ATE527383T1 - Multiplex-nukleinsäurenachweis - Google Patents
Multiplex-nukleinsäurenachweisInfo
- Publication number
- ATE527383T1 ATE527383T1 AT05813533T AT05813533T ATE527383T1 AT E527383 T1 ATE527383 T1 AT E527383T1 AT 05813533 T AT05813533 T AT 05813533T AT 05813533 T AT05813533 T AT 05813533T AT E527383 T1 ATE527383 T1 AT E527383T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid detection
- sample
- novel
- multiplex nucleic
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 239000000523 sample Substances 0.000 abstract 5
- 230000003321 amplification Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/NL2005/000807 WO2007061284A1 (en) | 2005-11-22 | 2005-11-22 | Multiplex nucleic acid detection |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE527383T1 true ATE527383T1 (de) | 2011-10-15 |
Family
ID=36396665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05813533T ATE527383T1 (de) | 2005-11-22 | 2005-11-22 | Multiplex-nukleinsäurenachweis |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120021930A1 (de) |
EP (1) | EP1969137B1 (de) |
JP (1) | JP2009516525A (de) |
AT (1) | ATE527383T1 (de) |
WO (1) | WO2007061284A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10533998B2 (en) | 2008-07-18 | 2020-01-14 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
EP2530167A1 (de) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Mikrofluidische Vorrichtungen |
WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US20090093378A1 (en) * | 2007-08-29 | 2009-04-09 | Helen Bignell | Method for sequencing a polynucleotide template |
CN101230404B (zh) * | 2008-02-04 | 2011-11-16 | 浙江理工大学 | 同时检测多种混合感染病毒的基因芯片 |
EP2315629B1 (de) | 2008-07-18 | 2021-12-15 | Bio-Rad Laboratories, Inc. | Tröpfchenbibliotheken |
CA2760439A1 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
EP2534267B1 (de) | 2010-02-12 | 2018-04-11 | Raindance Technologies, Inc. | Digitale analyse von analyten |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
EP3447155A1 (de) | 2010-09-30 | 2019-02-27 | Raindance Technologies, Inc. | Sandwichassays in tröpfchen |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
EP3859011A1 (de) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Verfahren zur bildung gemischter tröpfchen |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
CN102181443B (zh) * | 2011-03-21 | 2013-10-23 | 中国科学院植物研究所 | 一种多重检测基因组dna多态性的方法及其专用探针 |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013058907A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
EP3495817A1 (de) * | 2012-02-10 | 2019-06-12 | Raindance Technologies, Inc. | Molekulardiagnostischer screeningtest |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
US10227635B2 (en) * | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
US9222122B2 (en) | 2012-11-20 | 2015-12-29 | Src, Inc. | System and method for rapid detection and identification of nucleic acid labeled tags |
WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
EP3005200A2 (de) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Verfahren und systeme zur speicherung von sequenzlesedaten |
US9879313B2 (en) | 2013-06-25 | 2018-01-30 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
US20150141257A1 (en) * | 2013-08-02 | 2015-05-21 | Roche Nimblegen, Inc. | Sequence capture method using specialized capture probes (heatseq) |
KR20150029432A (ko) | 2013-09-10 | 2015-03-18 | 삼성전자주식회사 | 핵산 검출 방법 |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
WO2015057565A1 (en) | 2013-10-18 | 2015-04-23 | Good Start Genetics, Inc. | Methods for assessing a genomic region of a subject |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
CA2999708A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
CA3010579A1 (en) | 2015-01-06 | 2016-07-14 | Good Start Genetics, Inc. | Screening for structural variants |
EP4119677B1 (de) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
JP6979029B2 (ja) | 2016-03-24 | 2021-12-08 | バイオファイア・ダイアグノスティクス,リミテッド・ライアビリティ・カンパニー | 定量的増幅方法 |
EP3639022A4 (de) * | 2017-06-15 | 2021-03-10 | Technion - Research & Development Foundation Ltd | Zusammensetzungen und verfahren zur erkennung von genomvariationen |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
US20220025447A1 (en) | 2018-12-10 | 2022-01-27 | 10X Genomics, Inc. | Generating spatial arrays with gradients |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
EP3891300B1 (de) | 2019-12-23 | 2023-03-29 | 10X Genomics, Inc. | Verfahren zur räumlichen analyse mittels rna-template-ligation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
EP4153775A1 (de) | 2020-05-22 | 2023-03-29 | 10X Genomics, Inc. | Simultane räumlich-zeitliche messung der genexpression und der zellaktivität |
WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
EP4162074B1 (de) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon |
AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
EP4121555A1 (de) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes |
EP4196605A1 (de) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung |
WO2023218068A1 (en) * | 2022-05-12 | 2023-11-16 | Aplex Bio Ab | Methods and kits for detection of targets using pcr and padlock probes |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
US5719028A (en) | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
US20020034732A1 (en) * | 1997-07-30 | 2002-03-21 | Daniel J. Capon | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
JP4163386B2 (ja) | 1998-12-15 | 2008-10-08 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 環状化核酸プローブの増幅方法 |
US6593092B2 (en) * | 2000-04-04 | 2003-07-15 | Abbott Laboratories | Beta 2 adrenergic polymorphism detection |
AU2002246612B2 (en) * | 2000-10-24 | 2007-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic DNA |
EP1319718A1 (de) * | 2001-12-14 | 2003-06-18 | Keygene N.V. | Hochdurchsatzanalyse und Detektion von mehreren Zielsequenzen |
ATE554185T1 (de) * | 2003-02-27 | 2012-05-15 | Alnylam Pharmaceuticals Inc | Verfahren und konstrukte zur bewertung von rnai- zielen und effektormolekülen |
-
2005
- 2005-11-22 WO PCT/NL2005/000807 patent/WO2007061284A1/en active Application Filing
- 2005-11-22 JP JP2008542257A patent/JP2009516525A/ja active Pending
- 2005-11-22 EP EP05813533A patent/EP1969137B1/de not_active Not-in-force
- 2005-11-22 AT AT05813533T patent/ATE527383T1/de not_active IP Right Cessation
- 2005-11-22 US US12/085,407 patent/US20120021930A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2007061284A1 (en) | 2007-05-31 |
JP2009516525A (ja) | 2009-04-23 |
US20120021930A1 (en) | 2012-01-26 |
EP1969137A1 (de) | 2008-09-17 |
EP1969137B1 (de) | 2011-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE527383T1 (de) | Multiplex-nukleinsäurenachweis | |
WO2006128138A3 (en) | Biodetection by nucleic acid-templated chemistry | |
WO2009021031A3 (en) | Proximity ligation assay | |
DK2082238T3 (da) | Sekventiel analyse af biologiske prøver med intermediær fluorescensdetektorblegning | |
WO2008094902A3 (en) | Compositions and methods for the detection of a nucleic acid using a cleavage reaction | |
DK1381697T3 (da) | Cirkulær probe-amplifikation (CPA) af ringformede nukleinsyremolekyler | |
WO2009018003A3 (en) | Detection assays and use thereof | |
HK1150171A1 (en) | Compositions and methods for analysis of nucleic acid molecules during amplification reactions | |
ATE531820T1 (de) | Gesundheitszustandstest | |
WO2007030531A3 (en) | Reagents for testing and molecular imaging of liver cancer | |
MX2012004619A (es) | Ensayos regulados mediante proximidad para detectar proteinas de fusion oncogenicas. | |
WO2008105896A3 (en) | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label | |
BRPI0610092B8 (pt) | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado | |
DK1421211T3 (da) | Fremgangsmåder til detektion af DNA, som stammer fra forskellige individer | |
WO2008070865A3 (en) | Materials and methods for efficient and accurate detection of analytes | |
EA201170933A1 (ru) | Анализ нуклеиновых кислот, полученных из единичных клеток | |
WO2004027082A3 (en) | Methods and compositions for detecting targets | |
WO2007114986A3 (en) | Cooperative probes and methods of using them | |
WO2010107654A3 (en) | Split flow device for analyses of specific-binding partners | |
WO2009051214A1 (ja) | 核酸増幅法、それに用いる試薬及び試薬キット | |
CY1112553T1 (el) | Ανοσοπροσδιορισμοι υψηλης ευαισθησιας και κιτια για τον προσδιορισμο πεπτιδιων και πρωτεϊνων βιολογικου ενδιαφεροντος | |
BRPI0520067A2 (pt) | desenvolvimento de um ensaio de pcr em tempo real para a detecção de dna pneumocócico e diagnóstico da doença pneumocócica | |
WO2008085615A3 (en) | Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe | |
WO2006119326A3 (en) | Oligonucleotide probe/primer compositions and methods for polynucleotide detection | |
DK2021794T3 (da) | Anvendelse af protein S100A 12 som en markør for colorektal cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |