CN114040924A - 对lif具有特异性的结合分子及其用途 - Google Patents
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Abstract
本发明提供对LIF具有特异性的结合分子及其用途，具体而言，本发明提供结合LIF且抑制LIF活性的分离的抗体或其抗原结合部分。本发明亦提供本发明分离的抗体或其抗原结合部分在治疗疾病中的用途。
Description
PCT国内申请，说明书已公开。
Claims (121)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019108904 | 2019-09-29 | ||
| CNPCT/CN2019/108904 | 2019-09-29 | ||
| CNPCT/CN2020/077049 | 2020-02-27 | ||
| CN2020077049 | 2020-02-27 | ||
| PCT/CN2020/118247 WO2021057991A1 (zh) | 2019-09-29 | 2020-09-28 | 对lif具有特异性的结合分子及其用途 |
Publications (1)
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|---|---|
| CN114040924A true CN114040924A (zh) | 2022-02-11 |
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| CN202080046803.4A Pending CN114040924A (zh) | 2019-09-29 | 2020-09-28 | 对lif具有特异性的结合分子及其用途 |
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|---|---|
| US (1) | US20210403582A1 (zh) |
| EP (1) | EP4036114A4 (zh) |
| JP (1) | JP7538552B2 (zh) |
| KR (1) | KR20220087457A (zh) |
| CN (1) | CN114040924A (zh) |
| AU (1) | AU2020354255A1 (zh) |
| BR (1) | BR112022005909A2 (zh) |
| CA (1) | CA3156080A1 (zh) |
| CL (1) | CL2022000752A1 (zh) |
| IL (1) | IL291710A (zh) |
| MX (1) | MX2022003762A (zh) |
| TW (1) | TWI770619B (zh) |
| WO (1) | WO2021057991A1 (zh) |
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| WO2022228514A1 (zh) * | 2021-04-29 | 2022-11-03 | 北京浩古元方生物医药科技有限公司 | 抗人白血病抑制因子抗体及其用途 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130142808A1 (en) * | 2010-04-05 | 2013-06-06 | Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats (Icrea) | Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation |
| CN106573974A (zh) * | 2014-06-30 | 2017-04-19 | 阿费里斯股份公司 | 靶向骨桥蛋白的截短变体的疫苗和单克隆抗体及其用途 |
| WO2017089614A1 (en) * | 2015-11-27 | 2017-06-01 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Agents for the treatment of diseases associated with undesired cell proliferation |
| WO2018115960A1 (en) * | 2016-12-19 | 2018-06-28 | Mosaic Biomedicals, S.L. | Antibodies against lif and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| US8039218B2 (en) * | 2002-11-14 | 2011-10-18 | John Wayne Cancer Institute | Detection of cancer cells in body fluids |
| US20060204493A1 (en) | 2004-09-02 | 2006-09-14 | Genentech, Inc. | Heteromultimeric molecules |
| US20060275844A1 (en) * | 2005-04-19 | 2006-12-07 | Linke Steven P | Diagnostic markers of breast cancer treatment and progression and methods of use thereof |
| WO2007011856A2 (en) * | 2005-07-15 | 2007-01-25 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for differential diagnosis of chronic lymphocytic leukemia |
| WO2011035433A1 (en) * | 2009-09-23 | 2011-03-31 | University Health Network | Selected strains on serum-free growth media for proteomics analysis of lung cancer biomarkers |
| WO2019243893A1 (en) * | 2018-06-18 | 2019-12-26 | Mosaic Biomedicals Slu | Methods of quantifying lif and uses thereof |
-
2020
- 2020-09-28 WO PCT/CN2020/118247 patent/WO2021057991A1/zh active Application Filing
- 2020-09-28 CN CN202080046803.4A patent/CN114040924A/zh active Pending
- 2020-09-28 CA CA3156080A patent/CA3156080A1/en active Pending
- 2020-09-28 MX MX2022003762A patent/MX2022003762A/es unknown
- 2020-09-28 AU AU2020354255A patent/AU2020354255A1/en active Pending
- 2020-09-28 EP EP20870311.6A patent/EP4036114A4/en active Pending
- 2020-09-28 TW TW109133568A patent/TWI770619B/zh active
- 2020-09-28 JP JP2022519435A patent/JP7538552B2/ja active Active
- 2020-09-28 BR BR112022005909A patent/BR112022005909A2/pt unknown
- 2020-09-28 KR KR1020227014353A patent/KR20220087457A/ko active Search and Examination
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2021
- 2021-08-20 US US17/407,264 patent/US20210403582A1/en active Pending
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2022
- 2022-03-25 CL CL2022000752A patent/CL2022000752A1/es unknown
- 2022-03-27 IL IL291710A patent/IL291710A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130142808A1 (en) * | 2010-04-05 | 2013-06-06 | Fundacio Privada Institucio Catalana De Recerca I Estudis Avancats (Icrea) | Antibody recognizing human leukemia inhibitory factor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation |
| CN103797031A (zh) * | 2010-04-05 | 2014-05-14 | 瓦尔德希伯伦肿瘤研究所 | 识别人类白血病抑制因子(lif)的抗体和抗lif抗体在与有害细胞增殖相关疾病的治疗中的应用 |
| CN106573974A (zh) * | 2014-06-30 | 2017-04-19 | 阿费里斯股份公司 | 靶向骨桥蛋白的截短变体的疫苗和单克隆抗体及其用途 |
| WO2017089614A1 (en) * | 2015-11-27 | 2017-06-01 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Agents for the treatment of diseases associated with undesired cell proliferation |
| WO2018115960A1 (en) * | 2016-12-19 | 2018-06-28 | Mosaic Biomedicals, S.L. | Antibodies against lif and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210403582A1 (en) | 2021-12-30 |
| IL291710A (en) | 2022-05-01 |
| KR20220087457A (ko) | 2022-06-24 |
| CA3156080A1 (en) | 2021-04-01 |
| JP2022550121A (ja) | 2022-11-30 |
| JP7538552B2 (ja) | 2024-08-22 |
| WO2021057991A1 (zh) | 2021-04-01 |
| CL2022000752A1 (es) | 2022-11-18 |
| EP4036114A4 (en) | 2023-11-08 |
| MX2022003762A (es) | 2022-06-24 |
| AU2020354255A1 (en) | 2022-04-21 |
| TWI770619B (zh) | 2022-07-11 |
| BR112022005909A2 (pt) | 2022-10-11 |
| TW202112813A (zh) | 2021-04-01 |
| EP4036114A1 (en) | 2022-08-03 |
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