哈夫曼-拉罗切有限公司 |
用于制备包含特异性结合靶的至少一种结合实体的抗体Fc区缀合物的方法及其用途
|
EP3339328A1
(de)
|
2012-07-04 |
2018-06-27 |
F. Hoffmann-La Roche AG |
Anti-biotin-antikörper und verwendungsverfahren
|
EP3138580B1
(de)
|
2012-07-04 |
2021-03-03 |
F. Hoffmann-La Roche AG |
Kovalent verknüpfte antigen-antikörper-konjugate
|
HUE029435T2
(en)
|
2012-07-04 |
2017-02-28 |
Hoffmann La Roche |
Anti-theophylline antibodies and methods of their application
|
EP2869845B1
(de)
|
2012-07-06 |
2019-08-28 |
Genmab B.V. |
Dimerprotein mit dreifacher mutation
|
EP3632462A1
(de)
|
2012-07-06 |
2020-04-08 |
Genmab B.V. |
Dimerprotein mit dreifacher mutation
|
WO2014012082A2
(en)
|
2012-07-13 |
2014-01-16 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design an constructs
|
KR102273985B1
(ko)
|
2012-08-24 |
2021-07-06 |
추가이 세이야쿠 가부시키가이샤 |
FcγRIIb 특이적 Fc영역 개변체
|
EP3470431A1
(de)
|
2012-09-27 |
2019-04-17 |
Merus N.V. |
Bispezifische igg-antikörper als t-zell-engager
|
KR20150064068A
(ko)
|
2012-10-08 |
2015-06-10 |
로슈 글리카트 아게 |
2개의 Fab 단편을 포함하는 FC-부재 항체 및 이용 방법
|
US9278124B2
(en)
|
2012-10-16 |
2016-03-08 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
JP6371294B2
(ja)
|
2012-10-31 |
2018-08-08 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Dll4アンタゴニストによる処置の方法およびモニタリング
|
AU2013339038B2
(en)
|
2012-11-05 |
2017-12-21 |
Zenyaku Kogyo Kabushikikaisha |
Antibody and antibody composition production method
|
RU2670943C9
(ru)
|
2012-11-08 |
2018-11-26 |
Илэвэн Байотерапьютикс, Инк. |
Антагонисты ил-6 и их применение
|
ES2876009T3
(es)
|
2012-12-27 |
2021-11-11 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado
|
KR20220156667A
(ko)
|
2013-01-10 |
2022-11-25 |
젠맵 비. 브이 |
인간 IgG1 Fc 영역 변이체 및 그의 용도
|
DK2943511T3
(da)
|
2013-01-14 |
2019-10-21 |
Xencor Inc |
Nye heterodimeriske proteiner
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
US9738722B2
(en)
|
2013-01-15 |
2017-08-22 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
CA2896370A1
(en)
|
2013-02-26 |
2014-09-04 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
EP3708584A1
(de)
|
2013-02-26 |
2020-09-16 |
Roche Glycart AG |
Bispezifische antigenbindende moleküle zur t-zellen-aktivierung
|
US9908938B2
(en)
*
|
2013-03-14 |
2018-03-06 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof
|
CA2907181C
(en)
|
2013-03-15 |
2023-10-17 |
Viktor Roschke |
Multivalent and monovalent multispecific complexes and their uses
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
DK2970486T3
(en)
|
2013-03-15 |
2018-08-06 |
Xencor Inc |
MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
SG11201508910WA
(en)
|
2013-04-29 |
2015-11-27 |
Hoffmann La Roche |
Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases
|
ES2871383T3
(es)
|
2013-04-29 |
2021-10-28 |
Hoffmann La Roche |
Anticuerpos asimétricos modificados que se unen al receptor de Fc y procedimientos de uso
|
ES2746136T3
(es)
|
2013-04-29 |
2020-03-04 |
Hoffmann La Roche |
Anticuerpos modificados de unión a FcRn humano y procedimientos de uso
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
IL290613B1
(en)
|
2013-07-05 |
2024-07-01 |
Genmab As |
CD3 antibodies of human origin or chimeras
|
EA035319B1
(ru)
*
|
2013-07-31 |
2020-05-27 |
Эмджен Инк. |
СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ
|
BR112016006197B1
(pt)
|
2013-09-27 |
2023-04-11 |
Chugai Seiyaku Kabushiki Kaisha |
Método para produzir um anticorpo biespecífico de polipeptídeos
|
CA2922950A1
(en)
|
2013-09-30 |
2015-04-02 |
Shinya Ishii |
Method for producing antigen-binding molecule using modified helper phage
|
TW201546284A
(zh)
|
2013-10-01 |
2015-12-16 |
Kymab Ltd |
動物模式及治療分子
|
CN105612182B
(zh)
|
2013-10-11 |
2019-12-10 |
豪夫迈·罗氏有限公司 |
多特异性结构域交换共有可变轻链抗体
|
TWI652279B
(zh)
|
2013-11-11 |
2019-03-01 |
中外製藥股份有限公司 |
含改變的抗體可變區之抗原結合分子
|
CA3131724A1
(en)
|
2013-12-17 |
2015-06-25 |
Genentech, Inc. |
Anti-cd3 antibodies and methods of use
|
CA2932958A1
(en)
|
2013-12-20 |
2015-06-25 |
F. Hoffmann-La Roche Ag |
Humanized anti-tau(ps422) antibodies and methods of use
|
MX2016008098A
(es)
*
|
2013-12-20 |
2017-01-11 |
Hoffmann La Roche |
Anticuerpos biespecificos del receptor 2 de factor de crecimiento ipidermico himano (her2) y metodo de uso.
|
EP3089996B1
(de)
|
2014-01-03 |
2021-07-28 |
F. Hoffmann-La Roche AG |
Bispezifische anti-hapten-/anti-blut-hirn-schranke-rezeptor-antikörper, komplexe davon und deren verwendung als blut-hirn-schranke-shuttles
|
JP6602304B2
(ja)
|
2014-01-03 |
2019-11-06 |
エフ.ホフマン−ラ ロシュ アーゲー |
共有結合で連結されたヘリカー−抗ヘリカー抗体コンジュゲートおよびその用途
|
CA2930046A1
(en)
|
2014-01-03 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Covalently linked polypeptide toxin-antibody conjugates
|
BR112016015589A2
(pt)
|
2014-01-06 |
2017-10-31 |
Hoffmann La Roche |
módulos de trânsito monovalentes para a barreira hematoencefálica
|
EP3835318A1
(de)
|
2014-01-15 |
2021-06-16 |
F. Hoffmann-La Roche AG |
Fc-regionsvarianten mit modifizierten fcrn- und protein-a-bindungsfunktionen
|
BR112016018980A2
(pt)
|
2014-02-21 |
2017-10-10 |
Genentech Inc |
método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêutica
|
JP6771385B2
(ja)
|
2014-02-28 |
2020-10-21 |
メルス ナムローゼ フェンノートシャップ |
二重特異性抗体および医薬組成物
|
KR20240042540A
(ko)
|
2014-02-28 |
2024-04-02 |
메뤼스 엔.페. |
ErbB-2와 ErbB-3에 결합하는 항체
|
WO2015139046A1
(en)
|
2014-03-14 |
2015-09-17 |
Genentech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
WO2015143414A2
(en)
|
2014-03-21 |
2015-09-24 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that make single domain binding proteins
|
BR112016022385A2
(pt)
|
2014-03-28 |
2018-06-19 |
Xencor, Inc |
anticorpos específicos que se ligam a cd38 e cd3
|
WO2015153765A1
(en)
*
|
2014-04-01 |
2015-10-08 |
Adimab, Llc |
Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use
|
UA117289C2
(uk)
|
2014-04-02 |
2018-07-10 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифічне антитіло
|
WO2015150446A1
(en)
|
2014-04-02 |
2015-10-08 |
F. Hoffmann-La Roche Ag |
Method for detecting multispecific antibody light chain mispairing
|
MX2016012552A
(es)
|
2014-04-07 |
2017-01-09 |
Chugai Pharmaceutical Co Ltd |
Molecula ligada a antigeno inmunoactivada.
|
KR102603417B1
(ko)
|
2014-05-06 |
2023-11-20 |
제넨테크, 인크. |
포유동물 세포를 사용한 이종다량체 단백질의 생산
|
BR112016026299A2
(pt)
|
2014-05-13 |
2018-02-20 |
Chugai Seiyaku Kabushiki Kaisha |
molécula de ligação ao antígeno redirecionado à célula t para células tendo função de imunossupressão
|
EP3142750B1
(de)
|
2014-05-13 |
2020-07-01 |
The Trustees Of The University Of Pennsylvania |
Zusammensetzungen mit aav-expression von zwei antikörperkonstrukten und verwendungen davon
|
AR100978A1
(es)
|
2014-06-26 |
2016-11-16 |
Hoffmann La Roche |
LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
|
JP6654581B2
(ja)
|
2014-06-26 |
2020-02-26 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
抗brdu抗体および使用方法
|
SG11201610777VA
(en)
|
2014-07-11 |
2017-01-27 |
Genmab As |
Antibodies binding axl
|
EP2982692A1
(de)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispezifische Antikörper gegen CD3-Epsilon und BCMA
|
BR112016030462A2
(pt)
|
2014-08-04 |
2018-01-16 |
F. Hoffmann-La Roche Ag |
moléculas de ligação, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método de produção de uma molécula de ligação, composição farmacêutica, uso da molécula de ligação, método de tratamento de doenças e de indução da lise de células alvo
|
AR101846A1
(es)
|
2014-09-12 |
2017-01-18 |
Genentech Inc |
Anticuerpos anti-cll-1 e inmunoconjugados
|
SI3191135T1
(sl)
|
2014-09-12 |
2021-01-29 |
Genentech, Inc. |
Anti-HER2 protitelesa in imunokonjugati
|
CN107108724A
(zh)
|
2014-09-12 |
2017-08-29 |
豪夫迈·罗氏有限公司 |
半胱氨酸改造抗体和缀合物
|
MX2017003472A
(es)
|
2014-09-17 |
2017-10-31 |
Genentech Inc |
Inmunoconjugados que comprenden anticuerpos anti-her2.
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
TWI701435B
(zh)
|
2014-09-26 |
2020-08-11 |
日商中外製藥股份有限公司 |
測定fviii的反應性之方法
|
TWI700300B
(zh)
|
2014-09-26 |
2020-08-01 |
日商中外製藥股份有限公司 |
中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體
|
ES2850325T3
(es)
|
2014-10-09 |
2021-08-27 |
Engmab Sarl |
Anticuerpos biespecíficos contra CD3epsilon y ROR1
|
JP6625627B2
(ja)
|
2014-10-14 |
2019-12-25 |
ハロザイム インコーポレイテッド |
アデノシンデアミナーゼ−2(ada2)、その変異体の組成物およびそれを使用する方法
|
US20160176962A1
(en)
|
2014-10-31 |
2016-06-23 |
Oncomed Pharmaceuticals, Inc. |
Combination Therapy For Treatment Of Disease
|
US11773166B2
(en)
|
2014-11-04 |
2023-10-03 |
Ichnos Sciences SA |
CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
|
CA2960569A1
(en)
|
2014-11-06 |
2016-05-12 |
F. Hoffmann-Laroche Ag |
Fc-region variants with modified fcrn- and protein a-binding properties
|
HUE045466T2
(hu)
|
2014-11-06 |
2019-12-30 |
Hoffmann La Roche |
Fc-régió-variánsok módosított FcRn-kötéssel és alkalmazási eljárások
|
WO2016073894A1
(en)
|
2014-11-07 |
2016-05-12 |
Eleven Biotherapeutics, Inc. |
Therapeutic agents with increased ocular retention
|
KR20240023450A
(ko)
|
2014-11-07 |
2024-02-21 |
에프. 호프만 라-로셰 엘티디 |
향상된 il-6 항체
|
CR20170240A
(es)
|
2014-11-10 |
2018-04-03 |
Genentech Inc |
Anticuerpos anti-interleucina-33 y sus usos
|
US11008403B2
(en)
|
2014-11-19 |
2021-05-18 |
Genentech, Inc. |
Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use
|
EP3023437A1
(de)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispezifische Antikörper gegen CD3epsilon und BCMA
|
LT3221357T
(lt)
*
|
2014-11-20 |
2020-08-25 |
F. Hoffmann-La Roche Ag |
Bendros lengvosios grandinės ir naudojimo būdai
|
WO2016079050A1
(en)
|
2014-11-20 |
2016-05-26 |
F. Hoffmann-La Roche Ag |
Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists
|
TN2017000222A1
(en)
|
2014-11-26 |
2018-10-19 |
Xencor Inc |
Heterodimeric antibodies that bind cd3 and cd38
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
AU2015353409B2
(en)
|
2014-11-26 |
2019-05-09 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
EP3227332B1
(de)
|
2014-12-03 |
2019-11-06 |
F.Hoffmann-La Roche Ag |
Multispezifische antikörper
|
JP2018502840A
(ja)
|
2014-12-10 |
2018-02-01 |
ジェネンテック, インコーポレイテッド |
血液脳関門受容体抗体及び使用方法
|
US10865253B2
(en)
|
2014-12-19 |
2020-12-15 |
Genmab A/S |
Rodent bispecific heterodimeric proteins
|
SG11201700841QA
(en)
|
2014-12-19 |
2017-03-30 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
|
US10428155B2
(en)
|
2014-12-22 |
2019-10-01 |
Xencor, Inc. |
Trispecific antibodies
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
AU2016232715A1
(en)
|
2015-03-19 |
2017-09-28 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that select for light chain variable regions that bind antigen
|
US11142587B2
(en)
|
2015-04-01 |
2021-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide hetero-oligomer
|
CN107810012A
(zh)
|
2015-06-02 |
2018-03-16 |
豪夫迈·罗氏有限公司 |
使用抗il‑34抗体治疗神经疾病的组合物和方法
|
AR105026A1
(es)
|
2015-06-16 |
2017-08-30 |
Genentech Inc |
ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO
|
US10501545B2
(en)
|
2015-06-16 |
2019-12-10 |
Genentech, Inc. |
Anti-CLL-1 antibodies and methods of use
|
CN107810196B
(zh)
|
2015-06-24 |
2021-11-05 |
豪夫迈·罗氏有限公司 |
人源化的抗-Tau(pS422)抗体和使用方法
|
JP7021955B2
(ja)
*
|
2015-06-24 |
2022-03-03 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Her2及び血液脳関門受容体に特異的な三重特異性抗体及び使用方法
|
RS57928B1
(sr)
|
2015-07-10 |
2019-01-31 |
Merus Nv |
Antitela koja vezuju humani cd3
|
EP3730520A1
(de)
|
2015-07-10 |
2020-10-28 |
Genmab A/S |
Axl-spezifische antikörper-wirkstoff-konjugate zur krebsbehandlung
|
CN114989302A
(zh)
|
2015-07-15 |
2022-09-02 |
根马布股份公司 |
人源化或嵌合cd3抗体
|
ES2968074T3
(es)
|
2015-09-23 |
2024-05-07 |
Mereo Biopharma 5 Inc |
Anticuerpo bi-específico anti-VEGF/DLL4 para su uso en el tratamiento del cáncer de ovario resistente al platino
|
AR106188A1
(es)
|
2015-10-01 |
2017-12-20 |
Hoffmann La Roche |
Anticuerpos anti-cd19 humano humanizados y métodos de utilización
|
CA2990755A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffman-La Roche Ag |
Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
|
JP6734919B2
(ja)
|
2015-10-02 |
2020-08-05 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
同時結合を測定するための細胞ベースのfretアッセイ法
|
WO2017055393A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules
|
US20180282410A1
(en)
|
2015-10-02 |
2018-10-04 |
Hoffmann-La Roche Inc. |
Anti-cd3xrob04 bispecific t cell activating antigen binding molecules
|
CN108026177B
(zh)
|
2015-10-02 |
2021-11-26 |
豪夫迈·罗氏有限公司 |
双特异性抗cd19xcd3 t细胞活化性抗原结合分子
|
EP3356409A2
(de)
|
2015-10-02 |
2018-08-08 |
H. Hoffnabb-La Roche Ag |
Bispezifische antigenbindende moleküle zur t-zellen-aktivierung
|
EP3150637A1
(de)
|
2015-10-02 |
2017-04-05 |
F. Hoffmann-La Roche AG |
Multispezifische antikörper
|
MA43345A
(fr)
|
2015-10-02 |
2018-08-08 |
Hoffmann La Roche |
Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
|
WO2017055385A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xgd2 bispecific t cell activating antigen binding molecules
|
US10287352B2
(en)
|
2015-10-02 |
2019-05-14 |
Hoffman-La Roche Inc. |
Bispecific antibodies specific for PD1 and TIM3
|
AR106365A1
(es)
|
2015-10-02 |
2018-01-10 |
Hoffmann La Roche |
Moléculas biespecíficas de unión a antígeno activadoras de células t
|
WO2017055392A1
(en)
|
2015-10-02 |
2017-04-06 |
F. Hoffmann-La Roche Ag |
Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
|
JP7320944B2
(ja)
|
2015-10-08 |
2023-08-04 |
マクロジェニクス,インコーポレーテッド |
B7‐h3に特異的に結合する分子及びpd‐1に特異的に結合する分子
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
MA45326A
(fr)
|
2015-10-20 |
2018-08-29 |
Genentech Inc |
Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
|
PL3365373T3
(pl)
|
2015-10-23 |
2021-08-23 |
Merus N.V. |
Molekuły wiążące, które hamują wzrost nowotworu
|
SG10202006332PA
(en)
*
|
2015-10-29 |
2020-08-28 |
Hoffmann La Roche |
Transgenic rabbit with common light chain
|
BR112018006562A2
(pt)
|
2015-10-29 |
2018-12-11 |
Hoffmann La Roche |
anticorpos, ácido nucleico, célula hospedeira, método para produzir um anticorpo, conjugado e uso de um anticorpo
|
JP2018534930A
(ja)
|
2015-10-30 |
2018-11-29 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体及びコンジュゲート
|
EP3378488A4
(de)
|
2015-11-18 |
2019-10-30 |
Chugai Seiyaku Kabushiki Kaisha |
Verfahren zur verbesserung der humoralen immunreaktion
|
US11660340B2
(en)
|
2015-11-18 |
2023-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
|
CA3007030A1
(en)
|
2015-12-07 |
2017-06-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and psma
|
CA2997406C
(en)
|
2015-12-09 |
2024-05-28 |
F. Hoffmann-La Roche Ag |
Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release
|
EP3178848A1
(de)
|
2015-12-09 |
2017-06-14 |
F. Hoffmann-La Roche AG |
Type ii anti-cd20 antikörper zur verringerung der bildung von antikörpern gegen medikamente
|
BR112018009312A8
(pt)
|
2015-12-28 |
2019-02-26 |
Chugai Pharmaceutical Co Ltd |
método para promover eficiência de purificação de polipeptídeo contendo região de fc
|
AU2016381694A1
(en)
|
2015-12-30 |
2018-07-05 |
Genentech, Inc. |
Use of tryptophan derivatives for protein formulations
|
JP7008023B2
(ja)
|
2015-12-30 |
2022-01-25 |
ジェネンテック, インコーポレイテッド |
低減されたポリソルベート分解を有する製剤
|
AU2017205089B2
(en)
|
2016-01-08 |
2023-10-05 |
F. Hoffmann-La Roche Ag |
Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
|
BR112018017031A2
(pt)
|
2016-02-23 |
2019-01-22 |
Sesen Bio Inc |
formulações de antagonista de il-6 e usos das mesmas
|
TW202214700A
(zh)
|
2016-03-14 |
2022-04-16 |
日商中外製藥股份有限公司 |
用於癌之治療的細胞傷害誘導治療劑
|
PE20231511A1
(es)
|
2016-03-22 |
2023-09-26 |
Hoffmann La Roche |
Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3
|
JP7058609B2
(ja)
|
2016-04-15 |
2022-04-22 |
アルパイン イミューン サイエンシズ インコーポレイテッド |
Icosリガンドバリアント免疫調節タンパク質およびその使用
|
SG11201808783XA
(en)
|
2016-04-15 |
2018-11-29 |
Alpine Immune Sciences Inc |
Cd80 variant immunomodulatory proteins and uses thereof
|
CR20180509A
(es)
|
2016-05-02 |
2019-02-15 |
Hoffmann La Roche |
Contorsbody - un ligante de diana monocatenario
|
EP3458101B1
(de)
|
2016-05-20 |
2020-12-30 |
H. Hoffnabb-La Roche Ag |
Protac-antikörper-konjugate und verfahren zur verwendung
|
WO2017205741A1
(en)
|
2016-05-27 |
2017-11-30 |
Genentech, Inc. |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
EP3252078A1
(de)
|
2016-06-02 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Typ ii anti-cd20 antikörper und anti-cd20/cd3 bispecific antikörper zur behandlung von krebs
|
CN109476648B
(zh)
|
2016-06-06 |
2022-09-13 |
豪夫迈·罗氏有限公司 |
司维司群抗体-药物缀合物和使用方法
|
IL263542B1
(en)
|
2016-06-14 |
2024-06-01 |
Xencor Inc |
Bispecific antibodies inhibit immunological checkpoint
|
AR108800A1
(es)
|
2016-06-17 |
2018-09-26 |
Genentech Inc |
Purificación de anticuerpos multiespecíficos
|
US10316088B2
(en)
|
2016-06-28 |
2019-06-11 |
Xencor, Inc. |
Heterodimeric antibodies that bind somatostatin receptor 2
|
CA3029627A1
(en)
|
2016-07-01 |
2018-01-04 |
Resolve Therapeutics, Llc |
Optimized binuclease fusions and methods
|
JP6983824B2
(ja)
|
2016-07-04 |
2021-12-17 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
新規抗体フォーマット
|
UA128304C2
(uk)
|
2016-07-14 |
2024-06-05 |
Ґенмаб А/С |
Мультиспецифічне антитіло до cd40 і cd137
|
WO2018014260A1
(en)
|
2016-07-20 |
2018-01-25 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific antigen binding proteins and methods of use thereof
|
US11471488B2
(en)
|
2016-07-28 |
2022-10-18 |
Alpine Immune Sciences, Inc. |
CD155 variant immunomodulatory proteins and uses thereof
|
WO2018022945A1
(en)
|
2016-07-28 |
2018-02-01 |
Alpine Immune Sciences, Inc. |
Cd112 variant immunomodulatory proteins and uses thereof
|
WO2018022946A1
(en)
|
2016-07-28 |
2018-02-01 |
Alpine Immune Sciences, Inc. |
Cd155 variant immunomodulatory proteins and uses thereof
|
EP3496763A1
(de)
|
2016-08-11 |
2019-06-19 |
Genentech, Inc. |
Pyrrolobenzodiazepin-prodrugs und antikörperkonjugate davon
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
EP3509637A4
(de)
|
2016-09-06 |
2020-05-27 |
Chugai Seiyaku Kabushiki Kaisha |
Verfahren zur verwendung eines bispezifischen antikörpers mit erkennung des gerinnungsfaktors ix und/oder aktivierten gerinnungsfaktors ix und gerinnungsfaktors x und/oder aktivierten gerinnungsfaktors x
|
IL290517B1
(en)
|
2016-09-14 |
2024-08-01 |
Teneobio Inc |
CD3 binding antibodies
|
WO2018060301A1
(en)
|
2016-09-30 |
2018-04-05 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies against cd3
|
WO2018060035A1
(en)
|
2016-09-30 |
2018-04-05 |
F. Hoffmann-La Roche Ag |
Spr-based dual-binding assay for the functional analysis of multispecific molecules
|
EP3522933B1
(de)
|
2016-10-05 |
2021-12-15 |
F. Hoffmann-La Roche AG |
Verfahren zur herstellung von antikörperarzneimittelkonjugaten
|
WO2018068201A1
(en)
|
2016-10-11 |
2018-04-19 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against ctla-4
|
BR112019007288A2
(pt)
|
2016-10-14 |
2019-07-09 |
Xencor Inc |
proteína heterodimérica biespecífica, composições de ácido nucleico e de vetor de expressão, vetor de expressão, célula hospedeira, e, métodos para produzir proteína heterodimérica biespecífica e para tratar câncer em um paciente
|
SG11201903693QA
(en)
|
2016-11-01 |
2019-05-30 |
Genmab Bv |
Polypeptide variants and uses thereof
|
CN109923128A
(zh)
|
2016-11-15 |
2019-06-21 |
基因泰克公司 |
用于用抗cd20/抗cd3双特异性抗体进行治疗的给药
|
TW201829463A
(zh)
|
2016-11-18 |
2018-08-16 |
瑞士商赫孚孟拉羅股份公司 |
抗hla-g抗體及其用途
|
WO2018102612A1
(en)
|
2016-12-02 |
2018-06-07 |
Juno Therapeutics, Inc. |
Engineered b cells and related compositions and methods
|
KR20230052309A
(ko)
|
2016-12-21 |
2023-04-19 |
테네오바이오, 인코포레이티드 |
항-bcma 중쇄-단독 항체
|
KR20240101717A
(ko)
|
2017-02-10 |
2024-07-02 |
젠맵 비. 브이 |
폴리펩티드 변이체 및 그의 용도
|
WO2018162749A1
(en)
|
2017-03-09 |
2018-09-13 |
Genmab A/S |
Antibodies against pd-l1
|
NZ756132A
(en)
|
2017-03-10 |
2022-02-25 |
Hoffmann La Roche |
Method for producing multispecific antibodies
|
AU2018235838B2
(en)
|
2017-03-16 |
2023-12-14 |
Alpine Immune Sciences, Inc. |
CD80 variant immunomodulatory proteins and uses thereof
|
PT3596116T
(pt)
|
2017-03-16 |
2023-12-04 |
Alpine Immune Sciences Inc |
Proteínas imunomoduladoras de pd-l1 variante e suas utilizações
|
CA3053812A1
(en)
|
2017-03-16 |
2018-09-20 |
Alpine Immune Sciences, Inc. |
Pd-l2 variant immunomodulatory proteins and uses thereof
|
US11492399B2
(en)
|
2017-03-24 |
2022-11-08 |
Zenyaku Kogyo Co., Ltd. |
Anti-IgM/B cell surface antigen bispecific antibody
|
CN110650752A
(zh)
|
2017-03-31 |
2020-01-03 |
美勒斯公司 |
用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体
|
JP7330942B2
(ja)
|
2017-03-31 |
2023-08-22 |
ジェンマブ ホールディング ビー.ブイ. |
二重特異性抗cd37抗体、モノクローナル抗cd37抗体、およびそれらの使用方法
|
SG11201909218RA
(en)
|
2017-04-03 |
2019-11-28 |
Hoffmann La Roche |
Antibodies binding to steap-1
|
EP3606947B1
(de)
|
2017-04-03 |
2022-12-21 |
F. Hoffmann-La Roche AG |
Immunokonjugat von il-2 mit einem bispezifischen antikörper gerichtet gegen pd-1 und tim-3
|
MA49033B1
(fr)
|
2017-04-03 |
2022-10-31 |
Hoffmann La Roche |
Immunoconjugué d'un anticorps contre pd-1 avec il-2 mutée ou avec il-15
|
TWI707871B
(zh)
|
2017-04-05 |
2020-10-21 |
瑞士商赫孚孟拉羅股份公司 |
抗lag3抗體
|
UA128451C2
(uk)
|
2017-04-05 |
2024-07-17 |
Ф. Хоффманн-Ля Рош Аг |
Біспецифічне антитіло, яке специфічно зв'язується з pd1 і lag3
|
CN110770255A
(zh)
|
2017-04-11 |
2020-02-07 |
印希彼有限公司 |
具有受限cd3结合的多特异性多肽构建体及其使用方法
|
CN110505883A
(zh)
|
2017-04-13 |
2019-11-26 |
豪夫迈·罗氏有限公司 |
供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂
|
JP2020522254A
(ja)
*
|
2017-05-31 |
2020-07-30 |
エルスター セラピューティクス, インコーポレイテッド |
骨髄増殖性白血病(mpl)タンパク質に結合する多特異性分子およびその使用
|
JP2020521791A
(ja)
|
2017-06-02 |
2020-07-27 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
がんの治療のためのii型抗cd20抗体及び抗cd20/cd30二重特異性抗体
|
KR20200027944A
(ko)
|
2017-06-07 |
2020-03-13 |
젠맵 비. 브이 |
돌연변이된 igg 육량체에 기초한 치료 항체
|
JP7303126B2
(ja)
|
2017-06-20 |
2023-07-04 |
テネオバイオ, インコーポレイテッド |
抗bcma重鎖のみ抗体
|
CN110945026B
(zh)
|
2017-06-20 |
2024-03-19 |
特纳奥尼股份有限公司 |
仅有重链的抗bcma抗体
|
GB201709970D0
(en)
|
2017-06-22 |
2017-08-09 |
Kymab Ltd |
Bispecific antigen-binding molecules
|
CN111132733A
(zh)
|
2017-06-30 |
2020-05-08 |
Xencor股份有限公司 |
含有IL-15/IL-15Rα和抗原结合结构域的靶向异源二聚体Fc融合蛋白
|
BR112020000209A8
(pt)
|
2017-07-06 |
2020-08-11 |
Merus Nv |
moléculas de ligação que modulam uma atividade biológica expressa por uma célula
|
GB201710984D0
(en)
|
2017-07-07 |
2017-08-23 |
Kymab Ltd |
Cells, vertebrates, populations & methods
|
AR112603A1
(es)
|
2017-07-10 |
2019-11-20 |
Lilly Co Eli |
Anticuerpos biespecíficos inhibidores de punto de control
|
AU2018298884A1
(en)
|
2017-07-14 |
2020-02-27 |
Immatics Biotechnologies Gmbh |
Improved dual specificity polypeptide molecule
|
DE102017115966A1
(de)
|
2017-07-14 |
2019-01-17 |
Immatics Biotechnologies Gmbh |
Polypeptidmolekül mit verbesserter zweifacher Spezifität
|
KR20200064062A
(ko)
|
2017-08-04 |
2020-06-05 |
젠맵 에이/에스 |
Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도
|
SG11202001050PA
(en)
|
2017-08-09 |
2020-03-30 |
Merus Nv |
Antibodies that bind egfr and cmet
|
EP3672986A1
(de)
|
2017-08-22 |
2020-07-01 |
Sanabio, LLC |
Lösliche interferonrezeptoren und ihre verwendungen
|
EP3457139A1
(de)
|
2017-09-19 |
2019-03-20 |
Promise Advanced Proteomics |
Antikörperähnliche peptide zur quantifizierung therapeutischer antikörper
|
AU2018338859A1
(en)
|
2017-09-29 |
2020-02-06 |
Chugai Seiyaku Kabushiki Kaisha |
Multispecific antigen-binding molecule having blood coagulation factor VIII (FVIII) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient
|
MA50360A
(fr)
|
2017-10-10 |
2020-08-19 |
Alpine Immune Sciences Inc |
Protéines immunomodulatrices de variants de ctla-4 et leurs utilisations
|
MA50404A
(fr)
|
2017-10-18 |
2020-08-26 |
Alpine Immune Sciences Inc |
Protéines immunomodulatrices à variants de ligand de icos variant, compositions et méthodes associées
|
BR112020007154A2
(pt)
|
2017-10-20 |
2020-09-29 |
F. Hoffmann-La Roche Ag |
método para produzir um polipeptídeo e polipeptídeos heterodimérico
|
CA3078676A1
(en)
|
2017-10-30 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
Method for in vivo generation of multispecific antibodies from monospecific antibodies
|
WO2019086395A1
(en)
|
2017-11-01 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
Trifab-contorsbody
|
US11339221B2
(en)
|
2017-11-01 |
2022-05-24 |
Tufts Medical Center, Inc. |
Bispecific antibody constructs and methods of use
|
WO2019086394A1
(en)
|
2017-11-01 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
The compbody - a multivalent target binder
|
WO2019086499A1
(en)
|
2017-11-01 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
Novel tnf family ligand trimer-containing antigen binding molecules
|
KR20200079492A
(ko)
|
2017-11-01 |
2020-07-03 |
에프. 호프만-라 로슈 아게 |
이중특이성 2+1 컨터체
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
WO2019093342A1
(ja)
|
2017-11-08 |
2019-05-16 |
協和発酵キリン株式会社 |
CD40とEpCAMに結合するバイスペシフィック抗体
|
JP2021502100A
(ja)
|
2017-11-08 |
2021-01-28 |
ゼンコア インコーポレイテッド |
新規抗pd−1配列を用いた二重特異性および単一特異性抗体
|
EP3728302A1
(de)
|
2017-12-19 |
2020-10-28 |
Xencor, Inc. |
Modifizierte il-2-fc-fusionsproteine
|
CA3085596A1
(en)
|
2017-12-19 |
2019-06-27 |
Surrozen, Inc. |
Anti-frizzled antibodies and methods of use
|
EP3731867A4
(de)
|
2017-12-19 |
2022-04-06 |
Surrozen Operating, Inc. |
Anti-lrp5/6-antikörper und verfahren zur verwendung
|
CN118271444A
(zh)
|
2017-12-19 |
2024-07-02 |
瑟罗泽恩奥普瑞汀公司 |
Wnt替代分子和其用途
|
KR102575787B1
(ko)
|
2017-12-21 |
2023-09-08 |
에프. 호프만-라 로슈 아게 |
Hla-a2/wt1에 결합하는 항체
|
EP3728327A1
(de)
|
2017-12-22 |
2020-10-28 |
F. Hoffmann-La Roche AG |
Abreicherung von leichtkettigen fehlgepaarten antikörpervarianten durch hydrophobe interaktionschromatographie
|
MX2020006715A
(es)
|
2017-12-27 |
2020-08-20 |
Teneobio Inc |
Anticuerpos especificos del heterodimero de cd3-delta/epsilon.
|
JP7314146B2
(ja)
|
2017-12-28 |
2023-07-25 |
中外製薬株式会社 |
細胞傷害誘導治療剤
|
WO2019129221A1
(en)
|
2017-12-28 |
2019-07-04 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against tigit
|
EP3731865A1
(de)
|
2017-12-29 |
2020-11-04 |
F. Hoffmann-La Roche AG |
Verfahren zur verbesserung der vegf-rezeptor-blockierenden selektivität eines anti-vegf-antikörpers
|
CA3087149A1
(en)
|
2018-01-03 |
2019-07-11 |
Alpine Immune Sciences, Inc. |
Multi-domain immunomodulatory proteins and methods of use thereof
|
SG11202004233UA
(en)
|
2018-01-15 |
2020-06-29 |
Nanjing Legend Biotech Co Ltd |
Single-domain antibodies and variants thereof against pd-1
|
US20210107988A1
(en)
|
2018-01-24 |
2021-04-15 |
Genmab B.V. |
Polypeptide variants and uses thereof
|
US20200354457A1
(en)
|
2018-01-31 |
2020-11-12 |
Hoffmann-La Roche Inc. |
Bispecific antibodies comprising an antigen-binding site binding to lag3
|
CN111630063A
(zh)
|
2018-01-31 |
2020-09-04 |
豪夫迈·罗氏有限公司 |
稳定化的免疫球蛋白结构域
|
EP3749359A1
(de)
|
2018-02-06 |
2020-12-16 |
F. Hoffmann-La Roche AG |
Behandlung von ophthalmologischen erkrankungen
|
CR20200391A
(es)
|
2018-02-08 |
2020-10-19 |
Genentech Inc |
Moléculas biespecíficas de unión al antígeno y métodos de uso
|
TWI829667B
(zh)
|
2018-02-09 |
2024-01-21 |
瑞士商赫孚孟拉羅股份公司 |
結合gprc5d之抗體
|
CA3115461A1
(en)
|
2018-03-09 |
2019-09-12 |
AskGene Pharma, Inc. |
Novel cytokine prodrugs
|
MA52152A
(fr)
|
2018-03-12 |
2021-01-20 |
Genmab As |
Anticorps
|
AU2019245243A1
(en)
|
2018-03-29 |
2020-09-03 |
Genentech, Inc |
Modulating lactogenic activity in mammalian cells
|
KR20200139189A
(ko)
|
2018-03-30 |
2020-12-11 |
메뤼스 엔.페. |
다가 항체
|
AU2019241350A1
(en)
|
2018-03-30 |
2020-07-30 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies against LAG-3 and uses thereof
|
CN112469477A
(zh)
|
2018-04-04 |
2021-03-09 |
Xencor股份有限公司 |
与成纤维细胞活化蛋白结合的异源二聚体抗体
|
KR20210006913A
(ko)
|
2018-04-11 |
2021-01-19 |
인히브릭스, 인크. |
제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도
|
AR115052A1
(es)
|
2018-04-18 |
2020-11-25 |
Hoffmann La Roche |
Anticuerpos multiespecíficos y utilización de los mismos
|
AU2019256529A1
(en)
|
2018-04-18 |
2020-11-26 |
Xencor, Inc. |
TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and TIM-3 antigen binding domains
|
KR20210010862A
(ko)
|
2018-04-18 |
2021-01-28 |
젠코어 인코포레이티드 |
IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도
|
WO2019211472A1
(en)
|
2018-05-03 |
2019-11-07 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
GB201808927D0
(en)
|
2018-05-31 |
2018-07-18 |
Institute Of Cancer Res Royal Cancer Hospital |
Materials and methods for monitoring the development of resistance of cancers to treatment
|
MA52742A
(fr)
|
2018-06-09 |
2021-04-14 |
Boehringer Ingelheim Int |
Anticorps bispécifiques dll3-cd3
|
WO2019241758A1
(en)
|
2018-06-15 |
2019-12-19 |
Alpine Immune Sciences, Inc. |
Pd-1 variant immunomodulatory proteins and uses thereof
|
WO2019244973A1
(ja)
|
2018-06-20 |
2019-12-26 |
中外製薬株式会社 |
標的細胞に対する免疫反応を活性化する方法およびその組成物
|
US20210371539A1
(en)
|
2018-06-22 |
2021-12-02 |
Genmab Holding B.V. |
Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof
|
JP7534281B2
(ja)
|
2018-07-13 |
2024-08-14 |
ジェンマブ エー/エス |
Cd38抗体を使用したトロゴサイトーシスを介した治療
|
SG11202012993SA
(en)
|
2018-07-13 |
2021-02-25 |
Genmab As |
Variants of cd38 antibody and uses thereof
|
EP3827019A1
(de)
|
2018-07-24 |
2021-06-02 |
Inhibrx, Inc. |
Multispezifische polypeptidkonstrukte mit einer eingeschränkten cd3-bindungsdomäne und einer rezeptorbindungsregion sowie verfahren zu deren verwendung
|
WO2020023702A1
(en)
|
2018-07-25 |
2020-01-30 |
AskGene Pharma, Inc. |
Novel il-21 prodrugs and methods of use thereof
|
US11220554B2
(en)
|
2018-09-07 |
2022-01-11 |
Novo Nordisk A/S |
Procoagulant antibodies
|
SG11202100418PA
(en)
*
|
2018-08-01 |
2021-02-25 |
Novo Nordisk As |
Improved procoagulant antibodies
|
CA3106537A1
(en)
|
2018-08-08 |
2020-02-13 |
Genentech, Inc. |
Use of tryptophan derivatives and l-methionine for protein formulation
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
AU2019340647A1
(en)
*
|
2018-09-10 |
2021-03-11 |
Genentech, Inc. |
Systems and methods for affinity capillary electrophoresis
|
MA53651A
(fr)
|
2018-09-19 |
2021-07-28 |
Alpine Immune Sciences Inc |
Méthodes et utilisations de protéines de fusion de variant cd80 et constructions associées
|
CN113195523A
(zh)
|
2018-10-03 |
2021-07-30 |
Xencor股份有限公司 |
IL-12异源二聚体Fc融合蛋白
|
MA53812A
(fr)
|
2018-10-04 |
2021-08-11 |
Genmab Holding B V |
Compositions pharmaceutiques comprenant des anticorps anti-cd37 bispécifiques
|
TW202021986A
(zh)
|
2018-10-11 |
2020-06-16 |
美商英伊布里克斯公司 |
5t4單域抗體及其治療性組合物
|
CA3115082A1
(en)
|
2018-10-11 |
2020-04-16 |
Inhibrx, Inc. |
B7h3 single domain antibodies and therapeutic compositions thereof
|
US11208485B2
(en)
|
2018-10-11 |
2021-12-28 |
Inhibrx, Inc. |
PD-1 single domain antibodies and therapeutic compositions thereof
|
EP3864045A2
(de)
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Dll3-einzeldomänenantikörper und therapeutische zusammensetzungen davon
|
JP2022505450A
(ja)
|
2018-10-24 |
2022-01-14 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
コンジュゲート化された化学的分解誘導物質および使用方法
|
MA54052A
(fr)
|
2018-10-29 |
2022-02-09 |
Hoffmann La Roche |
Formulation d'anticorps
|
WO2020089437A1
(en)
|
2018-10-31 |
2020-05-07 |
Engmab Sàrl |
Combination therapy
|
SG11202104300PA
(en)
|
2018-11-06 |
2021-05-28 |
Genmab As |
Antibody formulation
|
AU2019389151A1
(en)
|
2018-11-30 |
2021-06-10 |
Alpine Immune Sciences, Inc. |
CD86 variant immunomodulatory proteins and uses thereof
|
AU2019392711A1
(en)
|
2018-12-05 |
2021-05-20 |
Morphosys Ag |
Multispecific antigen-binding molecules
|
WO2020123275A1
(en)
|
2018-12-10 |
2020-06-18 |
Genentech, Inc. |
Photocrosslinking peptides for site specific conjugation to fc-containing proteins
|
GB201820687D0
(en)
|
2018-12-19 |
2019-01-30 |
Kymab Ltd |
Antagonists
|
EP3723858B1
(de)
|
2018-12-21 |
2021-10-27 |
Kymab Limited |
Fixaxfx-bispezifischer antikörper mit einer gemeinsamen leichten kette
|
WO2020127619A1
(en)
|
2018-12-21 |
2020-06-25 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3
|
US20220017635A1
(en)
|
2018-12-28 |
2022-01-20 |
Kyowa Kirin Co., Ltd. |
BISPECIFIC ANTIBODY BINDING TO TfR
|
JP2022515473A
(ja)
|
2018-12-28 |
2022-02-18 |
エフ.ホフマン-ラ ロシュ アーゲー |
免疫応答が増幅された患者における治療的使用のためのペプチド-mhc-i-抗体融合タンパク質
|
JP7440516B2
(ja)
*
|
2018-12-31 |
2024-02-28 |
メルス ナムローゼ フェンノートシャップ |
切断多価多量体
|
WO2020142740A1
(en)
|
2019-01-04 |
2020-07-09 |
Resolve Therapeutics, Llc |
Treatment of sjogren's disease with nuclease fusion proteins
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
JP2022523946A
(ja)
|
2019-03-01 |
2022-04-27 |
ゼンコア インコーポレイテッド |
Enpp3およびcd3に結合するヘテロ二量体抗体
|
JP7412440B2
(ja)
|
2019-03-29 |
2024-01-12 |
エフ. ホフマン-ラ ロシュ アーゲー |
アビド結合多重特異性抗体を作製する方法
|
JP7249432B2
(ja)
|
2019-03-29 |
2023-03-30 |
エフ. ホフマン-ラ ロシュ アーゲー |
多価分子の機能分析のための、sprをベースとする結合アッセイ
|
CA3135632A1
(en)
|
2019-04-17 |
2020-10-22 |
Novo Nordisk A/S |
Bispecific antibodies
|
MX2021012607A
(es)
|
2019-04-17 |
2022-03-11 |
Alpine Immune Sciences Inc |
Metodos y usos de proteinas de fusion de ligando icos (icosl) variante.
|
CN113924314A
(zh)
|
2019-04-25 |
2022-01-11 |
豪夫迈·罗氏有限公司 |
通过多肽链交换活化的治疗性多特异性多肽
|
AU2020263910A1
(en)
|
2019-04-25 |
2021-10-21 |
F. Hoffmann-La Roche Ag |
Activatable therapeutic multispecific polypeptides with extended half-life
|
AU2020261250A1
(en)
|
2019-04-25 |
2021-10-14 |
F. Hoffmann-La Roche Ag |
Generation of antibody-derived polypeptides by polypeptide chain exchange
|
US20220315661A1
(en)
|
2019-05-09 |
2022-10-06 |
Genmab B.V. |
Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
|
WO2020229378A1
(en)
|
2019-05-13 |
2020-11-19 |
F. Hoffmann-La Roche Ag |
Interference-suppressed pharmacokinetic immunoassay
|
WO2020230901A1
(ja)
|
2019-05-15 |
2020-11-19 |
協和キリン株式会社 |
Cd40とgpc3に結合するバイスペシフィック抗体
|
KR20220008820A
(ko)
|
2019-05-15 |
2022-01-21 |
쿄와 기린 가부시키가이샤 |
Cd40과 fap에 결합하는 이중 특이적 항체
|
AU2020288499A1
(en)
|
2019-06-05 |
2022-01-27 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody cleavage site-binding molecule
|
CN114341189A
(zh)
|
2019-06-12 |
2022-04-12 |
奥美药业有限公司 |
全新il-15前药及其应用
|
CA3140816A1
(en)
|
2019-06-14 |
2020-12-17 |
Nathan Trinklein |
Multispecific heavy chain antibodies binding to cd22 and cd3
|
AU2020294880B2
(en)
|
2019-06-19 |
2024-05-02 |
F. Hoffmann-La Roche Ag |
Method for the generation of a protein expressing cell by targeted integration using Cre mRNA
|
CN114026224B
(zh)
|
2019-06-26 |
2024-03-15 |
豪夫迈·罗氏有限公司 |
具有sirt-1基因敲除的哺乳动物细胞系
|
JP2022538139A
(ja)
|
2019-07-02 |
2022-08-31 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
変異体インターロイキン-2及び抗cd8抗体を含む免疫複合体
|
CR20220049A
(es)
|
2019-07-10 |
2022-03-02 |
Chugai Pharmaceutical Co Ltd |
Moléculas de unión a claudina-6 y usos de las mismas
|
AR119382A1
(es)
|
2019-07-12 |
2021-12-15 |
Hoffmann La Roche |
Anticuerpos de pre-direccionamiento y métodos de uso
|
AR119393A1
(es)
|
2019-07-15 |
2021-12-15 |
Hoffmann La Roche |
Anticuerpos que se unen a nkg2d
|
WO2021011673A2
(en)
|
2019-07-16 |
2021-01-21 |
Ming Jin |
Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease
|
CR20220019A
(es)
|
2019-07-31 |
2022-02-11 |
Hoffmann La Roche |
Anticuerpos que se fijan a gprc5d
|
EP4004045A1
(de)
|
2019-07-31 |
2022-06-01 |
F. Hoffmann-La Roche AG |
An gprc5d bindende antikörper
|
JP2022544771A
(ja)
|
2019-08-12 |
2022-10-21 |
アスクジーン・ファーマ・インコーポレイテッド |
優先的にil-2rアルファに結合するil-2融合タンパク質
|
US20220289822A1
(en)
|
2019-08-21 |
2022-09-15 |
AskGene Pharma, Inc. |
Novel il-21 prodrugs and methods of use thereof
|
US20210130492A1
(en)
|
2019-09-18 |
2021-05-06 |
Genentech, Inc. |
Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use
|
US20210130495A1
(en)
*
|
2019-09-27 |
2021-05-06 |
Agenus Inc. |
Heterodimeric proteins
|
WO2021062406A1
(en)
|
2019-09-28 |
2021-04-01 |
AskGene Pharma, Inc. |
Cytokine prodrugs and dual-prodrugs
|
CN114040924A
(zh)
|
2019-09-29 |
2022-02-11 |
北京加科思新药研发有限公司 |
对lif具有特异性的结合分子及其用途
|
US20220411529A1
(en)
|
2019-11-06 |
2022-12-29 |
Genmab B.V. |
Antibody variant combinations and uses thereof
|
CN114641270A
(zh)
|
2019-11-15 |
2022-06-17 |
豪夫迈·罗氏有限公司 |
防止水性蛋白质溶液中可见颗粒的形成
|
IL293423A
(en)
|
2019-12-13 |
2022-07-01 |
Genentech Inc |
Anti-ly6g6d antibodies and methods of use
|
CR20220256A
(es)
|
2019-12-18 |
2022-08-31 |
Hoffmann La Roche |
Anticuerpos que se unen a hla-a2/mage-a4
|
BR112022012010A2
(pt)
|
2019-12-18 |
2022-08-30 |
Hoffmann La Roche |
Anticorpos, ácido nucleico isolado, célula hospedeira, formulação farmacêutica, uso do anticorpo, método de produção de um anticorpo, método de tratamento de um indivíduo que tem câncer e método de tratamento de um indivíduo que tem uma doença inflamatória ou autoimune
|
GB201919061D0
(en)
|
2019-12-20 |
2020-02-05 |
Ucb Biopharma Sprl |
Multi-specific antibody
|
GB201919062D0
(en)
|
2019-12-20 |
2020-02-05 |
Ucb Biopharma Sprl |
Antibody
|
PE20221186A1
(es)
|
2019-12-23 |
2022-08-05 |
Genentech Inc |
Anticuerpos especificos de apolipoproteina l1 y metodos de uso
|
US20230058982A1
(en)
|
2019-12-27 |
2023-02-23 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-ctla-4 antibody and use thereof
|
CN114930170A
(zh)
|
2020-01-02 |
2022-08-19 |
豪夫迈·罗氏有限公司 |
用于测定脑中的治疗性抗体量的方法
|
AU2021205981A1
(en)
|
2020-01-11 |
2022-07-14 |
AskGene Pharma, Inc. |
Novel masked cytokines and methods of use thereof
|
CA3167657A1
(en)
|
2020-01-15 |
2021-07-22 |
F. Hoffmann-La Roche Ag |
Methods to decrease impurities from recombinant protein manufacturing processes
|
BR112022013553A2
(pt)
|
2020-01-16 |
2022-09-06 |
Genmab As |
Composição farmacêutica, anticorpo, e, método para tratar uma doença
|
AU2021213177A1
(en)
|
2020-01-29 |
2022-08-18 |
Inhibrx Biosciences, Inc. |
CD28 single domain antibodies and multivalent and multispecific constructs thereof
|
GB202001447D0
(en)
|
2020-02-03 |
2020-03-18 |
Ucb Biopharma Sprl |
Antibodies
|
WO2021155916A1
(en)
|
2020-02-04 |
2021-08-12 |
BioNTech SE |
Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
|
WO2021173844A1
(en)
|
2020-02-26 |
2021-09-02 |
Biograph 55, Inc. |
C19 c38 bispecific antibodies
|
PE20230252A1
(es)
|
2020-03-13 |
2023-02-07 |
Genentech Inc |
Anticuerpos anti-interleucina-33 y sus usos de estos
|
TW202200624A
(zh)
|
2020-03-18 |
2022-01-01 |
丹麥商珍美寶股份有限公司 |
抗體
|
CA3169908A1
(en)
|
2020-03-26 |
2021-09-30 |
Genentech, Inc. |
Modified mammalian cells having reduced host cell proteins
|
EP4144370A4
(de)
|
2020-03-30 |
2024-05-15 |
Mie University |
Bispezifischer antikörper
|
US20230121511A1
(en)
|
2020-03-31 |
2023-04-20 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing multispecific antigen-binding molecules
|
MX2022012541A
(es)
|
2020-04-15 |
2022-11-07 |
Hoffmann La Roche |
Inmunoconjugados.
|
IL296664A
(en)
|
2020-04-24 |
2022-11-01 |
Hoffmann La Roche |
Enzyme and pathway modulation with sulfhydryl compounds and their derivatives
|
EP4121172A1
(de)
|
2020-04-29 |
2023-01-25 |
Teneobio, Inc. |
Multispezifische schwerkettige antikörper mit modifizierten schwerkettigen konstanten regionen
|
MX2022013465A
(es)
|
2020-04-30 |
2023-01-11 |
Bristol Myers Squibb Co |
Metodos para tratar eventos adversos relacionados con citocinas.
|
US20210371538A1
(en)
|
2020-05-08 |
2021-12-02 |
Genmab A/S |
Bispecific antibodies against cd3 and cd20
|
IL297980A
(en)
|
2020-05-08 |
2023-01-01 |
Alpine Immune Sciences Inc |
Immunomodulatory proteins that inhibit april and baff and methods of using them
|
IL298038A
(en)
|
2020-05-11 |
2023-01-01 |
Hoffmann La Roche |
Combined treatment with modified pbmcs and an immune couple
|
WO2021231976A1
(en)
|
2020-05-14 |
2021-11-18 |
Xencor, Inc. |
Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
|
WO2021228917A1
(en)
|
2020-05-15 |
2021-11-18 |
F. Hoffmann-La Roche Ag |
Prevention of visible particle formation in parenteral protein solutions
|
WO2021233853A1
(en)
|
2020-05-19 |
2021-11-25 |
F. Hoffmann-La Roche Ag |
The use of chelators for the prevention of visible particle formation in parenteral protein solutions
|
AU2021281828A1
(en)
|
2020-05-27 |
2023-02-02 |
Arialys Therapeutics, Inc. |
Anti-human NR1 antibody derivative
|
BR112022024996A2
(pt)
|
2020-06-08 |
2022-12-27 |
Hoffmann La Roche |
Anticorpos, ácido nucleico, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, agente terapêutico, uso do anticorpo e método para tratar um indivíduo com hepatite b
|
WO2021255146A1
(en)
|
2020-06-19 |
2021-12-23 |
F. Hoffmann-La Roche Ag |
Antibodies binding to cd3 and cea
|
TW202216767A
(zh)
|
2020-06-19 |
2022-05-01 |
瑞士商赫孚孟拉羅股份公司 |
與CD3及FolR1結合之抗體
|
TWI811703B
(zh)
|
2020-06-19 |
2023-08-11 |
瑞士商赫孚孟拉羅股份公司 |
與cd3及cd19結合之抗體
|
JP2023530961A
(ja)
|
2020-06-19 |
2023-07-20 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
Cd3に結合する抗体
|
KR20230025783A
(ko)
|
2020-06-19 |
2023-02-23 |
에프. 호프만-라 로슈 아게 |
면역 활성화 Fc 도메인 결합 분자
|
MX2022016453A
(es)
|
2020-06-24 |
2023-02-01 |
Genentech Inc |
Lineas celulares resistentes a la apoptosis.
|
WO2022006153A1
(en)
|
2020-06-29 |
2022-01-06 |
Resolve Therapeutics, Llc |
Treatment of sjogren's syndrome with nuclease fusion proteins
|
JP2023532764A
(ja)
|
2020-07-07 |
2023-07-31 |
エフ. ホフマン-ラ ロシュ アーゲー |
治療用タンパク質製剤の安定剤としての代替界面活性剤
|
CA3187277A1
(en)
|
2020-07-10 |
2022-01-13 |
F. Hoffmann-La Roche Ag |
Antibodies which bind to cancer cells and target radionuclides to said cells
|
AU2021308653A1
(en)
|
2020-07-17 |
2023-02-16 |
Genentech, Inc. |
Anti-Notch2 antibodies and methods of use
|
WO2022020288A1
(en)
|
2020-07-21 |
2022-01-27 |
Genentech, Inc. |
Antibody-conjugated chemical inducers of degradation of brm and methods thereof
|
US20230293680A1
(en)
|
2020-07-23 |
2023-09-21 |
Genmab B.V. |
A composition of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
BR112023000537A2
(pt)
|
2020-07-31 |
2023-01-31 |
Chugai Pharmaceutical Co Ltd |
Composições farmacêuticas incluindo célula que expressa o receptor quimérico
|
JP2023537470A
(ja)
*
|
2020-08-03 |
2023-09-01 |
ヤンセン バイオテツク,インコーポレーテツド |
ウイルス治療における多方向バイオ輸送のための材料及び方法
|
AU2021322046A1
(en)
|
2020-08-06 |
2023-02-02 |
BioNTech SE |
Binding agents for coronavirus S protein
|
AU2021329378A1
(en)
|
2020-08-19 |
2023-03-23 |
Xencor, Inc. |
Anti-CD28 compositions
|
WO2022044248A1
(ja)
|
2020-08-28 |
2022-03-03 |
中外製薬株式会社 |
ヘテロ二量体Fcポリペプチド
|
WO2022047222A2
(en)
|
2020-08-28 |
2022-03-03 |
Genentech, Inc. |
Crispr/cas9 multiplex knockout of host cell proteins
|
MX2023002541A
(es)
|
2020-09-10 |
2023-03-14 |
Genmab As |
Anticuerpo biespecifico contra el cumulo de diferenciacion 3 (cd3) y el cumulo de diferenciacion 20 (cd20) en terapia combinada para el tratamiento del linfoma difuso de celulas b grandes.
|
MX2023002545A
(es)
|
2020-09-10 |
2023-03-14 |
Genmab As |
Anticuerpo biespecifico contra cumulo de diferenciacion 3 (cd3) y cumulo de diferenciacion 20 (cd20) en terapia de combinacion para el tratamiento de linfoma difuso de celulas b grandes.
|
MX2023002546A
(es)
|
2020-09-10 |
2023-03-14 |
Genmab As |
Anticuerpos biespecificos contra cumulo de diferenciacion 3 (cd3) y contra cumulo de diferenciacion 20 (cd20) para tratar leucemia linfocitica cronica.
|
CN116406293A
(zh)
|
2020-09-10 |
2023-07-07 |
健玛保 |
用于治疗滤泡性淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体
|
MX2023002540A
(es)
|
2020-09-10 |
2023-03-14 |
Genmab As |
Anticuerpo biespecifico contra el cumulo de diferenciacion 3 (cd3) y el cumulo de diferenciacion 20 (cd20) en terapia combinada para el tratamiento del linfoma folicular.
|
AU2021339006A1
(en)
|
2020-09-10 |
2023-04-13 |
Genmab A/S |
Bispecific antibody against CD3 and CD20 in combination therapy for treating diffuse large B-cell lymphoma
|
IL301258A
(en)
|
2020-09-21 |
2023-05-01 |
Genentech Inc |
Purification of multispecific antibodies
|
IL301366A
(en)
|
2020-09-24 |
2023-05-01 |
Hoffmann La Roche |
Mammalian cell lines with genetic knockout
|
EP4221742A1
(de)
|
2020-10-02 |
2023-08-09 |
Genmab A/S |
Antikörper mit fähigkeit zur bindung an ror2 und bispezifische antikörper mit bindung an ror2 und cd3
|
JP2023544407A
(ja)
|
2020-10-05 |
2023-10-23 |
ジェネンテック, インコーポレイテッド |
抗FcRH5/抗CD3二重特異性抗体による処置のための投与
|
AR123855A1
(es)
|
2020-10-20 |
2023-01-18 |
Genentech Inc |
Anticuerpos anti-mertk conjugados con peg y métodos de uso
|
JP2023548249A
(ja)
|
2020-11-10 |
2023-11-15 |
上海齊魯制藥研究中心有限公司 |
クローディン18a2及びcd3に対する二重特異性抗体及びその使用
|
CA3200954A1
(en)
|
2020-11-16 |
2022-05-19 |
F. Hoffmann-La Roche Ag |
Fab high mannose glycoforms
|
JP7078237B1
(ja)
|
2020-11-16 |
2022-05-31 |
アステラス製薬株式会社 |
抗tspan8-抗cd3二重特異性抗体及び抗tspan8抗体
|
WO2022122654A1
(en)
|
2020-12-07 |
2022-06-16 |
UCB Biopharma SRL |
Multi-specific antibodies and antibody combinations
|
AR124250A1
(es)
|
2020-12-07 |
2023-03-01 |
UCB Biopharma SRL |
Anticuerpos
|
CR20230263A
(es)
|
2020-12-17 |
2023-08-21 |
Hoffmann La Roche |
Anticuerpos anti-hla-g y uso de estos
|
JP2023553692A
(ja)
|
2020-12-18 |
2023-12-25 |
エフ. ホフマン-ラ ロシュ アーゲー |
標的治療のための前駆体タンパク質及びキット
|
EP4267734A1
(de)
|
2020-12-22 |
2023-11-01 |
F. Hoffmann-La Roche AG |
Oligonukleotide zum targeting von xbp1
|
AU2022206061A1
(en)
|
2021-01-06 |
2023-07-06 |
F. Hoffmann-La Roche Ag |
Combination therapy employing a pd1-lag3 bispecific antibody and a cd20 t cell bispecific antibody
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
WO2022152656A1
(en)
|
2021-01-12 |
2022-07-21 |
F. Hoffmann-La Roche Ag |
Split antibodies which bind to cancer cells and target radionuclides to said cells
|
KR20230131205A
(ko)
|
2021-01-13 |
2023-09-12 |
에프. 호프만-라 로슈 아게 |
병용 요법
|
US20240076355A1
(en)
|
2021-01-14 |
2024-03-07 |
AskGene Pharma, Inc. |
Interferon Prodrugs and Methods of Making and Using the Same
|
EP4284819A1
(de)
|
2021-02-01 |
2023-12-06 |
Askgene Pharma, Inc. |
Chimäre moleküle mit einem il-10- oder tgf-beta-agonisten-polypeptid
|
JP2024509695A
(ja)
|
2021-02-03 |
2024-03-05 |
ジェネンテック, インコーポレイテッド |
多重特異性結合タンパク質分解プラットフォームおよび使用方法
|
WO2022178103A1
(en)
|
2021-02-17 |
2022-08-25 |
AskGene Pharma, Inc. |
Il-2 receptor beta subunit mutants
|
CN116888473A
(zh)
|
2021-02-18 |
2023-10-13 |
豪夫迈·罗氏有限公司 |
用于解析复杂、多步骤抗体相互作用的方法
|
WO2022192403A1
(en)
|
2021-03-09 |
2022-09-15 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cldn6
|
US11859012B2
(en)
|
2021-03-10 |
2024-01-02 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and GPC3
|
AR125074A1
(es)
|
2021-03-12 |
2023-06-07 |
Genentech Inc |
Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecíficos anti-klk5 / klk7 y métodos de uso
|
EP4305056A1
(de)
|
2021-03-12 |
2024-01-17 |
Genmab A/S |
Nicht aktivierende antikörpervarianten
|
WO2022197877A1
(en)
|
2021-03-19 |
2022-09-22 |
Genentech, Inc. |
Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents
|
TW202304946A
(zh)
|
2021-03-31 |
2023-02-01 |
瑞士商赫孚孟拉羅股份公司 |
藉由混合模式層析純化抗體
|
WO2022206872A1
(zh)
|
2021-03-31 |
2022-10-06 |
江苏恒瑞医药股份有限公司 |
截短的taci多肽及其融合蛋白和用途
|
JP2024513474A
(ja)
|
2021-04-09 |
2024-03-25 |
エフ. ホフマン-ラ ロシュ アーゲー |
異種ポリペプチドを発現する細胞クローンを選択するための方法
|
US20240190993A1
(en)
|
2021-04-14 |
2024-06-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method to improve the anti-tumoral activity of macrophages
|
US20240228659A1
(en)
|
2021-04-14 |
2024-07-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method to improve nk cells cytotoxicity
|
EP4326855A1
(de)
|
2021-04-19 |
2024-02-28 |
Genentech, Inc. |
Modifizierte säugerzellen
|
TW202244059A
(zh)
|
2021-04-30 |
2022-11-16 |
瑞士商赫孚孟拉羅股份公司 |
用抗cd20/抗cd3雙特異性抗體進行治療之給藥
|
EP4330282A1
(de)
|
2021-04-30 |
2024-03-06 |
F. Hoffmann-La Roche AG |
Dosierung für kombinationsbehandlung mit bispezifischem anti-cd20/anti-cd3-antikörper und anti-cd79b-antikörper-wirkstoffkonjugat
|
US20240254224A1
(en)
|
2021-05-03 |
2024-08-01 |
UCB Biopharma SRL |
Antibodies
|
EP4333869A1
(de)
|
2021-05-07 |
2024-03-13 |
Alpine Immune Sciences, Inc. |
Verfahren zur dosierung und behandlung mit einem taci-fc-fusionsimmunmodulatorischen protein
|
KR20240004949A
(ko)
|
2021-05-07 |
2024-01-11 |
젠맵 에이/에스 |
B7h4 및 cd3에 결합하는 이중특이적 항체를 포함하는 제약 조성물
|
TW202306990A
(zh)
|
2021-05-12 |
2023-02-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
特異性結合rankl和ngf的抗原結合分子及其醫藥用途
|
JP2024517907A
(ja)
|
2021-05-14 |
2024-04-23 |
江蘇恒瑞医薬股▲ふん▼有限公司 |
抗原結合分子
|
KR20240010469A
(ko)
|
2021-05-21 |
2024-01-23 |
제넨테크, 인크. |
관심 재조합 생성물의 생성을 위한 변형된 세포
|
US20240279358A1
(en)
|
2021-06-16 |
2024-08-22 |
Alector Llc |
Monovalent anti-mertk antibodies and methods of use thereof
|
JP2024527262A
(ja)
|
2021-06-16 |
2024-07-24 |
アレクトル エルエルシー |
二重特異性抗MerTK及び抗PDL1抗体ならびにその使用方法
|
KR20240021859A
(ko)
|
2021-06-18 |
2024-02-19 |
에프. 호프만-라 로슈 아게 |
이중특이적 항-ccl2 항체
|
JP2024523438A
(ja)
|
2021-06-21 |
2024-06-28 |
ジェンマブ エー/エス |
Cd137結合物質とpd-l1結合物質の組合せ投薬レジメン
|
EP4359083A1
(de)
|
2021-06-24 |
2024-05-01 |
Erasca, Inc. |
Antikörper gegen egfr und deren verwendungen
|
IL308633A
(en)
|
2021-06-25 |
2024-01-01 |
Chugai Pharmaceutical Co Ltd |
Use of anti-CTLA-4 antibodies
|
TW202317627A
(zh)
|
2021-06-25 |
2023-05-01 |
日商中外製藥股份有限公司 |
抗ctla-4抗體
|
EP4363449A2
(de)
|
2021-07-02 |
2024-05-08 |
Genentech, Inc. |
Verfahren und zusammensetzungen zur behandlung von krebs
|
US20230197278A1
(en)
|
2021-07-13 |
2023-06-22 |
Genentech, Inc. |
Multi-variate model for predicting cytokine release syndrome
|
KR20240032889A
(ko)
|
2021-07-14 |
2024-03-12 |
제넨테크, 인크. |
항-c-c 모티프 케모카인 수용체 8(ccr8) 항체 및 사용 방법
|
AU2022309554A1
(en)
|
2021-07-14 |
2024-02-22 |
Jiangsu Hengrui Pharmaceuticals Co., Ltd. |
Antigen-binding molecule specifically binding to hgfr and egfr, and pharmaceutical use thereof
|
EP4373859A1
(de)
|
2021-07-22 |
2024-05-29 |
F. Hoffmann-La Roche AG |
Heterodimere fc-domänen-antikörper
|
JP2024527020A
(ja)
|
2021-07-27 |
2024-07-19 |
モルフォシス・アーゲー |
抗原結合分子の組合せ
|
EP4377351A1
(de)
|
2021-07-28 |
2024-06-05 |
F. Hoffmann-La Roche AG |
Verfahren und zusammensetzungen zur behandlung von krebs
|
CN117794953A
(zh)
|
2021-08-03 |
2024-03-29 |
豪夫迈·罗氏有限公司 |
双特异性抗体及使用方法
|
GB202111905D0
(en)
|
2021-08-19 |
2021-10-06 |
UCB Biopharma SRL |
Antibodies
|
TW202328192A
(zh)
|
2021-09-06 |
2023-07-16 |
荷蘭商珍美寶公司 |
能結合cd27之抗體、彼之變異體及彼等之用途
|
KR20240052854A
(ko)
|
2021-09-08 |
2024-04-23 |
조인트 스탁 컴퍼니 "바이오케드" |
Mhc 단백질 기반 이종 이량체를 포함하는 이중 특이적 항체
|
TW202323277A
(zh)
|
2021-09-23 |
2023-06-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
抗klb抗體及用途
|
WO2023053282A1
(ja)
|
2021-09-29 |
2023-04-06 |
中外製薬株式会社 |
がんの治療に用いるための細胞傷害誘導治療剤
|
KR20240067099A
(ko)
|
2021-09-30 |
2024-05-16 |
지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 |
항-il23 항체 융합 단백질 및 용도
|
US20230190806A1
(en)
|
2021-10-06 |
2023-06-22 |
Immatics Biotechnologies Gmbh |
Methods of treating metastatic lesions and compositions thereof
|
KR20240082388A
(ko)
|
2021-10-08 |
2024-06-10 |
추가이 세이야쿠 가부시키가이샤 |
프리필드 시린지 제제의 조제 방법
|
PE20241175A1
(es)
|
2021-10-08 |
2024-05-28 |
Genmab As |
Anticuerpos de union a cd30 y cd3
|
WO2023062048A1
(en)
|
2021-10-14 |
2023-04-20 |
F. Hoffmann-La Roche Ag |
Alternative pd1-il7v immunoconjugates for the treatment of cancer
|
EP4416174A1
(de)
|
2021-10-14 |
2024-08-21 |
F. Hoffmann-La Roche AG |
Interleukin-7-immunkonjugate
|
WO2023081925A1
(en)
|
2021-11-08 |
2023-05-11 |
Immatics Biotechnologies Gmbh |
Adoptive cell therapy combination treatment and compositions thereof
|
CN118284809A
(zh)
|
2021-11-25 |
2024-07-02 |
豪夫迈·罗氏有限公司 |
少量抗体副产物的定量
|
AR127887A1
(es)
|
2021-12-10 |
2024-03-06 |
Hoffmann La Roche |
Anticuerpos que se unen a cd3 y plap
|
CA3238353A1
(en)
|
2021-12-13 |
2023-06-22 |
William Robert ARATHOON |
Anti-abcb1 antibodies
|
WO2023117325A1
(en)
|
2021-12-21 |
2023-06-29 |
F. Hoffmann-La Roche Ag |
Method for the determination of hydrolytic activity
|
WO2023141445A1
(en)
|
2022-01-19 |
2023-07-27 |
Genentech, Inc. |
Anti-notch2 antibodies and conjugates and methods of use
|
US20230303693A1
(en)
|
2022-01-28 |
2023-09-28 |
Genmab A/S |
Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
|
WO2023144290A1
(en)
|
2022-01-28 |
2023-08-03 |
Genmab A/S |
Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
|
WO2023159220A1
(en)
|
2022-02-18 |
2023-08-24 |
Kenjockety Biotechnology, Inc. |
Anti-cd47 antibodies
|
WO2023172883A1
(en)
|
2022-03-07 |
2023-09-14 |
Alpine Immune Sciences, Inc. |
Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses
|
WO2023174521A1
(en)
|
2022-03-15 |
2023-09-21 |
Genmab A/S |
Binding agents binding to epcam and cd137
|
WO2023175064A1
(en)
|
2022-03-17 |
2023-09-21 |
Astrazeneca Ab |
Methods for purifying bispecific antibodies
|
US20230414750A1
(en)
|
2022-03-23 |
2023-12-28 |
Hoffmann-La Roche Inc. |
Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
|
WO2023191816A1
(en)
|
2022-04-01 |
2023-10-05 |
Genentech, Inc. |
Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
|
WO2023198839A2
(en)
|
2022-04-13 |
2023-10-19 |
Genmab A/S |
Bispecific antibodies against cd3 and cd20
|
WO2023198727A1
(en)
|
2022-04-13 |
2023-10-19 |
F. Hoffmann-La Roche Ag |
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|
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(en)
|
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Improved production cells
|
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(zh)
|
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丹麥商諾佛 儂迪克股份有限公司 |
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|
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(en)
|
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|
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(en)
|
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Binding agents capable of binding to cd27 in combination therapy
|
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(en)
|
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Binding agents capable of binding to cd27 in combination therapy
|
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(zh)
*
|
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|
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(en)
|
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Rna compositions targeting hiv
|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(zh)
|
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|
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(en)
|
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Cd98hc antigen-binding domains and uses therefor
|
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(en)
|
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Alpine Immune Sciences, Inc. |
Methods and uses of taci-fc fusion immunomodulatory protein
|
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(en)
|
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2024-04-11 |
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Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies
|
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(en)
|
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Combination therapy of a gprc5d tcb and imids
|
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(en)
|
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Combination therapy of a gprc5d tcb and cd38 antibodies
|
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(en)
|
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Combination therapy of a gprc5d tcb and proteasome inhibitors
|
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(en)
|
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Method for classifying cells
|
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(en)
|
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Anti-trkb/cd3 antibodies and uses thereof
|
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(en)
|
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Predicting response to il-6 antagonists
|
WO2024091991A1
(en)
|
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2024-05-02 |
Genentech, Inc. |
Therapeutic and diagnostic methods for multiple myeloma
|
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(en)
|
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Cd38 antibodies and uses thereof
|
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(en)
|
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Genmab A/S |
Bispecific antibodies against cd3 and cd20 for treating richter's syndrome
|
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(en)
|
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Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods
|
WO2024100170A1
(en)
|
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2024-05-16 |
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Antibodies binding to hla-a*02/foxp3
|
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(en)
|
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Antigen binding molecules
|
WO2024104988A1
(en)
|
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Recombinant binding proteins with activatable effector domain
|
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(en)
|
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Method for increasing recombinant protein expression
|
WO2024110905A1
(en)
|
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2024-05-30 |
Beigene, Ltd. |
Anti-cea antibody drug conjugates and methods of use
|
WO2024119193A2
(en)
|
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2024-06-06 |
AskGene Pharma, Inc. |
Mutant il-2 polypeptides and il-2 prodrugs
|
WO2024129594A1
(en)
|
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Genentech, Inc. |
Optimizing polypeptide sialic acid content
|
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(en)
|
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Rna compositions targeting hiv
|
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(en)
|
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Multispecific antibodies and uses thereof
|
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(en)
|
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Beigene, Ltd. |
Anti-cmet antibodies and methods of use
|
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(en)
|
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Recombinant fc domain - il2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides
|
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(en)
|
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Antibodies binding to csf1r and cd3
|
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(en)
|
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Methods and compositions for treating urothelial bladder cancer
|
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(en)
|
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Methods and compositions for treating non-small cell lung cancer and triple-negative breast cancer
|