CA2789425C - Digital analyte analysis with polymerase error correction - Google Patents
Digital analyte analysis with polymerase error correction Download PDFInfo
- Publication number
- CA2789425C CA2789425C CA2789425A CA2789425A CA2789425C CA 2789425 C CA2789425 C CA 2789425C CA 2789425 A CA2789425 A CA 2789425A CA 2789425 A CA2789425 A CA 2789425A CA 2789425 C CA2789425 C CA 2789425C
- Authority
- CA
- Canada
- Prior art keywords
- droplets
- nucleic acid
- target
- droplet
- target nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30416310P | 2010-02-12 | 2010-02-12 | |
| US61/304,163 | 2010-02-12 | ||
| US33149010P | 2010-05-05 | 2010-05-05 | |
| US61/331,490 | 2010-05-05 | ||
| US34715810P | 2010-05-21 | 2010-05-21 | |
| US61/347,158 | 2010-05-21 | ||
| US38893710P | 2010-10-01 | 2010-10-01 | |
| US61/388,937 | 2010-10-01 | ||
| PCT/US2011/024615 WO2011100604A2 (en) | 2010-02-12 | 2011-02-11 | Digital analyte analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2789425A1 CA2789425A1 (en) | 2011-08-18 |
| CA2789425C true CA2789425C (en) | 2020-04-28 |
Family
ID=44368475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2789425A Active CA2789425C (en) | 2010-02-12 | 2011-02-11 | Digital analyte analysis with polymerase error correction |
Country Status (5)
| Country | Link |
|---|---|
| US (13) | US9074242B2 (enExample) |
| EP (4) | EP4484577A3 (enExample) |
| JP (7) | JP5934657B2 (enExample) |
| CA (1) | CA2789425C (enExample) |
| WO (1) | WO2011100604A2 (enExample) |
Families Citing this family (225)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| EP1663497B2 (en) | 2003-09-05 | 2020-03-25 | Stokes Bio Limited | A microfluidic analysis system |
| US9597644B2 (en) | 2003-09-05 | 2017-03-21 | Stokes Bio Limited | Methods for culturing and analyzing cells |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US7955864B2 (en) | 2005-08-22 | 2011-06-07 | Life Technologies Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| EP2363205A3 (en) | 2006-01-11 | 2014-06-04 | Raindance Technologies, Inc. | Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors |
| EP2298438A1 (en) | 2006-02-07 | 2011-03-23 | Stokes Bio Limited | A microfluidic droplet queuing network |
| EP2530168B1 (en) | 2006-05-11 | 2015-09-16 | Raindance Technologies, Inc. | Microfluidic Devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| FR2934050B1 (fr) * | 2008-07-15 | 2016-01-29 | Univ Paris Curie | Procede et dispositif de lecture d'une emulsion |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
| US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
| US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
| US9921154B2 (en) | 2011-03-18 | 2018-03-20 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays |
| US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US20140179544A1 (en) * | 2012-09-07 | 2014-06-26 | Bio-Rad Laboratories, Inc. | Compositions, systems and methods for droplet formation, spacing and detection |
| US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
| US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
| US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
| US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
| CA2738578C (en) | 2008-09-23 | 2021-05-04 | Quantalife, Inc. | Droplet-based assay system |
| US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US12162008B2 (en) | 2008-09-23 | 2024-12-10 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US12090480B2 (en) | 2008-09-23 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
| US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| CA2767056C (en) | 2009-09-02 | 2018-12-04 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| EP3842150A1 (en) | 2009-10-27 | 2021-06-30 | President and Fellows of Harvard College | Droplet creation techniques |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ， インコーポレイテッド | デジタル検体分析 |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| CA2767113A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Detection system for droplet-based assays |
| CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
| EP2556170A4 (en) | 2010-03-25 | 2014-01-01 | Quantalife Inc | TRAPPING TRANSPORT AND DETECTION SYSTEM |
| RU2565550C2 (ru) | 2010-09-24 | 2015-10-20 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| SG190074A1 (en) | 2010-11-01 | 2013-06-28 | Bio Rad Laboratories | System for forming emulsions |
| JP6096672B2 (ja) | 2010-12-07 | 2017-03-15 | ヌビオ，インコーポレイテッド | 検出体、プローブ、および阻害剤を用いた核酸標的検出 |
| EP2673380B1 (en) * | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| US12097495B2 (en) | 2011-02-18 | 2024-09-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| AU2012231098B2 (en) | 2011-03-18 | 2016-09-29 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
| AU2012236713B2 (en) | 2011-03-30 | 2016-11-24 | Bio-Rad Laboratories, Inc. | Injection of multiple volumes into or out of droplets |
| EP2691540B1 (en) | 2011-03-31 | 2016-01-20 | GnuBIO, Inc. | Managing variation in spectroscopic intensity measurements through the use of a reference component |
| CA2841425C (en) | 2011-03-31 | 2018-05-01 | Gnubio, Inc. | Scalable spectroscopic detection and measurement |
| WO2012149042A2 (en) | 2011-04-25 | 2012-11-01 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
| US20140134631A1 (en) * | 2011-07-04 | 2014-05-15 | National Research Council Of Canada | Centrifugal microfluidic platform |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| WO2013019751A1 (en) | 2011-07-29 | 2013-02-07 | Bio-Rad Laboratories, Inc., | Library characterization by digital assay |
| EP2761027B1 (en) * | 2011-09-30 | 2017-10-25 | Life Technologies Corporation | Methods and systems for visualizing and evaluating data |
| US10222391B2 (en) | 2011-12-07 | 2019-03-05 | The Johns Hopkins University | System and method for screening a library of samples |
| WO2013101741A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Channels with cross-sectional thermal gradients |
| WO2013101896A1 (en) | 2011-12-30 | 2013-07-04 | Quest Diagnostics Investments Incorporated | Nucleic acid analysis using emulsion pcr |
| CN107326085B (zh) * | 2012-02-03 | 2022-05-03 | 加州理工学院 | 多路生化测定中信号的编码和解码 |
| WO2013120089A1 (en) * | 2012-02-10 | 2013-08-15 | Raindance Technologies, Inc. | Molecular diagnostic screening assay |
| EP2817418B1 (en) * | 2012-02-24 | 2017-10-11 | Raindance Technologies, Inc. | Labeling and sample preparation for sequencing |
| CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| US11177020B2 (en) | 2012-02-27 | 2021-11-16 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
| WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
| EP2844768B1 (en) * | 2012-04-30 | 2019-03-13 | Raindance Technologies, Inc. | Digital analyte analysis |
| IN2015DN01609A (enExample) | 2012-08-03 | 2015-07-03 | California Inst Of Techn | |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| JP6367196B2 (ja) | 2012-08-14 | 2018-08-01 | テンエックス・ジェノミクス・インコーポレイテッド | マイクロカプセル組成物および方法 |
| US9422602B2 (en) * | 2012-08-15 | 2016-08-23 | Bio-Rad Laboratories, Inc. | Methods and compositions for determining nucleic acid degradation |
| EP2888375B1 (en) | 2012-08-23 | 2018-08-08 | Bio-Rad Laboratories, Inc. | Digital assays with a reporter for amplicon length |
| US9970052B2 (en) | 2012-08-23 | 2018-05-15 | Bio-Rad Laboratories, Inc. | Digital assays with a generic reporter |
| EP2895591A4 (en) * | 2012-09-12 | 2016-10-12 | Gnubio Inc | INTEGRATED MICROFLUIDIC SYSTEM, METHOD AND KIT FOR PERFORMING TESTS |
| FR2996545B1 (fr) | 2012-10-08 | 2016-03-25 | Ecole Polytech | Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant. |
| WO2014062726A1 (en) * | 2012-10-15 | 2014-04-24 | Bio-Rad Laboratories, Inc. | Digital telomerase assay |
| EP2917862B1 (en) * | 2012-11-07 | 2021-12-08 | Life Technologies Corporation | Visualization tools for digital pcr data |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN105074303B (zh) | 2013-01-25 | 2018-04-10 | 基纽拜奥股份有限公司 | 实施液滴膨胀的系统和方法 |
| US11110458B2 (en) | 2013-02-01 | 2021-09-07 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| WO2014121203A1 (en) * | 2013-02-01 | 2014-08-07 | Bio-Rad Laboratories, Inc. | Digital assay for telomere length |
| CN105074060B (zh) * | 2013-02-01 | 2018-04-10 | 伯乐生命医学产品有限公司 | 用于靶水平的计算的使用数据排除的多重数字分析 |
| KR102190198B1 (ko) | 2013-02-08 | 2020-12-14 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| SG10201710049RA (en) | 2013-03-08 | 2018-01-30 | Bio Rad Laboratories Inc | Compositions, methods and systems for polymerase chain reaction assays |
| WO2014144495A1 (en) | 2013-03-15 | 2014-09-18 | Abvitro, Inc. | Single cell bar-coding for antibody discovery |
| CN105492455B (zh) * | 2013-03-15 | 2019-05-03 | 伯乐生命医学产品有限公司 | 利用通用报告物的数字测定 |
| US20140272996A1 (en) * | 2013-03-15 | 2014-09-18 | Bio-Rad Laboratories, Inc. | Droplet generator with collection tube |
| WO2014145555A1 (en) * | 2013-03-15 | 2014-09-18 | Lariat Biosciences, Inc. | Microfluidic methods for manipulating dna |
| GB201304810D0 (en) * | 2013-03-15 | 2013-05-01 | Isis Innovation | Assay |
| US9347095B2 (en) | 2013-03-15 | 2016-05-24 | Bio-Rad Laboratories, Inc. | Digital assays for mutation detection |
| EP4566715A3 (en) * | 2013-04-02 | 2025-08-27 | Bio-Rad Laboratories, Inc. | Systems and methods for handling microfluidic droplets |
| WO2014168043A1 (ja) * | 2013-04-09 | 2014-10-16 | 東京エレクトロン株式会社 | 測定装置及び測定方法 |
| US9403294B2 (en) | 2013-04-17 | 2016-08-02 | Bio-Rad Laboratories, Inc. | Method of making a droplet-generating device |
| SG11201508193TA (en) | 2013-04-17 | 2015-11-27 | Agency Science Tech & Res | Method for generating extended sequence reads |
| WO2014172373A2 (en) * | 2013-04-19 | 2014-10-23 | Raindance Technologies, Inc | Digital analyte analysis |
| EP3004391B1 (en) | 2013-05-29 | 2019-03-27 | Bio-Rad Laboratories, Inc. | Methods for sequencing in emulsion based microfluidics |
| US9766261B2 (en) | 2013-05-29 | 2017-09-19 | Bio-Rad Laboratories, Inc. | Low cost optical high speed discrete measurement system |
| SG11201600605UA (en) * | 2013-06-28 | 2016-02-26 | Life Technologies Corp | Methods and systems for visualizing data quality |
| CN105555972B (zh) | 2013-07-25 | 2020-07-31 | 伯乐生命医学产品有限公司 | 遗传测定 |
| WO2015031528A1 (en) | 2013-08-27 | 2015-03-05 | Gnubio, Inc. | Microfluidic devices and methods of their use |
| US9567645B2 (en) | 2013-08-28 | 2017-02-14 | Cellular Research, Inc. | Massively parallel single cell analysis |
| US9555411B2 (en) | 2013-09-30 | 2017-01-31 | Gnubio, Inc. | Microfluidic cartridge devices and methods of use and assembly |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| JP2017504307A (ja) | 2013-10-07 | 2017-02-09 | セルラー リサーチ， インコーポレイテッド | アレイ上のフィーチャーをデジタルカウントするための方法およびシステム |
| US10130950B2 (en) | 2013-11-27 | 2018-11-20 | Bio-Rad Laboratories, Inc. | Microfluidic droplet packing |
| EP2878374B1 (en) * | 2013-11-29 | 2021-05-12 | IMEC vzw | Method for performing digital PCR |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US9988681B2 (en) | 2013-12-18 | 2018-06-05 | James M. Sikela | Diagnosis and prognosis of severity of autism spectrum disorders |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| CN103911427A (zh) * | 2014-01-27 | 2014-07-09 | 上海涌泰生物医药科技有限公司 | 一种基于数字pcr平台检测基因点突变的方法和试剂盒 |
| WO2015173658A2 (en) | 2014-05-14 | 2015-11-19 | Mark Davis | Microfluidic devices that include channels that are slidable relative to each other and methods of use thereof |
| WO2015189336A1 (en) | 2014-06-11 | 2015-12-17 | Samplix S.A.R.L. | Nucleotide sequence exclusion enrichment by droplet sorting (needls) |
| EP4574974A3 (en) | 2014-06-26 | 2025-10-08 | 10x Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| WO2016004022A2 (en) | 2014-06-30 | 2016-01-07 | Gnubio, Inc. | Floating thermal contact enabled pcr |
| JP6722657B2 (ja) | 2014-08-20 | 2020-07-15 | スリーエム イノベイティブ プロパティズ カンパニー | 試料の分割及び分析のためのデバイス及び方法 |
| KR102541849B1 (ko) | 2014-09-15 | 2023-06-09 | 에이비비트로, 엘엘씨 | 고-처리량 뉴클레오티드 라이브러리 서열결정 |
| CA2967635C (en) * | 2014-11-14 | 2023-06-06 | Athena Diagnostics, Inc. | Methods to detect a silent carrier genotype |
| US10233490B2 (en) | 2014-11-21 | 2019-03-19 | Metabiotech Corporation | Methods for assembling and reading nucleic acid sequences from mixed populations |
| US10280451B2 (en) | 2015-01-09 | 2019-05-07 | Bio-Rad Laboratories, Inc. | Detection of genome editing |
| US10233505B2 (en) | 2015-01-16 | 2019-03-19 | Kansas State University Research Foundation | Co-detection and association of multiple genes from the same genome in a sample |
| JP6692834B2 (ja) | 2015-02-09 | 2020-05-13 | スリングショット バイオサイエンシーズ， インコーポレイテッド | 調整可能な光学特性を有するヒドロゲル粒子およびその使用の方法 |
| EP3259371B1 (en) | 2015-02-19 | 2020-09-02 | Becton, Dickinson and Company | High-throughput single-cell analysis combining proteomic and genomic information |
| CN107208158B (zh) | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | 空间上可寻址的分子条形编码 |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| EP3835431B1 (en) | 2015-03-30 | 2022-11-02 | Becton, Dickinson and Company | Methods for combinatorial barcoding |
| US11390914B2 (en) | 2015-04-23 | 2022-07-19 | Becton, Dickinson And Company | Methods and compositions for whole transcriptome amplification |
| EP4674985A3 (en) | 2015-04-24 | 2026-04-01 | The Johns Hopkins University | Compositions and methods related to characterizing proviral reservoirs |
| WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
| WO2017004250A1 (en) | 2015-06-29 | 2017-01-05 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis |
| US9938572B1 (en) | 2015-09-08 | 2018-04-10 | Raindance Technologies, Inc. | System and method for forming an emulsion |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ， インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
| US11207690B2 (en) | 2015-12-22 | 2021-12-28 | 3M Innovative Properties Company | Stem-well films for sample partitioning |
| WO2017119904A1 (en) | 2016-01-08 | 2017-07-13 | Hewlett-Packard Development Company, L.P. | Polymerase chain reaction device including ejection nozzles |
| EP4219519A3 (en) | 2016-04-01 | 2023-09-13 | Chromacode, Inc. | Competitive probes for engineering signal generation |
| CA3022377A1 (en) | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Targeted measure of transcriptional activity related to hormone receptors |
| EP3452614B1 (en) | 2016-05-02 | 2023-06-28 | Becton, Dickinson and Company | Accurate molecular barcoding |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| CN109074430B (zh) | 2016-05-26 | 2022-03-29 | 贝克顿迪金森公司 | 分子标记计数调整方法 |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10066263B2 (en) | 2016-06-17 | 2018-09-04 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
| WO2018008083A1 (ja) * | 2016-07-05 | 2018-01-11 | 株式会社日立製作所 | Ｄｎａ検出方法およびそのための装置 |
| EP3269444A1 (en) * | 2016-07-14 | 2018-01-17 | Base4 Innovation Ltd | Method of identifying droplets in a stack and an associated sequencer |
| US10654040B2 (en) * | 2016-08-18 | 2020-05-19 | Northeastern University | Platform for liquid droplet formation and isolation |
| AU2017331459B2 (en) | 2016-09-26 | 2023-04-13 | Becton, Dickinson And Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| US11371101B2 (en) | 2016-10-27 | 2022-06-28 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| KR102790039B1 (ko) | 2016-11-08 | 2025-04-04 | 벡톤 디킨슨 앤드 컴퍼니 | 세포 표지 분류 방법 |
| AU2017359048B2 (en) | 2016-11-08 | 2022-07-21 | Becton, Dickinson And Company | Methods for expression profile classification |
| JP2020500517A (ja) * | 2016-11-28 | 2020-01-16 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ | 連続流小滴反応に関連するシステムおよび方法 |
| WO2018115978A2 (en) | 2016-12-23 | 2018-06-28 | University Of Limerick | Water-in-oil-in water emulsions for analysis of biological and chemical samples |
| JP6754301B2 (ja) * | 2017-01-05 | 2020-09-09 | 株式会社日立製作所 | ドロップレットデジタルｐｃｒの測定方法および測定装置 |
| ES2961580T3 (es) | 2017-01-13 | 2024-03-12 | Cellular Res Inc | Revestimiento hidrófilo de canales de fluidos |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| WO2018226293A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
| KR101979834B1 (ko) * | 2017-08-11 | 2019-05-17 | 한국과학기술원 | 미세유체장치를 이용한 다중유전자 디지털 신호 분석장치 및 이의 분석방법 |
| US11072820B2 (en) | 2017-10-19 | 2021-07-27 | Bio-Rad Laboratories, Inc. | Digital amplification assays with unconventional and/or inverse changes in photoluminescence |
| US20190136296A1 (en) * | 2017-11-09 | 2019-05-09 | E.I. Spectra, Llc | Ultra-Sensitive Platform for Nucleic acid detection using a novel method, Scanning Digital polymerase chain reaction (PCR) |
| WO2019126209A1 (en) | 2017-12-19 | 2019-06-27 | Cellular Research, Inc. | Particles associated with oligonucleotides |
| JP2019115300A (ja) * | 2017-12-27 | 2019-07-18 | キヤノン株式会社 | 油性組成物、油性組成物を用いた方法、試料の分析方法及び液滴生成装置 |
| EP3543351B1 (en) | 2018-03-19 | 2022-08-10 | Ricoh Company, Ltd. | Nucleic acid sample-contained container, method for producing nucleic acid sample-contained container, and nucleic acid sample |
| JP7326778B2 (ja) * | 2018-03-19 | 2023-08-16 | 株式会社リコー | 核酸試料含有容器、核酸試料含有容器の製造方法、核酸試料含有容器の製造装置及び核酸試料含有容器の製造プログラム、並びに、核酸試料 |
| CA3095588A1 (en) | 2018-04-02 | 2019-10-10 | Dropworks, Inc. | Systems and methods for serial flow emulsion processes |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| EP3788170B1 (en) | 2018-05-03 | 2025-01-01 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
| EP3788171B1 (en) | 2018-05-03 | 2023-04-05 | Becton, Dickinson and Company | High throughput multiomics sample analysis |
| JP7066540B2 (ja) | 2018-06-14 | 2022-05-13 | 株式会社日立製作所 | デジタルｐｃｒの測定方法および測定装置 |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
| US11512356B2 (en) | 2018-11-08 | 2022-11-29 | Tokitae Llc | Systems and methods for particle multiplexing in droplets |
| EP3877520B1 (en) | 2018-11-08 | 2025-03-19 | Becton, Dickson And Company | Whole transcriptome analysis of single cells using random priming |
| EP4745247A2 (en) | 2018-12-13 | 2026-05-20 | Becton Dickinson Co | SELECTIVE EXTENSION IN A SINGLE-CELL WHOLE-TRANSCRIPTOME ANALYSIS |
| US11358137B2 (en) | 2018-12-26 | 2022-06-14 | Industrial Technology Research Institute | Tubular structure for producing droplets and method for producing droplets |
| WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| CN113574178B (zh) | 2019-01-23 | 2024-10-29 | 贝克顿迪金森公司 | 与抗体关联的寡核苷酸 |
| CN120099139A (zh) | 2019-02-14 | 2025-06-06 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| US11965208B2 (en) | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
| EP3760194A1 (en) | 2019-07-01 | 2021-01-06 | DBV Technologies | Method of depositing a substance on a substrate |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| EP4055160B1 (en) | 2019-11-08 | 2024-04-10 | Becton Dickinson and Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
| EP4073573A4 (en) | 2019-12-10 | 2024-04-10 | Enumerix, Inc. | Methods and systems for three-dimensional lightsheet imaging |
| WO2021146219A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Cell capture using du-containing oligonucleotides |
| EP4090763B1 (en) | 2020-01-13 | 2024-12-04 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
| WO2021144903A1 (ja) * | 2020-01-16 | 2021-07-22 | 株式会社日立ハイテク | Ｄｎａ検出方法およびｄｎａ検出システム |
| TW202141019A (zh) | 2020-01-24 | 2021-11-01 | 美商史林夏特生化公司 | 類細胞校正粒子之組合物與方法 |
| ES2993319T3 (en) | 2020-01-29 | 2024-12-27 | Becton Dickinson Co | Barcoded wells for spatial mapping of single cells through sequencing |
| CN115151810A (zh) | 2020-02-25 | 2022-10-04 | 贝克顿迪金森公司 | 实现使用单细胞样品作为单色补偿对照的双特异性探针 |
| US11066697B1 (en) * | 2020-03-31 | 2021-07-20 | Northeastern University | Colorimetric and multiplexed isothermal RNA-based assay for SARS-CoV-2 and other viral diagnostics and cell analysis |
| US11162136B1 (en) | 2020-04-15 | 2021-11-02 | Enumerix, Inc. | Systems and methods for generation of emulsions with suitable clarity with applications of use |
| CN115485556B (zh) | 2020-05-04 | 2026-02-03 | 弹弓生物科学公司 | 用于多路复用测定的被动光学条形码化的组合物和方法 |
| US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| CN115803445A (zh) | 2020-06-02 | 2023-03-14 | 贝克顿迪金森公司 | 用于5撇基因表达测定的寡核苷酸和珠 |
| JP7016382B2 (ja) * | 2020-06-22 | 2022-02-21 | 株式会社日立製作所 | ドロップレットデジタルｐｃｒの測定方法および測定装置 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| CN117241878A (zh) | 2021-03-05 | 2023-12-15 | 伊努梅里斯公司 | 用于生成微滴和执行数字分析的系统和方法 |
| CN117794646A (zh) | 2021-06-04 | 2024-03-29 | 伊努梅里斯公司 | 用于单细胞条形码化和测序的组合物、方法和系统 |
| WO2022259334A1 (ja) | 2021-06-07 | 2022-12-15 | 株式会社日立ハイテク | Ｄｎａ検出方法およびｄｎａ検出システム |
| US12252745B2 (en) | 2021-09-02 | 2025-03-18 | Enumerix, Inc. | Detection and digital quantitation of multiple targets |
| EP4423250A1 (en) | 2021-10-29 | 2024-09-04 | Slingshot Biosciences, Inc. | Hydrogel particles as feeder cells and as synthetic antigen presenting cells |
| EP4453246A4 (en) | 2021-12-20 | 2025-12-24 | Countable Labs Inc | DIGITAL DETECTION AND QUANTIFICATION OF MULTIPLE TARGETS |
| WO2023215886A1 (en) | 2022-05-05 | 2023-11-09 | Slingshot Biosciences, Inc. | Engineered particles as red blood cell mimics and compositions containing same for hematology |
| WO2023235885A1 (en) | 2022-06-02 | 2023-12-07 | Slingshot Biosciences, Inc. | Apoptotic cell mimic |
| CN120712108A (zh) | 2022-10-26 | 2025-09-26 | 弹弓生物科学公司 | 具有可调整光学性质的大小可调整合成颗粒和用于使用其进行免疫细胞激活的方法 |
| CN121752740A (zh) * | 2023-08-04 | 2026-03-27 | 生物辐射实验室股份有限公司 | 选择性数字多重化 |
| CN121986254A (zh) | 2023-08-29 | 2026-05-05 | 弹弓生物科学公司 | Cd34干细胞模拟物 |
Family Cites Families (1096)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US209A (en) | 1837-05-30 | Improvement in the manufacture of saddle-trees | ||
| US7514A (en) | 1850-07-16 | Feeding apparatus op straw-cutters | ||
| US2097692A (en) | 1936-03-23 | 1937-11-02 | Bohn Aluminium & Brass Corp | Method and machine for forming bearing shells |
| US2164172A (en) | 1938-04-30 | 1939-06-27 | Gen Electric | Liquid-dispensing apparatus |
| US2636855A (en) | 1948-03-25 | 1953-04-28 | Hilger & Watts Ltd | Method of producing photoconductive coatings |
| US2656508A (en) | 1949-08-27 | 1953-10-20 | Wallace H Coulter | Means for counting particles suspended in a fluid |
| US2692800A (en) | 1951-10-08 | 1954-10-26 | Gen Electric | Nozzle flow control |
| US2797149A (en) | 1953-01-08 | 1957-06-25 | Technicon International Ltd | Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents |
| US2879141A (en) | 1955-11-16 | 1959-03-24 | Technicon Instr | Automatic analyzing apparatus |
| US2971700A (en) | 1957-07-22 | 1961-02-14 | Vilbiss Co | Apparatus for coating articles with chemically reactive liquids |
| GB1143839A (enExample) | 1965-10-15 | |||
| CH455414A (de) | 1966-01-10 | 1968-07-15 | Bachofen Willy A | Einbauelement zur optischen Durchflusskontrolle an Rohrleitungen |
| US3479141A (en) | 1967-05-17 | 1969-11-18 | Technicon Corp | Method and apparatus for analysis |
| US3980541A (en) | 1967-06-05 | 1976-09-14 | Aine Harry E | Electrode structures for electric treatment of fluids and filters using same |
| US3621059A (en) | 1969-07-30 | 1971-11-16 | Du Pont | Amides of hexafluoropropylene oxide polymer acids and polyalklene oxide |
| US3784471A (en) | 1970-05-11 | 1974-01-08 | Avco Corp | Solid additives dispersed in perfluorinated liquids with perfluoroalkyl ether dispersants |
| US3828085A (en) | 1970-07-09 | 1974-08-06 | Allied Chem | Novel amidoamine oxides |
| DE2100685C2 (de) | 1971-01-08 | 1983-09-22 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von reinen 4-Amino-5-halogen-pyridazonen-(6) |
| US3698635A (en) | 1971-02-22 | 1972-10-17 | Ransburg Electro Coating Corp | Spray charging device |
| US3816331A (en) | 1972-07-05 | 1974-06-11 | Ncr | Continuous encapsulation and device therefor |
| US3832646A (en) | 1972-10-06 | 1974-08-27 | Westinghouse Electric Corp | Common mode noise suppressing circuit adjustment sequence |
| CH563807A5 (en) | 1973-02-14 | 1975-07-15 | Battelle Memorial Institute | Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets |
| CH564966A5 (enExample) | 1974-02-25 | 1975-08-15 | Sauter Fr Ag Fabrik Elektrisch | |
| US3930061A (en) | 1974-04-08 | 1975-12-30 | Ransburg Corp | Electrostatic method for forming structures and articles |
| US4059552A (en) | 1974-06-21 | 1977-11-22 | The Dow Chemical Company | Cross-linked water-swellable polymer particles |
| US3960187A (en) | 1974-07-23 | 1976-06-01 | Usm Corporation | Method and device for metering and dispersing fluid materials |
| US3982541A (en) | 1974-07-29 | 1976-09-28 | Esperance Jr Francis A L | Eye surgical instrument |
| DK150802C (da) | 1974-09-16 | 1988-02-01 | Bifok Ab | Fremgangsmaade og apparat til kontinuerlig hoejhastighedsanalyse af en vaeskeproeve i en baererstroem |
| US4098897A (en) | 1975-04-14 | 1978-07-04 | Beecham Group Limited | Anti bacterial agents |
| US4034966A (en) | 1975-11-05 | 1977-07-12 | Massachusetts Institute Of Technology | Method and apparatus for mixing particles |
| US4014469A (en) | 1975-11-17 | 1977-03-29 | Kozo Sato | Nozzle of gas cutting torch |
| JPS5372016A (en) | 1976-12-08 | 1978-06-27 | Toyo Tire & Rubber Co Ltd | Apparatus for preparation and supply of heavy oil w/o emulsion fuel |
| US4117550A (en) | 1977-02-14 | 1978-09-26 | Folland Enertec Ltd. | Emulsifying system |
| US4091042A (en) | 1977-08-19 | 1978-05-23 | American Cyanamid Company | Continuous adiabatic process for the mononitration of benzene |
| US4130394A (en) | 1977-10-03 | 1978-12-19 | Technicon Instruments Corporation | Short sample detection |
| ZA791659B (en) | 1978-04-17 | 1980-04-30 | Ici Ltd | Process and apparatus for spraying liquid |
| SU1226392A1 (ru) | 1978-08-11 | 1986-04-23 | Научно-исследовательский институт часовой промышленности | Редуктор электронно-механических наружных часов с шаговым двигателем |
| US4210809A (en) | 1979-03-16 | 1980-07-01 | Technicon Instruments Corporation | Method and apparatus for the non-invasive determination of the characteristics of a segmented fluid stream |
| US4279345A (en) | 1979-08-03 | 1981-07-21 | Allred John C | High speed particle sorter using a field emission electrode |
| US4315754A (en) | 1979-08-28 | 1982-02-16 | Bifok Ab | Flow injection analysis with intermittent flow |
| US4266721A (en) | 1979-09-17 | 1981-05-12 | Ppg Industries, Inc. | Spray application of coating compositions utilizing induction and corona charging means |
| JPS5665627A (en) | 1979-11-05 | 1981-06-03 | Agency Of Ind Science & Technol | Method of combining particles of liquid, etc. |
| US4253846A (en) | 1979-11-21 | 1981-03-03 | Technicon Instruments Corporation | Method and apparatus for automated analysis of fluid samples |
| DE3168903D1 (en) | 1980-08-28 | 1985-03-28 | Du Pont | Flow analysis |
| GB2097692B (en) | 1981-01-10 | 1985-05-22 | Shaw Stewart P D | Combining chemical reagents |
| GB2092497B (en) | 1981-02-06 | 1985-01-16 | Honda Motor Co Ltd | Welding torch assembly |
| JPS6057907B2 (ja) | 1981-06-18 | 1985-12-17 | 工業技術院長 | 液体の混合噴霧化方法 |
| US4439980A (en) | 1981-11-16 | 1984-04-03 | The United States Of America As Represented By The Secretary Of The Navy | Electrohydrodynamic (EHD) control of fuel injection in gas turbines |
| DE3230289A1 (de) | 1982-08-14 | 1984-02-16 | Bayer Ag, 5090 Leverkusen | Herstellung von pharmazeutischen oder kosmetischen dispersionen |
| ATE41610T1 (de) | 1982-10-13 | 1989-04-15 | Ici Plc | Elektrostatische spruehanlage. |
| US4853336A (en) | 1982-11-15 | 1989-08-01 | Technicon Instruments Corporation | Single channel continuous flow system |
| CA1238900A (en) | 1982-11-15 | 1988-07-05 | Stephen Saros | Single channel continuous slug flow mixing of discrete fluid components |
| US4533634A (en) | 1983-01-26 | 1985-08-06 | Amf Inc. | Tissue culture medium |
| US4585209A (en) | 1983-10-27 | 1986-04-29 | Harry E. Aine | Miniature valve and method of making same |
| US4618476A (en) | 1984-02-10 | 1986-10-21 | Eastman Kodak Company | Capillary transport device having speed and meniscus control means |
| US4566908A (en) | 1984-02-24 | 1986-01-28 | Mita Industrial Company, Limited | Azoic pigments having a silica core |
| US4865444A (en) | 1984-04-05 | 1989-09-12 | Mobil Oil Corporation | Apparatus and method for determining luminosity of hydrocarbon fuels |
| US4675285A (en) | 1984-09-19 | 1987-06-23 | Genetics Institute, Inc. | Method for identification and isolation of DNA encoding a desired protein |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| GB8504254D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Spraying apparatus |
| GB8504916D0 (en) | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
| US4676274A (en) | 1985-02-28 | 1987-06-30 | Brown James F | Capillary flow control |
| US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5656493A (en) | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4739044A (en) | 1985-06-13 | 1988-04-19 | Amgen | Method for derivitization of polynucleotides |
| US4801529A (en) | 1985-06-18 | 1989-01-31 | Brandeis University | Methods for isolating mutant microoganisms using microcapsules coated with indicator material |
| US4963498A (en) | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| GB8604328D0 (en) | 1986-02-21 | 1986-03-26 | Ici Plc | Producing spray of droplets of liquid |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US4916070A (en) | 1986-04-14 | 1990-04-10 | The General Hospital Corporation | Fibrin-specific antibodies and method of screening for the antibodies |
| US5204112A (en) | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US4767929A (en) | 1986-10-06 | 1988-08-30 | The United States Of America As Represented By The United State Department Of Energy | Extended range radiation dose-rate monitor |
| US4767515A (en) | 1987-07-30 | 1988-08-30 | The United States Of America As Represented By The United States Department Of Energy | Surface area generation and droplet size control in solvent extraction systems utilizing high intensity electric fields |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| CA1303740C (en) | 1987-08-21 | 1992-06-16 | Kazuo Van | Optical disk for use in optical memory devices |
| JPS6489884A (en) | 1987-09-30 | 1989-04-05 | Sony Corp | White balance correction circuit |
| US4931225A (en) | 1987-12-30 | 1990-06-05 | Union Carbide Industrial Gases Technology Corporation | Method and apparatus for dispersing a gas into a liquid |
| US5180662A (en) | 1988-01-05 | 1993-01-19 | The United States Of America As Represented By The Department Of Health And Human Services | Cytotoxic T lymphocyte activation assay |
| US4856363A (en) | 1988-02-10 | 1989-08-15 | Wickes Manufacturing Company | Parking brake assembly |
| US5185099A (en) | 1988-04-20 | 1993-02-09 | Institut National De Recherche Chimique Appliquee | Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics |
| US5055390A (en) | 1988-04-22 | 1991-10-08 | Massachusetts Institute Of Technology | Process for chemical manipulation of non-aqueous surrounded microdroplets |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5498523A (en) | 1988-07-12 | 1996-03-12 | President And Fellows Of Harvard College | DNA sequencing with pyrophosphatase |
| US5096615A (en) | 1988-07-19 | 1992-03-17 | The United States Of America As Represented By The United States Department Of Energy | Solid aerosol generator |
| US5104813A (en) | 1989-04-13 | 1992-04-14 | Biotrack, Inc. | Dilution and mixing cartridge |
| US4981580A (en) | 1989-05-01 | 1991-01-01 | Coulter Corporation | Coincidence arbitration in a flow cytomery sorting system |
| NZ229355A (en) | 1989-05-31 | 1991-12-23 | Nz Ministry Forestry | Spray nozzle assembly; flexible fluid outlet within nozzle to atomise fluid |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| CA2016981C (en) | 1989-06-12 | 1994-09-27 | Mark Joseph Devaney, Jr. | Temperature control device and reaction vessel |
| AU639008B2 (en) | 1989-06-22 | 1993-07-15 | Alliance Pharmaceutical Corporation | Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| GB8917963D0 (en) | 1989-08-05 | 1989-09-20 | Scras | Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| DE3930376A1 (de) | 1989-09-12 | 1991-03-21 | Biotest Ag | Enzymimmunometrisches bestimmungsverfahren unter verwendung von peroxidase als markierungsenzym |
| ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
| US5310653A (en) | 1989-10-24 | 1994-05-10 | Board Of Regents, The University Of Texas System | Tumor marker protein and antibodies thereto for cancer risk assessment or diagnosis |
| US5093602A (en) | 1989-11-17 | 1992-03-03 | Charged Injection Corporation | Methods and apparatus for dispersing a fluent material utilizing an electron beam |
| US4941959A (en) | 1989-11-27 | 1990-07-17 | Martin Marietta Energy Systems, Inc. | Electric field-driven, magnetically-stabilized ferro-emulsion phase contactor |
| US5122360A (en) | 1989-11-27 | 1992-06-16 | Martin Marietta Energy Systems, Inc. | Method and apparatus for the production of metal oxide powder |
| US5207973A (en) | 1989-11-27 | 1993-05-04 | Martin Marietta Energy Systems, Inc. | Method and apparatus for the production of metal oxide powder |
| US5313009A (en) | 1990-01-04 | 1994-05-17 | Nrm International Technologies C.V. | Nitration process |
| US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
| JP3176607B2 (ja) | 1990-02-07 | 2001-06-18 | 群馬大学長 | 均一な液滴の形成方法 |
| DE59004556D1 (de) | 1990-02-16 | 1994-03-24 | Wagner Gmbh J | Verfahren zum Betreiben einer elektrostatischen Druckluft-Farbspritzpistole. |
| US5523162A (en) | 1990-04-03 | 1996-06-04 | Ppg Industries, Inc. | Water repellent surface treatment for plastic and coated plastic substrates |
| SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| WO1992003734A1 (en) | 1990-08-20 | 1992-03-05 | Alain De Weck | A method for measuring t-lymphocyte responses by chemiluminescent assays |
| DE476178T1 (de) | 1990-09-21 | 1992-07-23 | Bioplex Medical B.V., Vaals | Geraet zum anbringen von blutstillendem stoff auf perforierten blutgefaessen. |
| US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
| FR2669028B1 (fr) | 1990-11-13 | 1992-12-31 | Rhone Poulenc Chimie | Procede de fabrication d'oxalates doubles de terres rares et d'ammonium et leurs utilisations pour la fabrication d'oxydes de terres rares. |
| KR100236506B1 (ko) | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
| US5490505A (en) | 1991-03-07 | 1996-02-13 | Masimo Corporation | Signal processing apparatus |
| US6110700A (en) | 1991-03-11 | 2000-08-29 | The General Hospital Corporation | PRAD1 cyclin and its cDNA |
| US5262027A (en) | 1991-03-22 | 1993-11-16 | Martin Marietta Energy Systems, Inc. | Method of using an electric field controlled emulsion phase contactor |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| NZ242896A (en) | 1991-05-30 | 1996-05-28 | Blood Res Center | Apparatus and methods for analysing blood components especially leukocyte content |
| NZ264353A (en) | 1991-05-30 | 1996-05-28 | For Blood Research Inc Centre | Method of collecting or purifying leukocytes from a fluid sample, apparatus, immune response inhibitor test |
| US5460945A (en) | 1991-05-30 | 1995-10-24 | Center For Blood Research, Inc. | Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response |
| DE4119955C2 (de) | 1991-06-18 | 2000-05-31 | Danfoss As | Miniatur-Betätigungselement |
| EP0546174B1 (en) | 1991-06-29 | 1997-10-29 | Miyazaki-Ken | Monodisperse single and double emulsions and production thereof |
| GB9117191D0 (en) | 1991-08-08 | 1991-09-25 | Tioxide Chemicals Limited | Preparation of titanium derivatives |
| ES2130177T3 (es) | 1991-08-10 | 1999-07-01 | Medical Res Council | Tratamiento de poblaciones de celulas. |
| DE4143573C2 (de) | 1991-08-19 | 1996-07-04 | Fraunhofer Ges Forschung | Vorrichtung zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter, dielektrischer Teilchen |
| ES2112916T3 (es) | 1991-10-15 | 1998-04-16 | Multilyte Ltd | Ensayo de union que utiliza un reactivo marcado. |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| JP3164919B2 (ja) | 1991-10-29 | 2001-05-14 | ゼロックス コーポレーション | 二色性ボールの形成方法 |
| US6048690A (en) * | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
| US5344489A (en) | 1991-11-15 | 1994-09-06 | Manfred R. Kuehnle | Synthetic, monodispersed color pigments for the coloration of media such as printing inks, and method and apparatus for making same |
| US5612188A (en) | 1991-11-25 | 1997-03-18 | Cornell Research Foundation, Inc. | Automated, multicompartmental cell culture system |
| JP3398957B2 (ja) | 1991-12-24 | 2003-04-21 | ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Ｄｎａの特定部位の突然変異誘発 |
| US5413924A (en) | 1992-02-13 | 1995-05-09 | Kosak; Kenneth M. | Preparation of wax beads containing a reagent for release by heating |
| JP2675945B2 (ja) | 1992-02-21 | 1997-11-12 | 富士写真フイルム株式会社 | ハロゲン化銀乳剤 |
| US5241159A (en) | 1992-03-11 | 1993-08-31 | Eastman Kodak Company | Multi-zone heating for a fuser roller |
| US6107059A (en) | 1992-04-29 | 2000-08-22 | Affymax Technologies N.V. | Peptide library and screening method |
| DE69319427T2 (de) | 1992-05-01 | 1998-12-10 | Univ Pennsylvania | Analyse bei messung des durchflusswiderstandes |
| US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
| US5587128A (en) | 1992-05-01 | 1996-12-24 | The Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification devices |
| US5486335A (en) | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
| US5744366A (en) | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5397605A (en) | 1992-05-29 | 1995-03-14 | Barbieri; Girolamo | Method and apparatus for electrostatically coating a workpiece with paint |
| SE500071C2 (sv) | 1992-06-25 | 1994-04-11 | Vattenfall Utveckling Ab | Anordning för blandning av två fluider, i synnerhet vätskor med olika temperatur |
| DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
| JPH0665609A (ja) | 1992-08-25 | 1994-03-08 | Mitsubishi Materials Corp | 鉄系焼結鍛造体の製造方法 |
| RU2048522C1 (ru) | 1992-10-14 | 1995-11-20 | Институт белка РАН | Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления |
| GB9225098D0 (en) | 1992-12-01 | 1993-01-20 | Coffee Ronald A | Charged droplet spray mixer |
| US6105571A (en) | 1992-12-22 | 2000-08-22 | Electrosols, Ltd. | Dispensing device |
| IL104384A (en) | 1993-01-13 | 1996-11-14 | Yeda Res & Dev | Method for screening catalytic non-enzyme polypeptides and proteins |
| US5436149A (en) | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
| JPH06265447A (ja) | 1993-03-16 | 1994-09-22 | Hitachi Ltd | 微量反応装置およびこれを使用する微量成分測定装置 |
| DE4308839C2 (de) | 1993-03-19 | 1997-04-30 | Jordanow & Co Gmbh | Vorrichtung zum Mischen von Strömungsmedien |
| FR2703263B1 (fr) | 1993-03-31 | 1995-05-19 | Rhone Poulenc Nutrition Animal | Procédé de préparation de sphérules de principes actifs. |
| EP0620432B1 (en) | 1993-04-15 | 2004-08-25 | Zeptosens AG | Method for controlling sample introduction in microcolumn separation techniques and sampling device |
| JPH09500007A (ja) | 1993-04-19 | 1997-01-07 | スチュアート エイ コーフマン | 新規化合物生成に関するランダム化学 |
| WO1994023738A1 (en) | 1993-04-19 | 1994-10-27 | Medisorb Technologies International L.P. | Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression |
| DE69417553T2 (de) | 1993-04-22 | 1999-10-07 | Federalloy, Inc. | Sanitaereinrichtungen |
| DE69431719T2 (de) * | 1993-06-25 | 2003-09-18 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Hybridisierung und sequenzierung von nukleinsäuren |
| US7229770B1 (en) | 1998-10-01 | 2007-06-12 | The Regents Of The University Of California | YKL-40 as a marker and prognostic indicator for cancers |
| US20040091923A1 (en) | 1993-07-23 | 2004-05-13 | Bio-Rad Laboratories, Inc. | Linked linear amplification of nucleic acids |
| US5417235A (en) | 1993-07-28 | 1995-05-23 | Regents Of The University Of Michigan | Integrated microvalve structures with monolithic microflow controller |
| US5403617A (en) | 1993-09-15 | 1995-04-04 | Mobium Enterprises Corporation | Hybrid pulsed valve for thin film coating and method |
| US6776094B1 (en) | 1993-10-04 | 2004-08-17 | President & Fellows Of Harvard College | Kit For Microcontact Printing |
| US5512131A (en) | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
| WO1995011922A1 (en) | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US6165778A (en) | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
| US6316208B1 (en) | 1994-01-07 | 2001-11-13 | Memorial Sloan-Kettering Cancer Center | Methods for determining isolated p27 protein levels and uses thereof |
| DE4402038A1 (de) | 1994-01-25 | 1995-07-27 | Borries Horst Von | Durchdrückpackung |
| PH31414A (en) | 1994-02-24 | 1998-10-29 | Boehringer Ingelheim Int | Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples. |
| WO1995024929A2 (en) | 1994-03-15 | 1995-09-21 | Brown University Research Foundation | Polymeric gene delivery system |
| US5989815A (en) | 1994-03-18 | 1999-11-23 | University Of Utah Research Foundation | Methods for detecting predisposition to cancer at the MTS gene |
| GB9406171D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| JPH07270319A (ja) | 1994-03-30 | 1995-10-20 | Mochida Pharmaceut Co Ltd | ヘテロポリ酸を用いたアデニル基含有物質の測定方法 |
| US5587081A (en) | 1994-04-26 | 1996-12-24 | Jet-Tech, Inc. | Thermophilic aerobic waste treatment process |
| FR2720943B1 (fr) | 1994-06-09 | 1996-08-23 | Applic Transferts Technolo | Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples. |
| GB9411671D0 (en) | 1994-06-10 | 1994-08-03 | Univ Singapore | Tumor diagnosis and prognosis |
| BR9502777A (pt) | 1994-06-13 | 1996-04-23 | Praxair Technology Inc | Equipamento e processo para a atomização de combustível líquido |
| US5750988A (en) | 1994-07-11 | 1998-05-12 | Hewlett-Packard Company | Orthogonal ion sampling for APCI mass spectrometry |
| US6653626B2 (en) | 1994-07-11 | 2003-11-25 | Agilent Technologies, Inc. | Ion sampling for APPI mass spectrometry |
| US5641658A (en) | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
| US6124439A (en) | 1994-08-17 | 2000-09-26 | The Rockefeller University | OB polypeptide antibodies and method of making |
| US5935331A (en) | 1994-09-09 | 1999-08-10 | Matsushita Electric Industrial Co., Ltd. | Apparatus and method for forming films |
| US5762775A (en) | 1994-09-21 | 1998-06-09 | Lockheed Martin Energy Systems, Inc. | Method for electrically producing dispersions of a nonconductive fluid in a conductive medium |
| US5680283A (en) | 1994-09-30 | 1997-10-21 | Kabushiki Kaisha Toshiba | Magnetic head and magnetic disk drive |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| JPH08153669A (ja) | 1994-11-30 | 1996-06-11 | Hitachi Ltd | 薄膜形成方法及び形成装置 |
| US5813988A (en) | 1995-02-03 | 1998-09-29 | Research Foundation | Time-resolved diffusion tomographic imaging in highly scattering turbid media |
| WO1996029629A2 (en) | 1995-03-01 | 1996-09-26 | President And Fellows Of Harvard College | Microcontact printing on surfaces and derivative articles |
| US5661222A (en) | 1995-04-13 | 1997-08-26 | Dentsply Research & Development Corp. | Polyvinylsiloxane impression material |
| WO1996034112A1 (en) | 1995-04-24 | 1996-10-31 | Chromaxome Corp. | Methods for generating and screening novel metabolic pathways |
| US5840254A (en) | 1995-06-02 | 1998-11-24 | Cdc Technologies, Inc. | Apparatus for mixing fluids for analysis |
| WO1996039212A2 (en) | 1995-06-06 | 1996-12-12 | Quantic Biomedical Partners | Wound sealant preparation and application device and method |
| US5882856A (en) | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
| US5910408A (en) | 1995-06-07 | 1999-06-08 | The General Hospital Corporation | Catalytic DNA having ligase activity |
| US5756122A (en) | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
| HUP9900879A2 (hu) | 1995-06-07 | 1999-08-30 | Alliance Pharmaceutical Corp. | Fordított fluor-szénhidrogén emulziós készítmények gyógyszeradagoláshoz |
| DE69614768T2 (de) | 1995-06-14 | 2002-06-20 | Tonen Corp., Tokio/Tokyo | Emulsionsspaltung durch Mikroorganismen |
| TW293783B (enExample) | 1995-06-16 | 1996-12-21 | Ciba Geigy Ag | |
| AU6541596A (en) | 1995-06-16 | 1997-01-15 | University Of Washington | Microfabricated differential extraction device and method |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| US20020022261A1 (en) | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
| US5789206A (en) | 1995-07-07 | 1998-08-04 | Myriad Genetics, Inc. | Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes |
| EP0754738B1 (en) | 1995-07-19 | 2003-03-12 | Nippon Telegraph And Telephone Corporation | Water repellent composition, fluorocarbon polymer coating composition and coating film therefrom |
| US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| AU6691496A (en) | 1995-08-01 | 1997-02-26 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
| US5636400A (en) | 1995-08-07 | 1997-06-10 | Young; Keenan L. | Automatic infant bottle cleaner |
| JP3232525B2 (ja) | 1995-08-22 | 2001-11-26 | 信越化学工業株式会社 | 撥水処理剤 |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| EP0851938A1 (en) | 1995-09-22 | 1998-07-08 | Terragen Diversity Inc. | Method for isolating xylanase gene sequences from soil dna, compositions useful in such method and compositions obtained thereby |
| US5851769A (en) | 1995-09-27 | 1998-12-22 | The Regents Of The University Of California | Quantitative DNA fiber mapping |
| US6243373B1 (en) | 1995-11-01 | 2001-06-05 | Telecom Internet Ltd. | Method and apparatus for implementing a computer network/internet telephone system |
| US6562605B1 (en) | 1995-11-13 | 2003-05-13 | Genencor International, Inc. | Extraction of water soluble biomaterials from fluids using a carbon dioxide/surfactant mixture |
| JP3759986B2 (ja) | 1995-12-07 | 2006-03-29 | フロイント産業株式会社 | シームレスカプセルおよびその製造方法 |
| US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| US5808691A (en) | 1995-12-12 | 1998-09-15 | Cirrus Logic, Inc. | Digital carrier synthesis synchronized to a reference signal that is asynchronous with respect to a digital sampling clock |
| US5733526A (en) | 1995-12-14 | 1998-03-31 | Alliance Pharmaceutical Corp. | Hydrocarbon oil/fluorochemical preparations and methods of use |
| US5681600A (en) | 1995-12-18 | 1997-10-28 | Abbott Laboratories | Stabilization of liquid nutritional products and method of making |
| US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
| US5868322A (en) | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
| JP2975943B2 (ja) | 1996-02-20 | 1999-11-10 | 農林水産省食品総合研究所長 | エマルションの製造方法及びエマルションの製造装置 |
| US6355198B1 (en) | 1996-03-15 | 2002-03-12 | President And Fellows Of Harvard College | Method of forming articles including waveguides via capillary micromolding and microtransfer molding |
| AU2290897A (en) | 1996-04-04 | 1997-10-29 | Novartis Ag | Device for counting small particles and a sorting apparatus comprising such a device |
| EP0832436A1 (en) | 1996-04-15 | 1998-04-01 | Dade Behring Inc. | Apparatus and method for analysis |
| US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US6207397B1 (en) | 1996-04-18 | 2001-03-27 | Ariad Pharmaceuticals, Inc. | In vitro fluorescence polarization assay |
| GB9608129D0 (en) | 1996-04-19 | 1996-06-26 | Central Research Lab Ltd | Method and apparatus for diffusive transfer between immiscible fluids |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| GB9608540D0 (en) | 1996-04-25 | 1996-07-03 | Medical Res Council | Isolation of enzymes |
| ES2140998B1 (es) | 1996-05-13 | 2000-10-16 | Univ Sevilla | Procedimiento de atomizacion de liquidos. |
| US6189803B1 (en) | 1996-05-13 | 2001-02-20 | University Of Seville | Fuel injection nozzle and method of use |
| US6299145B1 (en) | 1996-05-13 | 2001-10-09 | Universidad De Sevilla | Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber |
| US6187214B1 (en) | 1996-05-13 | 2001-02-13 | Universidad De Seville | Method and device for production of components for microfabrication |
| US6405936B1 (en) | 1996-05-13 | 2002-06-18 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
| US6248378B1 (en) | 1998-12-16 | 2001-06-19 | Universidad De Sevilla | Enhanced food products |
| US6116516A (en) | 1996-05-13 | 2000-09-12 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
| US6386463B1 (en) | 1996-05-13 | 2002-05-14 | Universidad De Sevilla | Fuel injection nozzle and method of use |
| US6196525B1 (en) | 1996-05-13 | 2001-03-06 | Universidad De Sevilla | Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber |
| CA2255774C (en) | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US5726404A (en) | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch |
| US5840506A (en) | 1996-06-05 | 1998-11-24 | Thomas Jefferson University | Methods for the diagnosis and prognosis of cancer |
| US6083693A (en) | 1996-06-14 | 2000-07-04 | Curagen Corporation | Identification and comparison of protein-protein interactions that occur in populations |
| US5876771A (en) | 1996-06-20 | 1999-03-02 | Tetra Laval Holdings & Finance, Sa | Process and article for determining the residence time of a food particle |
| US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| AU726987B2 (en) | 1996-06-28 | 2000-11-30 | Caliper Life Sciences, Inc. | Electropipettor and compensation means for electrophoretic bias |
| CA2258481C (en) | 1996-06-28 | 2006-05-23 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
| CA2258489C (en) | 1996-06-28 | 2004-01-27 | Caliper Technologies Corporation | High-throughput screening assay systems in microscale fluidic devices |
| AU729537B2 (en) | 1996-06-28 | 2001-02-01 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| AU4114397A (en) | 1996-07-15 | 1998-02-09 | Kemgas Limited | Production of powders |
| US6252129B1 (en) | 1996-07-23 | 2001-06-26 | Electrosols, Ltd. | Dispensing device and method for forming material |
| US6146828A (en) | 1996-08-14 | 2000-11-14 | Exact Laboratories, Inc. | Methods for detecting differences in RNA expression levels and uses therefor |
| US6203993B1 (en) | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| JP2002503334A (ja) | 1996-09-04 | 2002-01-29 | テクニカル ユニバーシティ オブ デンマーク | 粒子の分離と分析用のマイクロフローシステム |
| US5884846A (en) | 1996-09-19 | 1999-03-23 | Tan; Hsiaoming Sherman | Pneumatic concentric nebulizer with adjustable and capillaries |
| US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| US6120666A (en) | 1996-09-26 | 2000-09-19 | Ut-Battelle, Llc | Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same |
| US5858187A (en) | 1996-09-26 | 1999-01-12 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing electrodynamic focusing on a microchip |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| CA2236867A1 (en) | 1996-09-27 | 1998-04-02 | Icos Corporation | Method to identify compounds for disrupting protein/protein interactions |
| US6140053A (en) | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US7054674B2 (en) | 1996-11-19 | 2006-05-30 | Astron Clinica Limited | Method of and apparatus for investigating tissue histology |
| GB9624003D0 (en) | 1996-11-19 | 1997-01-08 | Univ Birmingham | Method and apparatus for measurement of skin histology |
| AU746549B2 (en) | 1996-11-20 | 2002-05-02 | Becton Dickinson & Company | Microfabricated isothermal nucleic acid amplification devices and methods |
| WO1998023733A2 (en) | 1996-11-27 | 1998-06-04 | University Of Washington | Thermostable polymerases having altered fidelity |
| US6310354B1 (en) | 1996-12-03 | 2001-10-30 | Erkki Soini | Method and a device for monitoring nucleic acid amplification reactions |
| US5958703A (en) | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
| US20030104372A1 (en) | 1996-12-23 | 2003-06-05 | Pyrosequencing Ab. | Allele specific primer extension |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US20020034737A1 (en) | 1997-03-04 | 2002-03-21 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
| DK0971946T3 (da) | 1997-01-21 | 2006-10-30 | Gen Hospital Corp | Selektion af proteiner ved anvendelse af RNA-protein-fusioner |
| JPH10259038A (ja) | 1997-01-24 | 1998-09-29 | Samsung Corning Co Ltd | 耐久性撥水ガラス及びその製造方法 |
| US5890745A (en) | 1997-01-29 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Micromachined fluidic coupler |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| EP1030733A4 (en) | 1997-02-05 | 2000-08-30 | California Inst Of Techn | Microfluidic sub-millisecond mixers |
| JPH10217477A (ja) | 1997-02-07 | 1998-08-18 | Fuji Xerox Co Ltd | インクジェット記録装置 |
| EP1009802B1 (en) | 1997-02-12 | 2004-08-11 | Eugene Y. Chan | Methods for analyzimg polymers |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| US6307957B1 (en) | 1997-02-28 | 2001-10-23 | Electro-Optical Sciences Inc | Multispectral imaging and characterization of biological tissue |
| US6208749B1 (en) | 1997-02-28 | 2001-03-27 | Electro-Optical Sciences, Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
| US6081612A (en) | 1997-02-28 | 2000-06-27 | Electro Optical Sciences Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
| US6045755A (en) | 1997-03-10 | 2000-04-04 | Trega Biosciences,, Inc. | Apparatus and method for combinatorial chemistry synthesis |
| US5994068A (en) | 1997-03-11 | 1999-11-30 | Wisconsin Alumni Research Foundation | Nucleic acid indexing |
| US6023540A (en) | 1997-03-14 | 2000-02-08 | Trustees Of Tufts College | Fiber optic sensor with encoded microspheres |
| EP0975969A4 (en) | 1997-03-18 | 2002-07-31 | Chromaxome Corp | METHODS OF SORTING COMPOUNDS USING ENCAPSULATED CELLS |
| US6268165B1 (en) | 1997-03-19 | 2001-07-31 | The Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian cancer |
| US6316213B1 (en) | 1997-03-19 | 2001-11-13 | The Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian, breast and lung cancer |
| US6294344B1 (en) | 1997-03-19 | 2001-09-25 | The Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian cancer |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| JPH10288131A (ja) | 1997-04-11 | 1998-10-27 | Yanmar Diesel Engine Co Ltd | ディーゼル機関の噴射ノズル |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| US5879892A (en) | 1997-04-25 | 1999-03-09 | Ludwig Institute For Cancer Research | Leukemia associated genes |
| JP4102459B2 (ja) | 1997-05-14 | 2008-06-18 | 森下仁丹株式会社 | 生体高分子を合成するシームレスカプセルおよびその製造方法 |
| JP2002503336A (ja) | 1997-05-16 | 2002-01-29 | アルバータ リサーチ カウンシル | 微量流通システムおよびその使用方法 |
| US6004025A (en) | 1997-05-16 | 1999-12-21 | Life Technologies, Inc. | Automated liquid manufacturing system |
| US6632619B1 (en) | 1997-05-16 | 2003-10-14 | The Governors Of The University Of Alberta | Microfluidic system and methods of use |
| US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
| US20020015997A1 (en) | 1997-06-16 | 2002-02-07 | Lafferty William Michael | Capillary array-based sample screening |
| US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
| US6074879A (en) | 1997-06-23 | 2000-06-13 | Bayer Corporation | Synthetic polymer particles for use as standards and calibrators in flow cytometry |
| JP2843319B1 (ja) | 1997-06-27 | 1999-01-06 | 科学技術振興事業団 | マイクロストリップガスチャンバー高速データ収集システム及びそれを用いた試料の測定方法 |
| ES2283936T3 (es) | 1997-07-07 | 2007-11-01 | Medical Research Council | Procedimiento de clasificacion in vitro. |
| JP3557859B2 (ja) | 1997-07-15 | 2004-08-25 | コニカミノルタホールディングス株式会社 | ハロゲン化銀写真乳剤、その製造方法およびハロゲン化銀写真感光材料 |
| US6403373B1 (en) | 1997-10-10 | 2002-06-11 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| US20050037397A1 (en) | 2001-03-28 | 2005-02-17 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| US6165578A (en) | 1997-07-23 | 2000-12-26 | Matsushita Electric Industrial Co., Ltd. | Optical information recording medium and method for producing the same |
| FR2767064B1 (fr) | 1997-08-07 | 1999-11-12 | Centre Nat Rech Scient | Procede de liberation d'un principe actif contenu dans une emulsion multiple |
| US5980936A (en) | 1997-08-07 | 1999-11-09 | Alliance Pharmaceutical Corp. | Multiple emulsions comprising a hydrophobic continuous phase |
| NZ328751A (en) | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| WO2000042209A1 (en) | 1999-01-15 | 2000-07-20 | Ljl Biosystems, Inc. | Methods and apparatus for detecting polynucleotide hybridization |
| US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
| US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
| US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
| US6103537A (en) | 1997-10-02 | 2000-08-15 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
| US6511803B1 (en) | 1997-10-10 | 2003-01-28 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US6008003A (en) | 1997-10-28 | 1999-12-28 | Promega Corporation | Non-invasive diagnostic method for interstitial cystitis and bladder cancer |
| GB9723262D0 (en) | 1997-11-05 | 1998-01-07 | British Nuclear Fuels Plc | Reactions of aromatic compounds |
| US6162421A (en) | 1997-11-17 | 2000-12-19 | Revlon Consumer Products Corporation | Pigmented water-in-oil emulsion cosmetic sticks |
| US5927852A (en) | 1997-12-01 | 1999-07-27 | Minnesota Mining And Manfacturing Company | Process for production of heat sensitive dispersions or emulsions |
| US6972170B1 (en) | 1997-12-01 | 2005-12-06 | Sloan-Kettering Institute For Cancer Research | Markers for prostate cancer |
| EP1037858A1 (en) | 1997-12-17 | 2000-09-27 | Universidad de Sevilla | Device and method for creating spherical particles of uniform size |
| US5972615A (en) | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| WO1999037814A1 (en) | 1998-01-22 | 1999-07-29 | Luminex Corporation | Microparticles with multiple fluorescent signals |
| GB2334271B (en) | 1998-02-17 | 2000-09-20 | Sofitech Nv | Water based drilling fluid with shale swelling inhibiting agent and phosphonate |
| TW575562B (en) | 1998-02-19 | 2004-02-11 | Agrevo Uk Ltd | Fungicides |
| US7022821B1 (en) | 1998-02-20 | 2006-04-04 | O'brien Timothy J | Antibody kit for the detection of TADG-15 protein |
| US6064149A (en) | 1998-02-23 | 2000-05-16 | Micron Technology Inc. | Field emission device with silicon-containing adhesion layer |
| US6897018B1 (en) | 1998-02-25 | 2005-05-24 | The United States Of America As Represented By The Department Of Health And Human Services | DLC-1 gene deleted in cancers |
| US6292756B1 (en) | 1998-02-26 | 2001-09-18 | Premier Instruments, Inc. | Narrow band infrared water fraction apparatus for gas well and liquid hydrocarbon flow stream use |
| FR2776538B1 (fr) | 1998-03-27 | 2000-07-21 | Centre Nat Rech Scient | Moyens de pulverisation electrohydrodynamique |
| JP3081880B2 (ja) | 1998-03-30 | 2000-08-28 | 農林水産省食品総合研究所長 | マイクロスフィアの連続製造装置 |
| JP3109471B2 (ja) | 1998-03-31 | 2000-11-13 | 日本電気株式会社 | 洗浄・乾燥装置及び半導体装置の製造ライン |
| FI980874A7 (fi) | 1998-04-20 | 1999-10-21 | Wallac Oy | Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi |
| US6395253B2 (en) | 1998-04-23 | 2002-05-28 | The Regents Of The University Of Michigan | Microspheres containing condensed polyanionic bioactive agents and methods for their production |
| US20060269558A1 (en) | 1998-04-27 | 2006-11-30 | Murphy Gerald P | Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors |
| US5997636A (en) | 1998-05-01 | 1999-12-07 | Instrumentation Technology Associates, Inc. | Method and apparatus for growing crystals |
| DE19822674A1 (de) | 1998-05-20 | 1999-12-09 | Gsf Forschungszentrum Umwelt | Gaseinlaß für eine Ionenquelle |
| EP1190229B1 (en) | 1998-05-22 | 2011-10-26 | California Institute Of Technology | Microfabricated cell sorter |
| US6659370B1 (en) | 1998-05-25 | 2003-12-09 | Fuji Bc Engineering Co., Ltd. | Liquid spray device and cutting method |
| WO1999064836A1 (en) | 1998-06-08 | 1999-12-16 | Caliper Technologies Corp. | Microfluidic devices, systems and methods for performing integrated reactions and separations |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6576420B1 (en) | 1998-06-23 | 2003-06-10 | Regents Of The University Of California | Method for early diagnosis of, and determination of prognosis in, cancer |
| US7700568B2 (en) * | 1998-06-30 | 2010-04-20 | Sloan-Kettering Institute For Cancer Research | Uses of DNA-PK |
| JP2981547B1 (ja) | 1998-07-02 | 1999-11-22 | 農林水産省食品総合研究所長 | クロスフロー型マイクロチャネル装置及び同装置を用いたエマルションの生成または分離方法 |
| EP1100889A4 (en) | 1998-07-17 | 2002-03-06 | Mirus Corp | SURFACTANT SOLUTIONS |
| US6003794A (en) | 1998-08-04 | 1999-12-21 | Progressive Grower Technologies, Inc. | Electrostatic spray module |
| EP1102864B1 (en) | 1998-08-07 | 2006-05-24 | Cellay LLC | Gel microdrops in genetic analysis |
| US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
| CN100525876C (zh) | 1998-09-17 | 2009-08-12 | 阿德文生物系统公司 | 产生液体电喷射的方法 |
| EP2306195A3 (en) | 1998-09-18 | 2012-04-25 | Massachusetts Institute of Technology | Biological applications of semiconductor nanocrystals |
| DE19845078A1 (de) | 1998-09-30 | 2000-04-06 | Basf Ag | Farbstoffhaltige Polymerpartikel |
| CA2347182C (en) | 1998-10-13 | 2004-06-15 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
| US6591852B1 (en) | 1998-10-13 | 2003-07-15 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
| US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
| US6601613B2 (en) | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
| US6960433B1 (en) | 1998-10-19 | 2005-11-01 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| US6902892B1 (en) | 1998-10-19 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| US7022472B2 (en) | 1998-10-22 | 2006-04-04 | Diadexus, Inc. | Mutations in human MLH1 and human MSH2 genes useful in diagnosing colorectal cancer |
| US6086740A (en) | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
| US20030045491A1 (en) | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| US6614598B1 (en) | 1998-11-12 | 2003-09-02 | Institute Of Technology, California | Microlensing particles and applications |
| US6569631B1 (en) | 1998-11-12 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes |
| US6450189B1 (en) | 1998-11-13 | 2002-09-17 | Universidad De Sevilla | Method and device for production of components for microfabrication |
| US6139303A (en) | 1998-11-20 | 2000-10-31 | United Technologies Corporation | Fixture for disposing a laser blocking material in an airfoil |
| US6353226B1 (en) | 1998-11-23 | 2002-03-05 | Abbott Laboratories | Non-invasive sensor capable of determining optical parameters in a sample having multiple layers |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| US20030069601A1 (en) | 1998-12-15 | 2003-04-10 | Closys Corporation | Clotting cascade initiating apparatus and methods of use |
| US6205353B1 (en) | 1998-12-22 | 2001-03-20 | Research Foundation Of Cuny | Time-resolved optical backscattering tomographic image reconstruction in scattering turbid media |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| US6565727B1 (en) | 1999-01-25 | 2003-05-20 | Nanolytics, Inc. | Actuators for microfluidics without moving parts |
| US6600077B1 (en) | 1999-01-29 | 2003-07-29 | Board Of Trustees Operating Michigan State University | Biocatalytic synthesis of quinic acid and conversion to hydroquinone |
| US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
| GB9903841D0 (en) | 1999-02-20 | 1999-04-14 | Imp College Innovations Ltd | Diagnosis and treatment of cancer |
| AU3316600A (en) | 1999-02-22 | 2000-09-21 | Torben F. Orntoft | Gene expression in bladder tumors |
| US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| US6633031B1 (en) | 1999-03-02 | 2003-10-14 | Advion Biosciences, Inc. | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
| US6942978B1 (en) | 1999-03-03 | 2005-09-13 | The Board Of Trustees Of The University Of Arkansas | Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof |
| US6171850B1 (en) | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
| US6428053B1 (en) | 1999-03-12 | 2002-08-06 | California Institute Of Technology | Micromachined fluidic coupler and method of making the same |
| CN1181337C (zh) | 2000-08-08 | 2004-12-22 | 清华大学 | 微流体系统中实体分子的操纵方法及相关试剂盒 |
| DE19911777A1 (de) | 1999-03-17 | 2000-09-21 | Merck Patent Gmbh | Verfahren zur Herstellung von kosmetischen Formulierungen |
| JP2000271475A (ja) | 1999-03-23 | 2000-10-03 | Shinji Katsura | 油中水滴エマルジョンの微小操作による微小化学反応制御法 |
| US6174160B1 (en) | 1999-03-25 | 2001-01-16 | University Of Washington | Staged prevaporizer-premixer |
| US7153700B1 (en) | 1999-03-26 | 2006-12-26 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for diagnosing and predicting the behavior of cancer |
| AU4910300A (en) | 1999-04-08 | 2000-11-14 | Bernd Penth | Method and device for carrying out chemical and physical processes |
| US6267353B1 (en) | 1999-04-19 | 2001-07-31 | Pbm, Inc. | Self draining valve |
| US20030215821A1 (en) | 1999-04-20 | 2003-11-20 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
| KR20020005721A (ko) | 1999-04-23 | 2002-01-17 | 추후기재 | 하이 매스 전달 전기분무기 |
| US6682940B2 (en) | 1999-05-04 | 2004-01-27 | Dan A. Pankowsky | Products and methods for single parameter and multiparameter phenotyping of cells |
| WO2000068671A2 (en) | 1999-05-12 | 2000-11-16 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
| US6592821B1 (en) | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| CA2373347A1 (en) | 1999-05-17 | 2000-11-23 | Caliper Technologies Corporation | Focusing of microparticles in microfluidic systems |
| US6738502B1 (en) * | 1999-06-04 | 2004-05-18 | Kairos Scientific, Inc. | Multispectral taxonomic identification |
| US20060169800A1 (en) | 1999-06-11 | 2006-08-03 | Aradigm Corporation | Aerosol created by directed flow of fluids and devices and methods for producing same |
| CA2374232C (en) | 1999-06-11 | 2013-08-20 | Aradigm Corporation | Method for producing an aerosol |
| US6630006B2 (en) | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
| US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
| JP3623479B2 (ja) | 1999-06-22 | 2005-02-23 | テカン トレーディング アーゲー | 小型化されたインビトロ増幅アッセイを行うための装置および方法 |
| JP2003502655A (ja) | 1999-06-22 | 2003-01-21 | アジレント・テクノロジーズ・インコーポレーテッド | 微小流体デバイスの操作用装置 |
| US6210396B1 (en) | 1999-06-24 | 2001-04-03 | Medtronic, Inc. | Guiding catheter with tungsten loaded band |
| NZ533466A (en) | 1999-06-28 | 2005-10-28 | California Inst Of Techn | Microfabricated elastomeric valve and pump systems |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US7195670B2 (en) | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
| US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
| US6977145B2 (en) | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6632800B1 (en) | 1999-08-17 | 2003-10-14 | Mayo Foundation For Medical Education And Research | System for monitoring the expression of transgenes |
| WO2001014589A2 (en) | 1999-08-20 | 2001-03-01 | Luminex Corporation | Liquid array technology |
| US7163801B2 (en) | 1999-09-01 | 2007-01-16 | The Burnham Institute | Methods for determining the prognosis for cancer patients using tucan |
| US6439103B1 (en) | 1999-09-07 | 2002-08-27 | Vector Engineering Co. | Hydraulic and pneumatic cylinder construction |
| GB9921155D0 (en) | 1999-09-08 | 1999-11-10 | Medical Res Council | Selection system |
| ATE400813T1 (de) | 1999-09-10 | 2008-07-15 | Takashi Muramatsu | Tumormarker für frühes krebsstadium |
| US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| TW507305B (en) * | 1999-09-18 | 2002-10-21 | Samsung Electronics Co Ltd | Method of measuring etched state of semiconductor wafer |
| US20010050881A1 (en) | 1999-09-20 | 2001-12-13 | Depaoli David W. | Continuous flow, electrohydrodynamic micromixing apparatus and methods |
| US6998232B1 (en) | 1999-09-27 | 2006-02-14 | Quark Biotech, Inc. | Methods of diagnosing bladder cancer |
| US6890487B1 (en) | 1999-09-30 | 2005-05-10 | Science & Technology Corporation ©UNM | Flow cytometry for high throughput screening |
| DE19947496C2 (de) | 1999-10-01 | 2003-05-22 | Agilent Technologies Inc | Mikrofluidischer Mikrochip |
| US6506551B1 (en) | 1999-10-08 | 2003-01-14 | North Shore - Long Island Jewish Research Institute | CD38 as a prognostic indicator in B cell chronic lymphocytic leukemia |
| US7393634B1 (en) | 1999-10-12 | 2008-07-01 | United States Of America As Represented By The Secretary Of The Air Force | Screening for disease susceptibility by genotyping the CCR5 and CCR2 genes |
| US20030190644A1 (en) | 1999-10-13 | 2003-10-09 | Andreas Braun | Methods for generating databases and databases for identifying polymorphic genetic markers |
| AU775272B2 (en) | 1999-10-28 | 2004-07-29 | Agensys, Inc. | 36P6D5: secreted tumor antigen |
| US20020048777A1 (en) | 1999-12-06 | 2002-04-25 | Shujath Ali | Method of diagnosing monitoring, staging, imaging and treating prostate cancer |
| DE19961257C2 (de) | 1999-12-18 | 2002-12-19 | Inst Mikrotechnik Mainz Gmbh | Mikrovermischer |
| US7510707B2 (en) | 1999-12-20 | 2009-03-31 | New York University Mt. Sinai School Of Medicine | PAR, a novel marker gene for breast and prostate cancers |
| DE59904983D1 (de) | 1999-12-23 | 2003-05-15 | Muehlbauer Ernst Gmbh & Co Kg | Dynamischer Mischer für zahnärztliche Abdruckmassen |
| DE60038127T2 (de) | 2000-01-06 | 2009-03-05 | Caliper Life Sciences, Inc., Mountain View | Methoden und syteme zur überwachung intrazellulärer bindereaktionen |
| WO2001051918A1 (en) | 2000-01-12 | 2001-07-19 | Ut-Battelle, Llc | A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream |
| EP1259545A2 (en) | 2000-01-21 | 2002-11-27 | Ludwig Institute For Cancer Research | Small cell lung cancer associated antigens and uses therefor |
| US20010032053A1 (en) | 2000-01-24 | 2001-10-18 | Hielscher Andreas H. | Imaging of a scattering medium using the equation of radiative transfer |
| AU2001234779A1 (en) | 2000-02-03 | 2001-08-14 | Nanoscale Combinatorial Synthesis, Inc. | Structure identification methods using mass measurements |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US6530944B2 (en) | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US6323040B1 (en) | 2000-02-15 | 2001-11-27 | Ryan S. Raz | System for biological specimen preparation |
| US6355193B1 (en) | 2000-03-01 | 2002-03-12 | Gale Stott | Method for making a faux stone concrete panel |
| GB2359765B (en) | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
| JP2003527299A (ja) | 2000-03-10 | 2003-09-16 | フロー・フォーカシング・インコーポレーテッド | 高粘性液体を収束させることにより光ファイバを製作する方法 |
| US7485454B1 (en) | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| ITPR20000017A1 (it) | 2000-03-15 | 2001-09-15 | Lino Lanfranchi | Apparato per il controllo di contenitori, in particolare preforme |
| JP3442338B2 (ja) | 2000-03-17 | 2003-09-02 | 株式会社日立製作所 | Ｄｎａ分析装置、ｄｎａ塩基配列決定装置、ｄｎａ塩基配列決定方法、および反応モジュール |
| US20020012971A1 (en) | 2000-03-20 | 2002-01-31 | Mehta Tammy Burd | PCR compatible nucleic acid sieving medium |
| ES2264440T3 (es) | 2000-03-24 | 2007-01-01 | Micromet Ag | Amplificacion de mrna. |
| US6565010B2 (en) | 2000-03-24 | 2003-05-20 | Praxair Technology, Inc. | Hot gas atomization |
| US20010039016A1 (en) | 2000-03-27 | 2001-11-08 | Waldman Scott A. | Use of expression profiling for identifying molecular markers useful for diagnosis of metastatic cancer |
| DE10015109A1 (de) | 2000-03-28 | 2001-10-04 | Peter Walzel | Verfahren und Vorrichtungen zur Herstellung gleich großer Tropfen |
| EP1285106A2 (en) | 2000-03-31 | 2003-02-26 | Micronics, Inc. | Protein crystallization in microfluidic structures |
| US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
| WO2001077392A2 (en) | 2000-04-10 | 2001-10-18 | Matthew Ashby | Methods for the survey and genetic analysis of populations |
| US6481453B1 (en) | 2000-04-14 | 2002-11-19 | Nanostream, Inc. | Microfluidic branch metering systems and methods |
| WO2001080283A1 (en) | 2000-04-18 | 2001-10-25 | Waters Investments Limited | Improved electrospray and other lc/ms interfaces |
| JP2001301154A (ja) | 2000-04-20 | 2001-10-30 | Dainippon Printing Co Ltd | 電圧印加により表面張力が低下する液体の電界ジェットによる付着方法 |
| US6469094B1 (en) | 2000-04-28 | 2002-10-22 | Xerox Corporation | Polymerization processes |
| CN1189159C (zh) | 2000-05-05 | 2005-02-16 | 欧莱雅 | 含水溶性美容活性组分水性核的微胶囊及含其的组合物 |
| US6828098B2 (en) | 2000-05-20 | 2004-12-07 | The Regents Of The University Of Michigan | Method of producing a DNA library using positional amplification based on the use of adaptors and nick translation |
| DE10025290B4 (de) | 2000-05-22 | 2005-03-24 | Fico I.T.M. S.A. | Sonnenblenden-Außenflächen |
| US20010048900A1 (en) | 2000-05-24 | 2001-12-06 | Bardell Ronald L. | Jet vortex mixer |
| US6686184B1 (en) | 2000-05-25 | 2004-02-03 | President And Fellows Of Harvard College | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks |
| US6645432B1 (en) | 2000-05-25 | 2003-11-11 | President & Fellows Of Harvard College | Microfluidic systems including three-dimensionally arrayed channel networks |
| US6777450B1 (en) | 2000-05-26 | 2004-08-17 | Color Access, Inc. | Water-thin emulsions with low emulsifier levels |
| JP3939077B2 (ja) | 2000-05-30 | 2007-06-27 | 大日本スクリーン製造株式会社 | 基板洗浄装置 |
| US20060263888A1 (en) | 2000-06-02 | 2006-11-23 | Honeywell International Inc. | Differential white blood count on a disposable card |
| US6680178B2 (en) | 2000-06-02 | 2004-01-20 | The Regents Of The University Of California | Profiling of protease specificity using combinatorial fluorogenic substrate libraries |
| US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| US7049072B2 (en) | 2000-06-05 | 2006-05-23 | University Of South Florida | Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state |
| US6974667B2 (en) | 2000-06-14 | 2005-12-13 | Gene Logic, Inc. | Gene expression profiles in liver cancer |
| US6592321B2 (en) | 2000-08-03 | 2003-07-15 | Demag Cranes & Components Gmbh | Control and guiding device for manually operating a handling unit, and modular construction kit for making such devices of different configuration |
| FR2812942B1 (fr) * | 2000-08-08 | 2002-10-31 | Commissariat Energie Atomique | Dispositif d'imagerie de fluorescence en lumiere polarisee |
| US20040005582A1 (en) | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
| US6301055B1 (en) | 2000-08-16 | 2001-10-09 | California Institute Of Technology | Solid immersion lens structures and methods for producing solid immersion lens structures |
| US6682890B2 (en) | 2000-08-17 | 2004-01-27 | Protein Design Labs, Inc. | Methods of diagnosing and determining prognosis of colorectal cancer |
| DE10041823C2 (de) | 2000-08-25 | 2002-12-19 | Inst Mikrotechnik Mainz Gmbh | Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide |
| US20030148273A1 (en) | 2000-08-26 | 2003-08-07 | Shoulian Dong | Target enrichment and amplification |
| US6610499B1 (en) | 2000-08-31 | 2003-08-26 | The Regents Of The University Of California | Capillary array and related methods |
| JP2002071687A (ja) * | 2000-08-31 | 2002-03-12 | Canon Inc | 変異遺伝子のスクリーニング方法 |
| JP3993372B2 (ja) | 2000-09-13 | 2007-10-17 | 独立行政法人理化学研究所 | リアクタの製造方法 |
| GB0022458D0 (en) | 2000-09-13 | 2000-11-01 | Medical Res Council | Directed evolution method |
| US6739036B2 (en) | 2000-09-13 | 2004-05-25 | Fuji Machine Mfg., Co., Ltd. | Electric-component mounting system |
| AU2001296874A1 (en) | 2000-09-15 | 2002-03-26 | Envirtue Biotechnologies, Inc | Assessment of ecosystem health by evaluating multiple biomarkers in a nonhuman organism |
| WO2002023163A1 (en) | 2000-09-15 | 2002-03-21 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| DE10045586C2 (de) | 2000-09-15 | 2002-07-18 | Alstom Power Boiler Gmbh | Verfahren sowie Einrichtung zur Reinigung von Schwefeldioxid enthaltenden Rauchgasen |
| AU2001292728A1 (en) | 2000-09-18 | 2002-03-26 | Thomas Jefferson University | Compositions and methods for identifying and targeting stomach and esophageal cancer cells |
| US6775405B1 (en) | 2000-09-29 | 2004-08-10 | Koninklijke Philips Electronics, N.V. | Image registration system and method using cross-entropy optimization |
| US6508988B1 (en) | 2000-10-03 | 2003-01-21 | California Institute Of Technology | Combinatorial synthesis system |
| IL150020A0 (en) | 2000-10-10 | 2002-12-01 | Diversa Corp | High throughput or capillary-based screening for a bioactivity or biomolecule |
| JP2004537712A (ja) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | 多重細胞分析システム |
| CA2424893A1 (en) | 2000-10-19 | 2002-07-25 | Structural Genomix, Inc. | Apparatus and method for identification of crystals by in-situ x-ray diffraction |
| JP3946430B2 (ja) | 2000-10-20 | 2007-07-18 | 株式会社日立製作所 | 内燃機関のバルブタイミング制御装置 |
| GB0026424D0 (en) | 2000-10-28 | 2000-12-13 | Ncimb Ltd | Genetic analysis of microorganisms |
| WO2002040874A1 (en) | 2000-11-16 | 2002-05-23 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
| US6778724B2 (en) | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
| KR100426453B1 (ko) | 2000-11-28 | 2004-04-13 | 김진우 | 인간 자궁경부암 2 원암 유전자 및 이에 의해 코딩되는단백질, 이를 포함하는 발현벡터 및 이 벡터로 형질전환된세포 |
| US6849423B2 (en) | 2000-11-29 | 2005-02-01 | Picoliter Inc | Focused acoustics for detection and sorting of fluid volumes |
| AU2002236507A1 (en) | 2000-11-29 | 2002-06-11 | Cangen International | Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer |
| EP1385488A2 (en) | 2000-12-07 | 2004-02-04 | President And Fellows Of Harvard College | Methods and compositions for encapsulating active agents |
| US20040096515A1 (en) | 2001-12-07 | 2004-05-20 | Bausch Andreas R. | Methods and compositions for encapsulating active agents |
| AU2002239823B2 (en) | 2001-01-08 | 2008-01-17 | President And Fellows Of Harvard College | Valves and pumps for microfluidic systems and method for making microfluidic systems |
| US7279883B2 (en) | 2001-01-23 | 2007-10-09 | Lydia L. Sohn | Particle analyzer and methods for use thereof |
| KR100475649B1 (ko) | 2001-01-29 | 2005-03-10 | 배석철 | 항암활성을 나타내는 ｒｕｎｘ３ 유전자 및 그의 용도 |
| WO2002060275A1 (en) | 2001-01-31 | 2002-08-08 | Kraft Foods Holdings, Inc. | Production of capsules and particles for improvement of food products |
| ES2180405B1 (es) | 2001-01-31 | 2004-01-16 | Univ Sevilla | Dispositivo y procedimiento para producir chorros liquidos compuestos multicomponentes estacionarios y capsulas multicomponente y/o multicapa de tamaño micro y nanometrico. |
| EP1741482B1 (en) | 2001-02-23 | 2008-10-15 | Japan Science and Technology Agency | Process and apparatus for producing microcapsules |
| JP3805746B2 (ja) | 2001-02-23 | 2006-08-09 | 独立行政法人科学技術振興機構 | 液体微粒子のハンドリング方法およびその装置 |
| DE60211857T2 (de) | 2001-02-23 | 2006-12-21 | Japan Science And Technology Agency, Kawaguchi | Verfahren zur herstellung einer emulsion und vorrichtung dafür |
| US6936264B2 (en) | 2001-03-05 | 2005-08-30 | The Procter & Gamble Company | Delivery of reactive agents via multiple emulsions for use in shelf stable products |
| NO325061B1 (no) | 2001-03-06 | 2008-01-28 | Photosense As | Fremgangsmate og arrangement for bestemmelse av den optiske egenskap av et multisjiktvev |
| KR100916074B1 (ko) | 2001-03-09 | 2009-09-08 | 바이오마이크로 시스템즈, 인크. | 어레이에 대한 마이크로유체 인터페이스 방법 및인터페이스용 시스템 |
| WO2002072892A1 (en) | 2001-03-12 | 2002-09-19 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
| US6717136B2 (en) | 2001-03-19 | 2004-04-06 | Gyros Ab | Microfludic system (EDI) |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US20030064414A1 (en) | 2001-03-30 | 2003-04-03 | Benecky Michael J. | Rapid assessment of coagulation activity in whole blood |
| US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
| EP1384022A4 (en) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | NUCLEIC ACID AMPLIFICATION USING MICROFLUID DEVICES |
| US7318642B2 (en) | 2001-04-10 | 2008-01-15 | Essilor International (Compagnie Générale d'Optique) | Progressive addition lenses with reduced unwanted astigmatism |
| US7756558B2 (en) | 2004-05-24 | 2010-07-13 | Trutouch Technologies, Inc. | Apparatus and methods for mitigating the effects of foreign interferents on analyte measurements in spectroscopy |
| ATE364685T1 (de) | 2001-04-25 | 2007-07-15 | Cornell Res Foundation Inc | Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis |
| US20020164271A1 (en) | 2001-05-02 | 2002-11-07 | Ho Winston Z. | Wavelength-coded bead for bioassay and signature recogniton |
| KR101012182B1 (ko) | 2001-05-11 | 2011-02-07 | 파나소닉 주식회사 | 생체분자 기판 및 그것을 이용한 검사 및 진단의 방법 및 장치 |
| US7320027B1 (en) | 2001-05-14 | 2008-01-15 | At&T Corp. | System having generalized client-server computing |
| WO2002095362A2 (en) | 2001-05-24 | 2002-11-28 | New Objective, Inc. | Method and apparatus for feedback controlled electrospray |
| JP3570714B2 (ja) | 2001-05-24 | 2004-09-29 | 株式会社リコー | 現像剤収納容器及び画像形成装置 |
| WO2002097122A1 (en) | 2001-05-26 | 2002-12-05 | One Cell Systems, Inc. | Secretion of proteins by encapsulated cells |
| EP1262545A1 (de) | 2001-05-31 | 2002-12-04 | Direvo Biotech AG | Mikrostrukturen und deren Verwendung für die gerichtete Evolution von Biomolekülen |
| US6719840B2 (en) | 2001-06-08 | 2004-04-13 | Syrrx, Inc. | In situ crystal growth and crystallization |
| US6797056B2 (en) | 2001-06-08 | 2004-09-28 | Syrrx, Inc. | Microfluidic method employing delivery of plural different fluids to same lumen |
| GB0114854D0 (en) | 2001-06-18 | 2001-08-08 | Medical Res Council | Selective gene amplification |
| GB0114856D0 (en) | 2001-06-18 | 2001-08-08 | Medical Res Council | Selection by avidity capture |
| US6444169B1 (en) | 2001-06-18 | 2002-09-03 | Ralston Purina Company | Test-device for threshold glucose detection in urine |
| DE60239535D1 (de) | 2001-06-18 | 2011-05-05 | Rosetta Inpharmatics Llc | Diagnose und prognose von brustkrebspatientinnen |
| US7171311B2 (en) | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
| US20030015425A1 (en) | 2001-06-20 | 2003-01-23 | Coventor Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
| EP1410031A2 (en) | 2001-06-28 | 2004-04-21 | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. | Methods of preparing multicolor quantum dot tagged beads and conjugates thereof |
| US6553944B1 (en) | 2001-07-03 | 2003-04-29 | Virginia A. Allen | Wrist worn leash retaining device |
| WO2003006948A2 (en) | 2001-07-10 | 2003-01-23 | Wisconsin Alumni Research Foundation | Surface plasmon resonance imaging of micro-arrays |
| US6656267B2 (en) | 2001-07-10 | 2003-12-02 | Structural Genomix, Inc. | Tray for macromolecule crystallization and method of using the same |
| CA2353030A1 (en) | 2001-07-13 | 2003-01-13 | Willem Jager | Caster mounted reel mower |
| US7314599B2 (en) | 2001-07-17 | 2008-01-01 | Agilent Technologies, Inc. | Paek embossing and adhesion for microfluidic devices |
| EP1421365A1 (en) | 2001-07-19 | 2004-05-26 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
| WO2003008649A1 (en) | 2001-07-20 | 2003-01-30 | Board Of Regents, The University Of Texas System | Methods and compositions relating to hpv-associated pre-cancerous and cancerous growths, including cin |
| US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
| WO2003011443A2 (en) | 2001-07-27 | 2003-02-13 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| US7700293B2 (en) | 2001-08-02 | 2010-04-20 | The Regents Of The University Of Michigan | Expression profile of prostate cancer |
| CA2456334A1 (en) | 2001-08-16 | 2003-02-27 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Molecular characteristics of non-small cell lung cancer |
| WO2003015890A1 (en) | 2001-08-20 | 2003-02-27 | President And Fellows Of Harvard College | Fluidic arrays and method of using |
| US6520425B1 (en) | 2001-08-21 | 2003-02-18 | The University Of Akron | Process and apparatus for the production of nanofibers |
| JP2003053996A (ja) | 2001-08-22 | 2003-02-26 | Canon Inc | インク供給機構および該インク供給機構を備えたインクジェット記録装置 |
| WO2003021227A2 (en) | 2001-09-05 | 2003-03-13 | The Children's Hospital Of Philadelphia | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors |
| US7390463B2 (en) | 2001-09-07 | 2008-06-24 | Corning Incorporated | Microcolumn-based, high-throughput microfluidic device |
| DE10145568A1 (de) | 2001-09-14 | 2003-04-03 | Knoell Hans Forschung Ev | Verfahren zur Kultivierung und Analyse mikrobieller Einzelzellkulturen |
| FR2829948B1 (fr) | 2001-09-21 | 2004-07-09 | Commissariat Energie Atomique | Procede de deplacement d'un fluide d'interet dans un capillaire et microsysteme fluidique |
| DE10149725B4 (de) | 2001-10-09 | 2004-04-15 | Promos Technologies, Inc. | Anisotroper Herstellungsprozess von Oxidschichten in einem Substratgraben |
| AU2002360272A1 (en) | 2001-10-10 | 2003-04-22 | Superarray Bioscience Corporation | Detecting targets by unique identifier nucleotide tags |
| US7179420B2 (en) | 2001-10-25 | 2007-02-20 | Techelan, Llc | Apparatus comprising a particle sorter/dispenser and method therefor |
| US6670142B2 (en) | 2001-10-26 | 2003-12-30 | The Regents Of The University Of California | Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells |
| US20040076966A1 (en) | 2001-10-30 | 2004-04-22 | J. Brian Windsor | Method and system for the co-isolation of cognate DNA, RNA and protein sequences and method for screening co-isolates for defined activities |
| US6464336B1 (en) | 2001-10-31 | 2002-10-15 | Eastman Kodak Company | Ink jet printing with color-balanced ink drops mixed using bleached ink |
| US7308364B2 (en) | 2001-11-07 | 2007-12-11 | The University Of Arkansas For Medical Sciences | Diagnosis of multiple myeloma on gene expression profiling |
| US7371736B2 (en) | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| EP1451365A4 (en) | 2001-11-13 | 2006-09-13 | Rubicon Genomics Inc | DNA AMPLIFICATION AND SEQUENCING WITH DNA MOLECULES CREATED BY RANDOM FRAGMENTATION |
| JP2003149136A (ja) | 2001-11-13 | 2003-05-21 | Shimadzu Corp | 光画像計測方法 |
| WO2003044232A1 (en) | 2001-11-16 | 2003-05-30 | The Johns Hopkins University School Of Medicine | Method of detection of prostate cancer |
| GB0127564D0 (en) | 2001-11-16 | 2002-01-09 | Medical Res Council | Emulsion compositions |
| US7163790B2 (en) | 2001-11-28 | 2007-01-16 | Bio-Rad Laboratories, Inc. | Parallel polymorphism scoring by amplification and error correction |
| WO2003048295A1 (en) | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Microfluidic device and methods of using same |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| GB0129374D0 (en) | 2001-12-07 | 2002-01-30 | Univ Brunel | Test apparatus |
| US6800849B2 (en) | 2001-12-19 | 2004-10-05 | Sau Lan Tang Staats | Microfluidic array devices and methods of manufacture and uses thereof |
| US6949342B2 (en) | 2001-12-21 | 2005-09-27 | Whitehead Institute For Biomedical Research | Prostate cancer diagnosis and outcome prediction by expression analysis |
| US20030198972A1 (en) | 2001-12-21 | 2003-10-23 | Erlander Mark G. | Grading of breast cancer |
| US20030144260A1 (en) | 2002-01-03 | 2003-07-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method |
| US20050064423A1 (en) | 2002-01-08 | 2005-03-24 | Toshiro Higuchi | Pcr method by electrostatic transportation, hybridization method for electrostatic transportation and devices therefor |
| US20050079501A1 (en) * | 2002-01-25 | 2005-04-14 | Hisashi Koike | Method and apparatus for detecting nucleic acid data |
| JP2003222633A (ja) | 2002-01-30 | 2003-08-08 | Nippon Sheet Glass Co Ltd | マイクロチップ |
| US7341211B2 (en) | 2002-02-04 | 2008-03-11 | Universidad De Sevilla | Device for the production of capillary jets and micro-and nanometric particles |
| WO2003067217A2 (en) | 2002-02-08 | 2003-08-14 | Integriderm, Inc. | Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays |
| EP1490411B1 (en) | 2002-02-11 | 2009-01-21 | Rhodia Chimie | Method for controlling the stability of emulsions and stabilized emulsions |
| US7101467B2 (en) | 2002-03-05 | 2006-09-05 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems |
| WO2003076052A1 (en) | 2002-03-05 | 2003-09-18 | Caliper Life Sciences, Inc. | Mixed mode microfluidic systems |
| DK2258872T3 (da) | 2002-03-13 | 2013-11-18 | Genomic Health Inc | Genekspressionsprofilering i biopsier af tumorvæv |
| EP1488006B1 (en) | 2002-03-20 | 2008-05-28 | InnovativeBio.Biz | Microcapsules with controlable permeability encapsulating a nucleic acid amplification reaction mixture and their use as reaction compartments for parallels reactions |
| US7348142B2 (en) | 2002-03-29 | 2008-03-25 | Veridex, Lcc | Cancer diagnostic panel |
| WO2003085379A2 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US7147763B2 (en) | 2002-04-01 | 2006-12-12 | Palo Alto Research Center Incorporated | Apparatus and method for using electrostatic force to cause fluid movement |
| GB0207533D0 (en) | 2002-04-02 | 2002-05-08 | Oxford Glycosciences Uk Ltd | Protein |
| JPWO2003085399A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 白血病、前白血病または非白血病性悪性血液疾患の判定方法及び診断薬 |
| US6976590B2 (en) | 2002-06-24 | 2005-12-20 | Cytonome, Inc. | Method and apparatus for sorting particles |
| CN101078718A (zh) | 2002-05-08 | 2007-11-28 | 松下电器产业株式会社 | 含生物分子珠粒的管和使用它的分析装置 |
| US7901939B2 (en) | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
| US7129091B2 (en) | 2002-05-09 | 2006-10-31 | University Of Chicago | Device and method for pressure-driven plug transport and reaction |
| ATE486043T1 (de) | 2002-05-20 | 2010-11-15 | Danisco Us Inc | Peptidderivate und deren verwendung zur synthese von verbundwerkstoffen auf siliciumbasis |
| US20040018525A1 (en) | 2002-05-21 | 2004-01-29 | Bayer Aktiengesellschaft | Methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasma |
| US20030219754A1 (en) | 2002-05-23 | 2003-11-27 | Oleksy Jerome E. | Fluorescence polarization detection of nucleic acids |
| US7314567B2 (en) | 2002-05-24 | 2008-01-01 | Protolife Srl. | Method for transferring heterogeneous liquids in microchannels without the occurrence of mixing |
| WO2003101401A2 (en) | 2002-06-03 | 2003-12-11 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
| US7218959B2 (en) | 2002-06-05 | 2007-05-15 | Research Foundation Of City University | Hybrid-dual-fourier tomographic algorithm for a fast three-dimensionial optical image reconstruction in turbid media |
| JP3883060B2 (ja) | 2002-06-17 | 2007-02-21 | 株式会社リガク | 結晶評価装置 |
| US7776348B2 (en) | 2002-06-26 | 2010-08-17 | L'oreal S.A. | Water-in-oil emulsion foundation |
| JP2006507921A (ja) | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| US20050019776A1 (en) | 2002-06-28 | 2005-01-27 | Callow Matthew James | Universal selective genome amplification and universal genotyping system |
| US7244961B2 (en) | 2002-08-02 | 2007-07-17 | Silicon Valley Scientific | Integrated system with modular microfluidic components |
| US7150412B2 (en) | 2002-08-06 | 2006-12-19 | Clean Earth Technologies Llc | Method and apparatus for electrostatic spray |
| EP2607369B1 (en) | 2002-08-23 | 2015-09-23 | Illumina Cambridge Limited | Modified nucleotides for polynucleotide sequencing |
| GB0220063D0 (en) | 2002-08-29 | 2002-10-09 | Isis Innovation | Magnetic particle and process for preparation |
| AU2003288902A1 (en) | 2002-09-06 | 2004-04-08 | Genteric, Inc. | Microcapsules and methods of use |
| GB0221053D0 (en) | 2002-09-11 | 2002-10-23 | Medical Res Council | Single-molecule in vitro evolution |
| CA2498713A1 (en) | 2002-09-17 | 2004-04-01 | Richard Abraham Joseph | Real-time detection of nucleic acid reactions |
| US7078681B2 (en) | 2002-09-18 | 2006-07-18 | Agilent Technologies, Inc. | Multimode ionization source |
| US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| US7357937B2 (en) | 2002-09-24 | 2008-04-15 | Therox, Inc. | Perfluorocarbon emulsions with non-fluorinated surfactants |
| DE60229890D1 (de) | 2002-09-30 | 2008-12-24 | Hoffmann La Roche | Oligonukleotide zur genotypisierung des thymidylat-synthase gens |
| US6966990B2 (en) | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
| EP1585583B1 (en) | 2002-10-23 | 2010-04-07 | The Trustees of Princeton University | Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields |
| US20040136497A1 (en) | 2002-10-30 | 2004-07-15 | Meldrum Deirdre R | Preparation of samples and sample evaluation |
| WO2004039489A2 (en) | 2002-11-01 | 2004-05-13 | Cellectricon Ab | Computer programs,workstations, systems and methods for microfluidic substrates in cell |
| US20040086892A1 (en) * | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Universal tag assay |
| GB2395196B (en) | 2002-11-14 | 2006-12-27 | Univ Cardiff | Microfluidic device and methods for construction and application |
| US20060003333A1 (en) | 2002-11-19 | 2006-01-05 | Singulex, Inc. | Preparation of defined highly labeled probes |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| JP2004354364A (ja) | 2002-12-02 | 2004-12-16 | Nec Corp | 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法 |
| US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| AU2003294377A1 (en) | 2002-12-18 | 2004-07-29 | Ciphergen Biosystems, Inc. | Serum biomarkers in lung cancer |
| NZ541234A (en) | 2002-12-20 | 2008-06-30 | Amgen Inc | Asthma and allergic inflammation modulators |
| EP1587940A4 (en) * | 2002-12-20 | 2006-06-07 | Caliper Life Sciences Inc | SINGLE MOLECULAR AMPLIFICATION AND DNA PROOF |
| US20050042639A1 (en) | 2002-12-20 | 2005-02-24 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA length |
| US8275554B2 (en) | 2002-12-20 | 2012-09-25 | Caliper Life Sciences, Inc. | System for differentiating the lengths of nucleic acids of interest in a sample |
| WO2004061085A2 (en) | 2002-12-30 | 2004-07-22 | The Regents Of The University Of California | Methods and apparatus for pathogen detection and analysis |
| AU2004205898B2 (en) | 2003-01-17 | 2009-11-19 | The Research Foundation Of State University Of New York | Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods |
| US20040142329A1 (en) * | 2003-01-17 | 2004-07-22 | Ingeneus Corporation | Probe conjugation to increase multiplex binding motif preference |
| WO2004065628A1 (en) | 2003-01-21 | 2004-08-05 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| WO2004066941A2 (en) | 2003-01-24 | 2004-08-12 | Bayer Pharmaceuticals Corporation | Expression profiles for colon cancer and methods of use |
| US6832787B1 (en) | 2003-01-24 | 2004-12-21 | Sandia National Laboratories | Edge compression manifold apparatus |
| CA2513889A1 (en) | 2003-01-29 | 2004-08-19 | 454 Corporation | Double ended sequencing |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| US7595195B2 (en) | 2003-02-11 | 2009-09-29 | The Regents Of The University Of California | Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles |
| DE10307227A1 (de) | 2003-02-14 | 2004-08-26 | Cytocentrics Ccs Gmbh | Verfahren und Vorrichtung zum Kontaktieren einer Mikrofluidstruktur |
| US7361474B2 (en) | 2003-02-24 | 2008-04-22 | United States Of America As Represented By The Department Of Veterans Affairs | Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer |
| WO2004075734A2 (en) | 2003-02-25 | 2004-09-10 | Inlight Solutions, Inc. | DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION |
| JP2007524374A (ja) | 2003-02-28 | 2007-08-30 | プレキシコン，インコーポレーテッド | Ｐｙｋ２結晶構造および使用 |
| EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
| WO2004092708A2 (en) | 2003-03-07 | 2004-10-28 | University Of North Carolina At Chapel Hill | Methods for the electrochemical detection of target compounds |
| US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
| US7045040B2 (en) | 2003-03-20 | 2006-05-16 | Asm Nutool, Inc. | Process and system for eliminating gas bubbles during electrochemical processing |
| ITTO20030222A1 (it) | 2003-03-25 | 2004-09-26 | Giuseppe Bonfiglio | Dispositivo per la generazione casuale di numeri e/o codici. |
| KR100620303B1 (ko) | 2003-03-25 | 2006-09-13 | 도요다 지도샤 가부시끼가이샤 | 가스저장탱크 및 그 제조방법 |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US6926313B1 (en) | 2003-04-02 | 2005-08-09 | Sandia National Laboratories | High pressure capillary connector |
| EP3023140B1 (en) | 2003-04-10 | 2019-10-09 | President and Fellows of Harvard College | Formation and control of fluidic species |
| US7378233B2 (en) | 2003-04-12 | 2008-05-27 | The Johns Hopkins University | BRAF mutation T1796A in thyroid cancers |
| CA2525029A1 (en) | 2003-05-02 | 2004-11-18 | Health Research, Inc. | Use of jag2 expression in diagnosis of plasma cell disorders |
| US20050095611A1 (en) | 2003-05-02 | 2005-05-05 | Chan Daniel W. | Identification of biomarkers for detecting pancreatic cancer |
| US7262059B2 (en) | 2003-05-06 | 2007-08-28 | Thrombodyne, Inc. | Systems and methods for measuring fluid properties |
| WO2004102204A1 (en) | 2003-05-16 | 2004-11-25 | Global Technologies (Nz) Ltd | Method and apparatus for mixing sample and reagent in a suspension fluid |
| DE10322893A1 (de) | 2003-05-19 | 2004-12-16 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Vorrichtung und Verfahren zum Zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten |
| DE112004001376D2 (de) | 2003-05-19 | 2006-04-13 | Knoell Hans Forschung Ev | Vorrichtung und Verfahren zur Strukturierung von Flüssigkeiten und zum zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten |
| JP4466991B2 (ja) | 2003-05-22 | 2010-05-26 | 英明 森山 | 結晶成長装置及び方法 |
| US7544506B2 (en) | 2003-06-06 | 2009-06-09 | Micronics, Inc. | System and method for heating, cooling and heat cycling on microfluidic device |
| WO2004111641A2 (en) | 2003-06-12 | 2004-12-23 | University Of Manitoba | Methods for detecting cancer and monitoring cancer progression |
| EP3170906B1 (en) | 2003-06-24 | 2018-08-22 | Genomic Health, Inc. | Prediction of likelihood of cancer recurrence |
| JP2005037346A (ja) | 2003-06-25 | 2005-02-10 | Aisin Seiki Co Ltd | マイクロ流体制御システム |
| JP2007527699A (ja) | 2003-06-26 | 2007-10-04 | エグゾニ・テラピューティック・ソシエテ・アノニム | 前立腺特異的遺伝子、ならびにその前立腺癌治療および診断のための標的としての使用 |
| US7115230B2 (en) | 2003-06-26 | 2006-10-03 | Intel Corporation | Hydrodynamic focusing devices |
| JP2005016482A (ja) | 2003-06-27 | 2005-01-20 | Aisin Seiki Co Ltd | 弁開閉時期制御装置 |
| AU2003903296A0 (en) | 2003-06-30 | 2003-07-10 | Raustech Pty Ltd | Chemical compositions of matter |
| GB0315438D0 (en) | 2003-07-02 | 2003-08-06 | Univ Manchester | Analysis of mixed cell populations |
| CA2531105C (en) | 2003-07-05 | 2015-03-17 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| BRPI0412725B8 (pt) | 2003-07-17 | 2021-07-27 | Pacific Edge Biotechnology Ltd | marcadores para detecção de câncer gástrico |
| US20050014165A1 (en) | 2003-07-18 | 2005-01-20 | California Pacific Medical Center | Biomarker panel for colorectal cancer |
| US20070065810A1 (en) | 2003-07-18 | 2007-03-22 | Georgetown University | Diagnosis and treatment of cervical cancer |
| EP1654066B1 (en) | 2003-07-31 | 2014-11-12 | Handylab, Inc. | Processing particle-containing samples |
| US8114978B2 (en) | 2003-08-05 | 2012-02-14 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| US20050032238A1 (en) | 2003-08-07 | 2005-02-10 | Nanostream, Inc. | Vented microfluidic separation devices and methods |
| US7473531B1 (en) | 2003-08-08 | 2009-01-06 | Colora Corporation | Pancreatic cancer targets and uses thereof |
| CN104069784B (zh) | 2003-08-27 | 2017-01-11 | 哈佛大学 | 流体物种的电子控制 |
| US7745221B2 (en) | 2003-08-28 | 2010-06-29 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
| EP1663497B2 (en) | 2003-09-05 | 2020-03-25 | Stokes Bio Limited | A microfluidic analysis system |
| CA2537955A1 (en) | 2003-09-05 | 2005-03-17 | Royal Women's Hospital | Diagnostic marker for ovarian cancer |
| CA2536949A1 (en) | 2003-09-08 | 2005-03-24 | Health Research, Inc. | Detection of 13q14 chromosomal alterations |
| US7354706B2 (en) | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| ATE461292T1 (de) | 2003-09-10 | 2010-04-15 | Althea Technologies Inc | Erstellung von expressionsprofilen unter verwendung von mikroarrays |
| US7504214B2 (en) | 2003-09-19 | 2009-03-17 | Biotheranostics, Inc. | Predicting outcome with tamoxifen in breast cancer |
| WO2005029041A2 (en) * | 2003-09-19 | 2005-03-31 | Applera Corporation | High density sequence detection methods and apparatus |
| AU2004274724B2 (en) | 2003-09-22 | 2009-09-10 | Trisogen Biotechnology Limited Partnership | Methods and kits useful for detecting an alteration in a locus copy number |
| US20060269971A1 (en) | 2003-09-26 | 2006-11-30 | Mount Sinai Hospital | Methods for detecting prostate cancer |
| JP2007533971A (ja) | 2003-09-30 | 2007-11-22 | シンギュレックス・インコーポレイテッド | 粒子検出の分析精度を改善する方法 |
| US7332280B2 (en) | 2003-10-14 | 2008-02-19 | Ronald Levy | Classification of patients having diffuse large B-cell lymphoma based upon gene expression |
| US20050221341A1 (en) | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
| US7204431B2 (en) | 2003-10-31 | 2007-04-17 | Agilent Technologies, Inc. | Electrospray ion source for mass spectroscopy |
| WO2005041884A2 (en) | 2003-10-31 | 2005-05-12 | Engineered Release Systems, Inc | Polymer-based microstructures |
| CN101039951A (zh) | 2003-11-03 | 2007-09-19 | 基因信息公司 | 肝癌生物标志物 |
| GB0325653D0 (en) | 2003-11-03 | 2003-12-10 | Medical Res Council | CST emulsions |
| EP1694869A2 (en) | 2003-11-10 | 2006-08-30 | Investigen, Inc. | Methods of preparing nucleic acid for detection |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US20050103690A1 (en) | 2003-11-19 | 2005-05-19 | Aisin Seiki Kabushiki Kaisha | Micro liquid control system |
| WO2005049787A2 (en) * | 2003-11-24 | 2005-06-02 | Yeda Research And Development Co.Ltd. | Compositions and methods for in vitro sorting of molecular and cellular libraries |
| US8632994B2 (en) | 2003-12-01 | 2014-01-21 | Dako Denmark A/S | Methods and compositions for immuno-histochemical detection |
| AU2004312893B2 (en) | 2003-12-31 | 2010-06-17 | President And Fellows Of Harvard College | Assay device and method |
| JP4437202B2 (ja) | 2004-01-09 | 2010-03-24 | 学校法人慶應義塾 | 色素沈着部位の遠隔診療システム |
| US7389879B2 (en) | 2004-01-21 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Sorting particles |
| US7569662B2 (en) | 2004-01-27 | 2009-08-04 | Compugen Ltd | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer |
| WO2005084116A2 (en) | 2004-01-27 | 2005-09-15 | Compugen Usa, Inc. | Calcium channel variants |
| ES2432040T3 (es) | 2004-01-28 | 2013-11-29 | 454 Life Sciences Corporation | Amplificación de ácido nucleico con emulsión de flujo continuo |
| US20050186215A1 (en) | 2004-02-04 | 2005-08-25 | Kwok Tim T. | CUDR as biomarker for cancer progression and therapeutic response |
| US20060195266A1 (en) | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
| WO2005084109A2 (en) | 2004-03-08 | 2005-09-15 | Medigen Biotechnology Corporation | Cancer specific gene mh15 |
| KR100552706B1 (ko) | 2004-03-12 | 2006-02-20 | 삼성전자주식회사 | 핵산 증폭 방법 및 장치 |
| TW200600785A (en) | 2004-03-23 | 2006-01-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancer |
| KR20080075045A (ko) | 2004-03-24 | 2008-08-13 | 트리패스 이미징, 인코포레이티드 | 자궁경부 질환의 검사 방법 및 조성물 |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| KR100885177B1 (ko) * | 2004-04-12 | 2009-02-23 | 학교법인 포항공과대학교 | 표적 ｄｎａ 또는 ｒｎａ 탐지용 올리고뉴클레오티드 |
| US7665393B2 (en) | 2004-04-22 | 2010-02-23 | Black & Decker Inc. | Table saw guard |
| WO2005103106A1 (en) | 2004-04-23 | 2005-11-03 | Eugenia Kumacheva | Method of producing polymeric particles with selected size, shape, morphology and composition |
| AU2005241093B2 (en) | 2004-05-04 | 2008-06-05 | Institute Of Virology Of Slovak Academy Of Sciences | MN/CA IX/ CA9 and renal cancer prognosis |
| US7622281B2 (en) | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
| US7828175B2 (en) | 2004-05-21 | 2010-11-09 | Pepsico, Inc. | Beverage dispensing system with a head capable of dispensing plural different beverages |
| CA2566806A1 (en) | 2004-05-25 | 2006-01-19 | Helicos Biosciences Corporation | Methods and devices for nucleic acid sequence determination |
| US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
| US20090008253A1 (en) | 2004-06-04 | 2009-01-08 | Crystal Vision Microsystems Llc | Device and Process for Continuous On-Chip Flow Injection Analysis |
| WO2006009910A2 (en) | 2004-06-17 | 2006-01-26 | The Regents Of The University Of California | Time-resolved optometric fluorescence detection for skin diagnostics |
| US7991557B2 (en) | 2004-06-19 | 2011-08-02 | Genenews Corporation | Computer system and methods for constructing biological classifiers and uses thereof |
| US20070154889A1 (en) | 2004-06-25 | 2007-07-05 | Veridex, Llc | Methods and reagents for the detection of melanoma |
| US7655470B2 (en) | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
| US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
| WO2006002641A1 (en) | 2004-07-02 | 2006-01-12 | Versamatrix A/S | Spherical radiofrequency-encoded beads |
| WO2006010047A2 (en) | 2004-07-09 | 2006-01-26 | Tripath Imaging, Inc. | Methods and compositions for the detection of ovarian cancer |
| US7670792B2 (en) | 2004-07-14 | 2010-03-02 | The Regents Of The University Of California | Biomarkers for early detection of ovarian cancer |
| US20060100788A1 (en) | 2004-07-14 | 2006-05-11 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| EP1985715A3 (en) | 2004-07-16 | 2008-12-31 | Oncomethylome Sciences, S.A. | ESR1 and cervical cancer |
| GB0416038D0 (en) | 2004-07-16 | 2004-08-18 | Portland Press Ltd | Document display system |
| US20060078475A1 (en) | 2004-07-29 | 2006-04-13 | Yu-Chong Tai | Modular microfluidic packaging system |
| US7405002B2 (en) | 2004-08-04 | 2008-07-29 | Agency For Science, Technology And Research | Coated water-soluble nanoparticles comprising semiconductor core and silica coating |
| JP2006058652A (ja) | 2004-08-20 | 2006-03-02 | Toshiba Corp | トナー |
| US7759111B2 (en) | 2004-08-27 | 2010-07-20 | The Regents Of The University Of California | Cell encapsulation microfluidic device |
| CN101052468B (zh) | 2004-09-09 | 2012-02-01 | 居里研究所 | 采用共线电场的微流控装置 |
| US20060068398A1 (en) | 2004-09-24 | 2006-03-30 | Cepheid | Universal and target specific reagent beads for nucleic acid amplification |
| JPWO2006035773A1 (ja) | 2004-09-30 | 2008-05-15 | 日本碍子株式会社 | 液滴吐出圧電デバイス |
| US7698287B2 (en) | 2004-09-30 | 2010-04-13 | Microsoft Corporation | Design of spreadsheet functions for working with tables of data |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US20060078894A1 (en) | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
| WO2006052823A2 (en) | 2004-11-05 | 2006-05-18 | The Regents Of The University Of California | Biomarkers for prostate cancer metastasis |
| US7416851B2 (en) | 2004-11-08 | 2008-08-26 | Institut Pasteur | Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of LPL/ADAM genes |
| US20130071836A9 (en) | 2004-11-08 | 2013-03-21 | Sungwhan An | Colon cancer biomarker discovery |
| WO2006051552A2 (en) | 2004-11-15 | 2006-05-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Directed evolution and selection using in vitro compartmentalization |
| WO2006060653A2 (en) | 2004-11-30 | 2006-06-08 | Veridex Llc | Lung cancer prognostics |
| US20070016078A1 (en) | 2004-12-06 | 2007-01-18 | Hoyt Clifford C | Systems and methods for in-vivo optical imaging and measurement |
| US20060160762A1 (en) | 2004-12-13 | 2006-07-20 | Children's Medical Center Corporation | Methods for the treatment, diagnosis, and prognosis of cancer |
| EP1838732A4 (en) | 2005-01-07 | 2010-07-14 | Univ Johns Hopkins | BIOMARKER FOR MELANOME |
| US7392908B2 (en) | 2005-01-12 | 2008-07-01 | Beckman Coulter, Inc. | Methods and apparatus for sorting particles hydraulically |
| WO2006078841A1 (en) | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
| ES2425568T3 (es) | 2005-01-21 | 2013-10-16 | Verisante Technology, Inc. | Método y aparato para la medición de cambios cancerosos a partir de mediciones espectrales de reflectancia obtenidas durante la toma de imágenes endoscópicas |
| US7442507B2 (en) | 2005-01-24 | 2008-10-28 | New York University School Of Medicine | Methods for detecting circulating mutant BRAF DNA |
| AU2006207954A1 (en) | 2005-01-28 | 2006-08-03 | Childrens Medical Center Corporation | Methods for diagnosis and prognosis of epithelial cancers |
| EP2272983A1 (en) | 2005-02-01 | 2011-01-12 | AB Advanced Genetic Analysis Corporation | Reagents, methods and libraries for bead-based sequencing |
| JP4047336B2 (ja) | 2005-02-08 | 2008-02-13 | 独立行政法人科学技術振興機構 | ゲル電極付セルソーターチップ |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| US7407757B2 (en) | 2005-02-10 | 2008-08-05 | Population Genetics Technologies | Genetic analysis by sequence-specific sorting |
| CA2597271A1 (en) | 2005-02-16 | 2006-08-24 | Dana-Farber Cancer Institute | Methods of detecting ovarian cancer |
| AU2006216925A1 (en) | 2005-02-17 | 2006-08-31 | Children's Medical Center Corporation | ADAMTS-7 as a biomarker for cancers of epithelial origin |
| KR101544351B1 (ko) | 2005-02-18 | 2015-08-13 | 캐논 유.에스. 라이프 사이언시즈, 인크. | 유기체의 게놈 ｄｎａ를 확인하기 위한 장치 및 방법 |
| CN101120252A (zh) | 2005-02-18 | 2008-02-06 | 儿童医疗中心有限公司 | 作为生物标记物用于上皮来源的癌症的诊断和预后的cyr61 |
| US7666595B2 (en) | 2005-02-25 | 2010-02-23 | The Brigham And Women's Hospital, Inc. | Biomarkers for predicting prostate cancer progression |
| WO2006092959A1 (ja) | 2005-03-01 | 2006-09-08 | Rohm Co., Ltd | マイクロ流路及びマイクロ流体チップ |
| CN101133529A (zh) | 2005-03-04 | 2008-02-27 | 独立行政法人科学技术振兴机构 | 宽带光放大器 |
| US9039273B2 (en) | 2005-03-04 | 2015-05-26 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
| US20070054119A1 (en) | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
| JP5069214B2 (ja) | 2005-03-11 | 2012-11-07 | ヴァーミリオン インコーポレイテッド | 卵巣癌及び子宮内膜癌のバイオマーカー：ヘプシジン |
| FR2882939B1 (fr) | 2005-03-11 | 2007-06-08 | Centre Nat Rech Scient | Dispositif de separation fluidique |
| US20060234264A1 (en) | 2005-03-14 | 2006-10-19 | Affymetrix, Inc. | Multiplex polynucleotide synthesis |
| US20060269934A1 (en) | 2005-03-16 | 2006-11-30 | Applera Corporation | Compositions and methods for clonal amplification and analysis of polynucleotides |
| EP1877762B1 (en) | 2005-04-06 | 2011-10-19 | President and Fellows of Harvard College | Molecular characterization with carbon nanotube control |
| US7918244B2 (en) | 2005-05-02 | 2011-04-05 | Massachusetts Institute Of Technology | Microfluidic bubble logic devices |
| US7570988B2 (en) | 2005-05-02 | 2009-08-04 | Wisconsin Alumni Research Foundation | Method for extraction of optical properties from diffuse reflectance spectra |
| US8084001B2 (en) | 2005-05-02 | 2011-12-27 | Cornell Research Foundation, Inc. | Photoluminescent silica-based sensors and methods of use |
| US7473530B2 (en) | 2005-05-04 | 2009-01-06 | Wayne State University | Method to detect lung cancer |
| WO2006122310A2 (en) | 2005-05-11 | 2006-11-16 | The Trustess Of The University Of Pennsylvania | System for testing |
| JP2008539759A (ja) | 2005-05-11 | 2008-11-20 | ナノリティックス・インコーポレイテッド | 多数の温度で生化学的又は化学的な反応を実施する方法及び装置 |
| WO2007021343A2 (en) | 2005-05-18 | 2007-02-22 | Cornell Research Foundation, Inc. | Pharmacokinetic-based culture system with biological barriers |
| US20090317798A1 (en) * | 2005-06-02 | 2009-12-24 | Heid Christian A | Analysis using microfluidic partitioning devices |
| US8407013B2 (en) | 2005-06-07 | 2013-03-26 | Peter K. Rogan | AB initio generation of single copy genomic probes |
| US7368242B2 (en) | 2005-06-14 | 2008-05-06 | Affymetrix, Inc. | Method and kits for multiplex hybridization assays |
| US7494776B2 (en) | 2005-07-07 | 2009-02-24 | Beckman Coulter, Inc. | Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands |
| US20070026439A1 (en) | 2005-07-15 | 2007-02-01 | Applera Corporation | Fluid processing device and method |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| FR2888912B1 (fr) | 2005-07-25 | 2007-08-24 | Commissariat Energie Atomique | Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif |
| US7632562B2 (en) | 2005-08-04 | 2009-12-15 | Eastman Kodak Company | Universal print media |
| JP4756948B2 (ja) | 2005-08-08 | 2011-08-24 | ベイバイオサイエンス株式会社 | フローサイトメータおよびフローサイトメトリ方法 |
| FR2893626B1 (fr) | 2005-11-18 | 2008-01-04 | Inst Francais Du Petrole | Fluide de puits comprenant une phase liquide fluoree |
| US7955864B2 (en) | 2005-08-22 | 2011-06-07 | Life Technologies Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
| JP5149184B2 (ja) | 2005-09-01 | 2013-02-20 | キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド | ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置 |
| WO2007026884A1 (ja) | 2005-09-02 | 2007-03-08 | Pola Chemical Industries Inc. | 皮膚の状態の判定方法及び皮膚の厚みの予測方法 |
| US7556776B2 (en) | 2005-09-08 | 2009-07-07 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
| US20090098057A1 (en) | 2007-10-16 | 2009-04-16 | Shiying Zheng | Silica-cored carrier particle |
| WO2007033385A2 (en) | 2005-09-13 | 2007-03-22 | Fluidigm Corporation | Microfluidic assay devices and methods |
| US8734003B2 (en) | 2005-09-15 | 2014-05-27 | Alcatel Lucent | Micro-chemical mixing |
| GB2429385C (en) | 2005-09-23 | 2008-04-24 | Astron Clinica Ltd | Image processing method and apparatus. |
| EP1948816B1 (en) | 2005-10-24 | 2011-12-07 | The Johns Hopkins University | Improved methods for beaming |
| CN101351708A (zh) | 2005-11-02 | 2009-01-21 | 拜尔健康护理有限责任公司 | 癌症的预测和预后以及监控癌症治疗的方法 |
| US20120021930A1 (en) | 2005-11-22 | 2012-01-26 | Stichting Dienst Landbouwkundig Onderzoek | Multiplex Nucleic Acid Detection |
| US7358231B1 (en) | 2005-12-01 | 2008-04-15 | Applera Corporation | Pancreatic cancer secreted targets and uses thereof |
| US7846664B2 (en) | 2005-12-07 | 2010-12-07 | The Regents Of The University Of California | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) |
| ATE481505T1 (de) | 2005-12-12 | 2010-10-15 | Us Gov Health & Human Serv | Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren |
| ES2277785B1 (es) | 2005-12-21 | 2008-06-16 | Oryzon Genomics, S.A. | Metodo de analisis de expresion diferencial en cancer colorectal. |
| CN101341410A (zh) | 2005-12-21 | 2009-01-07 | 霍夫曼—拉罗奇有限公司 | 通过测量粪便样品中血红蛋白和m2-pk的评定结肠直肠癌的方法 |
| EP2363205A3 (en) | 2006-01-11 | 2014-06-04 | Raindance Technologies, Inc. | Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors |
| US7544473B2 (en) | 2006-01-23 | 2009-06-09 | Population Genetics Technologies Ltd. | Nucleic acid analysis using sequence tokens |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| EP1987360B1 (en) | 2006-01-27 | 2012-03-07 | Tripath Imaging, Inc. | Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor |
| WO2007089541A2 (en) | 2006-01-27 | 2007-08-09 | President And Fellows Of Harvard College | Fluidic droplet coalescence |
| HUE030215T2 (en) * | 2006-02-02 | 2017-04-28 | Univ Leland Stanford Junior | Non-invasive fetal genetic screening by digital analysis |
| US8735169B2 (en) | 2006-02-07 | 2014-05-27 | Stokes Bio Limited | Methods for analyzing agricultural and environmental samples |
| EP2298438A1 (en) | 2006-02-07 | 2011-03-23 | Stokes Bio Limited | A microfluidic droplet queuing network |
| NZ570008A (en) | 2006-02-09 | 2011-10-28 | Univ South Florida | Detection of ovarian cancer by elevated levels of Bcl-2 in urine |
| DK1991698T3 (en) | 2006-03-01 | 2014-03-10 | Keygene Nv | "High-throughput" -sekvensbaseret detection of SNPs using ligeringsassays |
| WO2007103770A2 (en) | 2006-03-02 | 2007-09-13 | Ppd Biomarker Discovery Sciences, Llc | Compositions and methods for analyzing renal cancer |
| US20080058432A1 (en) | 2006-03-03 | 2008-03-06 | Yixin Wang | Molecular assay to predict recurrence of Duke's B colon cancer |
| JP2009530457A (ja) | 2006-03-21 | 2009-08-27 | ディーエスエム アイピー アセッツ ビー．ブイ． | 架橋ポリマーを含む微粒子 |
| EP2674435A3 (en) | 2006-03-24 | 2014-04-30 | Phenomenome Discoveries Inc. | Biomarkers useful for diagnosing prostate cancer, and methods thereof |
| US20090181864A1 (en) | 2006-03-31 | 2009-07-16 | Nam Trung Nguyen | Active control for droplet-based microfluidics |
| US7578219B2 (en) | 2006-03-31 | 2009-08-25 | Proxene Tools Co., Ltd. | Adjustable spanner with electronic strain gauge function |
| WO2007123744A2 (en) | 2006-03-31 | 2007-11-01 | Solexa, Inc. | Systems and devices for sequence by synthesis analysis |
| US8492168B2 (en) | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| US8613889B2 (en) | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| US7282337B1 (en) | 2006-04-14 | 2007-10-16 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
| US7815871B2 (en) | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US7702468B2 (en) * | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US20070259368A1 (en) | 2006-05-03 | 2007-11-08 | Genomictree, Inc. | Gastric cancer biomarker discovery |
| EP2530168B1 (en) | 2006-05-11 | 2015-09-16 | Raindance Technologies, Inc. | Microfluidic Devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2007135368A2 (en) | 2006-05-18 | 2007-11-29 | Solexa Limited | Dye compounds and the use of their labelled conjugates |
| WO2007140319A1 (en) | 2006-05-26 | 2007-12-06 | Meltzer Stephen J | Methylated promoters as biomarkers of colon cancer |
| WO2007140015A2 (en) | 2006-05-26 | 2007-12-06 | Althea Technologies, Inc | Biochemical analysis of partitioned cells |
| FR2901717A1 (fr) | 2006-05-30 | 2007-12-07 | Centre Nat Rech Scient | Procede de traitement de gouttes dans un circuit microfluidique. |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| CA2656022C (en) | 2006-06-19 | 2017-10-17 | The Johns Hopkins University | Single-molecule pcr on microparticles in water-in-oil emulsions |
| KR100813169B1 (ko) | 2006-07-21 | 2008-03-17 | 삼성전자주식회사 | 기울임을 갖는 광 센서 모듈 및 상기 광 센서 모듈을구비한 체지방 측정 장치 |
| WO2008011709A1 (en) | 2006-07-24 | 2008-01-31 | Miraculins Inc. | Biomarkers for use in the diagnosis and treatment of colorectal cancer |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| US20080050723A1 (en) | 2006-08-23 | 2008-02-28 | Nabil Belacel | Molecular method for diagnosis of colon cancer |
| EP2061909A2 (en) * | 2006-08-24 | 2009-05-27 | Illumina Cambridge Limited | Method for retaining even coverage of short insert libraries |
| WO2008026719A1 (en) | 2006-08-31 | 2008-03-06 | Toyo Seikan Kaisha, Ltd. | Nucleic acid amplification method |
| US7811778B2 (en) | 2006-09-06 | 2010-10-12 | Vanderbilt University | Methods of screening for gastrointestinal cancer |
| DE102006042040B4 (de) | 2006-09-07 | 2013-04-18 | Siemens Audiologische Technik Gmbh | Verfahren zur Anpassung eines Hörgeräts unter Verwendung eines genetischen Merkmals und Anordnung zur Durchführung des Verfahrens |
| US20080081330A1 (en) | 2006-09-28 | 2008-04-03 | Helicos Biosciences Corporation | Method and devices for analyzing small RNA molecules |
| CA2665053C (en) | 2006-09-29 | 2016-08-23 | The Administrators Of The Tulane Educational Fund | Methods and devices for simultaneously monitoring the characteristics of microscopic particles in suspension and the characteristics of soluble components during reactions |
| EP2074225B1 (en) | 2006-10-10 | 2014-12-03 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations |
| TWM319361U (en) | 2006-10-20 | 2007-09-21 | Tai Sol Electronics Co Ltd | Flexible heat pipe |
| US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
| WO2008069906A2 (en) | 2006-11-14 | 2008-06-12 | The Regents Of The University Of California | Digital expression of gene analysis |
| WO2008058384A1 (en) | 2006-11-15 | 2008-05-22 | University Health Network | Materials and methods for prognosing lung cancer survival |
| JP5743403B2 (ja) * | 2006-11-29 | 2015-07-01 | キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | デジタル式マルチプレックスｐｃｒアッセイに関する機器及び方法 |
| WO2008073290A1 (en) | 2006-12-08 | 2008-06-19 | The Board Of Trustees Of The University Of Arkansas | Tp53 gene expression and uses thereof |
| WO2008073856A2 (en) | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
| TW200825414A (en) | 2006-12-08 | 2008-06-16 | Univ Nat Taiwan | Biomarker molecule of gastrointestinal disease and measurement method thereof |
| US20100093107A1 (en) | 2006-12-14 | 2010-04-15 | University Of Massachusetts | Polymer-protein substrates for immunosorbent fluorescence assays |
| EP2639578B1 (en) | 2006-12-14 | 2016-09-14 | Life Technologies Corporation | Apparatus for measuring analytes using large scale fet arrays |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| CA2673017C (en) | 2006-12-21 | 2015-08-04 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| US8338166B2 (en) | 2007-01-04 | 2012-12-25 | Lawrence Livermore National Security, Llc | Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture |
| US20080171078A1 (en) | 2007-01-12 | 2008-07-17 | Mark Gray | Uniformly sized liposomes |
| US7807393B2 (en) | 2007-01-29 | 2010-10-05 | Northwestern University | Biomarkers for prostate cancer |
| WO2008093098A2 (en) * | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| EP2115161A4 (en) | 2007-02-02 | 2010-12-15 | Orion Genomics Llc | GENETIC METHYLATION IN THE DIAGNOSIS OF CANCERS |
| KR20100028526A (ko) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 및 나노유체 장치, 시스템 및 응용 |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US9029085B2 (en) | 2007-03-07 | 2015-05-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
| WO2008112193A1 (en) | 2007-03-12 | 2008-09-18 | Dana-Farber Cancer Institute | Prognostic, diagnostic, and cancer therapeutic uses of fanci and fanci modulating agents |
| EP2136786B8 (en) | 2007-03-28 | 2012-11-14 | President and Fellows of Harvard College | Apparatus for forming droplets |
| EP2479552B1 (en) | 2007-04-02 | 2015-09-02 | Acoustic Cytometry Systems, Inc. | Methods for enhanced analysis of acoustic field focused cells and particles |
| US20090062144A1 (en) | 2007-04-03 | 2009-03-05 | Nancy Lan Guo | Gene signature for prognosis and diagnosis of lung cancer |
| US8290625B2 (en) | 2007-04-04 | 2012-10-16 | Beckman Coulter, Inc. | Flow cytometer sorter |
| US10062107B1 (en) | 2007-04-18 | 2018-08-28 | Jacky Benmoha | Consolidated trading platform |
| WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US8691164B2 (en) | 2007-04-20 | 2014-04-08 | Celula, Inc. | Cell sorting system and methods |
| US20100130369A1 (en) | 2007-04-23 | 2010-05-27 | Advanced Liquid Logic, Inc. | Bead-Based Multiplexed Analytical Methods and Instrumentation |
| WO2008137772A1 (en) | 2007-05-04 | 2008-11-13 | Dermtech International | Diagnosis of melanoma by nucleic acid analysis |
| US7901888B2 (en) | 2007-05-09 | 2011-03-08 | The Regents Of The University Of California | Multigene diagnostic assay for malignant thyroid neoplasm |
| US20090029372A1 (en) | 2007-05-14 | 2009-01-29 | Kobenhavns Universitet | Adam12 as a biomarker for bladder cancer |
| WO2008150432A1 (en) | 2007-06-01 | 2008-12-11 | 454 Life Sciences Corporation | System and meth0d for identification of individual samples from a multiplex mixture |
| WO2009045579A2 (en) | 2007-06-14 | 2009-04-09 | The Regents Of The University Of California | Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics |
| US7820386B2 (en) | 2007-06-15 | 2010-10-26 | National Defense Medical Center | Cancer screening method |
| JP5282088B2 (ja) | 2007-06-21 | 2013-09-04 | ジェン−プロウブ インコーポレイテッド | 処理実行に使用する機器および容器 |
| CN101855553B (zh) | 2007-06-29 | 2014-06-11 | 韩国安国药品株式会社 | 卵巢癌的预测标记 |
| US20090017463A1 (en) | 2007-07-10 | 2009-01-15 | Vanderbilt University | Methods for predicting prostate cancer recurrence |
| WO2009011808A1 (en) | 2007-07-13 | 2009-01-22 | President And Fellows Of Harvard College | Droplet-based selection |
| AU2008276027B2 (en) | 2007-07-16 | 2014-09-04 | California Institute Of Technology | Arrays, substrates, devices, methods and systems for detecting target molecules |
| DE102007034020A1 (de) | 2007-07-20 | 2009-01-22 | Biotronik Crm Patent Ag | Aktives Element und Batterie sowie Verfahren zur Herstellung derselben |
| HUE061020T2 (hu) * | 2007-07-23 | 2023-05-28 | Univ Hong Kong Chinese | Nukleinsav-szekvencia kiegyensúlyozatlanságának meghatározására |
| US8454906B2 (en) | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| EP2178641B1 (en) | 2007-08-09 | 2018-04-11 | Progenity, Inc. | Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material |
| WO2009029229A2 (en) | 2007-08-24 | 2009-03-05 | President And Fellows Of Harvard College | Ferrofluid emulsions, particles, and systems and methods for making and using the same |
| WO2009032974A2 (en) | 2007-09-06 | 2009-03-12 | Tripath Imaging, Inc. | Nucleic acid-based methods for the detection of ovarian cancer |
| JP5707132B2 (ja) | 2007-09-07 | 2015-04-22 | フルイダイム コーポレイション | コピー数変動の決定、方法およびシステム |
| EP2188386A2 (en) | 2007-09-17 | 2010-05-26 | Universite De Strasbourg | Method for detecting or quantifying a truncating mutation |
| EP2201143B2 (en) | 2007-09-21 | 2016-08-24 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| WO2009049214A2 (en) | 2007-10-12 | 2009-04-16 | Northwestern University | Inhibition and treatment of prostate cancer metastasis |
| US20100086914A1 (en) | 2008-10-03 | 2010-04-08 | Roche Molecular Systems, Inc. | High resolution, high throughput hla genotyping by clonal sequencing |
| WO2009049889A1 (en) * | 2007-10-16 | 2009-04-23 | Roche Diagnostics Gmbh | High resolution, high throughput hla genotyping by clonal sequencing |
| US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| WO2009059430A1 (en) * | 2007-11-07 | 2009-05-14 | The University Of British Columbia | Microfluidic device and method of using same |
| US7923517B2 (en) | 2007-11-09 | 2011-04-12 | Ricoh Company, Ltd. | Polymer microparticles and production method for the same |
| US8462269B2 (en) | 2007-11-16 | 2013-06-11 | Mediatek Inc. | Devices and methods for extracting a synchronization signal from a video signal |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| EP2247638A1 (en) | 2007-12-20 | 2010-11-10 | DSM IP Assets B.V. | Hybrid polyurethane block copolymers with thermoplastic processability and thermoset properties |
| EP2235210B1 (en) * | 2007-12-21 | 2015-03-25 | President and Fellows of Harvard College | Methods for nucleic acid sequencing |
| JPWO2009081967A1 (ja) * | 2007-12-26 | 2011-05-06 | アークレイ株式会社 | 標的核酸配列の増幅方法およびそれに用いるプローブ |
| US9170060B2 (en) | 2008-01-22 | 2015-10-27 | Lawrence Livermore National Security, Llc | Rapid microfluidic thermal cycler for nucleic acid amplification |
| US20090226971A1 (en) | 2008-01-22 | 2009-09-10 | Neil Reginald Beer | Portable Rapid Microfluidic Thermal Cycler for Extremely Fast Nucleic Acid Amplification |
| WO2009117485A2 (en) | 2008-03-18 | 2009-09-24 | Balter, Inc. | Optical method for determining morphological parameters and physiological properties of tissue |
| EP2238449B1 (en) | 2008-01-24 | 2018-06-06 | Balter, Inc. | Method for discriminating between malignant and benign tissue lesions |
| US9487822B2 (en) | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
| US20090246788A1 (en) * | 2008-04-01 | 2009-10-01 | Roche Nimblegen, Inc. | Methods and Assays for Capture of Nucleic Acids |
| JP2009265751A (ja) | 2008-04-22 | 2009-11-12 | Oki Electric Ind Co Ltd | 文字認識装置、光学式文字認識システム及び文字認識プログラム |
| US9664619B2 (en) | 2008-04-28 | 2017-05-30 | President And Fellows Of Harvard College | Microfluidic device for storage and well-defined arrangement of droplets |
| US20110104725A1 (en) | 2008-05-02 | 2011-05-05 | Advanced Liquid Logic, Inc. | Method of Effecting Coagulation in a Droplet |
| US8852952B2 (en) | 2008-05-03 | 2014-10-07 | Advanced Liquid Logic, Inc. | Method of loading a droplet actuator |
| WO2009137606A1 (en) * | 2008-05-06 | 2009-11-12 | Tethys Bioscience, Inc. | Methods for use with nanoreactors |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| US20100124759A1 (en) | 2008-06-27 | 2010-05-20 | Massachusetts Institute Of Technology | Microfluidic droplets for metabolic engineering and other applications |
| UA102854C2 (ru) | 2008-06-30 | 2013-08-27 | Микробикс Байосистемз Инк. | Способ и устройство для сортирования клеток |
| US7888034B2 (en) * | 2008-07-01 | 2011-02-15 | 454 Life Sciences Corporation | System and method for detection of HIV tropism variants |
| US20110274706A1 (en) | 2010-05-04 | 2011-11-10 | General Electric Company | Nucleic acid delivery vehicle and uses thereof |
| WO2010005593A1 (en) | 2008-07-11 | 2010-01-14 | President And Fellows Of Harvard College | Systems and methods of droplet-based selection |
| FR2934050B1 (fr) | 2008-07-15 | 2016-01-29 | Univ Paris Curie | Procede et dispositif de lecture d'une emulsion |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US20100035252A1 (en) | 2008-08-08 | 2010-02-11 | Ion Torrent Systems Incorporated | Methods for sequencing individual nucleic acids under tension |
| PL3663411T3 (pl) | 2008-08-12 | 2022-02-07 | Stokes Bio Limited | Sposoby do cyfrowego pcr |
| US9180453B2 (en) | 2008-08-15 | 2015-11-10 | University Of Washington | Method and apparatus for the discretization and manipulation of sample volumes |
| WO2010021936A1 (en) | 2008-08-16 | 2010-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Digital pcr calibration for high throughput sequencing |
| WO2010027442A1 (en) | 2008-08-26 | 2010-03-11 | Becton, Dickinson And Company | Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis cytotoxin gene |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US20110218123A1 (en) | 2008-09-19 | 2011-09-08 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| EP2331763A1 (en) | 2008-10-02 | 2011-06-15 | Jerome O. Blomberg | Curbless multiple skylight system and smoke vent system |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US8546128B2 (en) | 2008-10-22 | 2013-10-01 | Life Technologies Corporation | Fluidics system for sequential delivery of reagents |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US9080211B2 (en) | 2008-10-24 | 2015-07-14 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
| WO2010056728A1 (en) | 2008-11-11 | 2010-05-20 | Helicos Biosciences Corporation | Nucleic acid encoding for multiplex analysis |
| IE20090904A1 (en) | 2008-11-26 | 2010-07-07 | Univ College Cork Nat Univ Ie | A process for preparing microparticles |
| US9404924B2 (en) | 2008-12-04 | 2016-08-02 | Massachusetts Institute Of Technology | Method of performing one-step, single cell RT-PCR |
| EP3587594B1 (en) | 2008-12-19 | 2022-04-13 | President and Fellows of Harvard College | Particle-assisted nucleic acid sequencing |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| EP2389455A4 (en) | 2009-01-26 | 2012-12-05 | Verinata Health Inc | METHODS AND COMPOSITIONS FOR IDENTIFYING A FETAL CELL |
| JP5382852B2 (ja) | 2009-02-06 | 2014-01-08 | 株式会社オンチップ・バイオテクノロジーズ | 使い捨てチップ型フローセルとそれを用いたフローサイトメーター |
| JP5457222B2 (ja) | 2009-02-25 | 2014-04-02 | エフ．ホフマン−ラ ロシュ アーゲー | 小型化ハイスループット核酸分析 |
| JP2010198393A (ja) | 2009-02-26 | 2010-09-09 | Alpine Electronics Inc | 地図表示装置 |
| US8481698B2 (en) | 2009-03-19 | 2013-07-09 | The President And Fellows Of Harvard College | Parallel proximity ligation event analysis |
| EP2230312A1 (en) | 2009-03-19 | 2010-09-22 | Helmholtz-Zentrum für Infektionsforschung GmbH | Probe compound for detecting and isolating enzymes and means and methods using the same |
| US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| DK2414547T3 (da) | 2009-04-02 | 2014-06-16 | Fluidigm Corp | Multiprimer-amplifikationsmetode til stregkodning af målnukleinsyrer |
| CN101892291A (zh) | 2009-05-08 | 2010-11-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种用于生物分子多重靶标检测的通用标签、探针及检测方法 |
| FR2945545B1 (fr) | 2009-05-14 | 2011-08-05 | Univ Aix Marseille Ii | Methode de detection d'adn procaryote extrait d'un echantillon de selles |
| US8673627B2 (en) | 2009-05-29 | 2014-03-18 | Life Technologies Corporation | Apparatus and methods for performing electrochemical reactions |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| EP4019977B1 (en) | 2009-06-26 | 2024-11-20 | President and Fellows of Harvard College | Fluid injection |
| CN102459630B (zh) | 2009-06-29 | 2014-04-30 | 株式会社东芝 | 样本分析方法和用于该方法的检测试剂盒 |
| SG177395A1 (en) | 2009-07-07 | 2012-02-28 | Agency Science Tech & Res | Methods of identifying a pair of binding partners |
| US9364831B2 (en) | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
| US20130288254A1 (en) | 2009-08-13 | 2013-10-31 | Advanced Liquid Logic, Inc. | Droplet Actuator and Droplet-Based Techniques |
| US9493822B2 (en) | 2009-09-01 | 2016-11-15 | Koninklijke Philips Electronics N.V. | Devices and methods for microarray selection |
| CA2767056C (en) | 2009-09-02 | 2018-12-04 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
| US9625454B2 (en) | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US9243290B2 (en) | 2009-10-09 | 2016-01-26 | Stc.Unm | Polony sequencing methods |
| EP2504448B1 (en) | 2009-11-25 | 2016-10-19 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| EP2336354A1 (en) | 2009-12-18 | 2011-06-22 | Roche Diagnostics GmbH | A method for the detection of a RNA molecule, a kit and a use related thereof |
| WO2011087789A2 (en) | 2009-12-22 | 2011-07-21 | Becton, Dickinson And Company | Methods for the detection of microorganisms |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| CA2786916A1 (en) | 2010-01-15 | 2011-07-21 | The University Of British Columbia | Multiplex amplification for the detection of nucleic acid variations |
| CN102753955B (zh) | 2010-01-15 | 2015-02-04 | 芯片生物技术株式会社 | 一次性芯片型流动室与利用其的细胞分选仪 |
| US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9494520B2 (en) | 2010-02-12 | 2016-11-15 | Raindance Technologies, Inc. | Digital analyte analysis |
| US20110257031A1 (en) | 2010-02-12 | 2011-10-20 | Life Technologies Corporation | Nucleic acid, biomolecule and polymer identifier codes |
| US9366632B2 (en) * | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ， インコーポレイテッド | デジタル検体分析 |
| JP5901046B2 (ja) | 2010-02-19 | 2016-04-06 | 国立大学法人 千葉大学 | ＯＡＴＰ１Ｂ３ｍＲＮＡの新規な選択的スプライシングバリアント |
| DK2539450T3 (da) | 2010-02-25 | 2016-05-30 | Advanced Liquid Logic Inc | Fremgangsmåde til fremstilling af nukleinsyrebiblioteker |
| US20110223314A1 (en) | 2010-03-10 | 2011-09-15 | Xiaoxiao Zhang | Efficient microencapsulation |
| CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
| WO2011141703A1 (en) | 2010-05-12 | 2011-11-17 | Protiva Biotherapeutics Inc. | Compositions and methods for silencing apolipoprotein b |
| JP2013531983A (ja) | 2010-06-11 | 2013-08-15 | パソジェニカ，インコーポレイテッド | 多重生物検出のための核酸ならびにその使用および製造方法 |
| CN103069006A (zh) | 2010-07-23 | 2013-04-24 | 艾索特里克斯遗传实验室有限责任公司 | 区别表达的胚胎或母源基因组区的鉴定及其用途 |
| US8821304B2 (en) | 2010-07-28 | 2014-09-02 | Whitewater West Industries Ltd. | Water eruption effect and interactive water play structure |
| GB2482911A (en) | 2010-08-20 | 2012-02-22 | Sphere Fluidics Ltd | Microdroplet emulsion system |
| EP2617061B1 (en) | 2010-09-15 | 2021-06-30 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP2625320B1 (en) | 2010-10-08 | 2019-03-27 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| DK2625295T3 (da) | 2010-10-08 | 2019-06-11 | Harvard College | High-throughput-immunsekvensering |
| US20120088691A1 (en) | 2010-10-08 | 2012-04-12 | Gao Chen | Highly multiplexed real-time pcr using encoded microbeads |
| US20130225623A1 (en) | 2010-10-27 | 2013-08-29 | Mount Sinai School Of Medicine | Methods of Treating Psychiatric or Neurological Disorders with MGLUR Antagonists |
| US8829171B2 (en) | 2011-02-10 | 2014-09-09 | Illumina, Inc. | Linking sequence reads using paired code tags |
| US9074251B2 (en) | 2011-02-10 | 2015-07-07 | Illumina, Inc. | Linking sequence reads using paired code tags |
| US8278711B2 (en) | 2010-11-23 | 2012-10-02 | General Electric Company | Semiconductor device and method of making the same |
| ES2615733T3 (es) | 2010-12-16 | 2017-06-08 | Gigagen, Inc. | Métodos para el análisis masivo paralelo de ácidos nucleicos en células individuales |
| US20120167142A1 (en) | 2010-12-23 | 2012-06-28 | Eldon Technology Limited | Methods and apparatuses to facilitate preselection of programming preferences |
| EP2659002B1 (en) | 2010-12-27 | 2017-02-01 | Abbott Molecular Inc. | Quantitating high titer samples by digital pcr |
| US20120164633A1 (en) | 2010-12-27 | 2012-06-28 | Ibis Biosciences, Inc. | Digital droplet sequencing |
| MX337700B (es) | 2011-01-26 | 2016-03-16 | Firestone Ind Products Co Llc | Pistón de muelle de gas así como un montaje de muelle de gas, sistema de suspensión, equipo y método que incluyen los mismos. |
| US20120244043A1 (en) | 2011-01-28 | 2012-09-27 | Sean Leblanc | Elastomeric gasket for fluid interface to a microfluidic chip |
| JP6069224B2 (ja) | 2011-01-31 | 2017-02-01 | アプライズ バイオ， インコーポレイテッド | 細胞において複数のエピトープを同定する方法 |
| WO2012106668A2 (en) | 2011-02-03 | 2012-08-09 | Fluidigm Corporation | Multifunctional probe-primers |
| EP2673380B1 (en) | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| EP2673382B1 (en) | 2011-02-11 | 2020-05-06 | Bio-Rad Laboratories, Inc. | Thermocycling device for nucleic acid amplification and methods of use |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| AU2012231098B2 (en) | 2011-03-18 | 2016-09-29 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| JP5711583B2 (ja) | 2011-03-28 | 2015-05-07 | 株式会社タムラ製作所 | リフロー装置 |
| WO2012139125A2 (en) | 2011-04-07 | 2012-10-11 | Life Technologies Corporation | System and methods for making and processing emulsions |
| AU2012242847B2 (en) | 2011-04-15 | 2017-01-19 | The Johns Hopkins University | Safe sequencing system |
| US9110026B2 (en) | 2011-05-05 | 2015-08-18 | Biopico Systems Inc | Microfluidic devices and methods based on massively parallel picoreactors for cell and molecular diagnostics |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
| US20130178378A1 (en) * | 2011-06-09 | 2013-07-11 | Andrew C. Hatch | Multiplex digital pcr |
| US9150916B2 (en) | 2011-06-24 | 2015-10-06 | Beat Christen | Compositions and methods for identifying the essential genome of an organism |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| FR2978498B1 (fr) | 2011-07-28 | 2018-03-02 | Valeo Equipements Electriques Moteur | Circuit de demarreur de vehicule automobile comportant un dispositif de rehaussement de tension et demarreur equipe |
| US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
| EP2753715A4 (en) | 2011-09-09 | 2015-05-20 | Univ Leland Stanford Junior | METHOD FOR OBTAINING A SEQUENCE |
| WO2013056241A2 (en) * | 2011-10-14 | 2013-04-18 | Pacific Biosciences Of California, Inc. | Real-time redox sequencing |
| US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
| WO2013101783A2 (en) | 2011-12-30 | 2013-07-04 | Bio-Rad Laboratories, Inc. | Methods and compositions for performing nucleic acid amplification reactions |
| US9701959B2 (en) | 2012-02-02 | 2017-07-11 | Invenra Inc. | High throughput screen for biologically active polypeptides |
| WO2013120089A1 (en) | 2012-02-10 | 2013-08-15 | Raindance Technologies, Inc. | Molecular diagnostic screening assay |
| US20130210638A1 (en) | 2012-02-10 | 2013-08-15 | Jeffrey Charles Olson | Methods for sequencing nucleic acid |
| EP2817418B1 (en) | 2012-02-24 | 2017-10-11 | Raindance Technologies, Inc. | Labeling and sample preparation for sequencing |
| EP2844768B1 (en) | 2012-04-30 | 2019-03-13 | Raindance Technologies, Inc. | Digital analyte analysis |
| US20160115532A1 (en) | 2012-08-10 | 2016-04-28 | Sequenta, Inc. | High sensitivity mutation detection using sequence tags |
| US9790546B2 (en) | 2012-08-31 | 2017-10-17 | Roche Molecular Systems, Inc. | Microfluidic chip, device and system for the generation of aqueous droplets in emulsion oil for nucleic acid amplification |
| US10752945B2 (en) | 2012-09-12 | 2020-08-25 | The Regents Of The University Of California | Accurate genome sequencing of single cells by single-stranded amplification and sequencing |
| US9783841B2 (en) | 2012-10-04 | 2017-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of target nucleic acids in a cellular sample |
| US9840734B2 (en) | 2012-10-22 | 2017-12-12 | Raindance Technologies, Inc. | Methods for analyzing DNA |
| GB201218909D0 (en) | 2012-10-22 | 2012-12-05 | Univ Singapore | Assay for the parallel detection of biological material based on PCR |
| EP2925447B1 (en) | 2012-11-30 | 2020-04-08 | The Broad Institute, Inc. | High-throughput dynamic reagent delivery system |
| US9297784B2 (en) | 2012-12-05 | 2016-03-29 | Caliper Life Sciences, Inc. | Device and method for extracting target objects from a sample |
| US9745571B2 (en) | 2013-03-07 | 2017-08-29 | Bio-Rad Laboratories, Inc. | Repetitive reverse transcription partition assay |
| US9273349B2 (en) | 2013-03-14 | 2016-03-01 | Affymetrix, Inc. | Detection of nucleic acids |
| CN116218963A (zh) | 2013-03-15 | 2023-06-06 | 伯乐生命医学产品有限公司 | 关联靶的数字测定 |
| CN105164246B (zh) | 2013-03-15 | 2018-09-25 | 富鲁达公司 | 用于分析定义的多细胞组合的方法和设备 |
| CN105339777B (zh) | 2013-03-15 | 2020-12-18 | 贝克曼考尔特公司 | 用于流式细胞仪的光学系统 |
| EP4566715A3 (en) | 2013-04-02 | 2025-08-27 | Bio-Rad Laboratories, Inc. | Systems and methods for handling microfluidic droplets |
| EP3004391B1 (en) | 2013-05-29 | 2019-03-27 | Bio-Rad Laboratories, Inc. | Methods for sequencing in emulsion based microfluidics |
| US20150011397A1 (en) | 2013-06-17 | 2015-01-08 | Kim Lewis | Methods for quantitative determination of multiple proteins in complex mixtures |
| CN105555972B (zh) | 2013-07-25 | 2020-07-31 | 伯乐生命医学产品有限公司 | 遗传测定 |
| US10343165B2 (en) | 2013-09-05 | 2019-07-09 | Bio-Rad Laboratories, Inc. | On-demand particle dispensing system |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| KR20240025725A (ko) | 2013-12-11 | 2024-02-27 | 아큐라젠 홀딩스 리미티드 | 희귀 서열 변이를 검출하기 위한 조성물 및 방법 |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| EP2986742A4 (en) | 2014-01-10 | 2016-12-07 | Bio Rad Laboratories Inc | INTERCALING DYES FOR DIFFERENTIAL DETECTION |
| US8820538B1 (en) | 2014-03-17 | 2014-09-02 | Namocell LLC | Method and apparatus for particle sorting |
| LT3134536T (lt) | 2014-04-21 | 2020-05-11 | President And Fellows Of Harvard College | Sistemos ir būdai, skirti nukleorūgščių brūkšniniam kodavimui |
| WO2015200541A1 (en) | 2014-06-24 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Digital pcr barcoding |
| EP4574974A3 (en) | 2014-06-26 | 2025-10-08 | 10x Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| KR101702745B1 (ko) | 2014-11-13 | 2017-02-03 | 인제대학교 산학협력단 | 단일세포 분리장치 및 방법 |
| EP3230393B1 (en) | 2014-12-12 | 2019-04-24 | Marcella Chiari | New clickable polymers and gels for microarray and other applications |
| JP6962563B2 (ja) | 2015-05-12 | 2021-11-05 | 株式会社オンチップ・バイオテクノロジーズ | 単一粒子解析方法およびその解析のためのシステム |
| JP6518515B2 (ja) | 2015-05-28 | 2019-05-22 | 山洋電気株式会社 | モータ用センサ |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| EP3387128A4 (en) | 2015-12-07 | 2019-12-04 | Bio-Rad Laboratories, Inc. | MULTIPLEXING IN PARTITIONS ON THE BASIS OF MICROPARTICLES |
| EP3397764A4 (en) | 2015-12-30 | 2019-05-22 | Bio-Rad Laboratories, Inc. | DIGITAL PROTEIN QUANTIFICATION |
| BR112018068866B1 (pt) | 2016-03-17 | 2022-11-29 | Bd Biosciences | Classificação de células utilizando um citômetro de fluxo de fluorescência de alto rendimento |
| KR101870865B1 (ko) | 2016-04-15 | 2018-06-26 | 재단법인 실감교류인체감응솔루션연구단 | 삼차원 정보증강 비디오 씨쓰루 디스플레이 장치 및 방법, 렉티피케이션 장치 |
| US10036024B2 (en) | 2016-06-03 | 2018-07-31 | Purdue Research Foundation | siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD) |
| WO2018044831A1 (en) | 2016-08-30 | 2018-03-08 | Integrated Dna Technologies, Inc. | Cleavable hairpin primers |
| US10611995B2 (en) | 2018-08-15 | 2020-04-07 | Deepcell, Inc. | Systems and methods for particle analysis |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| JP3232525U (ja) | 2021-03-26 | 2021-06-17 | 加奈 安田 | 建設機械のアタッチメント取付け冶具および建設機械 |
-
2011
- 2011-02-11 JP JP2012553050A patent/JP5934657B2/ja active Active
- 2011-02-11 EP EP24197924.4A patent/EP4484577A3/en active Pending
- 2011-02-11 EP EP11742907.6A patent/EP2534267B1/en not_active Revoked
- 2011-02-11 EP EP24157134.8A patent/EP4435111A1/en active Pending
- 2011-02-11 US US13/026,120 patent/US9074242B2/en active Active
- 2011-02-11 EP EP18157363.5A patent/EP3392349A1/en not_active Ceased
- 2011-02-11 US US13/026,107 patent/US8535889B2/en active Active
- 2011-02-11 CA CA2789425A patent/CA2789425C/en active Active
- 2011-02-11 WO PCT/US2011/024615 patent/WO2011100604A2/en not_active Ceased
-
2013
- 2013-02-22 US US13/773,868 patent/US9441266B2/en active Active
- 2013-03-12 US US13/796,901 patent/US9228229B2/en active Active
-
2014
- 2014-04-29 US US14/264,686 patent/US9127310B2/en active Active
-
2016
- 2016-02-09 US US15/019,355 patent/US9745617B2/en active Active
- 2016-05-09 JP JP2016093744A patent/JP6263225B2/ja active Active
-
2017
- 2017-08-28 US US15/688,250 patent/US11254968B2/en active Active
- 2017-12-15 JP JP2017240665A patent/JP6558603B2/ja active Active
-
2019
- 2019-07-02 JP JP2019123457A patent/JP6867442B2/ja active Active
-
2021
- 2021-04-08 JP JP2021065558A patent/JP7220247B2/ja active Active
-
2022
- 2022-01-13 US US17/574,780 patent/US12454718B2/en active Active
- 2022-11-22 US US17/992,304 patent/US12351860B2/en active Active
-
2023
- 2023-01-30 JP JP2023011532A patent/JP7562724B2/ja active Active
- 2023-09-12 US US18/465,623 patent/US12378598B2/en active Active
- 2023-11-20 US US18/514,645 patent/US12031175B2/en active Active
- 2023-12-12 US US18/536,935 patent/US12241116B2/en active Active
-
2024
- 2024-09-25 JP JP2024166709A patent/JP2025011128A/ja active Pending
-
2025
- 2025-10-20 US US19/362,971 patent/US20260117283A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12241116B2 (en) | Digital analyte analysis | |
| US12529097B2 (en) | Digital analyte analysis | |
| EP2844768B1 (en) | Digital analyte analysis | |
| US20190330683A1 (en) | Digital analyte analysis | |
| EP2986762B1 (en) | Digital analyte analysis | |
| WO2014172373A2 (en) | Digital analyte analysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160113 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250128 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20250128 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250128 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 15TH ANNIV.) - STANDARD Year of fee payment: 15 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260203 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260203 |