BRPI0610092B8 - métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado - Google Patents
métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associadoInfo
- Publication number
- BRPI0610092B8 BRPI0610092B8 BRPI0610092A BRPI0610092A BRPI0610092B8 BR PI0610092 B8 BRPI0610092 B8 BR PI0610092B8 BR PI0610092 A BRPI0610092 A BR PI0610092A BR PI0610092 A BRPI0610092 A BR PI0610092A BR PI0610092 B8 BRPI0610092 B8 BR PI0610092B8
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- methods
- analogue molecule
- detecting
- analyte
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Abstract
métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e para sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, usos do mesmo, de um composto, e de um método, molécula de ácido nucleico ou de análogo de ácido nucleico, produto de metalização, produto associado, e, composto. a invenção refere-se a métodos e reagentes para a detecção de analitos, e.g., ácidos nucleicos. os novos métodos e reagentes permitem uma detecção simples e sensível mesmo em amostras biológicas complexas.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67678505P | 2005-05-02 | 2005-05-02 | |
EP05009618 | 2005-05-02 | ||
EP05009618.9 | 2005-05-02 | ||
US60/676,785 | 2005-05-02 | ||
US75010005P | 2005-12-14 | 2005-12-14 | |
EP05027370.5 | 2005-12-14 | ||
EP05027370 | 2005-12-14 | ||
US60/750,100 | 2005-12-14 | ||
PCT/EP2006/004017 WO2006117161A2 (en) | 2005-05-02 | 2006-04-28 | New labelling strategies for the sensitive detection of analytes |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0610092A2 BRPI0610092A2 (pt) | 2008-12-09 |
BRPI0610092B1 BRPI0610092B1 (pt) | 2018-03-27 |
BRPI0610092B8 true BRPI0610092B8 (pt) | 2021-07-27 |
Family
ID=42676666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0610092A BRPI0610092B8 (pt) | 2005-05-02 | 2006-04-28 | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado |
Country Status (16)
Country | Link |
---|---|
US (1) | US8129315B2 (pt) |
EP (4) | EP2270228B1 (pt) |
JP (1) | JP4944098B2 (pt) |
AR (1) | AR053251A1 (pt) |
AT (1) | ATE479699T1 (pt) |
AU (1) | AU2006243370B2 (pt) |
BR (1) | BRPI0610092B8 (pt) |
CA (1) | CA2607530C (pt) |
DE (1) | DE602006016589D1 (pt) |
DK (1) | DK1877415T3 (pt) |
MX (1) | MX2007013296A (pt) |
PL (1) | PL1877415T3 (pt) |
PT (1) | PT1877415E (pt) |
SI (1) | SI1877415T1 (pt) |
TW (1) | TWI406952B (pt) |
WO (1) | WO2006117161A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
SI1877415T1 (sl) | 2005-05-02 | 2011-01-31 | Baseclick Gmbh | Nove označevalne strategije za senzitivno detekcijo analitov |
KR101335218B1 (ko) * | 2005-05-02 | 2013-12-12 | 바스프 에스이 | 분석물의 감응성 검출을 위한 신규한 표지화 전략 |
WO2007050811A2 (en) | 2005-10-27 | 2007-05-03 | The President And Fellows Of Harvard College | Methods and compositions for labeling nucleic acids |
US20070249014A1 (en) * | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
US8114636B2 (en) * | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
TW200808975A (en) * | 2006-04-28 | 2008-02-16 | Basf Ag | Molecular beacons for DNA-photography |
DK2089343T3 (da) * | 2006-10-31 | 2011-10-24 | Baseclick Gmbh | Click-kemi til fremstilling af reportermolekyler |
TW200827703A (en) * | 2006-11-09 | 2008-07-01 | Basf Ag | Photographic determination of analytes |
GB0718255D0 (en) * | 2007-09-19 | 2007-10-31 | Univ Edinburgh | Nucleobase characterisation |
EP2053131A1 (en) * | 2007-10-19 | 2009-04-29 | Ludwig-Maximilians-Universität München | Method for determining methylation at deoxycytosine residues |
DK2222341T3 (en) | 2007-11-21 | 2015-03-09 | Univ Georgia | AND METHODS alkynes of reacting alkynes of 1,3-dipole FUNCTIONAL COMPOUNDS |
US20110118142A1 (en) * | 2008-05-16 | 2011-05-19 | Life Technologies Corporation | Dual labeling methods for measuring cellular proliferation |
WO2010010198A2 (en) | 2008-07-25 | 2010-01-28 | Basf Se | New azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
US8618297B2 (en) | 2008-07-25 | 2013-12-31 | Basf Se | Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
AU2009298802A1 (en) * | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
EP2239053A1 (en) | 2009-04-09 | 2010-10-13 | baseclick GmbH | Click chemistry on heterogeneous catalysts |
EP3663750B1 (en) | 2009-05-29 | 2021-11-03 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
CN104540525A (zh) | 2012-07-10 | 2015-04-22 | 贝瑟克里科有限公司 | 大麻素修饰的核酸分子 |
CN111394444A (zh) | 2013-09-13 | 2020-07-10 | 生命技术公司 | 使用凝聚核酸颗粒的装置制备 |
EP3344782A1 (en) * | 2015-08-31 | 2018-07-11 | Life Technologies Corporation | Colorimetric labeling and detection methods and compositions |
CN113015740A (zh) * | 2018-10-05 | 2021-06-22 | 德克萨斯大学系统董事会 | 固相n-末端肽的捕获和释放 |
US20240052391A1 (en) | 2020-10-29 | 2024-02-15 | Dna Script | Enzymatic Synthesis of Polynucleotide Probes |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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GB2209754A (en) * | 1987-09-17 | 1989-05-24 | Thomas Lee Mattson | Polyaldehydic polynucleotides in use as probes,their preparation and use |
AU636110B2 (en) * | 1988-06-08 | 1993-04-22 | Nichols Institute Diagnostics | Assays utilizing sensitizer-induced production of detectable signal |
US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
EP2256133B1 (en) * | 1997-01-08 | 2016-12-14 | Sigma-Aldrich Co. LLC | Bioconjugation of macromolecules |
US7427678B2 (en) * | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
US6727356B1 (en) * | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
DE10013600A1 (de) * | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
KR20040087329A (ko) * | 2002-02-28 | 2004-10-13 | 아스트라제네카 아베 | 3-시클릴-5-(질소-함유 5-원 고리) 메틸-옥사졸리디논유도체 및 그의 항균제로서의 용도 |
WO2003079014A1 (en) | 2002-03-03 | 2003-09-25 | Activx Biosciences, Inc. | Tethered activity-based probes and uses thereof |
EP2226316B1 (en) | 2002-05-30 | 2016-01-13 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
AU2003297859A1 (en) * | 2002-12-13 | 2004-07-09 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
KR100540509B1 (ko) * | 2004-01-07 | 2006-01-11 | 학교법인 포항공과대학교 | 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체 |
US7745118B2 (en) * | 2004-04-08 | 2010-06-29 | Roche Nimblegen, Inc. | Comparative genomic resequencing |
WO2006116629A2 (en) | 2005-04-27 | 2006-11-02 | Siemens Medical Solutions Usa, Inc. | The preparation of molecular imaging probes using click chemistry |
SI1877415T1 (sl) | 2005-05-02 | 2011-01-31 | Baseclick Gmbh | Nove označevalne strategije za senzitivno detekcijo analitov |
WO2007050811A2 (en) | 2005-10-27 | 2007-05-03 | The President And Fellows Of Harvard College | Methods and compositions for labeling nucleic acids |
DK2089343T3 (da) * | 2006-10-31 | 2011-10-24 | Baseclick Gmbh | Click-kemi til fremstilling af reportermolekyler |
-
2006
- 2006-04-28 SI SI200630838T patent/SI1877415T1/sl unknown
- 2006-04-28 PT PT06742750T patent/PT1877415E/pt unknown
- 2006-04-28 PL PL06742750T patent/PL1877415T3/pl unknown
- 2006-04-28 CA CA2607530A patent/CA2607530C/en active Active
- 2006-04-28 JP JP2008509350A patent/JP4944098B2/ja active Active
- 2006-04-28 EP EP10171618.1A patent/EP2270228B1/en active Active
- 2006-04-28 EP EP06742750A patent/EP1877415B1/en active Active
- 2006-04-28 MX MX2007013296A patent/MX2007013296A/es not_active Application Discontinuation
- 2006-04-28 AU AU2006243370A patent/AU2006243370B2/en active Active
- 2006-04-28 WO PCT/EP2006/004017 patent/WO2006117161A2/en active Application Filing
- 2006-04-28 DK DK06742750.0T patent/DK1877415T3/da active
- 2006-04-28 EP EP10177873A patent/EP2266996A3/en not_active Withdrawn
- 2006-04-28 AR ARP060101744A patent/AR053251A1/es active IP Right Grant
- 2006-04-28 TW TW095115452A patent/TWI406952B/zh active
- 2006-04-28 EP EP10171611.6A patent/EP2256126B1/en active Active
- 2006-04-28 AT AT06742750T patent/ATE479699T1/de active
- 2006-04-28 BR BRPI0610092A patent/BRPI0610092B8/pt active IP Right Grant
- 2006-04-28 DE DE602006016589T patent/DE602006016589D1/de active Active
- 2006-04-28 US US11/913,156 patent/US8129315B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
SI1877415T1 (sl) | 2011-01-31 |
EP2256126A1 (en) | 2010-12-01 |
ATE479699T1 (de) | 2010-09-15 |
EP2270228A1 (en) | 2011-01-05 |
CA2607530A1 (en) | 2006-11-09 |
EP1877415B1 (en) | 2010-09-01 |
EP2270228B1 (en) | 2013-08-21 |
TWI406952B (zh) | 2013-09-01 |
EP1877415A2 (en) | 2008-01-16 |
BRPI0610092A2 (pt) | 2008-12-09 |
US20090215635A1 (en) | 2009-08-27 |
US8129315B2 (en) | 2012-03-06 |
PT1877415E (pt) | 2010-12-09 |
PL1877415T3 (pl) | 2011-02-28 |
WO2006117161A2 (en) | 2006-11-09 |
AU2006243370A1 (en) | 2006-11-09 |
BRPI0610092B1 (pt) | 2018-03-27 |
DK1877415T3 (da) | 2010-12-20 |
MX2007013296A (es) | 2007-12-13 |
EP2256126B1 (en) | 2015-07-01 |
JP2008539703A (ja) | 2008-11-20 |
CA2607530C (en) | 2014-07-08 |
EP2266996A3 (en) | 2011-06-15 |
AR053251A1 (es) | 2007-04-25 |
DE602006016589D1 (de) | 2010-10-14 |
TW200720441A (en) | 2007-06-01 |
WO2006117161A3 (en) | 2007-01-11 |
EP2266996A2 (en) | 2010-12-29 |
JP4944098B2 (ja) | 2012-05-30 |
AU2006243370B2 (en) | 2012-06-28 |
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/04/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |